Allantoicase (EC participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008] See more...

Aliases for ALLC Gene

Aliases for ALLC Gene

  • Allantoicase 2 3 5
  • Allantoate Amidinohydrolase 3 4
  • Probable Allantoicase 3 4
  • EC 4 51
  • ALC 2 3
  • ALLC 5

External Ids for ALLC Gene

Previous GeneCards Identifiers for ALLC Gene

  • GC02P003183
  • GC02P003348
  • GC02P003270
  • GC02P003199
  • GC02P003683
  • GC02P003705
  • GC02P003658

Summaries for ALLC Gene

Entrez Gene Summary for ALLC Gene

  • Allantoicase (EC participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]

GeneCards Summary for ALLC Gene

ALLC (Allantoicase) is a Protein Coding gene. Diseases associated with ALLC include Cutaneous Diphtheria and Macular Dystrophy, Patterned, 3. Among its related pathways are Metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include allantoicase activity.

UniProtKB/Swiss-Prot Summary for ALLC Gene

  • The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALLC Gene

Genomics for ALLC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALLC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J003659 Promoter 0.3 EPDnew 600.4 +12.8 12822 0.1 ALLC HSALNG0012592 HSALNG0012596 DCDC2C
GH02J003620 Enhancer 0.9 ENCODE dbSUPER 10.8 -24.2 -24188 0.8 RNF2 SOX13 GABPA PBX2 FOXK2 TCF7 FOXA1 FOXA2 EP300 TEAD1 piR-50437-352 COLEC11 RPS7 ALLC piR-45138
GH02J003624 Enhancer 0.6 ENCODE 11.1 -20.8 -20759 0.9 RELA IKZF2 EED RELB RUNX3 GATAD2B TCF12 IKZF1 EBF1 ATF2 piR-45138 COLEC11 ENSG00000237370 RPS7 ALLC ADI1 ENSG00000235078 piR-50437-352
GH02J003667 Enhancer 0.7 FANTOM5 ENCODE 7 +22.4 22417 1.5 RELA RUNX3 TCF12 BCL11A IKZF1 BHLHE40 BATF HSALNG0012596 piR-32214-350 ALLC DCDC2C
GH02J003704 Enhancer 0.3 Ensembl 9 +58.8 58821 0.4 EZH2 DCDC2C ENSG00000224661 LOC105373393 ALLC piR-48209-367 LOC105373395
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALLC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALLC

Top Transcription factor binding sites by QIAGEN in the ALLC gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ALLC Gene

Genomic Locations for ALLC Gene
57,304 bases
Plus strand
44,477 bases
Plus strand

Genomic View for ALLC Gene

Genes around ALLC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALLC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALLC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALLC Gene

Proteins for ALLC Gene

  • Protein details for ALLC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable allantoicase
    Protein Accession:
    Secondary Accessions:
    • B4DY77
    • Q53T95
    • Q5RL81
    • Q96RE6
    • Q9NZA7

    Protein attributes for ALLC Gene

    391 amino acids
    Molecular mass:
    43559 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALLC Gene


neXtProt entry for ALLC Gene

Selected DME Specific Peptides for ALLC Gene


Post-translational modifications for ALLC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALLC Gene

Domains & Families for ALLC Gene

Gene Families for ALLC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ALLC Gene

  • Allantoicase repeat

Suggested Antigen Peptide Sequences for ALLC Gene

GenScript: Design optimal peptide antigens:
  • Allantoate amidinohydrolase (ALLC_HUMAN)
  • cDNA FLJ60951, highly similar to Probable allantoicase (EC (B4DY77_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the allantoicase family.
  • Belongs to the allantoicase family.
genes like me logo Genes that share domains with ALLC: view

Function for ALLC Gene

Molecular function for ALLC Gene

UniProtKB/Swiss-Prot Function:
The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=allantoate + H2O = (S)-ureidoglycolate + urea; Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=;.

Enzyme Numbers (IUBMB) for ALLC Gene

Phenotypes From GWAS Catalog for ALLC Gene

Gene Ontology (GO) - Molecular Function for ALLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004037 allantoicase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ALLC: view
genes like me logo Genes that share phenotypes with ALLC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALLC

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALLC Gene

Localization for ALLC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALLC gene
Compartment Confidence
cytoskeleton 4
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
endosome 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ALLC Gene

Pathways & Interactions for ALLC Gene

PathCards logo

SuperPathways for ALLC Gene

SuperPathway Contained pathways
1 Metabolism
2 Metabolism of nucleotides
genes like me logo Genes that share pathways with ALLC: view

Pathways by source for ALLC Gene

2 KEGG pathways for ALLC Gene

Interacting Proteins for ALLC Gene

Gene Ontology (GO) - Biological Process for ALLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000256 allantoin catabolic process IBA 21873635
genes like me logo Genes that share ontologies with ALLC: view

No data available for SIGNOR curated interactions for ALLC Gene

Drugs & Compounds for ALLC Gene

(4) Drugs for ALLC Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urea Approved, Investigational Pharma 0
Water Approved Pharma 0
Allantoate Experimental Pharma Target 0

(2) Additional Compounds for ALLC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-Ureidoglycolic acid
  • (-)-Ureidoglycolate
  • (S)-Ureidoglycolate
  • (-)-Ureidoglycolic acid
  • (S)-[(Aminocarbonyl)amino]hydroxy-acetic acid
  • S-(-)-Ureidoglycolic acid
Allantoic acid
  • Bis[(aminocarbonyl)amino]acetic acid
  • Diureidoacetic acid
  • Bis[(aminocarbonyl)amino]acetate
  • Allantoate
  • Diureidoacetate
genes like me logo Genes that share compounds with ALLC: view

Transcripts for ALLC Gene

mRNA/cDNA for ALLC Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALLC

Alternative Splicing Database (ASD) splice patterns (SP) for ALLC Gene

No ASD Table

Relevant External Links for ALLC Gene

GeneLoc Exon Structure for

Expression for ALLC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALLC Gene

mRNA differential expression in normal tissues according to GTEx for ALLC Gene

This gene is overexpressed in Testis (x27.4) and Nerve - Tibial (x8.6).

