This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this g... See more...

Aliases for ALOX15 Gene

Aliases for ALOX15 Gene

  • Arachidonate 15-Lipoxygenase 2 3 4 5
  • 15-LOX-1 2 3 4
  • Polyunsaturated Fatty Acid Lipoxygenase ALOX15 3 4
  • Arachidonate 12-Lipoxygenase, Leukocyte-Type 3 4
  • Arachidonate Omega-6 Lipoxygenase 3 4
  • Hepoxilin A3 Synthase Alox15 3 4
  • Linoleate 13S-Lipoxygenase 3 4
  • 12/15-Lipoxygenase 3 4
  • 12-LOX 3 4
  • 15-LOX 3 4
  • LOG15 3 4
  • 15-Lipoxygenase Type 1 3
  • 15-Lipooxygenase-1 3
  • 15-LOX Type 1 3
  • EC 1.13.11.31 4
  • EC 1.13.11.33 4
  • EC 1.13.11.12 4
  • EC 1.13.11.- 4
  • EC 1.13.11 51
  • ALOX15 5

External Ids for ALOX15 Gene

Previous GeneCards Identifiers for ALOX15 Gene

  • GC17M004960
  • GC17M004879
  • GC17M004485
  • GC17M004740
  • GC17M004480
  • GC17M004534

Summaries for ALOX15 Gene

Entrez Gene Summary for ALOX15 Gene

  • This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

GeneCards Summary for ALOX15 Gene

ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include Asthma, Nasal Polyps, And Aspirin Intolerance and Periventricular Leukomalacia. Among its related pathways are Eicosanoid Synthesis and HETE and HPETE biosynthesis and metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. An important paralog of this gene is ALOX12.

UniProtKB/Swiss-Prot Summary for ALOX15 Gene

  • Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:23242647, PubMed:25293588, PubMed:1944593, PubMed:17052953, PubMed:8334154, PubMed:24282679). Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE (PubMed:1944593, PubMed:17052953, PubMed:8334154, PubMed:24282679). Also converts linoleic acid into 13-hydroperoxyoctadecadienoic acid (PubMed:8334154). Converts epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution between hydroperoxy and epoxy moieties leading to the formation of monocyclic endoperoxides (PubMed:25293588). May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3 (By similarity). Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed:21831839). In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass (By similarity).

Tocris Summary for ALOX15 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Gene Wiki entry for ALOX15 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALOX15 Gene

Genomics for ALOX15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALOX15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J004641 Promoter 0.5 EPDnew 600.7 +0.6 596 0.1 EZH2 HDAC2 ALOX15 LOC105371498 SMTNL2
GH17J004583 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +56.5 56465 7.8 CTCF PRDM10 ZNF692 ZIC2 RBFOX2 PKNOX1 PATZ1 ZNF501 ZNF600 ZNF341 SMTNL2 GGT6 RNU6-955P ALOX15 SHPK DERL2 VMO1 LINC01996
GH17J004575 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.3 +65.7 65652 2.5 HNRNPL GATAD2A ZIC2 RBFOX2 RXRB SP1 SOX13 ZBTB20 ESR1 CTBP1 piR-31432-268 piR-55650-268 piR-45471-242 piR-49732-225 piR-46662-265 RNU6-955P ALOX15 GGT6 SMTNL2 ZNF232-AS1
GH17J004594 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +47.1 47144 1.1 CTCF RBFOX2 REST NRF1 RAD21 HIC1 ZNF143 ZKSCAN8 RNU6-955P ALOX15 GGT6 SMTNL2 LINC01996
GH17J004678 Enhancer 0.9 Ensembl ENCODE 12.5 -37.4 -37407 3.4 CREB1 PRDM10 ZNF629 PRDM1 HDAC1 ZNF600 SP1 ZNF639 HMBOX1 JUND piR-56497-061 ARRB2 ALOX15 ZFP3 lnc-ALOX15-1 ENSG00000235085 PELP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALOX15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALOX15

Top Transcription factor binding sites by QIAGEN in the ALOX15 gene promoter:
  • ATF
  • c-Myc
  • GATA-1
  • HOXA5
  • LCR-F1
  • LUN-1
  • Max
  • Sp1
  • ZID

Genomic Locations for ALOX15 Gene

Genomic Locations for ALOX15 Gene
chr17:4,630,919-4,642,294
(GRCh38/hg38)
Size:
11,376 bases
Orientation:
Minus strand
chr17:4,534,197-4,545,589
(GRCh37/hg19)
Size:
11,393 bases
Orientation:
Minus strand

Genomic View for ALOX15 Gene

Genes around ALOX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALOX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALOX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX15 Gene

