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Aliases for ALG10B Gene
Aliases for ALG10B Gene
- ALG10 Alpha-1,2-Glucosyltransferase B 2 3 5
- Potassium Channel Regulator 1 2 3 4
- Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2- Glucosyltransferase 2 3
- Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol Alpha-1,2-Glucosyltransferase 3 4
- Asparagine-Linked Glycosylation Protein 10 Homolog B 3 4
- Alpha-1,2-Glucosyltransferase ALG10-A 3 4
- Alpha-2-Glucosyltransferase ALG10-B 3 4
- KCR1 3 4
- Asparagine-Linked Glycosylation 10 Homolog B (Yeast, Alpha-1,2-Glucosyltransferase) 3
- Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog B (Yeast) 2
- Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog B 3
- Putative Alpha-1,2-Glucosyltransferase ALG10-B 3
- Modifier Of The HERG Potassium Channel 3
- ALG10B, Alpha-1,2-Glucosyltransferase 3
- EC 2.4.1.256 4
- EC 2.4.1.16 52
- EC 2.4.1 52
- ALG10 3
External Ids for ALG10B Gene
- HGNC: 31088
- Entrez Gene: 144245
- Ensembl: ENSG00000175548
- OMIM: 603313
- UniProtKB: Q5I7T1
Previous GeneCards Identifiers for ALG10B Gene
- GC12U900492
- GC12P036998
- GC12P038710
- GC12P035735
Summaries for ALG10B Gene
GeneCards Summary for ALG10B Gene
ALG10B (ALG10 Alpha-1,2-Glucosyltransferase B) is a Protein Coding gene. Diseases associated with ALG10B include Long Qt Syndrome 2 and Long Qt Syndrome. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring hexosyl groups and dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity. An important paralog of this gene is ALG10.
UniProtKB/Swiss-Prot Summary for ALG10B Gene
-
Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity).
Additional gene information for ALG10B Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALG10B Gene
Genomics for ALG10B Gene
GeneHancer (GH) Regulatory Elements for ALG10B Gene
Promoters and enhancers for ALG10B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALG10B on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALG10B
- Top Transcription factor binding sites by QIAGEN in the ALG10B gene promoter:
-
- AML1a
- ATF6
- Evi-1
- FAC1
- LHX3b
- Pax-4a
- POU2F1
- POU2F1a
- SRY
Genomic Locations for ALG10B Gene
Genomic Locations for ALG10B Gene
- chr12:38,316,686-38,329,726
- (GRCh38/hg38)
- Size:
- 13,041 bases
- Orientation:
- Plus strand
- chr12:38,710,380-38,723,528
- (GRCh37/hg19)
- Size:
- 13,149 bases
- Orientation:
- Plus strand
Genomic View for ALG10B Gene
Genes around ALG10B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q12 by HGNC
- 12q12 by Entrez Gene
- 12q12 by Ensembl
ALG10B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALG10B Gene
Proteins for ALG10B Gene
-
Protein details for ALG10B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5I7T1-AG10B_HUMAN
- Recommended name:
- Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
- Protein Accession:
- Q5I7T1
- B2RPF4
Protein attributes for ALG10B Gene
- Size:
- 473 amino acids
- Molecular mass:
- 55448 Da
- Quaternary structure:
-
- Interacts with KCNH1 and KCNH2.
Selected DME Specific Peptides for ALG10B Gene
- Q5I7T1:
-
- LADNRHY
- FSVGNFY
Post-translational modifications for ALG10B Gene
Other Protein References for ALG10B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ALG10B (aa 104-153) polyclonal antibody
- Invitrogen Antibodies for ALG10B (AFLGC-ALG10B)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ALG10B
- Origene Custom Protein Services for ALG10B
Domains & Families for ALG10B Gene
Gene Families for ALG10B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for ALG10B Gene
- GenScript: Design optimal peptide antigens:
-
- Potassium channel regulator 1 (AG10B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5I7T1- Family:
-
- Belongs to the ALG10 glucosyltransferase family.
