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The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] See more...
Aliases for ALKBH3 Gene
Aliases for ALKBH3 Gene
External Ids for ALKBH3 Gene
- HGNC: 30141
- Entrez Gene: 221120
- Ensembl: ENSG00000166199
- OMIM: 610603
- UniProtKB: Q96Q83
Previous GeneCards Identifiers for ALKBH3 Gene
- GC11P043859
- GC11P043611
Summaries for ALKBH3 Gene
-
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ALKBH3 Gene
ALKBH3 (AlkB Homolog 3, Alpha-Ketoglutarate Dependent Dioxygenase) is a Protein Coding gene. Diseases associated with ALKBH3 include Salivary Gland Carcinoma and Combined Oxidative Phosphorylation Deficiency 30. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and L-ascorbic acid binding.
UniProtKB/Swiss-Prot Summary for ALKBH3 Gene
-
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410).
Additional gene information for ALKBH3 Gene
- HGNC(30141)
- Entrez Gene(221120)
- Ensembl(ENSG00000166199)
- OMIM(610603)
- UniProtKB(Q96Q83)
- Open Targets Platform(ENSG00000166199)
- Search for ALKBH3 at DataMed
- Search for ALKBH3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALKBH3 Gene
Genomics for ALKBH3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ALKBH3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALKBH3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALKBH3
- Top Transcription factor binding sites by QIAGEN in the ALKBH3 gene promoter:
-
- AREB6
- C/EBPbeta
- FOXI1
- FOXL1
- HFH-3
- Max1
- POU2F1
- POU2F1a
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for ALKBH3 Gene
Genomic Locations for ALKBH3 Gene
- chr11:43,880,811-43,920,274
- (GRCh38/hg38)
- Size:
- 39,464 bases
- Orientation:
- Plus strand
- chr11:43,902,357-43,941,825
- (GRCh37/hg19)
- Size:
- 39,469 bases
- Orientation:
- Plus strand
Genomic View for ALKBH3 Gene
Genes around ALKBH3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
ALKBH3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALKBH3 Gene
Proteins for ALKBH3 Gene
-
Protein details for ALKBH3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96Q83-ALKB3_HUMAN
- Recommended name:
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
- Protein Accession:
- Q96Q83
- A6NDJ1
- Q3SYI0
- Q6NX57
- Q96BU8
Protein attributes for ALKBH3 Gene
- Size:
- 286 amino acids
- Molecular mass:
- 33375 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Quaternary structure:
-
- Interacts with the ASCC complex composed of ASCC1, ASCC2 and ASCC3 (PubMed:29144457, PubMed:22055184). Interacts directly with ASCC3, and is thereby recruited to the ASCC complex (PubMed:22055184, PubMed:29144457). Interacts with OTUD4; the interaction is direct (PubMed:25944111). Interacts with USP7 and USP9X (PubMed:25944111).
- SequenceCaution:
-
- Sequence=AAH15155.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ALKBH3 Gene
Selected DME Specific Peptides for ALKBH3 Gene
- Q96Q83:
-
- FEMRKKPPPE
- NLTFRTVYPDPRGA
Post-translational modifications for ALKBH3 Gene
- Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination. OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'-polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ALKBH3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PCA1 / ALKBH3 Antibody
- G Biosciences Immunotag™ ALKBH3 Antibody
- Novus Biologicals Antibodies for ALKBH3
-
Abcam antibodies for ALKBH3
- Invitrogen Antibodies for ALKBH3 (AFLGC-Alkbh3)
-
Biorbyt antibodies for ALKBH3
-
Boster Bio Antibodies for ALKBH3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALKBH3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ALKBH3
- Origene Custom Protein Services for ALKBH3
- ProSpec Recombinant Proteins for ALKBH3
-
Signalway Proteins for ALKBH3
-
Abcam proteins for ALKBH3
Assay Products
- Novus Biologicals ELISA Kits for ALKBH3
Domains & Families for ALKBH3 Gene
Gene Families for ALKBH3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ALKBH3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ALKBH3 Gene
- GenScript: Design optimal peptide antigens:
-
- Prostate cancer antigen 1 (ALKB3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96Q83- Family:
-
- Belongs to the alkB family.