Proteins for ALOX15 Gene

  • Protein details for ALOX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16050-LOX15_HUMAN
    Recommended name:
    Polyunsaturated fatty acid lipoxygenase ALOX15
    Protein Accession:
    P16050
    Secondary Accessions:
    • A8K2P4
    • B7ZA11
    • Q8N6R7
    • Q99657

    Protein attributes for ALOX15 Gene

    Size:
    662 amino acids
    Molecular mass:
    74804 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    • Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for ALOX15 Gene

    Alternative splice isoforms for ALOX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX15 Gene

Selected DME Specific Peptides for ALOX15 Gene

P16050:
  • LDDFNRIFWCG
  • HLGQLDW
  • LWLVGQHGE
  • GIKANVILC
  • CPPDDLA
  • KFREELA
  • GMEELQAQLEKEL
  • WVRSSDF
  • WVPNAPCTMR
  • RYTLEIN
  • EEYFSGP
  • GTLFEADF
  • FGYQFLNG
  • LLFVKLRKRHLL
  • FNRIFWCGQSKLAE
  • DLPVDERFLEDK
  • MCIFTCTGQH
  • DAWFCNWISV
  • LYRWGNWKDG
  • PYEYLRPS

Post-translational modifications for ALOX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX15 Gene

Domains & Families for ALOX15 Gene

Gene Families for ALOX15 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for ALOX15 Gene

InterPro:
Blocks:
  • Lipoxygenase, LH2 domain
  • Lipoxygenase
  • Mammalian lipoxygenase signature
ProtoNet:

Suggested Antigen Peptide Sequences for ALOX15 Gene

GenScript: Design optimal peptide antigens:
  • Arachidonate 15-lipoxygenase, isoform CRA_a (D3DTK1_HUMAN)
  • Arachidonate omega-6 lipoxygenase (LOX15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16050

UniProtKB/Swiss-Prot:

LOX15_HUMAN :
  • The PLAT domain can bind calcium ions; this promotes association with membranes.
  • Belongs to the lipoxygenase family.
Domain:
  • The PLAT domain can bind calcium ions; this promotes association with membranes.
Family:
  • Belongs to the lipoxygenase family.
genes like me logo Genes that share domains with ALOX15: view

Function for ALOX15 Gene

Molecular function for ALOX15 Gene

UniProtKB/Swiss-Prot Function:
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:23242647, PubMed:25293588, PubMed:1944593, PubMed:17052953, PubMed:8334154, PubMed:24282679). Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE (PubMed:1944593, PubMed:17052953, PubMed:8334154, PubMed:24282679). Also converts linoleic acid into 13-hydroperoxyoctadecadienoic acid (PubMed:8334154). Converts epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution between hydroperoxy and epoxy moieties leading to the formation of monocyclic endoperoxides (PubMed:25293588). May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3 (By similarity). Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed:21831839). In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:10428, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57444; EC=1.13.11.31; Evidence={ECO:0000269|PubMed:1944593};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:16869, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57446; EC=1.13.11.33; Evidence={ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:1944593, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:8334154};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate; Xref=Rhea:RHEA:22780, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57466; EC=1.13.11.12; Evidence={ECO:0000269|PubMed:8334154};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate; Xref=Rhea:RHEA:50928, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:133900; Evidence={ECO:0000269|PubMed:8334154};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:50924, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:133899; Evidence={ECO:0000269|PubMed:8334154};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate; Xref=Rhea:RHEA:50288, ChEBI:CHEBI:15379, ChEBI:CHEBI:131964, ChEBI:CHEBI:132068; Evidence={ECO:0000269|PubMed:25293588};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50284, ChEBI:CHEBI:15379, ChEBI:CHEBI:131964, ChEBI:CHEBI:132065; Evidence={ECO:0000269|PubMed:25293588};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:50280, ChEBI:CHEBI:15379, ChEBI:CHEBI:131965, ChEBI:CHEBI:132067; Evidence={ECO:0000269|PubMed:25293588};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50276, ChEBI:CHEBI:15379, ChEBI:CHEBI:131965, ChEBI:CHEBI:132063; Evidence={ECO:0000269|PubMed:25293588};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:50152, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:82626; Evidence={ECO:0000269|PubMed:23242647};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:50140, ChEBI:CHEBI:15377, ChEBI:CHEBI:57446, ChEBI:CHEBI:132070; Evidence={ECO:0000269|PubMed:23242647};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:50216, ChEBI:CHEBI:57444, ChEBI:CHEBI:132129; Evidence={ECO:0000250|UniProtKB:Q02759};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50160, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132061; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate; Xref=Rhea:RHEA:50176, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132075; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50168, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132073; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50172, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132074; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:43472, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:83336; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate; Xref=Rhea:RHEA:50824, ChEBI:CHEBI:15379, ChEBI:CHEBI:77226, ChEBI:CHEBI:133799; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate; Xref=Rhea:RHEA:50836, ChEBI:CHEBI:15379, ChEBI:CHEBI:77224, ChEBI:CHEBI:133798; Evidence={ECO:0000250|UniProtKB:P16469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50156, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132062; Evidence={ECO:0000250|UniProtKB:P12530};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate; Xref=Rhea:RHEA:50180, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132078; Evidence={ECO:0000250|UniProtKB:P12530};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50188, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132076; Evidence={ECO:0000250|UniProtKB:P12530};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50184, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132077; Evidence={ECO:0000250|UniProtKB:P12530};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-irradiation.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3 uM for (9Z,12Z)-octadecadienoate {ECO:0000269|PubMed:8334154}; KM=12 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:8334154}; KM=3.8 uM for (9Z,12Z)-octadecadienoate {ECO:0000269|PubMed:24282679}; Vmax=10.6 umol/min/mg enzyme toward (9Z,12Z)-octadecadienoate {ECO:0000269|PubMed:8334154}; Vmax=5.6 umol/min/mg enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:8334154}; Note=kcat is 14.4 sec(-1) with (9Z,12Z)-octadecadienoate as substrate. {ECO:0000269|PubMed:24282679}; pH dependence: Optimum pH is 7 with (9Z,12Z)-octadecadienoate as substrate. {ECO:0000269|PubMed:8334154};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is increased by binding phosphatidylinositol phosphates, especially phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (PubMed:17052953). Inactivated at 37 degrees Celsius by (13S)-hydroperoxy-(9Z,11E)-octadecadienoate (PubMed:8334154).
GENATLAS Biochemistry:
arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,upregulated by mutant TP53 and maybe involved in the development of prostate or colorectal carcinomas

