Aliases for ALKBH7 Gene
External Ids for ALKBH7 Gene
Previous HGNC Symbols for ALKBH7 Gene
Previous GeneCards Identifiers for ALKBH7 Gene
GeneCards Summary for ALKBH7 Gene
ALKBH7 (AlkB Homolog 7) is a Protein Coding gene. Among its related pathways are DNA Damage and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include dioxygenase activity.
UniProtKB/Swiss-Prot Summary for ALKBH7 Gene
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).