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This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets ... See more...
Aliases for ALOX12 Gene
Aliases for ALOX12 Gene
- Arachidonate 12-Lipoxygenase, 12S Type 2 3 5
- 12S-LOX 2 3 4
- Polyunsaturated Fatty Acid Lipoxygenase ALOX12 3 4
- Arachidonate 12-Lipoxygenase, 12S-Type 2 3
- Arachidonate (12S)-Lipoxygenase 3 4
- Arachidonate (15S)-Lipoxygenase 3 4
- Platelet-Type Lipoxygenase 12 3 4
- Lipoxin Synthase 12-LO 3 4
- 12S-Lipoxygenase 3 4
- Platelet 12-LOX 2 3
- LOG12 3 4
- Arachidonate 15-Lipoxygenase,15S-Type 3
External Ids for ALOX12 Gene
- HGNC: 429
- Entrez Gene: 239
- Ensembl: ENSG00000108839
- OMIM: 152391
- UniProtKB: P18054
Previous GeneCards Identifiers for ALOX12 Gene
- GC17P007287
- GC17P007630
- GC17P006741
- GC17P007099
- GC17P006840
- GC17P006899
- GC17P006998
Summaries for ALOX12 Gene
-
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
GeneCards Summary for ALOX12 Gene
ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) is a Protein Coding gene. Diseases associated with ALOX12 include Toxoplasmosis and Squamous Cell Carcinoma. Among its related pathways are Eicosanoid Synthesis and HETE and HPETE biosynthesis and metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and arachidonate 12-lipoxygenase activity. An important paralog of this gene is ALOX15.
UniProtKB/Swiss-Prot Summary for ALOX12 Gene
-
Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922). Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8250832, PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). In contrast does not react towards methyl esters of linoleic and arachidonic acids (By similarity). Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4 (PubMed:8250832). Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor (PubMed:9751607, PubMed:16638750). Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance (PubMed:23578768). May also play a role in the control of cell migration and proliferation (PubMed:22237009).
-
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.
Additional gene information for ALOX12 Gene
- HGNC(429)
- Entrez Gene(239)
- Ensembl(ENSG00000108839)
- OMIM(152391)
- UniProtKB(P18054)
- Open Targets Platform(ENSG00000108839)
- Monarch Initiative
- Search for ALOX12 at DataMed
- Search for ALOX12 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALOX12 Gene
Genomics for ALOX12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ALOX12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALOX12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALOX12
- Top Transcription factor binding sites by QIAGEN in the ALOX12 gene promoter:
-
- AML1a
- FOXL1
- Lmo2
- LyF-1
- Nkx2-5
- YY1
- Zic1
- ZIC2
Genomic Locations for ALOX12 Gene
Genomic Locations for ALOX12 Gene
- chr17:6,993,791-7,010,754
- (GRCh38/hg38)
- Size:
- 16,964 bases
- Orientation:
- Plus strand
- chr17:6,899,384-6,914,055
- (GRCh37/hg19)
- Size:
- 14,672 bases
- Orientation:
- Plus strand
Genomic View for ALOX12 Gene
Genes around ALOX12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by HGNC
- 17p13.1 by Entrez Gene
- 17p13.1 by Ensembl
ALOX12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALOX12 Gene
Proteins for ALOX12 Gene
-
Protein details for ALOX12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18054-LOX12_HUMAN
- Recommended name:
- Polyunsaturated fatty acid lipoxygenase ALOX12
- Protein Accession:
- P18054
- O95569
- Q6ISF8
- Q9UQM4
Protein attributes for ALOX12 Gene
- Size:
- 663 amino acids
- Molecular mass:
- 75694 Da
- Cofactor:
- Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Quaternary structure:
- No Data Available
Protein Expression for ALOX12 Gene
Selected DME Specific Peptides for ALOX12 Gene
- P18054:
-
- CPPDDLA
- GMEELQAQLEKEL
- WVPNAPCTMR
Post-translational modifications for ALOX12 Gene
Other Protein References for ALOX12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ALOX12 / 12 Lipoxygenase Antibody
- Creative Diagnostics Anti-ALOX12 monoclonal antibody, clone FQS22491(C)
- Creative Biolabs Recombinant Anti-Human ALOX12 Antibody and Mouse Anti-ALOX12 Recombinant Antibody (2D10)
- Novus Biologicals Antibodies for ALOX12
-
Abcam antibodies for ALOX12
- Invitrogen Antibodies for ALOX12 (AFLGC-ALOX12)
-
Boster Bio Antibodies for ALOX12
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALOX12
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ALOX12
- Origene Custom Protein Services for ALOX12
-
Signalway Proteins for ALOX12
-
Abcam proteins for ALOX12
Assay Products
- Creative Diagnostics Human ALOX12 ELISA Matched Antibody Pair
- Novus Biologicals ELISA Kits for ALOX12
Domains & Families for ALOX12 Gene
Gene Families for ALOX12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for ALOX12 Gene
- InterPro:
- Blocks:
-
- Lipoxygenase, LH2 domain
- Lipoxygenase
- Mammalian lipoxygenase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for ALOX12 Gene
- GenScript: Design optimal peptide antigens:
-
- Platelet-type lipoxygenase 12 (LOX12_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P18054- Family:
-
- Belongs to the lipoxygenase family.
