Aliases for ALKBH8 Gene

Aliases for ALKBH8 Gene

  • AlkB Homolog 8, TRNA Methyltransferase 2 3 5
  • S-Adenosyl-L-Methionine-Dependent TRNA Methyltransferase ABH8 3 4
  • TRNA (Carboxymethyluridine(34)-5-O)-Methyltransferase ABH8 3 4
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH8 3 4
  • Alkylated DNA Repair Protein AlkB Homolog 8 3 4
  • TRNA Methyltransferase 9 Related 2 3
  • TRMT9A 2 3
  • ABH8 3 4
  • TRM9 2 3
  • AlkB, Alkylation Repair Homolog 8 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 8 3
  • TRNA Methyltransferase 9 Homolog 3
  • AlkB Homologue 8 3
  • EC 1.14.11.- 4
  • EC 2.1.1.229 4
  • MGC10235 2
  • ALKBH8 5
  • MRT71 3
  • TRMT9 3

External Ids for ALKBH8 Gene

Previous GeneCards Identifiers for ALKBH8 Gene

  • GC11M106879
  • GC11M107373
  • GC11M103298

Summaries for ALKBH8 Gene

GeneCards Summary for ALKBH8 Gene

ALKBH8 (AlkB Homolog 8, TRNA Methyltransferase) is a Protein Coding gene. Diseases associated with ALKBH8 include Intellectual Developmental Disorder, Autosomal Recessive 71 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TRMT9B.

UniProtKB/Swiss-Prot Summary for ALKBH8 Gene

  • Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).

Additional gene information for ALKBH8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALKBH8 Gene

Genomics for ALKBH8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALKBH8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J107561 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.7 1720 5.9 CTCF PRDM10 ZNF629 TFE3 SIX5 LEF1 IKZF1 ZNF692 JUND LARP7 ALKBH8 ELMOD1 NPAT piR-38344-025 CWF19L2
GH11J107567 Enhancer 0.2 Ensembl 600.7 -1.5 -1455 0.4 ALKBH8 piR-46501-019 ELMOD1
GH11J108008 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 -444.3 -444252 3.6 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 CUL5 ENSG00000288012 NONHSAG009537.2 NPAT CWF19L2 ALKBH8 DDX10 POGLUT3 ATM ACAT1
GH11J107927 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10 -363.3 -363255 2.8 SP1 CREB1 HNRNPL ZNF629 REST IKZF1 KDM1A ZNF692 BACH1 FOS SLC35F2 RAB39A NPAT CWF19L2 CUL5 ALKBH8 DDX10 ASS1P13 piR-42694-032
GH11J107691 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.2 -125.4 -125355 1 ZXDB ZSCAN5C OSR2 ZNF580 ZBTB17 WT1 OVOL3 PRDM4 JUND ZNF843 ALKBH8 ELMOD1 piR-52294-029 HSALNG0086968 SLN LOC112267904
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALKBH8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALKBH8

Top Transcription factor binding sites by QIAGEN in the ALKBH8 gene promoter:
  • CUTL1
  • Evi-1
  • GATA-6
  • Msx-1
  • Nkx2-2
  • POU2F1
  • POU2F1a
  • STAT1
  • TBP

Genomic Locations for ALKBH8 Gene

Genomic Locations for ALKBH8 Gene
chr11:107,502,726-107,565,746
(GRCh38/hg38)
Size:
63,021 bases
Orientation:
Minus strand
chr11:107,373,452-107,436,472
(GRCh37/hg19)
Size:
63,021 bases
Orientation:
Minus strand

Genomic View for ALKBH8 Gene

Genes around ALKBH8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKBH8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKBH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH8 Gene

Proteins for ALKBH8 Gene

  • Protein details for ALKBH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BT7-ALKB8_HUMAN
    Recommended name:
    Alkylated DNA repair protein alkB homolog 8
    Protein Accession:
    Q96BT7
    Secondary Accessions:
    • B1Q2M0
    • B4DEF6
    • Q8N989

    Protein attributes for ALKBH8 Gene

    Size:
    664 amino acids
    Molecular mass:
    75208 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts with TRMT112.
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 4]: May be due to competing donor splice site.

    Three dimensional structures from OCA and Proteopedia for ALKBH8 Gene

    Alternative splice isoforms for ALKBH8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH8 Gene

Post-translational modifications for ALKBH8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALKBH8 Gene

Domains & Families for ALKBH8 Gene

Gene Families for ALKBH8 Gene

Protein Domains for ALKBH8 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Ribosomal L23 protein
ProtoNet:

Suggested Antigen Peptide Sequences for ALKBH8 Gene

GenScript: Design optimal peptide antigens:
  • S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 (ALKB8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96BT7

UniProtKB/Swiss-Prot:

ALKB8_HUMAN :
  • Belongs to the alkB family.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH8: view

Function for ALKBH8 Gene

Molecular function for ALKBH8 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43208, Rhea:RHEA-COMP:10407, Rhea:RHEA-COMP:10408, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74851, ChEBI:CHEBI:74882; EC=2.1.1.229; Evidence={ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:31079898};.
UniProtKB/Swiss-Prot Induction:
Up-regulated after DNA damage. Induction is mediated via ATM.

