Aliases for ALG10B Gene
Aliases for ALG10B Gene
- ALG10B, Alpha-1,2-Glucosyltransferase 2 3 5
- Potassium Channel Regulator 1 2 3 4
- Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2- Glucosyltransferase 2 3
- Asparagine-Linked Glycosylation Protein 10 Homolog B 3 4
- Alpha-1,2-Glucosyltransferase ALG10-A 3 4
- Alpha-2-Glucosyltransferase ALG10-B 3 4
- KCR1 3 4
- Asparagine-Linked Glycosylation 10 Homolog B (Yeast, Alpha-1,2-Glucosyltransferase) 3
- Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog B (Yeast) 2
- Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol Alpha-1,2-Glucosyltransferase 3
- Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog B 3
- Putative Alpha-1,2-Glucosyltransferase ALG10-B 3
- Modifier Of The HERG Potassium Channel 3
- EC 2.4.1.256 4
- ALG10 3
External Ids for ALG10B Gene
- HGNC: 31088
- Entrez Gene: 144245
- Ensembl: ENSG00000175548
- UniProtKB: Q5I7T1
Previous GeneCards Identifiers for ALG10B Gene
- GC12U900492
- GC12P036998
- GC12P038710
- GC12P035735
Summaries for ALG10B Gene
GeneCards Summary for ALG10B Gene
ALG10B (ALG10B, Alpha-1,2-Glucosyltransferase) is a Protein Coding gene. Diseases associated with ALG10B include Long Qt Syndrome and Amyotrophic Lateral Sclerosis Type 5. Among its related pathways are N-Glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring hexosyl groups and dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity. An important paralog of this gene is ALG10.
UniProtKB/Swiss-Prot for ALG10B Gene
-
Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity).
Additional gene information for ALG10B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG10B Gene
Genomics for ALG10B Gene
GeneHancer (GH) Regulatory Elements for ALG10B Gene
Promoters and enhancers for ALG10B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J038315 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 681.8 | +0.2 | 206 | 1.7 | PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 CBX5 | ALG10B CPNE8 GC12P038329 | |
| GH12J038903 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 22.4 | +588.8 | 588797 | 4.5 | HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 | ENSG00000257718 CPNE8 ALG10B ENSG00000258119 | |
| GH12J039122 | Enhancer | 0.5 | ENCODE | 10.5 | +806.7 | 806714 | 2.2 | SP1 STAT1 KLF1 ZNF354B | ALG10B GC12P039117 ENSG00000270718 | |
| GH12J038282 | Enhancer | 0.3 | ENCODE | 0.3 | -33.5 | -33524 | 0.2 | JUND | ENSG00000253016 GC12M038276 ALG10B GC12P038172 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ALG10B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ALG10B gene promoter:
-
- SRY
- ATF6
- Pax-4a
- FAC1
- AML1a
- Evi-1
- POU2F1
- POU2F1a
- LHX3b
Regulatory Element Products
Genomic Locations for ALG10B Gene
Genomic Locations for ALG10B Gene
- chr12:38,316,578-38,329,728
- (GRCh38/hg38)
- Size:
- 13,151 bases
- Orientation:
- Plus strand
- chr12:38,710,380-38,723,528
- (GRCh37/hg19)
- Size:
- 13,149 bases
- Orientation:
- Plus strand
Genomic View for ALG10B Gene
Genes around ALG10B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q12 by Entrez Gene
- 12q12 by HGNC
- 12q12 by Ensembl
ALG10B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALG10B Gene
Proteins for ALG10B Gene
-
Protein details for ALG10B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5I7T1-AG10B_HUMAN
- Recommended name:
- Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
- Protein Accession:
- Q5I7T1
- B2RPF4
Protein attributes for ALG10B Gene
- Size:
- 473 amino acids
- Molecular mass:
- 55448 Da
- Quaternary structure:
-
- Interacts with KCNH1 and KCNH2.