Enzyme Numbers (IUBMB) for ALOX15 Gene

Phenotypes From GWAS Catalog for ALOX15 Gene

Gene Ontology (GO) - Molecular Function for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004052 arachidonate 12-lipoxygenase activity IBA,IDA 1944593
GO:0005506 iron ion binding ISS --
GO:0005515 protein binding IPI 21831839
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 17052953
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ALOX15: view
genes like me logo Genes that share phenotypes with ALOX15: view

Animal Models for ALOX15 Gene

MGI Knock Outs for ALOX15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX15

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX15 Gene

Localization for ALOX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX15 Gene

Cytoplasm, cytosol. Cell membrane. Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). {ECO:0000250 UniProtKB:P39654}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALOX15 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 3
extracellular 2
cytoskeleton 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005811 lipid droplet IEA,IDA 19528634
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA,ISS --
GO:0016020 membrane IEA,IDA 21831839
genes like me logo Genes that share ontologies with ALOX15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ALOX15 Gene

Pathways & Interactions for ALOX15 Gene

genes like me logo Genes that share pathways with ALOX15: view

Pathways by source for ALOX15 Gene

1 GeneGo (Thomson Reuters) pathway for ALOX15 Gene
  • HETE and HPETE biosynthesis and metabolism
1 Qiagen pathway for ALOX15 Gene
  • DHA Signaling

UniProtKB/Swiss-Prot P16050-LOX15_HUMAN

  • Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.

SIGNOR curated interactions for ALOX15 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification ISS --
GO:0002820 negative regulation of adaptive immune response ISS --
GO:0006629 lipid metabolic process IEA,IDA 23242647
GO:0006631 fatty acid metabolic process IEA --
GO:0006646 phosphatidylethanolamine biosynthetic process ISS --
genes like me logo Genes that share ontologies with ALOX15: view

Drugs & Compounds for ALOX15 Gene

(18) Drugs for ALOX15 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved, Experimental Pharma 1560
linoleic acid Approved, Experimental Pharma Agonist, Full agonist, Activator, Pore Blocker, Channel blocker 0
Oxygen Approved, Vet_approved Pharma 0
cannabidiol Approved, Investigational Pharma Agonist, Partial agonist, Antagonist, Channel blocker, Activator, Enzyme, inhibitor 0
arachidonic acid Experimental Pharma Activator, Agonist, Inhibitor, Activation, Potentiation 40

(14) Additional Compounds for ALOX15 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
13-L-Hydroperoxylinoleic acid
  • (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoate
  • (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
  • (9Z,11E,13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
  • 13S-Hydroperoxy-9Z,11E-octadecadienoic acid
  • 13-L-Hydroperoxylinoleate
33964-75-9
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
70981-96-3
9(S)-HPODE

