Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALKBH6 Gene

Aliases for ALKBH6 Gene

  • AlkB Homolog 6 2 3 5
  • Alkylated DNA Repair Protein AlkB Homolog 6 3 4
  • ABH6 3 4
  • Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 6 3
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH6 3
  • AlkB, Alkylation Repair Homolog 6 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 6 3
  • Alkylation Repair Homolog 6 3
  • EC 1.14.11.- 4

External Ids for ALKBH6 Gene

Previous GeneCards Identifiers for ALKBH6 Gene

  • GC19M041192
  • GC19M036500
  • GC19M033005

Summaries for ALKBH6 Gene

GeneCards Summary for ALKBH6 Gene

ALKBH6 (AlkB Homolog 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

UniProtKB/Swiss-Prot for ALKBH6 Gene

  • Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.

Additional gene information for ALKBH6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH6 Gene

Genomics for ALKBH6 Gene

GeneHancer (GH) Regulatory Elements for ALKBH6 Gene

Promoters and enhancers for ALKBH6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J036013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.0 6 2.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B LOC101927572 ALKBH6 ENSG00000248101 WDR62 ZNF345 ZNF850 KMT2B ZNF567 PROSER3 TMEM147-AS1
GH19J035710 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +299.1 299050 10 ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 ZNF263 SP3 ZFP41 KMT2B ZBTB32 PIR52641 ZNF567 TMEM147-AS1 ZNF529 ZNF599 ZNF461 U2AF1L4 RBM42
GH19J035641 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +370.7 370713 4.6 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 ETV2 COX6B1 KMT2B RBM42 TMEM147-AS1 PROSER3 ZNF792 HAUS5 ZNF529 ZNF566
GH19J036138 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -126.3 -126288 3.7 CLOCK MLX FEZF1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC LOC105372385 GC19P036884 CAPNS1 ZNF345 TMEM147-AS1 ZNF567 ZNF850 HAUS5 ZNF790-AS1 RBM42
GH19J036526 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10 -514.0 -513967 2.8 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF260 ZNF566 ENSG00000228629 ZNF567 ZNF383 ZNF527 ZNF345 ZNF585B ZNF850 ZNF790
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ALKBH6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALKBH6 gene promoter:
  • E2F
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • Nkx2-5
  • FOXO3
  • FOXO3a
  • FOXO3b

Genomic Locations for ALKBH6 Gene

Genomic Locations for ALKBH6 Gene
chr19:36,009,116-36,014,243
(GRCh38/hg38)
Size:
5,128 bases
Orientation:
Minus strand
chr19:36,500,022-36,505,141
(GRCh37/hg19)
Size:
5,120 bases
Orientation:
Minus strand

Genomic View for ALKBH6 Gene

Genes around ALKBH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKBH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKBH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH6 Gene

Proteins for ALKBH6 Gene

  • Protein details for ALKBH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRA9-ALKB6_HUMAN
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
    Protein Accession:
    Q3KRA9
    Secondary Accessions:
    • A5LGM8
    • A6NLP1
    • A8MU96

    Protein attributes for ALKBH6 Gene

    Size:
    238 amino acids
    Molecular mass:
    26483 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts with VCPKMT.
    SequenceCaution:
    • Sequence=AAI05802.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ALKBH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH6 Gene

Post-translational modifications for ALKBH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALKBH6 Gene

Domains & Families for ALKBH6 Gene

Gene Families for ALKBH6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for ALKBH6 Gene

Suggested Antigen Peptide Sequences for ALKBH6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRA9

UniProtKB/Swiss-Prot:

ALKB6_HUMAN :
  • Belongs to the alkB family.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH6: view

Function for ALKBH6 Gene

Molecular function for ALKBH6 Gene

UniProtKB/Swiss-Prot Function:
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.