Post-translational modifications for ALG10B Gene
Other Protein References for ALG10B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for ALG10B
- GeneTex ALG10B Antibody for ALG10B
-
Biorbyt antibodies for ALG10B
-
Boster Bio Antibodies for ALG10B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ALG10B
- Origene Custom Protein Services for ALG10B
- Search GeneTex for Proteins for ALG10B
Assay Products
No data available for DME Specific Peptides for ALG10B Gene
Domains & Families for ALG10B Gene
Gene Families for ALG10B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for ALG10B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5I7T1- Family:
-
- Belongs to the ALG10 glucosyltransferase family.
Function for ALG10B Gene
Molecular function for ALG10B Gene
- UniProtKB/Swiss-Prot Function:
- Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
Enzyme Numbers (IUBMB) for ALG10B Gene
Phenotypes From GWAS Catalog for ALG10B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA,IDA | 14525949 |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0106073 | dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity | IEA | -- |
Phenotypes for ALG10B Gene
- GenomeRNAi human phenotypes for ALG10B:
-
- Synthetic lethal with imatinib mesylate
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ALG10B
-
CRISPR Products
-
OriGene CRISPR knockouts for ALG10B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALG10B
- genomics-online: gRNA clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- Applied Biological Materials CRISPR for ALG10B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALG10B
- GenScript: Design CRISPR guide RNA sequences for ALG10B
miRNA for ALG10B Gene
- miRTarBase miRNAs that target ALG10B
-
- hsa-mir-192-5p (MIRT026560)
- hsa-mir-26a-5p (MIRT050088)
- hsa-mir-3929 (MIRT186145)
- hsa-mir-4478 (MIRT186146)
- hsa-mir-4419b (MIRT186147)
- hsa-mir-188-3p (MIRT272739)
- hsa-mir-590-3p (MIRT272740)
- hsa-mir-4775 (MIRT272741)
- hsa-mir-186-5p (MIRT272742)
- hsa-mir-3133 (MIRT272744)
- hsa-mir-6513-5p (MIRT524917)
- hsa-mir-887-5p (MIRT524918)
- hsa-mir-3913-5p (MIRT524919)
- hsa-mir-3122 (MIRT524920)
- hsa-mir-450a-1-3p (MIRT524921)
- hsa-mir-6780a-5p (MIRT524922)
- hsa-mir-6779-5p (MIRT524923)
- hsa-mir-3689c (MIRT524924)
- hsa-mir-3689b-3p (MIRT524925)
- hsa-mir-3689a-3p (MIRT524926)
- hsa-mir-30b-3p (MIRT524927)
- hsa-mir-1273h-5p (MIRT524928)
- hsa-mir-6788-5p (MIRT524929)
- hsa-mir-30c-2-3p (MIRT524930)
- hsa-mir-30c-1-3p (MIRT524931)
- hsa-mir-6772-5p (MIRT524932)
- hsa-mir-6799-5p (MIRT524933)
- hsa-mir-6883-5p (MIRT524934)
- hsa-mir-6785-5p (MIRT524935)
- hsa-mir-4728-5p (MIRT524936)
- hsa-mir-149-3p (MIRT524937)
- hsa-mir-7106-5p (MIRT524938)
- hsa-mir-6089 (MIRT524939)
- hsa-mir-544b (MIRT524940)
- hsa-mir-483-5p (MIRT524941)
- hsa-mir-1261 (MIRT530523)
- hsa-mir-190a-3p (MIRT530524)
- hsa-mir-98-3p (MIRT530525)
- hsa-let-7f-1-3p (MIRT530526)
- hsa-let-7b-3p (MIRT530527)
- hsa-let-7a-3p (MIRT530528)
- hsa-mir-891a-3p (MIRT530529)
- hsa-mir-3688-5p (MIRT530530)
- hsa-mir-1255b-5p (MIRT530531)
- hsa-mir-1255a (MIRT530532)
- hsa-mir-6744-5p (MIRT530533)
- hsa-mir-4790-3p (MIRT530534)
- hsa-mir-5011-5p (MIRT530535)
- hsa-mir-4666a-3p (MIRT530536)
- hsa-mir-381-3p (MIRT530537)
- hsa-mir-300 (MIRT530538)
- hsa-mir-5696 (MIRT571253)
- hsa-mir-4729 (MIRT571254)
- hsa-mir-4733-5p (MIRT571255)
- hsa-mir-4786-5p (MIRT695026)
- hsa-mir-664a-5p (MIRT695027)
- hsa-mir-4794 (MIRT695028)
- hsa-mir-6849-3p (MIRT695029)
- hsa-mir-4459 (MIRT695030)
- hsa-mir-4433a-3p (MIRT695031)
- hsa-mir-4768-3p (MIRT695032)
- hsa-mir-433-5p (MIRT695033)
- hsa-mir-665 (MIRT695034)
- hsa-mir-1273e (MIRT695035)
- hsa-mir-6771-5p (MIRT695036)
- hsa-mir-4722-5p (MIRT695037)
- hsa-mir-7160-5p (MIRT695038)
- hsa-mir-6884-5p (MIRT695039)
- hsa-mir-485-5p (MIRT695040)
- hsa-mir-1827 (MIRT695041)
- hsa-mir-7153-5p (MIRT695042)
- hsa-mir-146b-5p (MIRT695043)