(5) Tocris Compounds for ALOX15 Gene

Compound Action Cas Number
2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor 132465-10-2
Baicalein 5- and 12-Lipoxygenase inhibitor 491-67-8
BAY-X 1005 Orally active 5-lipoxygenase activating protein (FLAP) inhibitor 128253-31-6
BW-B 70C 5-Lipoxygenase inhibitor 134470-38-5
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) 118414-82-7
genes like me logo Genes that share compounds with ALOX15: view

Transcripts for ALOX15 Gene

mRNA/cDNA for ALOX15 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX15

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ALOX15 Gene

GeneLoc Exon Structure for
ALOX15

Expression for ALOX15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALOX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x26.7) and Heart - Atrial Appendage (x4.6).

Protein differential expression in normal tissues from HIPED for ALOX15 Gene

This gene is overexpressed in Nasal epithelium (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALOX15 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALOX15

SOURCE GeneReport for Unigene cluster for ALOX15 Gene:

Hs.73809

mRNA Expression by UniProt/SwissProt for ALOX15 Gene:

P16050-LOX15_HUMAN
Tissue specificity: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.

Evidence on tissue expression from TISSUES for ALOX15 Gene

  • Blood(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Heart(2.5)
  • Intestine(2.5)
  • Kidney(2.2)
  • Muscle(2.1)
  • Liver(2.1)
  • Bone marrow(2)
  • Lymph node(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with ALOX15: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX15 Gene

Orthologs for ALOX15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ALOX15 30 31
  • 99.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ALOX12 31
  • 87 (a)
OneToOne
ALOX15 30
  • 86.86 (n)
Dog
(Canis familiaris)
Mammalia ALOX15 30 31
  • 84.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Alox15 30
  • 78.5 (n)
Mouse
(Mus musculus)
Mammalia Alox15 30 17 31
  • 77.79 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 67 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ALOX15 31
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii alox12 31
  • 44 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
ManyToMany
CSA.6148 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Species where no ortholog for ALOX15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ALOX15 Gene

ENSEMBL:
Gene Tree for ALOX15 (if available)
TreeFam:
Gene Tree for ALOX15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALOX15: view image

Paralogs for ALOX15 Gene

Paralogs for ALOX15 Gene

(6) SIMAP similar genes for ALOX15 Gene using alignment to 5 proteins:

  • LOX15_HUMAN
  • B7ZA11_HUMAN
  • D3DTK1_HUMAN
  • F5H0G8_HUMAN
  • I3L175_HUMAN

Pseudogenes.org Pseudogenes for ALOX15 Gene

genes like me logo Genes that share paralogs with ALOX15: view

Variants for ALOX15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALOX15 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
710975 Likely Benign: not provided 4,631,895(-) G/A SYNONYMOUS_VARIANT
717383 Likely Benign: not provided 4,639,499(-) C/G MISSENSE_VARIANT
717665 Likely Benign: not provided 4,631,891(-) T/C MISSENSE_VARIANT
722031 Benign: not provided 4,637,180(-) G/A SYNONYMOUS_VARIANT
727866 Benign: not provided 4,631,648(-) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ALOX15 Gene

Structural Variations from Database of Genomic Variants (DGV) for ALOX15 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv574274 CNV gain 21841781
nsv952111 CNV deletion 24416366
nsv962250 CNV duplication 23825009

Variation tolerance for ALOX15 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALOX15 Gene

Human Gene Mutation Database (HGMD)
ALOX15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALOX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX15 Gene

Disorders for ALOX15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ALOX15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma, nasal polyps, and aspirin intolerance
  • asa triad
periventricular leukomalacia
  • pvl
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

LOX15_HUMAN
  • Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Met at position 560 may confer interindividual susceptibility to coronary artery disease (CAD) (PubMed:17959182). {ECO:0000269 PubMed:17959182}.

Additional Disease Information for ALOX15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ALOX15: view

No data available for Genatlas for ALOX15 Gene

Publications for ALOX15 Gene

  1. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. (PMID: 17959182) Assimes TL … Quertermous T (Atherosclerosis 2008) 3 4 23 41
  2. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 23 41
  3. Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. (PMID: 18755188) Yoo H … Kim TY (FEBS letters 2008) 3 4 23
  4. 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. (PMID: 18392641) McCaskie PA … Palmer LJ (Human genetics 2008) 3 23 41
  5. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PMID: 17520163) Mullin BH … Wilson SG (Calcified tissue international 2007) 3 23 41

Products for ALOX15 Gene

Sources for ALOX15 Gene