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Aliases for ALKBH5 Gene
Aliases for ALKBH5 Gene
External Ids for ALKBH5 Gene
- HGNC: 25996
- NCBI Entrez Gene: 54890
- Ensembl: ENSG00000091542
- OMIM®: 613303
- UniProtKB/Swiss-Prot: Q6P6C2
Previous HGNC Symbols for ALKBH5 Gene
- OFOXD1
Previous GeneCards Identifiers for ALKBH5 Gene
- GC17P018031
- GC17P018086
- GC17P017840
Summaries for ALKBH5 Gene
GeneCards Summary for ALKBH5 Gene
ALKBH5 (AlkB Homolog 5, RNA Demethylase) is a Protein Coding gene. Diseases associated with ALKBH5 include Periosteal Chondrosarcoma and Smith-Magenis Syndrome. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include oxidative RNA demethylase activity.
UniProtKB/Swiss-Prot Summary for ALKBH5 Gene
-
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).
Additional gene information for ALKBH5 Gene
- HGNC (25996)
- NCBI Entrez Gene (54890)
- Ensembl (ENSG00000091542)
- OMIM® (613303)
- UniProtKB/Swiss-Prot (Q6P6C2)
- Open Targets Platform(ENSG00000091542)
- Search for ALKBH5 at DataMed
- Search for ALKBH5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALKBH5 Gene
Genomics for ALKBH5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ALKBH5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALKBH5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALKBH5
- Top Transcription factor binding sites by QIAGEN in the ALKBH5 gene promoter:
-
- c-Myc
- HEN1
- HTF
- ITF-2
- Max
- Pax-2
- Pax-2a
- Pax-5
- Tal-1beta
- XBP-1
Genomic Locations for ALKBH5 Gene
Latest Assembly
- chr17:18,183,078-18,209,954
- (GRCh38/hg38)
- Size:
- 26,877 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:18,087,142-18,113,268
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 26,127 bases
- Orientation:
- Plus strand
- chr17:18,086,392-18,113,268
- (GRCh37/hg19 by Ensembl)
- Size:
- 26,877 bases
- Orientation:
- Plus strand
Genomic View for ALKBH5 Gene
Genes around ALKBH5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2|17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
ALKBH5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALKBH5 Gene
Proteins for ALKBH5 Gene
-
Protein details for ALKBH5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P6C2-ALKB5_HUMAN
- Recommended name:
- RNA demethylase ALKBH5
- Protein Accession:
- Q6P6C2
- B4DVJ4
- D3DXC6
- Q9NXD6
Protein attributes for ALKBH5 Gene
- Size:
- 394 amino acids
- Molecular mass:
- 44256 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=BAA91078.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ALKBH5 Gene
Protein Expression for ALKBH5 Gene
Post-translational modifications for ALKBH5 Gene
Other Protein References for ALKBH5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ ALKBH5 Antibody
- Novus Biologicals Antibodies for ALKBH5
-
Abcam antibodies for ALKBH5
- Invitrogen Antibodies for ALKBH5 (AFLGC-ALKBH5)
-
Custom Antibody ServicesProSci Antibodies for ALKBH5
- Sino Biological Antibodies for ALKBH5
Protein products for research
-
OriGene Purified Proteins for ALKBH5
- Search Origene for MassSpec and Protein Over-expression Lysates for ALKBH5
- Origene Custom Protein Services for ALKBH5
- antibodies-online: Show 4 available ALKBH5 Proteins ranked by validation data
- Compare Top ALKBH5 Proteins
-
Quality Products:
-
Abcam proteins for ALKBH5
Assay products for research
No data available for DME Specific Peptides for ALKBH5 Gene
Domains & Families for ALKBH5 Gene
Gene Families for ALKBH5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ALKBH5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ALKBH5 Gene
- GenScript: Design optimal peptide antigens:
-
- Alkylated DNA repair protein alkB homolog 5 (ALKB5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6P6C2- Family:
-
- Belongs to the alkB family.
Function for ALKBH5 Gene
Molecular function for ALKBH5 Gene
- UniProtKB/Swiss-Prot Function:
- Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49520, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=1.14.11.53; Evidence={ECO:0000269|PubMed:24616105};.
- UniProtKB/Swiss-Prot Induction:
- By hypoxia, directly activated by HIF1A. Expression is regulated by PRMT7.
