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Aliases for ALG5 Gene

Aliases for ALG5 Gene

  • ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase 2 3 5
  • Asparagine-Linked Glycosylation 5 Homolog (Yeast, Dolichyl-Phosphate Beta-Glucosyltransferase) 2 3
  • Asparagine-Linked Glycosylation Protein 5 Homolog 3 4
  • DolP-Glucosyltransferase 3 4
  • Asparagine-Linked Glycosylation 5 Homolog (S. Cerevisiae, Dolichyl-Phosphate Beta-Glucosyltransferase) 3
  • Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate Beta-Glucosyltransferase Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate Beta-Glucosyltransferase Homolog 3
  • Dolichyl-Phosphate Beta-Glucosyltransferase 3
  • Dolichyl Phosphate Glucosyltransferase 3
  • Alg5, S. Cerevisiae, Homolog Of 3
  • EC 4
  • BA421P11.2 3

External Ids for ALG5 Gene

Previous GeneCards Identifiers for ALG5 Gene

  • GC13M035510
  • GC13M031510
  • GC13M036460
  • GC13M035321
  • GC13M036421
  • GC13M037523
  • GC13M018335

Summaries for ALG5 Gene

Entrez Gene Summary for ALG5 Gene

  • This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ALG5 Gene

ALG5 (ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase) is a Protein Coding gene. Diseases associated with ALG5 include Pontocerebellar Hypoplasia, Type 1C and Congenital Disorder Of Glycosylation, Type In. Among its related pathways are N-Glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include oligosaccharyl transferase activity and dolichyl-phosphate beta-glucosyltransferase activity.

Additional gene information for ALG5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG5 Gene

Genomics for ALG5 Gene

GeneHancer (GH) Regulatory Elements for ALG5 Gene

Promoters and enhancers for ALG5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J036997 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.7 +0.2 179 4.6 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 EXOSC8 ALG5 SUPT20H RFXAP SPART-AS1 SMAD9 CSNK1A1L
GH13J037746 Enhancer 0.7 ENCODE 11.4 -747.2 -747209 1.2 FEZF1 ZBTB40 ZNF547 ZNF26 NFE2 FOS NFE2L2 ZNF362 CEBPB ZNF843 EXOSC8 ALG5 GC13P037774 GC13P037655 TRPC4
GH13J036965 Enhancer 0.5 ENCODE 0.3 +34.1 34051 1.7 JUND MAZ JUN FOS FOXA1 SUPT20H PIR51208 EIF4A1P5 ALG5
GH13J037006 Enhancer 0.3 dbSUPER 0.4 -6.9 -6932 1.8 PRDM1 SUPT20H GC13P037009 ALG5 EXOSC8
GH13J036978 Enhancer 0.2 ENCODE 0.3 +20.8 20753 1.1 CSNK1A1L PIR51208 ALG5 EIF4A1P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALG5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALG5 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • Lmo2
  • Tal-1beta
  • aMEF-2
  • MEF-2A
  • ITF-2

Genomic Locations for ALG5 Gene

Genomic Locations for ALG5 Gene
50,492 bases
Minus strand
50,492 bases
Minus strand

Genomic View for ALG5 Gene

Genes around ALG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG5 Gene

Proteins for ALG5 Gene

  • Protein details for ALG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dolichyl-phosphate beta-glucosyltransferase
    Protein Accession:
    Secondary Accessions:
    • B4DR37
    • Q5TBA6

    Protein attributes for ALG5 Gene

    324 amino acids
    Molecular mass:
    36946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALG5 Gene


neXtProt entry for ALG5 Gene

Post-translational modifications for ALG5 Gene

  • Glycosylation at posLast=281281
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG5 Gene

No data available for DME Specific Peptides for ALG5 Gene

Domains & Families for ALG5 Gene

Gene Families for ALG5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ALG5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 2 family.
  • Belongs to the glycosyltransferase 2 family.
genes like me logo Genes that share domains with ALG5: view

Function for ALG5 Gene

Molecular function for ALG5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.

