Aliases for ALG1L2 Gene

Aliases for ALG1L2 Gene

  • ALG1 Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Like 2 2 3 5
  • Asparagine-Linked Glycosylation 1-Like 2 2 3
  • Putative Glycosyltransferase ALG1L2 3 4
  • EC 2.4.1.- 4
  • ALG1L2 5

External Ids for ALG1L2 Gene

Previous GeneCards Identifiers for ALG1L2 Gene

  • GC03P131284
  • GC03P129800
  • GC03P127184
  • GC03P130082
  • GC03P130084
  • GC03P130178
  • GC03P130190
  • GC03P130396

Summaries for ALG1L2 Gene

GeneCards Summary for ALG1L2 Gene

ALG1L2 (ALG1 Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Like 2) is a Protein Coding gene. Diseases associated with ALG1L2 include Ovarian Carcinosarcoma. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is ALG1.

UniProtKB/Swiss-Prot Summary for ALG1L2 Gene

Additional gene information for ALG1L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALG1L2 Gene

Genomics for ALG1L2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALG1L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J130081 Enhancer 0.6 Ensembl ENCODE 609.6 +0.6 570 3.6 ATF7 NR2F2 ATF2 ALG1L2 COL6A4P2 LINC02021 ENSG00000203644 piR-54297-003 LOC105374103
GH03J130093 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 19.4 +12.6 12606 2.3 PRDM10 LARP7 PKNOX1 TCF12 IKZF2 MNT EED NONO DPF2 RELB LINC02014 ALG1L2 COL6A4P2 NONHSAG036071.2 LOC105374103
GH03J130095 Promoter 0.6 Ensembl 17.7 +14.3 14270 0.2 PRDM10 IKZF1 TBX21 ZNF48 LINC02014 NONHSAG036071.2 COL6A4P2 ALG1L2 LINC02021 LOC105374103
GH03J129370 Enhancer 0.6 Ensembl 10 -710.7 -710730 0.6 ZSCAN4 PATZ1 HES1 KLF9 FOXK2 ZKSCAN1 ZNF444 PHF20 ADNP ZNF837 lnc-EFCAB12-3 piR-42694-114 FAM86HP RHO ALG1L2 H1-10 EFCAB12
GH03J130085 Enhancer 0.5 Ensembl 10.8 +4.6 4570 2 IKZF1 PKNOX1 SOX6 TCF7 CTBP1 MEIS2 ALG1L2 COL6A4P2 LINC02021 piR-54297-003 LOC105374103
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALG1L2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALG1L2

Genomic Locations for ALG1L2 Gene

Genomic Locations for ALG1L2 Gene
chr3:130,081,831-130,113,227
(GRCh38/hg38)
Size:
31,397 bases
Orientation:
Plus strand
chr3:129,800,674-129,832,070
(GRCh37/hg19)
Size:
31,397 bases
Orientation:
Plus strand

Genomic View for ALG1L2 Gene

Genes around ALG1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG1L2 Gene

Proteins for ALG1L2 Gene

  • Protein details for ALG1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J202-AG1L2_HUMAN
    Recommended name:
    Putative glycosyltransferase ALG1L2
    Protein Accession:
    C9J202

    Protein attributes for ALG1L2 Gene

    Size:
    215 amino acids
    Molecular mass:
    24154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALG1L2 Gene

Post-translational modifications for ALG1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALG1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALG1L2 Gene

Domains & Families for ALG1L2 Gene

Gene Families for ALG1L2 Gene

Protein Domains for ALG1L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALG1L2 Gene

GenScript: Design optimal peptide antigens:
  • Putative glycosyltransferase ALG1L2 (AG1L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

C9J202

UniProtKB/Swiss-Prot:

AG1L2_HUMAN :
  • Belongs to the glycosyltransferase group 1 family.
Family:
  • Belongs to the glycosyltransferase group 1 family.
genes like me logo Genes that share domains with ALG1L2: view

Function for ALG1L2 Gene

Molecular function for ALG1L2 Gene

UniProtKB/Swiss-Prot Function:
Putative glycosyltransferase.

Enzyme Numbers (IUBMB) for ALG1L2 Gene

Phenotypes From GWAS Catalog for ALG1L2 Gene

Gene Ontology (GO) - Molecular Function for ALG1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ALG1L2: view
genes like me logo Genes that share phenotypes with ALG1L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG1L2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALG1L2 Gene

Localization for ALG1L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALG1L2 gene
Compartment Confidence
endoplasmic reticulum 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (1)
  • Nucleoli fibrillar center (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALG1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
genes like me logo Genes that share ontologies with ALG1L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALG1L2 Gene

Pathways & Interactions for ALG1L2 Gene

PathCards logo

SuperPathways for ALG1L2 Gene

No Data Available

Interacting Proteins for ALG1L2 Gene

Gene Ontology (GO) - Biological Process for ALG1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IBA 21873635
GO:0097502 mannosylation IEA --
genes like me logo Genes that share ontologies with ALG1L2: view

No data available for Pathways by source and SIGNOR curated interactions for ALG1L2 Gene