Function for ALG10B Gene
Molecular function for ALG10B Gene
- UniProtKB/Swiss-Prot Function:
- Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+); Xref=Rhea:RHEA:29543, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9528, Rhea:RHEA-COMP:12633, Rhea:RHEA-COMP:12634, ChEBI:CHEBI:15378, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:132522, ChEBI:CHEBI:132523; EC=2.4.1.256; Evidence=. ;.
Enzyme Numbers (IUBMB) for ALG10B Gene
Phenotypes From GWAS Catalog for ALG10B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA,IDA | 14525949 |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0106073 | dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity | IEA | -- |
Phenotypes for ALG10B Gene
- GenomeRNAi human phenotypes for ALG10B:
-
- Synthetic lethal with imatinib mesylate
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALG10B - Select products 50% OFF >
- * ALG10B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ALG10B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALG10B
- genomics-online: gRNA clones - Search for available ALG10B gRNA products
- Overview of 62 available ALG10B gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALG10B
miRNA for ALG10B Gene
- miRTarBase miRNAs that target ALG10B
-
- hsa-mir-192-5p (MIRT026560)
- hsa-mir-26a-5p (MIRT050088)
- hsa-mir-3929 (MIRT186145)
- hsa-mir-4478 (MIRT186146)
- hsa-mir-4419b (MIRT186147)
- hsa-mir-188-3p (MIRT272739)
- hsa-mir-590-3p (MIRT272740)
- hsa-mir-4775 (MIRT272741)
- hsa-mir-186-5p (MIRT272742)
- hsa-mir-3133 (MIRT272744)
- hsa-mir-6513-5p (MIRT524917)
- hsa-mir-887-5p (MIRT524918)
- hsa-mir-3913-5p (MIRT524919)
- hsa-mir-3122 (MIRT524920)
- hsa-mir-450a-1-3p (MIRT524921)
- hsa-mir-6780a-5p (MIRT524922)
- hsa-mir-6779-5p (MIRT524923)
- hsa-mir-3689c (MIRT524924)
- hsa-mir-3689b-3p (MIRT524925)
- hsa-mir-3689a-3p (MIRT524926)
- hsa-mir-30b-3p (MIRT524927)
- hsa-mir-1273h-5p (MIRT524928)
- hsa-mir-6788-5p (MIRT524929)
- hsa-mir-30c-2-3p (MIRT524930)
- hsa-mir-30c-1-3p (MIRT524931)
- hsa-mir-6772-5p (MIRT524932)
- hsa-mir-6799-5p (MIRT524933)
- hsa-mir-6883-5p (MIRT524934)
- hsa-mir-6785-5p (MIRT524935)
- hsa-mir-4728-5p (MIRT524936)
- hsa-mir-149-3p (MIRT524937)
- hsa-mir-7106-5p (MIRT524938)
- hsa-mir-6089 (MIRT524939)
- hsa-mir-544b (MIRT524940)
- hsa-mir-483-5p (MIRT524941)
- hsa-mir-1261 (MIRT530523)
- hsa-mir-190a-3p (MIRT530524)
- hsa-mir-98-3p (MIRT530525)
- hsa-let-7f-1-3p (MIRT530526)
- hsa-let-7b-3p (MIRT530527)
- hsa-let-7a-3p (MIRT530528)
- hsa-mir-891a-3p (MIRT530529)
- hsa-mir-3688-5p (MIRT530530)
- hsa-mir-1255b-5p (MIRT530531)
- hsa-mir-1255a (MIRT530532)
- hsa-mir-6744-5p (MIRT530533)
- hsa-mir-4790-3p (MIRT530534)
- hsa-mir-5011-5p (MIRT530535)
- hsa-mir-4666a-3p (MIRT530536)
- hsa-mir-381-3p (MIRT530537)
- hsa-mir-300 (MIRT530538)
- hsa-mir-5696 (MIRT571253)
- hsa-mir-4729 (MIRT571254)
- hsa-mir-4733-5p (MIRT571255)
- hsa-mir-4786-5p (MIRT695026)
- hsa-mir-664a-5p (MIRT695027)
- hsa-mir-4794 (MIRT695028)
- hsa-mir-6849-3p (MIRT695029)
- hsa-mir-4459 (MIRT695030)
- hsa-mir-4433a-3p (MIRT695031)
- hsa-mir-4768-3p (MIRT695032)
- hsa-mir-433-5p (MIRT695033)
- hsa-mir-665 (MIRT695034)
- hsa-mir-1273e (MIRT695035)
- hsa-mir-6771-5p (MIRT695036)
- hsa-mir-4722-5p (MIRT695037)
- hsa-mir-7160-5p (MIRT695038)
- hsa-mir-6884-5p (MIRT695039)
- hsa-mir-485-5p (MIRT695040)
- hsa-mir-1827 (MIRT695041)
- hsa-mir-7153-5p (MIRT695042)
- hsa-mir-146b-5p (MIRT695043)
- hsa-mir-146a-5p (MIRT695044)
- hsa-mir-4649-3p (MIRT695045)
- hsa-mir-6746-5p (MIRT695046)
- hsa-mir-940 (MIRT695047)
- hsa-mir-6893-5p (MIRT695048)
- hsa-mir-6808-5p (MIRT695049)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALG10B
- Browse OriGene Inhibitory RNA Products For ALG10B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG10B