Function for ALKBH3 Gene
Molecular function for ALKBH3 Gene
- UniProtKB/Swiss-Prot Function:
- Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49516, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=1.14.11.54; Evidence={ECO:0000305|PubMed:26863196};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by ascorbate.
Enzyme Numbers (IUBMB) for ALKBH3 Gene
Phenotypes From GWAS Catalog for ALKBH3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 22055184 |
| GO:0008198 | ferrous iron binding | IDA | 16858410 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | IEA | -- |
| GO:0031418 | L-ascorbic acid binding | IEA | -- |
Phenotypes for ALKBH3 Gene
- MGI mutant phenotypes for ALKBH3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALKBH3:
-
- no effect
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability
- Synthetic lethal with Ras
- Increased CFP-tsO45G cell surface transport
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased HIV-1 infection
Animal Models for ALKBH3 Gene
- MGI Knock Outs for ALKBH3:
-
- Alkbh3 Alkbh3<tm1Klng>
Animal Model Products
-
Taconic Biosciences Mouse Models for ALKBH3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALKBH3 - Select products 50% OFF >
- * ALKBH3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ALKBH3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALKBH3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALKBH3
miRNA for ALKBH3 Gene
- miRTarBase miRNAs that target ALKBH3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALKBH3
- Browse OriGene Inhibitory RNA Products For ALKBH3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH3
Clone Products
- Applied Biological Materials (abm): Clones for ALKBH3 - Select products 50% OFF >
- * ALKBH3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ALKBH3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALKBH3
Cell Line Products
-
Horizon Cell Lines for ALKBH3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALKBH3 Gene
Localization for ALKBH3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALKBH3 Gene
- Nucleus. Cytoplasm. Note=Colocalizes with ASCC2 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage (PubMed:29144457). Predominantly localizes to the nucleus. {ECO:0000269 PubMed:12486230, ECO:0000269 PubMed:12594517, ECO:0000269 PubMed:17979886, ECO:0000269 PubMed:29144457}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (4)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ALKBH3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Damage Reversal | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for ALKBH3 Gene
4 Reactome pathways for ALKBH3 Gene
Interacting Proteins for ALKBH3 Gene
Selected Interacting proteins:
Q96Q83-ALKB3_HUMAN
ENSP00000302232
for ALKBH3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ALKBH3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006281 | DNA repair | IEA,IDA | 16858410 |
| GO:0006307 | DNA dealkylation involved in DNA repair | IEA,TAS | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0008283 | cell proliferation | IMP | 22055184 |
| GO:0035552 | oxidative single-stranded DNA demethylation | IEA,IMP | 22055184 |
No data available for SIGNOR curated interactions for ALKBH3 Gene
Transcripts for ALKBH3 Gene
mRNA/cDNA for ALKBH3 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000532962 1371 nts (view in UCSC)
- ENST00000527029 569 nts (view in UCSC)
- ENST00000302708 1544 nts (view in UCSC)
- ENST00000534171 764 nts (view in UCSC)
- ENST00000524742 842 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALKBH3 - Select products 50% OFF >
- * ALKBH3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ALKBH3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALKBH3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALKBH3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALKBH3
- Browse OriGene Inhibitory RNA Products For ALKBH3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH3
Clone Products
- Applied Biological Materials (abm): Clones for ALKBH3 - Select products 50% OFF >
- * ALKBH3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ALKBH3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALKBH3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for ALKBH3 Gene
- GeneLoc Exon Structure for
- ALKBH3
Expression for ALKBH3 Gene
This gene is overexpressed in Serum (61.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALKBH3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALKBH3
SOURCE GeneReport for Unigene cluster for ALKBH3 Gene:
Hs.720708mRNA Expression by UniProt/SwissProt for ALKBH3 Gene:
Q96Q83-ALKB3_HUMAN
Tissue specificity:
Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon.