Drugs & Compounds for ALG1L2 Gene

No Compound Related Data Available

Transcripts for ALG1L2 Gene

mRNA/cDNA for ALG1L2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG1L2

Alternative Splicing Database (ASD) splice patterns (SP) for ALG1L2 Gene

No ASD Table

Relevant External Links for ALG1L2 Gene

GeneLoc Exon Structure for
ALG1L2

Expression for ALG1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALG1L2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALG1L2

SOURCE GeneReport for Unigene cluster for ALG1L2 Gene:

Hs.722197
genes like me logo Genes that share expression patterns with ALG1L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG1L2 Gene

Orthologs for ALG1L2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ALG1L2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC739193 30
  • 98.44 (n)
Species where no ortholog for ALG1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ALG1L2 Gene

ENSEMBL:
Gene Tree for ALG1L2 (if available)
TreeFam:
Gene Tree for ALG1L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALG1L2: view image

Paralogs for ALG1L2 Gene

Paralogs for ALG1L2 Gene

(3) SIMAP similar genes for ALG1L2 Gene using alignment to 2 proteins:

  • AG1L2_HUMAN
  • H9XFA2_HUMAN

Pseudogenes.org Pseudogenes for ALG1L2 Gene

genes like me logo Genes that share paralogs with ALG1L2: view

Variants for ALG1L2 Gene

Additional dbSNP identifiers (rs#s) for ALG1L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ALG1L2 Gene

Variant ID Type Subtype PubMed ID
dgv128n73 CNV deletion 24416366
dgv180n111 CNV deletion 26073780
dgv2595n106 CNV deletion 24896259
dgv2596n106 CNV deletion 24896259
dgv46e213 CNV loss 24956385
dgv4860n100 CNV gain 25217958
dgv4861n100 CNV gain 25217958
dgv4862n100 CNV gain 25217958
dgv4864n100 CNV gain 25217958
dgv4865n100 CNV gain+loss 25217958
dgv4866n100 CNV gain 25217958
dgv4867n100 CNV gain 25217958
dgv4868n100 CNV gain 25217958
dgv4869n100 CNV gain+loss 25217958
dgv4872n100 CNV loss 25217958
dgv4873n100 CNV gain+loss 25217958
dgv4874n100 CNV gain 25217958
dgv4881n100 CNV gain 25217958
dgv4882n100 CNV gain+loss 25217958
dgv4883n100 CNV gain 25217958
dgv4885n100 CNV gain 25217958
dgv4888n100 CNV gain+loss 25217958
dgv4889n100 CNV gain 25217958
dgv4890n100 CNV gain 25217958
dgv4891n100 CNV gain 25217958
dgv4892n100 CNV loss 25217958
dgv4893n100 CNV gain+loss 25217958
dgv4894n100 CNV gain 25217958
dgv4895n100 CNV gain 25217958
dgv4896n100 CNV gain+loss 25217958
dgv4897n100 CNV loss 25217958
dgv4898n100 CNV loss 25217958
dgv4899n100 CNV loss 25217958
dgv4900n100 CNV gain 25217958
dgv8581n54 CNV loss 21841781
dgv8584n54 CNV loss 21841781
dgv8585n54 CNV gain 21841781
dgv885e199 CNV deletion 23128226
esv2422077 CNV deletion 20811451
esv2455918 CNV loss 19546169
esv24757 CNV gain+loss 19812545
esv2725909 CNV deletion 23290073
esv2725910 CNV deletion 23290073
esv2759177 CNV gain+loss 17122850
esv2760790 CNV loss 21179565
esv2763722 CNV gain+loss 21179565
esv3466 CNV loss 18987735
esv3562532 CNV deletion 23714750
esv3584792 CNV loss 24956385
esv3597754 CNV loss 21293372
esv3893773 CNV gain 25118596
esv5945 CNV loss 19470904
esv993528 CNV gain 20482838
nsv1001109 CNV loss 25217958
nsv1012843 CNV gain 25217958
nsv1013049 CNV gain+loss 25217958
nsv1013916 CNV gain+loss 25217958
nsv1071908 CNV deletion 25765185
nsv1110417 CNV duplication 24896259
nsv1150848 CNV deletion 26484159
nsv1160981 OTHER complex 26073780
nsv1160982 CNV deletion 26073780
nsv1160983 CNV deletion 26073780
nsv4001 CNV deletion 18451855
nsv428420 CNV gain 18775914
nsv433361 CNV gain 18776910
nsv437340 CNV loss 16327808
nsv442875 CNV loss 18776908
nsv499012 CNV loss 21111241
nsv508242 CNV deletion 20534489
nsv508954 CNV insertion 20534489
nsv591707 CNV loss 21841781
nsv820609 CNV deletion 20802225
nsv822252 CNV gain 20364138
nsv829723 CNV gain 17160897
nsv967062 CNV duplication 23825009
nsv998210 CNV loss 25217958

Additional Variant Information for ALG1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALG1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ALG1L2 Gene

Disorders for ALG1L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALG1L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian carcinosarcoma
  • ovarian malignant mesodermal mixed tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ALG1L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALG1L2 Gene

Publications for ALG1L2 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for ALG1L2 Gene

Sources for ALG1L2 Gene