- genomics-online: shRNA clones - Search for available ALG10B shRNA products
- Overview of 62 available ALG10B gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ALG10B - Select products 50% OFF >
- * ALG10B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ALG10B
- Addgene plasmids for ALG10B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALG10B
- genomics-online: cdna clones - Search for available ALG10B CDNA products
- Overview of 62 available ALG10B gene related products
- orf clones - Search for available ALG10B ORF products
- Overview of 62 available ALG10B gene related products
Cell Line Products
-
Horizon Cell Lines for ALG10B
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ALG10B Gene
Localization for ALG10B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALG10B Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 4 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | 14525949 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ALG10B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Metabolism | ||
| 3 | N-Glycan biosynthesis | ||
| 4 | Transport to the Golgi and subsequent modification | ||
| 5 | Synthesis of substrates in N-glycan biosythesis | ||
Pathways by source for ALG10B Gene
2 KEGG pathways for ALG10B Gene
UniProtKB/Swiss-Prot Q5I7T1-AG10B_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for ALG10B Gene
GPS-Prot Interaction Network for ALG10B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IMP | 14525949 |
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process | IEA | -- |
| GO:0060050 | positive regulation of protein glycosylation | IMP | 14525949 |
| GO:1901980 | positive regulation of inward rectifier potassium channel activity | IMP | 14525949 |
No data available for SIGNOR curated interactions for ALG10B Gene
Drugs & Compounds for ALG10B Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Dolichol-20 |
|
2067-66-5 |
|
|||
| Dolichyl b-D-glucosyl phosphate |
|
220496-27-5 |
|
Transcripts for ALG10B Gene
mRNA/cDNA for ALG10B Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308742 10050 bps (ENST00000308742.9)
- ENST00000548240 1565 bps (ENST00000548240.1)
- ENST00000551464 571 bps (ENST00000551464.1)
- ENST00000553138 1982 bps (ENST00000553138.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ALG10B - Select products 50% OFF >
- * ALG10B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ALG10B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALG10B
- genomics-online: gRNA clones - Search for available ALG10B gRNA products
- Overview of 62 available ALG10B gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALG10B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALG10B
- Browse OriGene Inhibitory RNA Products For ALG10B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG10B
- genomics-online: shRNA clones - Search for available ALG10B shRNA products
- Overview of 62 available ALG10B gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ALG10B - Select products 50% OFF >
- * ALG10B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ALG10B
- Addgene plasmids for ALG10B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALG10B
- genomics-online: cdna clones - Search for available ALG10B CDNA products
- Overview of 62 available ALG10B gene related products
- orf clones - Search for available ALG10B ORF products
- Overview of 62 available ALG10B gene related products
Relevant External Links for ALG10B Gene
- GeneLoc Exon Structure for
- ALG10B
Expression for ALG10B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALG10B
SOURCE GeneReport for Unigene cluster for ALG10B Gene:
Hs.259305mRNA Expression by UniProt/SwissProt for ALG10B Gene:
Q5I7T1-AG10B_HUMAN
Tissue specificity:
Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung, skeletal muscle and brain.