Enzyme Numbers (IUBMB) for ALKBH5 Gene
Phenotypes From GWAS Catalog for ALKBH5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IDA | 21264265 |
| GO:0035515 | oxidative RNA demethylase activity | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ALKBH5 Gene
- MGI mutant phenotypes for ALKBH5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALKBH5:
-
- Increased gamma-H2AX phosphorylation
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased viability in ovarian lineage
- Decreased homologous recombination repair frequency
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased caspase activity
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
Animal Models for ALKBH5 Gene
- MGI Knock Outs for ALKBH5:
-
- Alkbh5 Alkbh5<tm1.1Klng>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ALKBH5 - Starting at $85 >
- * ALKBH5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ALKBH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALKBH5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALKBH5
miRNA for ALKBH5 Gene
- miRTarBase miRNAs that target ALKBH5
-
- mmu-miR-17-5p (MIRT010034)
- mmu-miR-324-3p (MIRT010909)
- hsa-miR-615-3p (MIRT039912)
- hsa-miR-484 (MIRT042009)
- hsa-miR-96-5p (MIRT048722)
- hsa-miR-92a-3p (MIRT049251)
- hsa-miR-29b-2-5p (MIRT076209)
- hsa-miR-376a-5p (MIRT076210)
- hsa-miR-659-3p (MIRT076211)
- hsa-miR-1277-5p (MIRT076212)
- hsa-miR-3674 (MIRT076213)
- hsa-miR-4732-5p (MIRT076214)
- hsa-miR-4760-5p (MIRT076215)
- hsa-miR-5002-5p (MIRT076216)
- hsa-miR-8061 (MIRT076218)
- hsa-miR-3148 (MIRT285972)
- hsa-miR-766-5p (MIRT344366)
- hsa-miR-4435 (MIRT454003)
- hsa-miR-4531 (MIRT454004)
- hsa-miR-5196-5p (MIRT454005)
- hsa-miR-4747-5p (MIRT454006)
- hsa-miR-6739-5p (MIRT454007)
- hsa-miR-3153 (MIRT454008)
- hsa-miR-6733-5p (MIRT454009)
- hsa-miR-5703 (MIRT454010)
- hsa-miR-4516 (MIRT454011)
- hsa-miR-4434 (MIRT454012)
- hsa-miR-3202 (MIRT454013)
- hsa-miR-6770-5p (MIRT454014)
- hsa-miR-7515 (MIRT454015)
- hsa-miR-3190-5p (MIRT454016)
- hsa-miR-9500 (MIRT454017)
- hsa-miR-5584-5p (MIRT454018)
- hsa-miR-3154 (MIRT454019)
- hsa-miR-7150 (MIRT454020)
- hsa-miR-651-3p (MIRT454021)
- hsa-miR-4736 (MIRT454022)
- hsa-miR-4763-3p (MIRT454023)
- hsa-miR-1207-5p (MIRT454024)
- hsa-miR-3665 (MIRT454025)
- hsa-miR-1253 (MIRT454026)
- hsa-miR-4795-5p (MIRT454027)
- hsa-miR-125a-3p (MIRT454028)
- hsa-miR-4773 (MIRT454029)
- hsa-miR-3680-3p (MIRT560135)
- hsa-miR-4666b (MIRT560136)
- hsa-miR-5011-3p (MIRT560137)
- hsa-miR-609 (MIRT560138)
- hsa-miR-6797-3p (MIRT560139)
- hsa-miR-6076 (MIRT560140)
- hsa-miR-4722-5p (MIRT560141)
- hsa-miR-5681a (MIRT560142)
- hsa-miR-6886-5p (MIRT560143)
- hsa-miR-4459 (MIRT560144)
- hsa-miR-607 (MIRT568534)
- hsa-miR-5701 (MIRT568535)
- hsa-miR-4698 (MIRT568536)
- hsa-miR-6832-5p (MIRT568537)
- hsa-miR-8063 (MIRT568538)
- hsa-miR-656-3p (MIRT568539)
- hsa-miR-2278 (MIRT568540)
- mmu-miR-342-5p (MIRT584895)
- mmu-miR-298-5p (MIRT584896)
- mmu-miR-713 (MIRT584897)
- mmu-miR-203-3p (MIRT584898)
- mmu-miR-467f (MIRT590688)
- mmu-miR-466f-3p (MIRT590689)
- mmu-miR-362-3p (MIRT590690)
- mmu-miR-329-3p (MIRT590691)
- mmu-miR-466i-3p (MIRT590692)
- mmu-miR-501-5p (MIRT593127)
- mmu-miR-362-5p (MIRT593244)
- hsa-miR-193b-3p (MIRT728354)
- hsa-miR-193a-3p (MIRT728355)
- hsa-miR-1915-3p (MIRT738540)
- hsa-miR-4726-3p (MIRT747740)
- hsa-miR-665 (MIRT753618)
- hsa-miR-6764-5p (MIRT755046)
- hsa-miR-6840-3p (MIRT757303)
- hsa-miR-7977 (MIRT759993)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALKBH5
- Browse OriGene Inhibitory RNA Products For ALKBH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH5
Clone products for research
- Applied Biological Materials (abm): Clones for ALKBH5 - Starting at $45 >
- * ALKBH5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ALKBH5
- Addgene plasmids for ALKBH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALKBH5
Cell Lines for research
-
Horizon Cell Lines for ALKBH5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALKBH5 Gene
Localization for ALKBH5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALKBH5 Gene
- Nucleus speckle.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| golgi apparatus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nucleoplasm (2)
- Cytosol (1)
- Golgi apparatus (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 21264265 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016607 | nuclear speck | IEA,IDA | 23177736 |
Pathways & Interactions for ALKBH5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Damage Reversal | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for ALKBH5 Gene
3 Reactome pathways for ALKBH5 Gene
Interacting Proteins for ALKBH5 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| JUN | ||
| ATP5MF-PTCD1 | ||
| CSNK2A1 | ||
| DNAJB4 | ||
| ELAVL1 |
