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Aliases for ALG1L Gene

Aliases for ALG1L Gene

  • ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Like 2 3 5
  • Asparagine-Linked Glycosylation 1-Like 1 2 3
  • Putative Glycosyltransferase ALG1-Like 3
  • Asparagine-Linked Glycosylation 1-Like 2
  • Beta-1,4-Mannosyltransferase-Like 3
  • EC 2.4.1.- 4
  • ALG1L1 3

External Ids for ALG1L Gene

Previous GeneCards Identifiers for ALG1L Gene

  • GC03M127131
  • GC03M125648
  • GC03M123028

Summaries for ALG1L Gene

GeneCards Summary for ALG1L Gene

ALG1L (ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is ALG1.

UniProtKB/Swiss-Prot for ALG1L Gene

  • Putative glycosyltransferase.

Additional gene information for ALG1L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG1L Gene

Genomics for ALG1L Gene

GeneHancer (GH) Regulatory Elements for ALG1L Gene

Promoters and enhancers for ALG1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J125989 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 693.7 -38.6 -38603 1.8 ARID4B SIN3A ZBTB40 RAD21 YY1 ETS1 ZNF335 POLR2B EGR1 THAP11 ALG1L PIR42058 FAM86JP ROPN1B SLC41A3 CFAP100 ZXDC ENSG00000248607
GH03J125937 Promoter 0.9 EPDnew 650.4 +15.0 14992 0.1 KLF1 DPF2 FOXA1 ZFHX2 ZNF692 ZBTB48 EGR1 ZNF629 GLIS1 EGR2 ALG1L FAM86JP
GH03J126055 Enhancer 1.1 Ensembl ENCODE 43.3 -105.9 -105861 4.1 ARID4B BRCA1 ZNF48 ATF7 NFKBIZ SP5 REST SMARCB1 KAT8 NFIL3 ENSG00000248607 ALG1L FAM86JP SLC41A3 ALDH1L1-AS1 OR7E29P LOC105374085
GH03J126081 Enhancer 0.7 ENCODE 31.4 -130.0 -129985 1.5 CTCF ZNF146 MXI1 JUN MAX SIN3A ZBTB40 ZKSCAN1 POLR2A ADNP FAM86JP ALG1L SLC41A3 LOC105374085 ENSG00000248607
GH03J126099 Enhancer 0.6 ENCODE 32.7 -148.7 -148672 1.7 NR2F1 MAX JUNB MEF2B BATF ZIC2 ATF2 IRF4 BCL11A ATF7 SLC41A3 FAM86JP ALG1L ROPN1B LOC105374085
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ALG1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALG1L gene promoter:
  • p53
  • Evi-1
  • AP-1
  • POU3F2
  • AhR
  • Arnt
  • STAT5A
  • COMP1

Genomic Locations for ALG1L Gene

Genomic Locations for ALG1L Gene
chr3:125,928,840-125,952,098
(GRCh38/hg38)
Size:
23,259 bases
Orientation:
Minus strand
chr3:125,648,118-125,655,887
(GRCh37/hg19)
Size:
7,770 bases
Orientation:
Minus strand

Genomic View for ALG1L Gene

Genes around ALG1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG1L Gene

Proteins for ALG1L Gene

  • Protein details for ALG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMV1-ALG1L_HUMAN
    Recommended name:
    Putative glycosyltransferase ALG1-like
    Protein Accession:
    Q6GMV1
    Secondary Accessions:
    • D3DNA5

    Protein attributes for ALG1L Gene

    Size:
    187 amino acids
    Molecular mass:
    21132 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALG1L Gene

Post-translational modifications for ALG1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALG1L Gene

Domains & Families for ALG1L Gene

Gene Families for ALG1L Gene

Protein Domains for ALG1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALG1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GMV1

UniProtKB/Swiss-Prot:

ALG1L_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
genes like me logo Genes that share domains with ALG1L: view

Function for ALG1L Gene

Molecular function for ALG1L Gene

UniProtKB/Swiss-Prot Function:
Putative glycosyltransferase.

Enzyme Numbers (IUBMB) for ALG1L Gene

Phenotypes From GWAS Catalog for ALG1L Gene

Gene Ontology (GO) - Molecular Function for ALG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ALG1L: view
genes like me logo Genes that share phenotypes with ALG1L: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALG1L Gene

Localization for ALG1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALG1L gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
extracellular 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ALG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with ALG1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ALG1L Gene

Pathways & Interactions for ALG1L Gene

SuperPathways for ALG1L Gene

No Data Available

Interacting Proteins for ALG1L Gene

Gene Ontology (GO) - Biological Process for ALG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IBA --
GO:0097502 mannosylation IEA --
genes like me logo Genes that share ontologies with ALG1L: view

No data available for Pathways by source and SIGNOR curated interactions for ALG1L Gene

Drugs & Compounds for ALG1L Gene

No Compound Related Data Available

Transcripts for ALG1L Gene

mRNA/cDNA for ALG1L Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALG1L Gene

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG1L Gene

No ASD Table

Relevant External Links for ALG1L Gene

GeneLoc Exon Structure for
ALG1L
ECgene alternative splicing isoforms for
ALG1L

Expression for ALG1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALG1L Gene

mRNA differential expression in normal tissues according to GTEx for ALG1L Gene

This gene is overexpressed in Bladder (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of ALG1L Gene:

ALG1L

SOURCE GeneReport for Unigene cluster for ALG1L Gene:

Hs.591299

Evidence on tissue expression from TISSUES for ALG1L Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ALG1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG1L Gene

Orthologs for ALG1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALG1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALG1L 34 33
  • 97.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 28 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ALG1 34
  • 27 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Alg1 34
  • 26 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii alg1 34
  • 21 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18012 34
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T26A5.4 34
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG1 34
  • 13 (a)
OneToMany
Species where no ortholog for ALG1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALG1L Gene

ENSEMBL:
Gene Tree for ALG1L (if available)
TreeFam:
Gene Tree for ALG1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALG1L: view image

Paralogs for ALG1L Gene

Paralogs for ALG1L Gene

(2) SIMAP similar genes for ALG1L Gene using alignment to 1 proteins:

  • ALG1L_HUMAN
genes like me logo Genes that share paralogs with ALG1L: view

Variants for ALG1L Gene

Sequence variations from dbSNP and Humsavar for ALG1L Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000426629 -- 125,986,610(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000477606 -- 125,991,132(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000492585 -- 125,936,923(-) G/A 5_prime_UTR_variant, intron_variant
rs1000548895 -- 125,941,333(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000567267 -- 125,961,820(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ALG1L Gene

Variant ID Type Subtype PubMed ID
nsv967058 CNV duplication 23825009
nsv829716 CNV gain+loss 17160897
nsv591465 CNV gain 21841781
nsv1160975 CNV duplication 26073780
nsv1011457 CNV gain 25217958
esv2759174 CNV loss 17122850

Variation tolerance for ALG1L Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.11; 90.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALG1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALG1L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG1L Gene

Disorders for ALG1L Gene

Additional Disease Information for ALG1L

No disorders were found for ALG1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALG1L Gene

Publications for ALG1L Gene

  1. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung YJ … Rao DC (American journal of hypertension 2015) 3 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ALG1L Gene

Sources for ALG1L Gene

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