Enzyme Numbers (IUBMB) for ALKBH8 Gene

Phenotypes From GWAS Catalog for ALKBH8 Gene

Gene Ontology (GO) - Molecular Function for ALKBH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 22065580
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003824 catalytic activity IEA --
GO:0005506 iron ion binding IEA,ISS --
genes like me logo Genes that share ontologies with ALKBH8: view
genes like me logo Genes that share phenotypes with ALKBH8: view

Human Phenotype Ontology for ALKBH8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ALKBH8 Gene

MGI Knock Outs for ALKBH8:

Animal Model Products

  • Taconic Biosciences Mouse Models for ALKBH8

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH8

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for ALKBH8 Gene

Localization for ALKBH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH8 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. {ECO:0000269 PubMed:20308323}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALKBH8 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALKBH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20308323
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005829 cytosol IDA 20308323
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ALKBH8: view

Pathways & Interactions for ALKBH8 Gene

PathCards logo

SuperPathways for ALKBH8 Gene

genes like me logo Genes that share pathways with ALKBH8: view

Pathways by source for ALKBH8 Gene

Gene Ontology (GO) - Biological Process for ALKBH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002098 tRNA wobble uridine modification IMP 31079898
GO:0006974 cellular response to DNA damage stimulus IDA 20308323
GO:0008152 metabolic process IEA --
GO:0030488 tRNA methylation IMP 31079898
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with ALKBH8: view

No data available for SIGNOR curated interactions for ALKBH8 Gene

Drugs & Compounds for ALKBH8 Gene

(1) Drugs for ALKBH8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for ALKBH8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with ALKBH8: view

Transcripts for ALKBH8 Gene

mRNA/cDNA for ALKBH8 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH8

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2:
SP3:
SP4: -

Relevant External Links for ALKBH8 Gene

GeneLoc Exon Structure for
ALKBH8

Expression for ALKBH8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALKBH8 Gene

Protein differential expression in normal tissues from HIPED for ALKBH8 Gene

This gene is overexpressed in CD4 Tcells (48.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALKBH8 Gene



Protein tissue co-expression partners for ALKBH8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALKBH8

SOURCE GeneReport for Unigene cluster for ALKBH8 Gene:

Hs.503763

mRNA Expression by UniProt/SwissProt for ALKBH8 Gene:

Q96BT7-ALKB8_HUMAN
Tissue specificity: Widely expressed, with highest expression in spleen, followed by pancreas and lung.

Evidence on tissue expression from TISSUES for ALKBH8 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ALKBH8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKBH8 Gene

Orthologs for ALKBH8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALKBH8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ALKBH8 30 31
  • 99.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ALKBH8 30 31
  • 89.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ALKBH8 30 31
  • 85.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Alkbh8 30 17 31
  • 81.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Alkbh8 30
  • 80.57 (n)
Oppossum
(Monodelphis domestica)
Mammalia ALKBH8 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH8 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ALKBH8 30 31
  • 72.43 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia alkbh8 30
  • 66.94 (n)
Zebrafish
(Danio rerio)
Actinopterygii alkbh8 30 31
  • 60.15 (n)
OneToOne
Dr.17847 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG17807 30 31
  • 53.1 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011900 30
  • 50.33 (n)
Worm
(Caenorhabditis elegans)
Secernentea alkb-8 30 31
  • 47.79 (n)
ManyToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR181W 30
  • 50.85 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01023g 30
  • 49.37 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM9 30 31
  • 47.79 (n)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm9 30
  • 56.04 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01705 30
  • 44.22 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6013 31
  • 41 (a)
OneToOne
Species where no ortholog for ALKBH8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ALKBH8 Gene

ENSEMBL:
Gene Tree for ALKBH8 (if available)
TreeFam:
Gene Tree for ALKBH8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALKBH8: view image

Paralogs for ALKBH8 Gene

Paralogs for ALKBH8 Gene

Pseudogenes.org Pseudogenes for ALKBH8 Gene

genes like me logo Genes that share paralogs with ALKBH8: view

Variants for ALKBH8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALKBH8 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
636271 Pathogenic: INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 71 107,505,002(-) G/A NONSENSE
636272 Pathogenic: INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 71 107,504,867(-) AG/A FRAMESHIFT_VARIANT
721730 Benign: not provided 107,504,833(-) G/C MISSENSE_VARIANT
732297 Benign: not provided 107,510,924(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ALKBH8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ALKBH8 Gene

Variant ID Type Subtype PubMed ID
nsv556376 CNV gain 21841781

Variation tolerance for ALKBH8 Gene

Gene Damage Index Score: 4.83; 67.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALKBH8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALKBH8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH8 Gene

Disorders for ALKBH8 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ALKBH8 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
intellectual developmental disorder, autosomal recessive 71
  • mrt71
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
alpha-methylacetoacetic aciduria
  • 2-methyl-3-hydroxybutyric acidemia
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ALKB8_HUMAN
  • Intellectual developmental disorder, autosomal recessive 71 (MRT71) [MIM:618504]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRT71 features include impaired intellectual development, global developmental delay, mildly delayed walking, poor language, seizures in the first years of life, and behavioral abnormalities. {ECO:0000269 PubMed:31079898}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ALKBH8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ALKBH8: view

No data available for Genatlas for ALKBH8 Gene

Publications for ALKBH8 Gene

  1. ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. (PMID: 21285950) van den Born E … Falnes PØ (Nature communications 2011) 2 3 4
  2. Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. (PMID: 20123966) Songe-Møller L … Klungland A (Molecular and cellular biology 2010) 2 3 4
  3. A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression. (PMID: 19293182) Shimada K … Konishi N (Cancer research 2009) 3 4 23
  4. Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification. (PMID: 31079898) Monies D … Alkuraya FS (American journal of human genetics 2019) 3 4
  5. Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. (PMID: 22065580) Pastore C … Hunt JF (The Journal of biological chemistry 2012) 3 4

Products for ALKBH8 Gene

  • Signalway Proteins for ALKBH8

Sources for ALKBH8 Gene