GPS-Prot Interaction Network for ALKBH5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IDA | 21264265 |
| GO:0006307 | DNA dealkylation involved in DNA repair | TAS | -- |
| GO:0006397 | mRNA processing | IBA,IMP | 23177736 |
| GO:0006406 | mRNA export from nucleus | IBA,IMP | 23177736 |
| GO:0007283 | spermatogenesis | ISS | -- |
No data available for SIGNOR curated interactions for ALKBH5 Gene
Transcripts for ALKBH5 Gene
mRNA/cDNA for ALKBH5 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000399138 3159 nts (view in UCSC)
- ENST00000490106 2146 nts (view in UCSC)
- ENST00000541285 1605 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ALKBH5 - Starting at $85 >
- * ALKBH5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ALKBH5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALKBH5
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALKBH5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALKBH5
- Browse OriGene Inhibitory RNA Products For ALKBH5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH5
Clone products for research
- Applied Biological Materials (abm): Clones for ALKBH5 - Starting at $45 >
- * ALKBH5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ALKBH5
- Addgene plasmids for ALKBH5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALKBH5
Relevant External Links for ALKBH5 Gene
- GeneLoc Exon Structure for
- ALKBH5
Expression for ALKBH5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
This gene is overexpressed in Breast (10.6), Peripheral blood mononuclear cells (7.4), Stomach (7.0), and CD8 Tcells (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALKBH5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALKBH5
SOURCE GeneReport for Unigene cluster for ALKBH5 Gene:
Hs.744130mRNA Expression by UniProt/SwissProt for ALKBH5 Gene:
Q6P6C2-ALKB5_HUMAN
Tissue specificity:
Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.
Evidence on tissue expression from TISSUES for ALKBH5 Gene
- Nervous system(4.7)
- Liver(4.5)
- Spleen(4.4)
- Muscle(3)
- Skin(2.7)
- Heart(2.6)
- Kidney(2.6)
- Lung(2.3)
- Intestine(2.1)
- Blood(2.1)
Primer products for research
-
OriGene qPCR primer pairs for ALKBH5
-
OriGene qPCR primer pairs and template standards for ALKBH5
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKBH5 Gene
Orthologs for ALKBH5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ALKBH5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ALKBH5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ALKBH5 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ALKBH5 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Alkbh5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Alkbh5 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ALKBH5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ALKBH5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ALKBH5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | alkbh5 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | alkbh5 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10218 31 |
|
OneToOne |
- Species where no ortholog for ALKBH5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ALKBH5 Gene
- ENSEMBL:
- Gene Tree for ALKBH5 (if available)
- TreeFam:
- Gene Tree for ALKBH5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALKBH5: view image
Paralogs for ALKBH5 Gene
No data available for Paralogs for ALKBH5 Gene
Variants for ALKBH5 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.29;
6.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALKBH5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ALKBH5
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALKBH5 Gene
Disorders for ALKBH5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| periosteal chondrosarcoma |
|
|
| smith-magenis syndrome |
|
|
| wilms tumor 1 |
|
|
Search ALKBH5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALKBH5
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ALKBH5 Gene
Publications for ALKBH5 Gene
- Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. (PMID: 24778178) Xu C … Min J (The Journal of biological chemistry 2014) 2 3 4
- Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition. (PMID: 24616105) Feng C … Chen Z (The Journal of biological chemistry 2014) 3 4
- Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. (PMID: 24489119) Aik W … McDonough MA (Nucleic acids research 2014) 3 4
- ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. (PMID: 23177736) Zheng G … He C (Molecular cell 2013) 3 4
- Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). (PMID: 21264265) Thalhammer A … Pollard PJ (PloS one 2011) 3 4
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Products for ALKBH5 Gene
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Sources for ALKBH5 Gene
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