Aliases for ALOX12 Gene
Aliases for ALOX12 Gene
External Ids for ALOX12 Gene
- HGNC: 429
- Entrez Gene: 239
- Ensembl: ENSG00000108839
- OMIM: 152391
- UniProtKB: P18054
Previous GeneCards Identifiers for ALOX12 Gene
- GC17P007287
- GC17P007630
- GC17P006741
- GC17P007099
- GC17P006840
- GC17P006899
Summaries for ALOX12 Gene
-
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
GeneCards Summary for ALOX12 Gene
ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) is a Protein Coding gene. Diseases associated with ALOX12 include Toxoplasmosis and Prostate Cancer. Among its related pathways are Metabolism and Eicosanoid Synthesis. Gene Ontology (GO) annotations related to this gene include iron ion binding and arachidonate 12-lipoxygenase activity. An important paralog of this gene is ALOX15.
UniProtKB/Swiss-Prot for ALOX12 Gene
-
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
-
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.
Additional gene information for ALOX12 Gene
- Monarch Initiative
- Search for ALOX12 at DataMed
- Search for ALOX12 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX12 Gene
Genomics for ALOX12 Gene
GeneHancer (GH) Regulatory Elements for ALOX12 Gene
Promoters and enhancers for ALOX12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ALOX12 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ALOX12 Gene
Genomic Locations for ALOX12 Gene
- chr17:6,994,196-7,010,754
- (GRCh38/hg38)
- Size:
- 16,559 bases
- Orientation:
- Plus strand
- chr17:6,899,384-6,914,055
- (GRCh37/hg19)
Genomic View for ALOX12 Gene
Genes around ALOX12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
- 17p13.1 by Ensembl
ALOX12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALOX12 Gene
Proteins for ALOX12 Gene
-
Protein details for ALOX12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18054-LOX12_HUMAN
- Recommended name:
- Arachidonate 12-lipoxygenase, 12S-type
- Protein Accession:
- P18054
- O95569
- Q6ISF8
- Q9UQM4
Protein attributes for ALOX12 Gene
- Size:
- 663 amino acids
- Molecular mass:
- 75694 Da
- Cofactor:
- Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Quaternary structure:
- No Data Available
Protein Expression for ALOX12 Gene
Post-translational modifications for ALOX12 Gene
Other Protein References for ALOX12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ALOX12
- Invitrogen Antibodies for ALOX12
- GeneTex ALOX12 Antibody for ALOX12
-
Boster Bio Antibodies for ALOX12
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALOX12
Protein Products
-
OriGene Purified Proteins for ALOX12
- Search Origene for MassSpec and Protein Over-expression Lysates for ALOX12
- Origene Custom Protein Services for ALOX12
- Search GeneTex for Proteins for ALOX12
No data available for DME Specific Peptides for ALOX12 Gene
Domains & Families for ALOX12 Gene
Gene Families for ALOX12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for ALOX12 Gene
Suggested Antigen Peptide Sequences for ALOX12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P18054- Family:
-
- Belongs to the lipoxygenase family.
Function for ALOX12 Gene
Molecular function for ALOX12 Gene
- UniProtKB/Swiss-Prot Function:
- Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (5S,6R,15S)-trihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (5S,14R,15S)-trihydroxy-(6E,8Z,10E,12E)-eicosatetraenoate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by EGF.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=8 uM for arachidonate (at pH 7.0 and 37 degrees Celsius) {ECO:0000269 PubMed:1851637}; KM=10 uM for arachidonate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:8319693}; KM=6.2 uM for arachidonate (at pH 7.4) {ECO:0000269 PubMed:8250832}; KM=9 uM for linoleate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:8319693}; KM=7.9 uM for leukotriene A4 (at pH 7.4) {ECO:0000269 PubMed:8250832}; KM=3 uM for eicosa-5,8,11,14,17-pentaenoate (at pH 7.0 and 37 degrees Celsius) {ECO:0000269 PubMed:1851637}; KM=35 uM for eicosa-8,11,14-trienoate (at pH 7.0 and 37 degrees Celsius) {ECO:0000269 PubMed:1851637}; KM=14.3 uM for 5,6-epoxy-8,11,14-eicosatrienoate (at pH 7.4) {ECO:0000269 PubMed:8250832}; Vmax=3 umol/min/mg enzyme with arachidonate as substrate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:8319693}; Vmax=1.057 umol/min/mg enzyme with arachidonate as substrate (at pH 7.4) {ECO:0000269 PubMed:8250832}; Vmax=0.0375 umol/min/mg enzyme with linoleate as substrate (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:8319693}; Vmax=0.025 umol/min/mg enzyme with leukotriene A4 as substrate (at pH 7.4) {ECO:0000269 PubMed:8250832}; Vmax=0.985 umol/min/mg enzyme with 5,6-epoxy-8,11,14- eicosatrienoate as substrate (at pH 7.4) {ECO:0000269 PubMed:8250832}; pH dependence: Optimum pH is 7.5-8.0 (for arachidonate 12-lipoxygenase activity). {ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693};
- UniProtKB/Swiss-Prot Induction:
- Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites.