Enzyme Numbers (IUBMB) for ALG5 Gene

Gene Ontology (GO) - Molecular Function for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 oligosaccharyl transferase activity TAS 10359825
GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ALG5: view
genes like me logo Genes that share phenotypes with ALG5: view

miRNA for ALG5 Gene

miRTarBase miRNAs that target ALG5

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALG5 Gene

Localization for ALG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG5 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALG5 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IBA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG5: view

Pathways & Interactions for ALG5 Gene

genes like me logo Genes that share pathways with ALG5: view

UniProtKB/Swiss-Prot Q9Y673-ALG5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 10359825
GO:0006487 protein N-linked glycosylation IBA --
GO:0007368 determination of left/right symmetry IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with ALG5: view

No data available for SIGNOR curated interactions for ALG5 Gene

Drugs & Compounds for ALG5 Gene

(3) Drugs for ALG5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine 5'-diphosphate Experimental Pharma 0
Uridine diphosphate glucose Experimental Pharma 0
dolichol phosphate Pharma Competitive, Inhibitor 0

(2) Additional Compounds for ALG5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
Dolichyl b-D-glucosyl phosphate
  • Dolichol monophosphate glucose
  • Dolichyl b-delta-glucosyl phosphate
  • Dolichyl beta-D-glucosyl phosphate
  • Dolichyl beta-delta-glucosyl phosphate
  • Dolichyl monophosphate glucose
genes like me logo Genes that share compounds with ALG5: view

Transcripts for ALG5 Gene

mRNA/cDNA for ALG5 Gene

Unigene Clusters for ALG5 Gene

ALG5, dolichyl-phosphate beta-glucosyltransferase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -

Relevant External Links for ALG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALG5 Gene

Protein differential expression in normal tissues from HIPED for ALG5 Gene

This gene is overexpressed in Salivary gland (7.4) and Stomach (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALG5 Gene

Protein tissue co-expression partners for ALG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ALG5 Gene:


SOURCE GeneReport for Unigene cluster for ALG5 Gene:


mRNA Expression by UniProt/SwissProt for ALG5 Gene:

Tissue specificity: Expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung.

Evidence on tissue expression from TISSUES for ALG5 Gene

  • Liver(4.3)
  • Blood(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ALG5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG5 Gene

Orthologs for ALG5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALG5 34 33
  • 99.38 (n)
(Canis familiaris)
Mammalia ALG5 34 33
  • 91.77 (n)
(Bos Taurus)
Mammalia ALG5 34 33
  • 91.17 (n)
(Mus musculus)
Mammalia Alg5 16 34 33
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Alg5 33
  • 86.75 (n)
(Ornithorhynchus anatinus)
Mammalia ALG5 34
  • 84 (a)
(Monodelphis domestica)
Mammalia ALG5 34
  • 79 (a)
(Gallus gallus)
Aves ALG5 34 33
  • 78.52 (n)
(Anolis carolinensis)
Reptilia ALG5 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alg5 33
  • 71.78 (n)
Str.709 33
African clawed frog
(Xenopus laevis)
Amphibia alg5-prov 33
(Danio rerio)
Actinopterygii alg5 34 33
  • 68.11 (n)
wufk42e01 33
fruit fly
(Drosophila melanogaster)
Insecta CG7870 35
  • 60 (a)
wol 34 33
  • 58.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008315 33
  • 55.74 (n)
(Caenorhabditis elegans)
Secernentea H43I07.3 34 35 33
  • 53.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16071g 33
  • 53.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG5 36 34 33
  • 51.78 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL133C 33
  • 49.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39630 33
  • 57.41 (n)
(Oryza sativa)
Liliopsida Os03g0821800 33
  • 55.47 (n)
Os.4641 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
Cin.587 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg5 33
  • 50.28 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06386 33
  • 48.13 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.587 33
Species where no ortholog for ALG5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG5 Gene

Gene Tree for ALG5 (if available)
Gene Tree for ALG5 (if available)
Evolutionary constrained regions (ECRs) for ALG5: view image

Paralogs for ALG5 Gene

No data available for Paralogs for ALG5 Gene

Variants for ALG5 Gene

Sequence variations from dbSNP and Humsavar for ALG5 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs606231285 pathogenic, Pontocerebellar hypoplasia, type 1c 37,000,810(-) C/T upstream_transcript_variant
rs1000050038 -- 36,981,738(-) G/A intron_variant
rs1000065292 -- 36,959,590(-) G/T intron_variant
rs1000234291 -- 36,976,675(-) G/A/C intron_variant
rs1000261591 -- 36,997,015(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ALG5 Gene

Variant ID Type Subtype PubMed ID
esv2454960 CNV deletion 19546169
esv3303429 CNV mobile element insertion 20981092
esv3307969 CNV mobile element insertion 20981092
esv3419066 CNV insertion 20981092
esv3440089 CNV insertion 20981092
esv3892330 CNV gain 25118596
nsv1122805 CNV deletion 24896259
nsv1134302 CNV deletion 24896259
nsv522336 CNV gain 19592680

Variation tolerance for ALG5 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG5 Gene

Disorders for ALG5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ALG5 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ALG5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ALG5

genes like me logo Genes that share disorders with ALG5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALG5 Gene

Publications for ALG5 Gene

  1. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. (PMID: 10359825) Imbach T … Hennet T (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ALG5 Gene

Sources for ALG5 Gene

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