Function for ALOX12 Gene
Molecular function for ALOX12 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922). Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8250832, PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). In contrast does not react towards methyl esters of linoleic and arachidonic acids (By similarity). Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4 (PubMed:8250832). Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor (PubMed:9751607, PubMed:16638750). Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance (PubMed:23578768). May also play a role in the control of cell migration and proliferation (PubMed:22237009).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate; Xref=Rhea:RHEA:10428, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57444; EC=1.13.11.31; Evidence={ECO:0000269|PubMed:17493578, ECO:0000269|PubMed:22984144, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:8319693, ECO:0000269|PubMed:8500694};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate; Xref=Rhea:RHEA:16869, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57446; EC=1.13.11.33; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4; Xref=Rhea:RHEA:48584, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57463, ChEBI:CHEBI:67026; Evidence={ECO:0000269|PubMed:1851637, ECO:0000269|PubMed:8250832};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4; Xref=Rhea:RHEA:48588, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57463, ChEBI:CHEBI:67031; Evidence={ECO:0000269|PubMed:8250832};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O; Xref=Rhea:RHEA:53532, ChEBI:CHEBI:15377, ChEBI:CHEBI:78048, ChEBI:CHEBI:131958; Evidence={ECO:0000269|PubMed:23504711};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50184, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132077; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine; Xref=Rhea:RHEA:50172, ChEBI:CHEBI:15379, ChEBI:CHEBI:132071, ChEBI:CHEBI:132074; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate; Xref=Rhea:RHEA:50180, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132078; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate; Xref=Rhea:RHEA:50176, ChEBI:CHEBI:15379, ChEBI:CHEBI:132072, ChEBI:CHEBI:132075; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50188, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132076; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine; Xref=Rhea:RHEA:50168, ChEBI:CHEBI:15379, ChEBI:CHEBI:59002, ChEBI:CHEBI:132073; Evidence={ECO:0000269|PubMed:17493578};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50160, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132061; Evidence={ECO:0000269|PubMed:18311922};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine; Xref=Rhea:RHEA:50156, ChEBI:CHEBI:15379, ChEBI:CHEBI:132060, ChEBI:CHEBI:132062; Evidence={ECO:0000269|PubMed:18311922};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:41332, ChEBI:CHEBI:15379, ChEBI:CHEBI:77016, ChEBI:CHEBI:78048; Evidence={ECO:0000269|PubMed:25036362};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 12S-HpEPE; Xref=Rhea:RHEA:48704, ChEBI:CHEBI:15379, ChEBI:CHEBI:58562, ChEBI:CHEBI:90772; Evidence={ECO:0000269|PubMed:22984144};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:41328, ChEBI:CHEBI:15379, ChEBI:CHEBI:71589, ChEBI:CHEBI:78047; Evidence={ECO:0000269|PubMed:22984144};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate; Xref=Rhea:RHEA:22780, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57466;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:41324, ChEBI:CHEBI:15379, ChEBI:CHEBI:78043, ChEBI:CHEBI:78046; Evidence={ECO:0000250|UniProtKB:P39655};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50276, ChEBI:CHEBI:15379, ChEBI:CHEBI:131965, ChEBI:CHEBI:132063; Evidence={ECO:0000250|UniProtKB:P39655};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate; Xref=Rhea:RHEA:50284, ChEBI:CHEBI:15379, ChEBI:CHEBI:131964, ChEBI:CHEBI:132065; Evidence={ECO:0000250|UniProtKB:P39655};.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=8 uM for arachidonate (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:1851637}; KM=10 uM for arachidonate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269|PubMed:8319693}; KM=6.2 uM for arachidonate (at pH 7.4) {ECO:0000269|PubMed:8250832}; KM=9 uM for linoleate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269|PubMed:8319693}; KM=7.9 uM for leukotriene A4 (at pH 7.4) {ECO:0000269|PubMed:8250832}; KM=3 uM for eicosa-5,8,11,14,17-pentaenoate (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:1851637}; KM=35 uM for eicosa-8,11,14-trienoate (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:1851637}; KM=14.3 uM for 5,6-epoxy-8,11,14-eicosatrienoate (at pH 7.4) {ECO:0000269|PubMed:8250832}; KM=9.5 uM for arachidonic acid {ECO:0000269|PubMed:17493578}; KM=10.1 uM for N-arachidonoylglycine {ECO:0000269|PubMed:17493578}; KM=15.7 uM for N-arachidonoyl-L-alanine {ECO:0000269|PubMed:17493578}; KM=10.9 uM for N-arachidonoyl-gamma-aminobutyric acid {ECO:0000269|PubMed:17493578}; KM=9.7 uM for arachidonic acid {ECO:0000269|PubMed:25036362}; KM=5.1 uM for docosahexaenoate {ECO:0000269|PubMed:25036362}; KM=12.6 uM for arachidonic acid (in presence of calcium dichloride) {ECO:0000269|PubMed:25036362}; KM=7.1 uM for docosahexaenoate (in presence of calcium dichloride) {ECO:0000269|PubMed:25036362}; Vmax=3 umol/min/mg enzyme with arachidonate as substrate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269|PubMed:8319693}; Vmax=1.057 umol/min/mg enzyme with arachidonate as substrate (at pH 7.4) {ECO:0000269|PubMed:8250832}; Vmax=0.0375 umol/min/mg enzyme with linoleate as substrate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269|PubMed:8319693}; Vmax=0.025 umol/min/mg enzyme with leukotriene A4 as substrate (at pH 7.4) {ECO:0000269|PubMed:8250832}; Vmax=0.985 umol/min/mg enzyme with 5,6-epoxy-8,11,14-eicosatrienoate as substrate (at pH 7.4) {ECO:0000269|PubMed:8250832}; pH dependence: Optimum pH is 7.5-8.0 (for arachidonate 12-lipoxygenase activity). {ECO:0000269|PubMed:8250832, ECO:0000269|PubMed:8319693};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by EGF (PubMed:8912711). Arachidonic acid conversion is inhibited by (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate (13S,14S-epoxy-DHA) (PubMed:23504711). Arachidonate 12-lipoxygenase activity is decreased when PH decreases from 7.4 to 6 (By similarity).
- GENATLAS Biochemistry:
- arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,expressed in platelets erythroleukemia cells and umbilical vein endothelial cells,also in B cells and adult skin
Enzyme Numbers (IUBMB) for ALOX12 Gene
Phenotypes From GWAS Catalog for ALOX12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004052 | arachidonate 12-lipoxygenase activity | IBA,IDA | 1851637 |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10727209 |
| GO:0016165 | linoleate 13S-lipoxygenase activity | IBA,IDA | 8319693 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for ALOX12 Gene
- MGI mutant phenotypes for ALOX12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALOX12:
Animal Models for ALOX12 Gene
- MGI Knock Outs for ALOX12:
-
- Alox12 Alox12<tm1Fun>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALOX12 - Select products 50% OFF >
- * ALOX12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX12
miRNA for ALOX12 Gene
- miRTarBase miRNAs that target ALOX12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX12
- Browse OriGene Inhibitory RNA Products For ALOX12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX12
Clone Products
- Applied Biological Materials (abm): Clones for ALOX12 - Select products 50% OFF >
- * ALOX12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ALOX12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX12
Cell Line Products
-
Horizon Cell Lines for ALOX12
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX12 Gene
Localization for ALOX12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALOX12 Gene
- Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 8319693 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA,IDA | 8912711 |
| GO:0042383 | sarcolemma | IBA,IDA | 15107407 |
Pathways & Interactions for ALOX12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Arachidonic acid metabolism | ||
| 3 | HETE and HPETE biosynthesis and metabolism |
HETE and HPETE biosynthesis and metabolism
-
|
|
| 4 | Antifolate resistance | ||
| 5 | Linoleic acid metabolism | ||
Pathways by source for ALOX12 Gene
2 BioSystems pathways for ALOX12 Gene
5 KEGG pathways for ALOX12 Gene
1 GeneGo (Thomson Reuters) pathway for ALOX12 Gene
- HETE and HPETE biosynthesis and metabolism
UniProtKB/Swiss-Prot P18054-LOX12_HUMAN
- Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
Interacting Proteins for ALOX12 Gene
Selected Interacting proteins:
P18054-LOX12_HUMAN
ENSP00000251535
for ALOX12 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ALOX12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA,IDA | 17493578 |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0010656 | negative regulation of muscle cell apoptotic process | IMP | 23578768 |
No data available for SIGNOR curated interactions for ALOX12 Gene
Drugs & Compounds for ALOX12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Iron | Approved, Experimental | Pharma | 1560 | |||
| Oxygen | Approved, Vet_approved | Pharma | 0 | |||
| Celecoxib | Approved, Investigational | Pharma | Inhibitor, Inhibition | Selective cyclooxygenase-2 (COX-2) inhibitor | 536 | |
| arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation | 40 | ||
| Baicalein | Pharma | Lipoxygenases inhibitor, 5- and 12-Lipoxygenase inhibitor | 1 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 12(S)-HPETE |
|
71774-10-2 |
|
(5) Tocris Compounds for ALOX12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-TEDC | 5-, 12-, 15-Lipoxygenase inhibitor | 132465-10-2 |
| Baicalein | 5- and 12-Lipoxygenase inhibitor | 491-67-8 |
| BAY-X 1005 | Orally active 5-lipoxygenase activating protein (FLAP) inhibitor | 128253-31-6 |
| BW-B 70C | 5-Lipoxygenase inhibitor | 134470-38-5 |
| MK 886 | Inhibitor of 5-lipoxygenase-activating protein (FLAP) | 118414-82-7 |
(1) ApexBio Compounds for ALOX12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Baicalein | Lipoxygenases inhibitor | 491-67-8 |
Transcripts for ALOX12 Gene
mRNA/cDNA for ALOX12 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000251535 2392 nts (view in UCSC)
- ENST00000480801 443 nts (view in UCSC)
- ENST00000406228 1023 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALOX12 - Select products 50% OFF >
- * ALOX12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX12
- Browse OriGene Inhibitory RNA Products For ALOX12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX12
Clone Products
- Applied Biological Materials (abm): Clones for ALOX12 - Select products 50% OFF >
- * ALOX12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ALOX12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX12
Relevant External Links for ALOX12 Gene
- GeneLoc Exon Structure for
- ALOX12
Expression for ALOX12 Gene
mRNA differential expression in normal tissues according to GTEx for ALOX12 Gene
This gene is overexpressed in Vagina (x20.5), Esophagus - Mucosa (x9.5), and Cervix - Ectocervix (x7.1).
This gene is overexpressed in Cervix (24.9), Peripheral blood mononuclear cells (19.1), and Platelet (17.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALOX12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALOX12
SOURCE GeneReport for Unigene cluster for ALOX12 Gene:
Hs.654431mRNA Expression by UniProt/SwissProt for ALOX12 Gene:
P18054-LOX12_HUMAN
Tissue specificity:
Expressed in vascular smooth muscle cells.