Enzyme Numbers (IUBMB) for ALKBH6 Gene

Phenotypes From GWAS Catalog for ALKBH6 Gene

Gene Ontology (GO) - Molecular Function for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22948820
GO:0008198 ferrous iron binding IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IBA --
genes like me logo Genes that share ontologies with ALKBH6: view
genes like me logo Genes that share phenotypes with ALKBH6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALKBH6

CRISPR Products

miRNA for ALKBH6 Gene

miRTarBase miRNAs that target ALKBH6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALKBH6 Gene

Localization for ALKBH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALKBH6 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with ALKBH6: view

Pathways & Interactions for ALKBH6 Gene

SuperPathways for ALKBH6 Gene

No Data Available

Interacting Proteins for ALKBH6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368152%0d%0a9606.ENSP00000280758%0d%0a9606.ENSP00000410157%0d%0a
Selected Interacting proteins: ENSP00000368152 Q3KRA9-ALKB6_HUMAN for ALKBH6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ALKBH6: view

No data available for Pathways by source and SIGNOR curated interactions for ALKBH6 Gene

Drugs & Compounds for ALKBH6 Gene

No Compound Related Data Available

Transcripts for ALKBH6 Gene

Unigene Clusters for ALKBH6 Gene

AlkB, alkylation repair homolog 6 (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH6 Gene

No ASD Table

Relevant External Links for ALKBH6 Gene

GeneLoc Exon Structure for
ALKBH6
ECgene alternative splicing isoforms for
ALKBH6

Expression for ALKBH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALKBH6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALKBH6 Gene:

ALKBH6

SOURCE GeneReport for Unigene cluster for ALKBH6 Gene:

Hs.71941

mRNA Expression by UniProt/SwissProt for ALKBH6 Gene:

Q3KRA9-ALKB6_HUMAN
Tissue specificity: Widely expressed, with highest expression in testis and pancreas.

Evidence on tissue expression from TISSUES for ALKBH6 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ALKBH6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKBH6 Gene

Orthologs for ALKBH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALKBH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALKBH6 34 33
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ALKBH6 34 33
  • 90.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ALKBH6 34 33
  • 88.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh6 16 34 33
  • 86.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH6 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALKBH6 34
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3975 33
zebrafish
(Danio rerio)
Actinopterygii alkbh6 34 33
  • 58.85 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8694 33
fruit fly
(Drosophila melanogaster)
Insecta CG6144 34 33
  • 53.61 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003866 33
  • 52.84 (n)
worm
(Caenorhabditis elegans)
Secernentea B0564.2 34 33
  • 48.37 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G20350 33
  • 45.57 (n)
rice
(Oryza sativa)
Liliopsida Os10g0420000 33
  • 50.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for ALKBH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALKBH6 Gene

ENSEMBL:
Gene Tree for ALKBH6 (if available)
TreeFam:
Gene Tree for ALKBH6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALKBH6: view image

Paralogs for ALKBH6 Gene

No data available for Paralogs for ALKBH6 Gene

Variants for ALKBH6 Gene

Sequence variations from dbSNP and Humsavar for ALKBH6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000613564 -- 36,014,695(-) T/A upstream_transcript_variant
rs1000737033 -- 36,014,488(-) G/A upstream_transcript_variant
rs1002151520 -- 36,009,655(-) A/G intron_variant
rs1002221880 -- 36,009,405(-) G/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1002749180 -- 36,011,132(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ALKBH6 Gene

Variant ID Type Subtype PubMed ID
esv1000212 CNV deletion 20482838
dgv51n68 CNV loss 17160897

Variation tolerance for ALKBH6 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALKBH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALKBH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH6 Gene

Disorders for ALKBH6 Gene

Additional Disease Information for ALKBH6

No disorders were found for ALKBH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALKBH6 Gene

Publications for ALKBH6 Gene

  1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S … Falnes PØ (Nature communications 2012) 3 4 58
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 2 3 58
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 58
  4. Expression and sub-cellular localization of human ABH family molecules. (PMID: 17979886) Tsujikawa K … Yamamoto H (Journal of cellular and molecular medicine 2007) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ALKBH6 Gene

Sources for ALKBH6 Gene

Content
Loading form....