Primer Products
-
OriGene qPCR primer pairs for ALG10B
- genomics-online: primer clones - Search for available ALG10B Primer products
- Overview of 62 available ALG10B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG10B Gene
Orthologs for ALG10B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ALG10B 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | ALG10 31 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Alg10b 31 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | ALG10 31 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | alg10 31 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Alg10 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tag-179 31 30 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DIE2 33 31 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ALG10B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ALG10B Gene
- ENSEMBL:
- Gene Tree for ALG10B (if available)
- TreeFam:
- Gene Tree for ALG10B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALG10B: view image
Paralogs for ALG10B Gene
Variants for ALG10B Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ALG10B Gene
- AG10B_HUMAN-Q5I7T1
- Genetic variations in ALG10B may reduce susceptibility to acquired long QT syndrome.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALG10B Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs57963306 | - | p.Ser383Asn | |||
| rs61730283 | - | p.Ile446Val | |||
| rs6582584 | - | p.Ala84Gly |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1467n100 | CNV | gain | 25217958 |
| dgv1468n100 | CNV | gain | 25217958 |
| dgv1485n100 | CNV | gain | 25217958 |
| dgv1487n100 | CNV | gain | 25217958 |
| dgv196n27 | CNV | gain | 19166990 |
| dgv2572n54 | CNV | gain | 21841781 |
| dgv285n67 | CNV | gain | 20364138 |
| esv2362578 | CNV | deletion | 18987734 |
| esv2422349 | CNV | duplication | 17116639 |
| esv2422488 | CNV | duplication | 17116639 |
| esv2745769 | CNV | deletion | 23290073 |
| esv2751097 | CNV | gain | 17911159 |
| esv2759893 | CNV | gain+loss | 17122850 |
| esv2761088 | CNV | gain | 21179565 |
| esv34542 | CNV | gain | 17911159 |
| esv3629224 | CNV | gain | 21293372 |
| esv3629225 | CNV | loss | 21293372 |
| esv3892188 | CNV | gain | 25118596 |
| nsv1122723 | CNV | deletion | 24896259 |
| nsv469356 | CNV | gain | 19166990 |
| nsv558350 | CNV | gain | 21841781 |
| nsv558574 | CNV | gain | 21841781 |
| nsv818910 | CNV | gain | 17921354 |
| nsv826332 | CNV | gain | 20364138 |
| nsv826335 | CNV | gain | 20364138 |
| nsv8963 | CNV | loss | 18304495 |
| nsv976602 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.74;
57.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALG10B Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ALG10B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| long qt syndrome 2 |
|
|
| long qt syndrome |
|
|
| toxic myocarditis |
|
|
Search ALG10B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALG10B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ALG10B Gene
Publications for ALG10B Gene
- In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. (PMID: 15280551) Petersen CI … Balser JR (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23 54
- HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PMID: 19483685) Daly AK … International SAE Consortium (Nature genetics 2009) 3 41 54
- The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. (PMID: 14525949) Kupershmidt S … Balser JR (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 3 4 54
- Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6. (PMID: 31266804) Talbot BE … Schlondorff JS (The Journal of biological chemistry 2019) 3 54
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
ExternalLinks
Products for ALG10B Gene
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Sources for ALG10B Gene
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