Evidence on tissue expression from TISSUES for ALKBH3 Gene
- Nervous system(4.5)
- Lung(4.3)
- Liver(2.2)
- Intestine(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for ALKBH3
-
OriGene qPCR primer pairs and template standards for ALKBH3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKBH3 Gene
Orthologs for ALKBH3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ALKBH3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ALKBH3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ALKBH3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Alkbh3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Alkbh3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ALKBH3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ALKBH3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ALKBH3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | alkbh3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | alkbh3 30 31 |
|
OneToOne | |
| Dr.14529 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ALKBH3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ALKBH3 Gene
- ENSEMBL:
- Gene Tree for ALKBH3 (if available)
- TreeFam:
- Gene Tree for ALKBH3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALKBH3: view image
Paralogs for ALKBH3 Gene
No data available for Paralogs for ALKBH3 Gene
Variants for ALKBH3 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv630n106 | CNV | deletion | 24896259 |
| esv2028436 | CNV | deletion | 18987734 |
| esv2616474 | CNV | deletion | 19546169 |
| esv2663316 | CNV | deletion | 23128226 |
| esv2744413 | CNV | deletion | 23290073 |
| esv3434768 | CNV | insertion | 20981092 |
| esv3547674 | CNV | deletion | 23714750 |
| esv3626155 | CNV | loss | 21293372 |
| esv6093 | CNV | loss | 19470904 |
| nsv1076691 | CNV | deletion | 25765185 |
| nsv467867 | CNV | gain | 19166990 |
| nsv554171 | CNV | gain | 21841781 |
| nsv832138 | CNV | gain | 17160897 |
| nsv957189 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.06;
80.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALKBH3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ALKBH3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH3 Gene
Disorders for ALKBH3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| salivary gland carcinoma |
|
|
| combined oxidative phosphorylation deficiency 30 |
|
|
| prostate cancer |
|
|
| salivary gland disease |
|
|
Search ALKBH3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALKBH3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ALKBH3 Gene
Publications for ALKBH3 Gene
- DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. (PMID: 22055184) Dango S … Shi Y (Molecular cell 2011) 2 3 4
- The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. (PMID: 26863196) Dominissini D … He C (Nature 2016) 3 4
- Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome. (PMID: 26863410) Li X … Yi C (Nature chemical biology 2016) 3 4
- Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. (PMID: 25944111) Zhao Y … Mosammaparast N (The EMBO journal 2015) 3 4
- Prostate cancer antigen-1 as a potential novel marker for prostate cancer. (PMID: 17968469) Liu BQ … Liu RL (Asian journal of andrology 2007) 3 23
ExternalLinks
Products for ALKBH3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ALKBH3
- Origene Custom Protein Services for ALKBH3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALKBH3
- Browse OriGene Inhibitory RNA Products For ALKBH3
- OriGene qPCR primer pairs for ALKBH3
- OriGene qPCR primer pairs and template standards for ALKBH3
- OriGene CRISPR knockouts for ALKBH3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ALKBH3
- Sino Biological Human cDNA Clone for ALKBH3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for ALKBH3
- Novus Biologicals proteins and lysates for ALKBH3
- Novus Biologicals ELISA Kits for ALKBH3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for ALKBH3
- Abcam proteins for ALKBH3
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for ALKBH3
- Taconic Biosciences Mouse Models for ALKBH3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ALKBH3 (AFLGC-Alkbh3)
- VectorBuilder Custom and pre-made DNA vectors for ALKBH3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ALKBH3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ALKBH3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ALKBH3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ALKBH3
- antibodies-online: Show 17 available ALKBH3 Antibodies ranked by validation data
- Compare Top ALKBH3 Antibodies
- antibodies-online: Search results for available ALKBH3 related products ranked by validation data
- antibodies-online: Show 8 available ALKBH3 Proteins ranked by validation data
- Compare Top ALKBH3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ALKBH3
- Search Santa Cruz Biotechnology (SCBT) for ALKBH3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ALKBH3
- Horizon Cell Lines for ALKBH3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALKBH3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALKBH3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ALKBH3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALKBH3
- Boster Bio Antibodies for ALKBH3
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ALKBH3
- Signalway Proteins for ALKBH3
Sources for ALKBH3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB