Aliases for ALOX12 Gene
- Arachidonate 12-Lipoxygenase, 12S Type 2 3 5
- 12S-LOX 2 3 4
- Polyunsaturated Fatty Acid Lipoxygenase ALOX12 3 4
- Arachidonate 12-Lipoxygenase, 12S-Type 2 3
- Arachidonate (12S)-Lipoxygenase 3 4
- Arachidonate (15S)-Lipoxygenase 3 4
- Platelet-Type Lipoxygenase 12 3 4
- Lipoxin Synthase 12-LO 3 4
- 12S-Lipoxygenase 3 4
- Platelet 12-LOX 2 3
- LOG12 3 4
- Arachidonate 15-Lipoxygenase,15S-Type 3
External Ids for ALOX12 Gene
Previous GeneCards Identifiers for ALOX12 Gene
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
GeneCards Summary for ALOX12 Gene
ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) is a Protein Coding gene. Diseases associated with ALOX12 include Toxoplasmosis and Squamous Cell Carcinoma. Among its related pathways are Eicosanoid Synthesis and HETE and HPETE biosynthesis and metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and arachidonate 12-lipoxygenase activity. An important paralog of this gene is ALOX15.
UniProtKB/Swiss-Prot Summary for ALOX12 Gene
Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922). Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8250832, PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). In contrast does not react towards methyl esters of linoleic and arachidonic acids (By similarity). Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4 (PubMed:8250832). Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor (PubMed:9751607, PubMed:16638750). Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance (PubMed:23578768). May also play a role in the control of cell migration and proliferation (PubMed:22237009).
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.