Protein differential expression in normal tissues from HIPED for ALLC Gene

This gene is overexpressed in Platelet (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALLC Gene

Protein tissue co-expression partners for ALLC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALLC

SOURCE GeneReport for Unigene cluster for ALLC Gene:


Evidence on tissue expression from TISSUES for ALLC Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Skin(3.2)
  • Intestine(3.1)
  • Kidney(2.8)
  • Muscle(2.7)
  • Heart(2.6)
  • Lung(2.6)
  • Blood(2.6)
  • Liver(2.5)
  • Thyroid gland(2.4)
  • Pancreas(2.4)
  • Bone marrow(2.2)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with ALLC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALLC Gene

Orthologs for ALLC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALLC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALLC 30 31
  • 99.06 (n)
(Canis familiaris)
Mammalia ALLC 30 31
  • 84.27 (n)
(Bos Taurus)
Mammalia ALLC 30 31
  • 83.5 (n)
(Rattus norvegicus)
Mammalia Allc 30
  • 81.28 (n)
(Mus musculus)
Mammalia Allc 30 17 31
  • 80.17 (n)
(Monodelphis domestica)
Mammalia ALLC 31
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ALLC 31
  • 61 (a)
(Anolis carolinensis)
Reptilia ALLC 31
  • 53 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia allc 30
  • 64.11 (n)
LOC394447 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68581 30
(Danio rerio)
Actinopterygii allc 30 31
  • 60.93 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5701 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004501 30
  • 49.81 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04422g 30
  • 46.92 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER162C 30
  • 46.17 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL2 30 31 33
  • 46.16 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F7.09c 30
  • 48.5 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01816 30
  • 45.95 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14186 30
Species where no ortholog for ALLC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ALLC Gene

Gene Tree for ALLC (if available)
Gene Tree for ALLC (if available)
Evolutionary constrained regions (ECRs) for ALLC: view image

Paralogs for ALLC Gene

No data available for Paralogs for ALLC Gene

Variants for ALLC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ALLC Gene

Product of a polymorphic gene which also produces a longer 410-residue protein due to a polymorphism which affects Met-1, resulting in a longer protein starting at an upstream Met.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALLC Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
780812 Benign: not provided 3,697,400(+) G/A MISSENSE_VARIANT
780813 Benign: not provided 3,701,529(+) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ALLC Gene

Structural Variations from Database of Genomic Variants (DGV) for ALLC Gene

Variant ID Type Subtype PubMed ID
dgv3702n100 CNV gain 25217958
dgv6664n54 CNV loss 21841781
dgv6665n54 CNV loss 21841781
dgv6666n54 CNV loss 21841781
esv2428176 CNV deletion 19546169
esv2656614 CNV deletion 23128226
esv2660703 CNV deletion 23128226
esv2719525 CNV deletion 23290073
esv2719526 CNV deletion 23290073
esv2719527 CNV deletion 23290073
esv2760637 CNV loss 21179565
esv2763276 CNV gain+loss 21179565
esv27648 CNV loss 19812545
esv29025 CNV loss 19812545
esv32895 CNV loss 17666407
esv3307408 CNV mobile element insertion 20981092
esv3309382 CNV mobile element insertion 20981092
esv3321672 CNV insertion 20981092
esv3360936 CNV insertion 20981092
esv3551722 CNV deletion 23714750
esv3583622 CNV loss 25503493
esv3583623 CNV loss 25503493
esv3589663 CNV loss 21293372
esv3589665 CNV loss 21293372
nsv1013223 CNV gain 25217958
nsv1144888 CNV deletion 24896259
nsv2574 CNV insertion 18451855
nsv2575 CNV deletion 18451855
nsv468961 CNV gain 19166990
nsv498908 CNV loss 21111241
nsv517058 CNV loss 19592680
nsv523573 CNV loss 19592680
nsv580822 CNV gain 21841781
nsv580825 CNV gain 21841781
nsv818922 CNV gain 17921354
nsv828164 CNV loss 20364138

Variation tolerance for ALLC Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.72; 95.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALLC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for ALLC Gene

MalaCards: The human disease database

(28) MalaCards diseases for ALLC Gene - From: DISEASES

Disorder Aliases PubMed IDs
cutaneous diphtheria
macular dystrophy, patterned, 3
  • mdpt3
patterned macular dystrophy
  • patterned dystrophy of retinal pigment epithelium
  • campylobacter infections
toxic megacolon
  • megacolon, toxic
- elite association - COSMIC cancer census association via MalaCards
Search ALLC in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ALLC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALLC Gene

Publications for ALLC Gene

  1. Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. (PMID: 11054555) Vigetti D … Bernardini G (Gene 2000) 2 3 4 23
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Genomic organization and chromosome localization of the murine and human allantoicase gene. (PMID: 12036579) Vigetti D … Bernardini G (Gene 2002) 3 4
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3

Products for ALLC Gene

Sources for ALLC Gene