Evidence on tissue expression from TISSUES for ALOX12 Gene
- Skin(4.5)
- Blood(3.4)
- Nervous system(2.5)
- Heart(2.5)
- Muscle(2.5)
- Intestine(2.4)
- Kidney(2.1)
- Spleen(2.1)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for ALOX12
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX12 Gene
Orthologs for ALOX12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ALOX12 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ALOX12 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ALOX12 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Alox12 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Alox12 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | alox12 30 31 |
|
OneToMany | |
| wufb72a11 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| CSA.6148 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for ALOX12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ALOX12 Gene
- ENSEMBL:
- Gene Tree for ALOX12 (if available)
- TreeFam:
- Gene Tree for ALOX12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALOX12: view image
Paralogs for ALOX12 Gene
(6) SIMAP similar genes for ALOX12 Gene using alignment to 2 proteins:
- LOX12_HUMAN
- K7ENN9_HUMAN
Pseudogenes.org Pseudogenes for ALOX12 Gene
Variants for ALOX12 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALOX12 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714724 | Benign: not provided | 7,005,898(+) | G/A | MISSENSE_VARIANT | |
| 783067 | Likely Benign: not provided | 7,005,306(+) | G/A | MISSENSE_VARIANT | |
| 791340 | Benign: not provided | 6,998,976(+) | G/A | MISSENSE_VARIANT | |
| rs1126667 | - | p.Gln261Arg | |||
| rs114985038 | - | p.Asp134His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1008363 | CNV | loss | 20482838 |
| esv2422288 | CNV | deletion | 17116639 |
| nsv457659 | CNV | loss | 19166990 |
| nsv574322 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.21;
84.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALOX12 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX12 Gene
Disorders for ALOX12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| toxoplasmosis |
|
|
| squamous cell carcinoma |
|
|
| acute pericementitis |
|
|
| adenoma |
|
|
| prostate cancer |
|
Search ALOX12 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LOX12_HUMAN- Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:17460548}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to esophageal cancer (PubMed:17460548). {ECO:0000269 PubMed:17460548}.
- Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:17151091}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to colorectal cancer (PubMed:17460548). {ECO:0000269 PubMed:17460548}.
Additional Disease Information for ALOX12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for ALOX12 Gene
Publications for ALOX12 Gene
- Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. (PMID: 17151091) Tan W … Lin D (Carcinogenesis 2007) 3 4 23 41
- Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PMID: 17460548) Guo Y … Lin D (Pharmacogenetics and genomics 2007) 3 4 23 41
- Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 23 41
- Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. (PMID: 18755188) Yoo H … Kim TY (FEBS letters 2008) 3 4 23
- Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. (PMID: 18640486) Liu Y … Rich SS (American journal of kidney diseases : the official journal of the National Kidney Foundation 2008) 3 23 41
ExternalLinks
Products for ALOX12 Gene
- Custom Antibody ServicesOriGene Antibodies for ALOX12
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene Custom Protein Services for ALOX12
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- Browse OriGene Inhibitory RNA Products For ALOX12
- OriGene qPCR primer pairs for ALOX12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ALOX12
- Sino Biological Human cDNA Clone for ALOX12
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ALOX12
- Novus Biologicals proteins and lysates for ALOX12
- Novus Biologicals ELISA Kits for ALOX12
- Browse Antibodies
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- Abcam antibodies for ALOX12
- Abcam proteins for ALOX12
- Find your target
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- Invitrogen Antibodies for ALOX12 (AFLGC-ALOX12)
- ApexBio compounds for ALOX12
- VectorBuilder Custom and pre-made DNA vectors for ALOX12 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ALOX12 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ALOX12 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ALOX12 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ALOX12
- antibodies-online: Show 38 available ALOX12 Antibodies ranked by validation data
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- antibodies-online: Show 22 available ALOX12 Elisa Kits ranked by validation data
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- antibodies-online: Show 6 available ALOX12 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for ALOX12
- Search Santa Cruz Biotechnology (SCBT) for ALOX12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ALOX12
- Horizon Cell Lines for ALOX12
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX12
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ALOX12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX12
- Boster Bio Antibodies for ALOX12
- Browse Boster Bio ELISA Kits
Sources for ALOX12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
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- (22) IntAct
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- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (44) Atlas
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
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- (135) abm
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- (138) Monarch Initiative
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
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- (159) GeneImprint
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- (162) GtRNAdb
- (163) LncBase
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- (165) LNCipedia
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