- GENATLAS Biochemistry:
- arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,expressed in platelets erythroleukemia cells and umbilical vein endothelial cells,also in B cells and adult skin
Enzyme Numbers (IUBMB) for ALOX12 Gene
Phenotypes From GWAS Catalog for ALOX12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004052 | arachidonate 12-lipoxygenase activity | TAS | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10727209 |
| GO:0016165 | linoleate 13S-lipoxygenase activity | IDA | 8319693 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for ALOX12 Gene
- MGI mutant phenotypes for ALOX12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALOX12:
Animal Models for ALOX12 Gene
- MGI Knock Outs for ALOX12:
-
- Alox12 Alox12<tm1Fun>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ALOX12
-
CRISPR Products
-
OriGene CRISPR knockouts for ALOX12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX12
- genomics-online: gRNA clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- Applied Biological Materials CRISPR for ALOX12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX12
- GenScript: Design CRISPR guide RNA sequences for ALOX12
miRNA for ALOX12 Gene
- miRTarBase miRNAs that target ALOX12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX12
- Browse OriGene Inhibitory RNA Products For ALOX12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX12
- genomics-online: shRNA clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ALOX12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX12
- Applied Biological Materials Clones for ALOX12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ALOX12
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX12 Gene
Localization for ALOX12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALOX12 Gene
- Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
- Cytosol (3)
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 8319693 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IDA,IEA | 8912711 |
| GO:0042383 | sarcolemma | IDA | 15107407 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for ALOX12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Arachidonic acid metabolism | ||
| 3 | HETE and HPETE biosynthesis and metabolism | ||
| 4 | Antifolate resistance | ||
| 5 | Linoleic acid metabolism | ||
Pathways by source for ALOX12 Gene
2 BioSystems pathways for ALOX12 Gene
5 KEGG pathways for ALOX12 Gene
1 GeneGo (Thomson Reuters) pathway for ALOX12 Gene
UniProtKB/Swiss-Prot P18054-LOX12_HUMAN
- Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
Interacting Proteins for ALOX12 Gene
Selected Interacting proteins:
P18054-LOX12_HUMAN
ENSP00000251535
for ALOX12 Gene via
IID
UniProtKB
STRING
MINT
GPS-Prot Interaction Network for ALOX12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0010656 | negative regulation of muscle cell apoptotic process | IMP | 23578768 |
| GO:0019369 | arachidonic acid metabolic process | IEA,ISS | -- |
| GO:0019372 | lipoxygenase pathway | IEA,TAS | -- |
No data available for SIGNOR curated interactions for ALOX12 Gene
Drugs & Compounds for ALOX12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Oxygen | Approved, Vet_approved | Pharma | 0 | |||
| Celecoxib | Approved, Investigational | Pharma | Inhibition, Inhibitor | Selective cyclooxygenase-2 (COX-2) inhibitor | 459 | |
| arachidonic acid | Experimental | Nutra | Activator, Inhibitor, Agonist, Activation, Potentiation | 33 | ||
| Baicalein | Pharma | Lipoxygenases inhibitor, 5- and 12-Lipoxygenase inhibitor | 0 | |||
| MK 886 | Pharma | Inhibitor of 5-lipoxygenase-activating protein (FLAP) | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 | ||||
| 12(S)-HPETE |
|
71774-10-2 |
|
(5) Tocris Compounds for ALOX12 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-TEDC | 5-, 12-, 15-Lipoxygenase inhibitor | 132465-10-2 |
| Baicalein | 5- and 12-Lipoxygenase inhibitor | 491-67-8 |
| BAY-X 1005 | Orally active 5-lipoxygenase activating protein (FLAP) inhibitor | 128253-31-6 |
| BW-B 70C | 5-Lipoxygenase inhibitor | 134470-38-5 |
| MK 886 | Inhibitor of 5-lipoxygenase-activating protein (FLAP) | 118414-82-7 |
(2) ApexBio Compounds for ALOX12 Gene
Transcripts for ALOX12 Gene
mRNA/cDNA for ALOX12 Gene
- (16) Selected AceView cDNA sequences:
- (7) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000251535 2358 bps (uc002gdx.4)
- ENST00000406228 1023 bps (uc002gdz.5)
- ENST00000480801 443 bps (uc060agj.1)
Unigene Clusters for ALOX12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ALOX12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX12
- genomics-online: gRNA clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- Applied Biological Materials CRISPR for ALOX12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX12
- GenScript: Design CRISPR guide RNA sequences for ALOX12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX12
- Browse OriGene Inhibitory RNA Products For ALOX12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX12
- genomics-online: shRNA clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ALOX12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX12
- Applied Biological Materials Clones for ALOX12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ALOX12 Gene
mRNA differential expression in normal tissues according to GTEx for ALOX12 Gene
This gene is overexpressed in Vagina (x20.5), Esophagus - Mucosa (x9.5), and Cervix - Ectocervix (x7.1).
This gene is overexpressed in Cervix (24.9), Peripheral blood mononuclear cells (19.1), and Platelet (17.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALOX12 Gene
NURSA nuclear receptor signaling pathways regulating expression of ALOX12 Gene:
ALOX12SOURCE GeneReport for Unigene cluster for ALOX12 Gene:
Hs.654431mRNA Expression by UniProt/SwissProt for ALOX12 Gene:
P18054-LOX12_HUMAN
Tissue specificity:
Expressed in vascular smooth muscle cells.
Evidence on tissue expression from TISSUES for ALOX12 Gene
- Skin(4.4)
- Blood(3.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for ALOX12
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX12 Gene
Orthologs for ALOX12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ALOX12 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ALOX12 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ALOX12 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Alox12 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Alox12 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | alox12 34 33 |
|
OneToMany | |
| wufb72a11 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| CSA.6148 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ALOX12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ALOX12 Gene
- ENSEMBL:
- Gene Tree for ALOX12 (if available)
- TreeFam:
- Gene Tree for ALOX12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALOX12: view image
Paralogs for ALOX12 Gene
(6) SIMAP similar genes for ALOX12 Gene using alignment to 2 proteins:
- LOX12_HUMAN
- K7ENN9_HUMAN
Pseudogenes.org Pseudogenes for ALOX12 Gene
Variants for ALOX12 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000072006 | -- | 7,003,661(+) | C/T | intron_variant | |
| rs1000135530 | -- | 7,002,434(+) | C/T | intron_variant | |
| rs1000153685 | -- | 6,995,809(+) | C/A | coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant, upstream_transcript_variant | |
| rs1000226884 | -- | 7,006,678(+) | T/C | intron_variant | |
| rs1000538858 | -- | 6,999,248(+) | T/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1008363 | CNV | loss | 20482838 |
| esv2422288 | CNV | deletion | 17116639 |
| nsv457659 | CNV | loss | 19166990 |
| nsv574322 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.21;
84.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALOX12 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX12 Gene
Disorders for ALOX12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| toxoplasmosis |
|
|
| prostate cancer |
|
Search ALOX12 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LOX12_HUMAN- Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:17460548}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to esophageal cancer (PubMed:17460548). {ECO:0000269 PubMed:17460548}.
- Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:17151091}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to colorectal cancer (PubMed:17460548). {ECO:0000269 PubMed:17460548}.
Additional Disease Information for ALOX12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ALOX12 Gene
Publications for ALOX12 Gene
- Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PMID: 17460548) Guo Y … Lin D (Pharmacogenetics and genomics 2007) 3 4 22 44 58
- Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 22 44 58
- Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. (PMID: 18640486) Liu Y … Rich SS (American journal of kidney diseases : the official journal of the National Kidney Foundation 2008) 3 22 44 58
- Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PMID: 17520163) Mullin BH … Wilson SG (Calcified tissue international 2007) 3 22 44 58
- Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma. (PMID: 17236225) Gong Z … Xie D (Cancer 2007) 3 22 44 58
Products for ALOX12 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ALOX12
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ALOX12
- Search Origene for MassSpec and Protein Over-expression Lysates for ALOX12
- Origene Custom Protein Services for ALOX12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALOX12
- Browse OriGene Inhibitory RNA Products For ALOX12
- OriGene qPCR primer pairs for ALOX12
- OriGene CRISPR knockouts for ALOX12
- OriGene ORF clones in human for ALOX12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ALOX12
- GenScript: Next-day shipping of latest version cDNA ORF clones for ALOX12 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ALOX12
- GenScript Custom Assay Services for ALOX12
- GenScript Custom overexpressing Cell Line Services for ALOX12
- GenScript: Design CRISPR guide RNA sequences for ALOX12
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ALOX12
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ALOX12
- Novus Biologicals proteins and lysates for ALOX12
- Novus Biologicals ELISA Kits for ALOX12
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Invitrogen Antibodies for ALOX12
- ApexBio compounds for ALOX12
- Cyagen custom Knockout/knockin (KOKI) mouse models for ALOX12
- VectorBuilder custom plasmid, inducible vectors for ALOX12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 26 available ALOX12 Antibodies ranked by validation data
- Compare Top ALOX12 Antibodies
- antibodies-online: Search results for 14 available ALOX12 Elisa Kits ranked by validation data
- Compare Top ALOX12 Elisa Kits
- antibodies-online: Search results for 6 available ALOX12 Proteins ranked by validation data
- Compare Top ALOX12 Proteins
- GeneTex ALOX12 Antibody for ALOX12
- Search GeneTex for Proteins for ALOX12
- Santa Cruz Biotechnology (SCBT) Antibodies for ALOX12
- Search Santa Cruz Biotechnology (SCBT) for ALOX12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ALOX12
- Horizon Cell Lines for ALOX12
- genomics-online: cdna clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- orf clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- genomics-online: gRNA clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- genomics-online: primer clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- genomics-online: shRNA clones - Search results for 86 available ALOX12 gene related products
- Overview of 86 available ALOX12 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALOX12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALOX12
- GeneCopoeia miRNA 3'UTR Target clone products for ALOX12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALOX12
- Boster Bio Antibodies for ALOX12
- Browse Boster Bio ELISA Kits
Sources for ALOX12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio