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Aliases for ALKAL2 Gene

Aliases for ALKAL2 Gene

  • ALK And LTK Ligand 2 2 3 3 5
  • Family With Sequence Similarity 150 Member B 2 3
  • Augmentor Alpha 3 4
  • Protein FAM150B 3 4
  • AUG-Alpha 3 4
  • FAM150B 3 4
  • Family With Sequence Similarity 150, Member B 2
  • Augmentor-Alpha 2
  • Augmentor-Beta 3
  • PRO1097 3
  • RGPG542 3
  • AUGA 3

External Ids for ALKAL2 Gene

Previous HGNC Symbols for ALKAL2 Gene

  • FAM150B

Summaries for ALKAL2 Gene

GeneCards Summary for ALKAL2 Gene

ALKAL2 (ALK And LTK Ligand 2) is a Protein Coding gene. An important paralog of this gene is ALKAL1.

UniProtKB/Swiss-Prot for ALKAL2 Gene

  • Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.

Additional gene information for ALKAL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKAL2 Gene

Genomics for ALKAL2 Gene

GeneHancer (GH) Regulatory Elements for ALKAL2 Gene

Promoters and enhancers for ALKAL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J000289 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 667.3 -0.9 -913 1.3 ARID4B DNMT3B RAD21 NCOA2 ZNF614 ZNF143 MXD4 REST MIER2 KAT8 ALKAL2 SH3YL1 LOC101927262 ENSG00000277997
GH02J000287 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 650.7 +1.0 979 1 RNF2 ZBTB26 EZH2 ALKAL2 LOC101927262
GH02J000288 Enhancer 0.3 ENCODE 650.7 -0.2 -176 0.2 EZH2 ALKAL2 LOC101927262 ENSG00000277997
GH02J000260 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.9 +25.5 25487 6.6 PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SH3YL1 ACP1 ALKAL2 TMEM18 LOC101927262 ENSG00000227061 GC02M000255
GH02J000033 Enhancer 1 ENCODE dbSUPER 10.1 +252.6 252624 6.5 ELF3 PKNOX1 NFIB NEUROD1 SIN3A BMI1 RFX5 HSF1 SCRT2 FOS ALKAL2 LOC101927262 FAM110C LOC105373346 SH3YL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ALKAL2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ALKAL2 Gene

Genomic Locations for ALKAL2 Gene
chr2:279,558-288,880
(GRCh38/hg38)
Size:
9,323 bases
Orientation:
Minus strand
chr2:279,558-288,851
(GRCh37/hg19)
Size:
9,294 bases
Orientation:
Minus strand

Genomic View for ALKAL2 Gene

Genes around ALKAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKAL2 Gene

Proteins for ALKAL2 Gene

  • Protein details for ALKAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX46-ALKL2_HUMAN
    Recommended name:
    ALK and LTK ligand 2
    Protein Accession:
    Q6UX46
    Secondary Accessions:
    • B5MC76

    Protein attributes for ALKAL2 Gene

    Size:
    152 amino acids
    Molecular mass:
    16915 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALKAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKAL2 Gene

Post-translational modifications for ALKAL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ALKAL2 Gene

Domains & Families for ALKAL2 Gene

Gene Families for ALKAL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ALKAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALKAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX46

UniProtKB/Swiss-Prot:

ALKL2_HUMAN :
  • Belongs to the ALKAL family.
Family:
  • Belongs to the ALKAL family.
genes like me logo Genes that share domains with ALKAL2: view

Function for ALKAL2 Gene

Molecular function for ALKAL2 Gene

UniProtKB/Swiss-Prot Function:
Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.