- hsa-mir-146a-5p (MIRT695044)
- hsa-mir-4649-3p (MIRT695045)
- hsa-mir-6746-5p (MIRT695046)
- hsa-mir-940 (MIRT695047)
- hsa-mir-6893-5p (MIRT695048)
- hsa-mir-6808-5p (MIRT695049)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALG10B
- Browse OriGene Inhibitory RNA Products For ALG10B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG10B
- genomics-online: shRNA clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
Clone Products
- Sino Biological Human cDNA Clone for ALG10B
- VectorBuilder custom plasmid, inducible vectors for ALG10B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALG10B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALG10B
- genomics-online: cdna clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- orf clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- Applied Biological Materials Clones for ALG10B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ALG10B
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALG10B Gene
Localization for ALG10B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALG10B Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | 14525949 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ALG10B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Metabolism | ||
| 3 | N-Glycan biosynthesis | ||
| 4 | Transport to the Golgi and subsequent modification | ||
| 5 | Synthesis of substrates in N-glycan biosythesis | ||
Pathways by source for ALG10B Gene
2 KEGG pathways for ALG10B Gene
UniProtKB/Swiss-Prot Q5I7T1-AG10B_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for ALG10B Gene
GPS-Prot Interaction Network for ALG10B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IMP | 14525949 |
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process | IEA | -- |
| GO:0060050 | positive regulation of protein glycosylation | IMP | 14525949 |
| GO:1901980 | positive regulation of inward rectifier potassium channel activity | IMP | 14525949 |
No data available for SIGNOR curated interactions for ALG10B Gene
Drugs & Compounds for ALG10B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Dolichol-20 |
|
2067-66-5 |
|
|||
| Dolichyl b-D-glucosyl phosphate |
|
220496-27-5 |
|
Transcripts for ALG10B Gene
mRNA/cDNA for ALG10B Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000308742 10253 bps (uc001rln.5)
- ENST00000551464 571 bps (uc058mqw.1)
- ENST00000553138 1982 bps (uc058mqx.1)
- ENST00000548240 1565 bps (uc058mqy.1)
Unigene Clusters for ALG10B Gene
- ALG10B, alpha-1,2-glucosyltransferase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ALG10B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALG10B
- genomics-online: gRNA clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- Applied Biological Materials CRISPR for ALG10B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALG10B
- GenScript: Design CRISPR guide RNA sequences for ALG10B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALG10B
- Browse OriGene Inhibitory RNA Products For ALG10B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG10B
- genomics-online: shRNA clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
Clone Products
- Sino Biological Human cDNA Clone for ALG10B
- VectorBuilder custom plasmid, inducible vectors for ALG10B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALG10B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALG10B
- genomics-online: cdna clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- orf clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- Applied Biological Materials Clones for ALG10B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ALG10B Gene
NURSA nuclear receptor signaling pathways regulating expression of ALG10B Gene:
ALG10BSOURCE GeneReport for Unigene cluster for ALG10B Gene:
Hs.259305mRNA Expression by UniProt/SwissProt for ALG10B Gene:
Q5I7T1-AG10B_HUMAN
Tissue specificity:
Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung, skeletal muscle and brain.
Primer Products
-
OriGene qPCR primer pairs for ALG10B
- genomics-online: primer clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
-
Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG10B Gene
Orthologs for ALG10B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ALG10B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | ALG10 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Alg10b 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | ALG10 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | alg10 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Alg10 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tag-179 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DIE2 36 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ALG10B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ALG10B Gene
- ENSEMBL:
- Gene Tree for ALG10B (if available)
- TreeFam:
- Gene Tree for ALG10B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALG10B: view image
Paralogs for ALG10B Gene
Variants for ALG10B Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ALG10B Gene
- AG10B_HUMAN-Q5I7T1
- Genetic variations in ALG10B may reduce susceptibility to acquired long QT syndrome.
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000173381 | -- | 38,323,071(+) | A/G | 3_prime_UTR_variant, intron_variant | |
| rs1000279703 | -- | 38,323,731(+) | C/T | 3_prime_UTR_variant, intron_variant | |
| rs1000403506 | -- | 38,329,554(+) | T/G | 3_prime_UTR_variant | |
| rs1000510981 | -- | 38,324,545(+) | G/A | 3_prime_UTR_variant | |
| rs1000564781 | -- | 38,324,833(+) | T/C | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv976602 | CNV | duplication | 23825009 |
| nsv8963 | CNV | loss | 18304495 |
| nsv826335 | CNV | gain | 20364138 |
| nsv826332 | CNV | gain | 20364138 |
| nsv818910 | CNV | gain | 17921354 |
| nsv558574 | CNV | gain | 21841781 |
| nsv558350 | CNV | gain | 21841781 |
| nsv469356 | CNV | gain | 19166990 |
| nsv1122723 | CNV | deletion | 24896259 |
| esv3892188 | CNV | gain | 25118596 |
| esv3629225 | CNV | loss | 21293372 |
| esv3629224 | CNV | gain | 21293372 |
| esv34542 | CNV | gain | 17911159 |
| esv2761088 | CNV | gain | 21179565 |
| esv2759893 | CNV | gain+loss | 17122850 |
| esv2751097 | CNV | gain | 17911159 |
| esv2745769 | CNV | deletion | 23290073 |
| esv2422488 | CNV | duplication | 17116639 |
| esv2422349 | CNV | duplication | 17116639 |
| esv2362578 | CNV | deletion | 18987734 |
| dgv285n67 | CNV | gain | 20364138 |
| dgv2572n54 | CNV | gain | 21841781 |
| dgv196n27 | CNV | gain | 19166990 |
| dgv1487n100 | CNV | gain | 25217958 |
| dgv1485n100 | CNV | gain | 25217958 |
| dgv1468n100 | CNV | gain | 25217958 |
| dgv1467n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.74;
57.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALG10B Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ALG10B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| long qt syndrome |
|
|
| amyotrophic lateral sclerosis type 5 |
|
|
| three m syndrome 1 |
|
|
| hemorrhagic cystitis |
|
|
Search ALG10B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALG10B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ALG10B Gene
Publications for ALG10B Gene
- In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. (PMID: 15280551) Petersen CI … Balser JR (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58
- HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PMID: 19483685) Daly AK … International SAE Consortium (Nature genetics 2009) 3 44 58
- The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. (PMID: 14525949) Kupershmidt S … Balser JR (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- A KCR1 variant implicated in susceptibility to the long QT syndrome. (PMID: 20950623) Hayashi K … Yamagishi M (Journal of molecular and cellular cardiology 2011) 3 58
Products for ALG10B Gene
- Browse R&D Systems for Antibodies
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 32 available ALG10B Antibodies ranked by validation data
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- GeneTex ALG10B Antibody for ALG10B
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- Horizon Cell Lines for ALG10B
- genomics-online: cdna clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
- Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
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- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- orf clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
- Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- genomics-online: gRNA clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
- Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
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- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- genomics-online: primer clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
- Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- genomics-online: shRNA clones - Search results for 40 available ALG10B gene related products
- Overview of 40 available ALG10B gene related products
- Recommended
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-MBP
- pPB-N-His
- pPB-C-His
- pPB-His-GST
- pRS
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPM-C-His
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pDONR223
- pRFP-C-RS
- pGFP-V-RS
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Sources for ALG10B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
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