Phenotypes From GWAS Catalog for ALKAL2 Gene

Gene Ontology (GO) - Molecular Function for ALKAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26418745
GO:0030298 receptor signaling protein tyrosine kinase activator activity IDA 26418745
GO:0030971 receptor tyrosine kinase binding IDA 26418745
genes like me logo Genes that share ontologies with ALKAL2: view
genes like me logo Genes that share phenotypes with ALKAL2: view

miRNA for ALKAL2 Gene

miRTarBase miRNAs that target ALKAL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALKAL2 Gene

Localization for ALKAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKAL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALKAL2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ALKAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ALKAL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ALKAL2 Gene

Pathways & Interactions for ALKAL2 Gene

SuperPathways for ALKAL2 Gene

No Data Available

Interacting Proteins for ALKAL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384604%0d%0a9606.ENSP00000373700%0d%0a
Selected Interacting proteins: ENSP00000384604 Q6UX46-ALKL2_HUMAN for ALKAL2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for ALKAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010976 positive regulation of neuron projection development IDA 26418745
GO:0061098 positive regulation of protein tyrosine kinase activity IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 26418745
GO:0070378 positive regulation of ERK5 cascade IDA 26418745
genes like me logo Genes that share ontologies with ALKAL2: view

No data available for Pathways by source and SIGNOR curated interactions for ALKAL2 Gene

Drugs & Compounds for ALKAL2 Gene

No Compound Related Data Available

Transcripts for ALKAL2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALKAL2 Gene

No ASD Table

Relevant External Links for ALKAL2 Gene

GeneLoc Exon Structure for
ALKAL2
ECgene alternative splicing isoforms for
ALKAL2

Expression for ALKAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALKAL2 Gene:

ALKAL2

mRNA Expression by UniProt/SwissProt for ALKAL2 Gene:

Q6UX46-ALKL2_HUMAN
Tissue specificity: Widely expressed with highest levels in adrenal gland and modest levels in pancreas, testis and uterus.

Evidence on tissue expression from TISSUES for ALKAL2 Gene

  • Adrenal gland(2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKAL2 Gene

Orthologs for ALKAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALKAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM150B 34 33
  • 99.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM150B 33
  • 82.11 (n)
rat
(Rattus norvegicus)
Mammalia Fam150b 33
  • 79.13 (n)
mouse
(Mus musculus)
Mammalia Fam150b 34 33
  • 78.59 (n)
OneToOne
Alkal2 16
oppossum
(Monodelphis domestica)
Mammalia FAM150B 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM150B 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM150B 34 33
  • 69.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM150B 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam150b 33
  • 63.96 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329254 33
  • 57.65 (n)
fam150ba 34
  • 43 (a)
OneToMany
fam150bb 34
  • 35 (a)
OneToMany
Species where no ortholog for ALKAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALKAL2 Gene

ENSEMBL:
Gene Tree for ALKAL2 (if available)
TreeFam:
Gene Tree for ALKAL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALKAL2: view image

Paralogs for ALKAL2 Gene

Paralogs for ALKAL2 Gene

genes like me logo Genes that share paralogs with ALKAL2: view

Variants for ALKAL2 Gene

Sequence variations from dbSNP and Humsavar for ALKAL2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000235432 -- 286,251(-) G/A intron_variant
rs1000298119 -- 280,852(-) G/A intron_variant
rs1000327473 -- 281,183(-) T/A intron_variant
rs1000438974 -- 285,083(-) CC/C intron_variant
rs1000491307 -- 284,638(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ALKAL2 Gene

Variant ID Type Subtype PubMed ID
nsv833170 CNV loss 17160897
nsv833159 CNV loss 17160897
nsv1072370 CNV deletion 25765185
esv3589599 CNV gain 21293372
esv3589598 CNV gain 21293372
esv2759016 CNV gain 17122850
dgv3698n100 CNV gain 25217958

Variation tolerance for ALKAL2 Gene

Gene Damage Index Score: 0.08; 1.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALKAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALKAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKAL2 Gene

Disorders for ALKAL2 Gene

Additional Disease Information for ALKAL2

No disorders were found for ALKAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALKAL2 Gene

Publications for ALKAL2 Gene

  1. FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. (PMID: 26418745) Guan J … Palmer RH (eLife 2015) 2 3 4 58
  2. Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. (PMID: 26630010) Reshetnyak AV … Schlessinger J (Proceedings of the National Academy of Sciences of the United States of America 2015) 2 3 4 58
  3. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. (PMID: 25331893) Zhang H … Williams LT (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for ALKAL2 Gene

Sources for ALKAL2 Gene

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