ALG10 Gene (Protein Coding)

ALG10 Alpha-1,2-Glucosyltransferase

GC12P034022
GIFtS:
37
This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating f... See more...

Aliases for ALG10 Gene

Aliases for ALG10 Gene

  • ALG10 Alpha-1,2-Glucosyltransferase 2 3 5
  • ALG10A 2 3 4
  • Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2- Glucosyltransferase 2 3
  • Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol Alpha-1,2-Glucosyltransferase 3 4
  • Asparagine-Linked Glycosylation Protein 10 Homolog A 3 4
  • Alpha-1,2-Glucosyltransferase ALG10-A 3 4
  • Alpha-2-Glucosyltransferase ALG10-A 3 4
  • DIE2 2 3
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog (S. Pombe) 2
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog (Yeast) 2
  • Asparagine-Linked Glycosylation 10 Homolog (Yeast, Alpha-1,2-Glucosyltransferase) 3
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog 3
  • Derepression Of ITR1 Expression 2 Homolog (S. Cerevisiae) 2
  • Derepression Of ITR1 Expression 2 Homolog 3
  • Potassium Channel Regulator 1 3
  • Alpha2-Glucosyltransferase 3
  • EC 2.4.1.256 4
  • EC 2.4.1.16 51
  • FLJ14751 2
  • EC 2.4.1 51
  • ALG10 5
  • KCR1 3

External Ids for ALG10 Gene

Previous GeneCards Identifiers for ALG10 Gene

  • GC12P034075
  • GC12P034066
  • GC12P033915

Summaries for ALG10 Gene

Entrez Gene Summary for ALG10 Gene

  • This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]

GeneCards Summary for ALG10 Gene

ALG10 (ALG10 Alpha-1,2-Glucosyltransferase) is a Protein Coding gene. Diseases associated with ALG10 include Long Qt Syndrome 2 and Familial Long Qt Syndrome. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring hexosyl groups and dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity. An important paralog of this gene is ALG10B.

UniProtKB/Swiss-Prot Summary for ALG10 Gene

  • Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.

Additional gene information for ALG10 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALG10 Gene

Genomics for ALG10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ALG10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J034021 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 258.9 +0.2 232 2.5 MXD4 SP1 FEZF1 CEBPA ZNF217 SIX5 NR2C1 MNT IKZF1 SMAD5 ALG10 HSALNG0090351 ENSG00000245482
GH12J033534 Enhancer 0.4 Ensembl 34.8 -488.8 -488814 0.2 ZNF140 ZC3H11A ZNF202 ZNF266 ENSG00000257511 ALG10 SYT10 YARS2 piR-61101-128 piR-32023-055
GH12J033587 Enhancer 1.1 Ensembl ENCODE 8.3 -433.8 -433815 4.6 ARID3A MNT IKZF1 IRF2 HES1 MBD2 ZNF217 CEBPB ARNT ZNF395 ALG10 YARS2 ENSG00000255652 HSALNG0090334 lnc-SYT10-6 SYT10
GH12J034123 Enhancer 0.8 Ensembl ENCODE 7.6 +100.9 100905 0.4 CEBPA CTCF CEBPB REST TRIM22 SMC3 RAD21 TEAD3 SMARCA5 MLLT1 piR-39858-121 ALG10 HSALNG0090355 HSALNG0090358
GH12J033669 Enhancer 0.6 Ensembl ENCODE 8.2 -351.6 -351579 2.7 POU5F1 NANOG POLR2A RAD21 piR-43105-115 ALG10 lnc-SYT10-6 HSALNG0090334 SYT10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALG10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALG10

Top Transcription factor binding sites by QIAGEN in the ALG10 gene promoter:
  • AML1a
  • ATF6
  • Evi-1
  • FAC1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • SRY

Genomic Locations for ALG10 Gene

Latest Assembly
chr12:34,022,315-34,035,296
(GRCh38/hg38)
Size:
12,982 bases
Orientation:
Plus strand

Previous Assembly
chr12:34,175,431-34,181,237
(GRCh37/hg19 by Entrez Gene)
Size:
5,807 bases
Orientation:
Plus strand

chr12:34,175,216-34,182,629
(GRCh37/hg19 by Ensembl)
Size:
7,414 bases
Orientation:
Plus strand

Genomic View for ALG10 Gene

Genes around ALG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ALG10 Gene

Proteins for ALG10 Gene

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  • Protein details for ALG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKT4-AG10A_HUMAN
    Recommended name:
    Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
    Protein Accession:
    Q5BKT4
    Secondary Accessions:
    • Q6NS98
    • Q96DU0
    • Q96SM6

    Protein attributes for ALG10 Gene

    Size:
    473 amino acids
    Molecular mass:
    55606 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ALG10 Gene

Protein Expression for ALG10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ALG10 Gene

Q5BKT4:
  • LADNRHY
  • FSVGNFY

Post-translational modifications for ALG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALG10 Gene

Gene Families for ALG10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ALG10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALG10 Gene

GenScript: Design optimal peptide antigens:
  • Asparagine-linked glycosylation protein 10 homolog A (AG10A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5BKT4

UniProtKB/Swiss-Prot:

AG10A_HUMAN :
  • Belongs to the ALG10 glucosyltransferase family.
Family:
  • Belongs to the ALG10 glucosyltransferase family.
genes like me logo Genes that share domains with ALG10: view

Function for ALG10 Gene

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  6. Cell Lines for research

Molecular function for ALG10 Gene

UniProtKB/Swiss-Prot Function:
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+); Xref=Rhea:RHEA:29543, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9528, Rhea:RHEA-COMP:12633, Rhea:RHEA-COMP:12634, ChEBI:CHEBI:15378, ChEBI:CHEBI:57525, ChEBI:CHEBI:57683, ChEBI:CHEBI:132522, ChEBI:CHEBI:132523; EC=2.4.1.256;.

Enzyme Numbers (IUBMB) for ALG10 Gene

Phenotypes From GWAS Catalog for ALG10 Gene

Gene Ontology (GO) - Molecular Function for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with ALG10: view
genes like me logo Genes that share phenotypes with ALG10: view

Animal Models for ALG10 Gene

MGI Knock Outs for ALG10:
  • Alg10b Alg10b<tm1.1(KOMP)Vlcg>
  • Alg10b Alg10b<tm1(KOMP)Vlcg>

Animal Models for research

miRNA for ALG10 Gene

miRTarBase miRNAs that target ALG10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALG10 Gene

Localization for ALG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG10 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALG10 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG10: view

Pathways & Interactions for ALG10 Gene

genes like me logo Genes that share pathways with ALG10: view

UniProtKB/Swiss-Prot Q5BKT4-AG10A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation IBA 21873635
GO:0006488 dolichol-linked oligosaccharide biosynthetic process IEA --
genes like me logo Genes that share ontologies with ALG10: view

No data available for SIGNOR curated interactions for ALG10 Gene

Drugs & Compounds for ALG10 Gene

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(1) Drugs for ALG10 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2568

(2) Additional Compounds for ALG10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
 2067-66-5
Dolichyl b-D-glucosyl phosphate
  • Dolichyl b-D-glucosyl phosphoric acid
  • Dolichol monophosphate glucose
  • Dolichyl b-delta-glucosyl phosphate
  • Dolichyl beta-D-glucosyl phosphate
  • Dolichyl beta-delta-glucosyl phosphate
 220496-27-5
genes like me logo Genes that share compounds with ALG10: view

Transcripts for ALG10 Gene

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  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for ALG10 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALG10

Alternative Splicing Database (ASD) splice patterns (SP) for ALG10 Gene

No ASD Table

Relevant External Links for ALG10 Gene

GeneLoc Exon Structure for
ALG10

Expression for ALG10 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALG10 Gene

mRNA expression in normal human tissues for ALG10 Gene
mRNA expression by BioGPS for ALG10 GenemRNA expression by GTEx for ALG10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ALG10 Gene

This gene is overexpressed in Placenta (43.5), Platelet (17.0), and Blymphocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALG10 Gene



Protein tissue co-expression partners for ALG10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALG10

SOURCE GeneReport for Unigene cluster for ALG10 Gene:

Hs.102971

Evidence on tissue expression from TISSUES for ALG10 Gene

  • Nervous system(4.4)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ALG10: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG10 Gene

Orthologs for ALG10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ALG10 30 31
  • 98.87 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 31
  • 93 (a)
 OneToMany
ALG10 30
  • 90.77 (n)
Cow
(Bos Taurus)
 Mammalia ALG10 30 31
  • 90.77 (n)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Alg10 30
  • 84.85 (n)
Mouse
(Mus musculus)
 Mammalia Alg10b 30 17 31
  • 83.44 (n)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 79 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 76 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves ALG10 30 31
  • 71.2 (n)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 69 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia alg10 30
  • 66.52 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC100331575 30
  • 59.38 (n)
alg10 31
  • 56 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002420 30
  • 45.43 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Alg10 30 31
  • 45.3 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea tag-179 31
  • 33 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes DIE2 30 31
  • 46.21 (n)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E15797g 30
  • 45.13 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADL138C 30
  • 44.61 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G02410 30
  • 47.4 (n)
Rice
(Oryza sativa)
 Liliopsida Os04g0503700 30
  • 48.18 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes alg10 30
  • 49.3 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 40 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.14005 30
Species where no ortholog for ALG10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ALG10 Gene

ENSEMBL:
Gene Tree for ALG10 (if available)
TreeFam:
Gene Tree for ALG10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ALG10: view image

Paralogs for ALG10 Gene

Paralogs for ALG10 Gene

(1) SIMAP similar genes for ALG10 Gene using alignment to 3 proteins:

  • AG10A_HUMAN
  • F5GZZ6_HUMAN
  • F5H5T2_HUMAN
genes like me logo Genes that share paralogs with ALG10: view

Variants for ALG10 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALG10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs121908850 Risk Factor: Long QT syndrome 2 34,026,832(+) G/A
NM_032834.4(ALG10):c.1339G>A (p.Val447Ile) 		MISSENSE
rs185875444 Benign: not provided 34,026,298(+) G/A
NM_032834.4(ALG10):c.805G>A (p.Val269Ile) 		MISSENSE
rs77450248 Benign: not provided 34,025,895(+) A/C
NM_032834.4(ALG10):c.402A>C (p.Thr134=) 		SYNONYMOUS
rs78273253 Benign: not provided 34,026,222(+) C/T
NM_032834.4(ALG10):c.729C>T (p.Ser243=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ALG10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ALG10 Gene

Variant ID Type Subtype PubMed ID
dgv1432n100 CNV gain 25217958
dgv1433n100 CNV gain 25217958
dgv1436n100 CNV gain 25217958
dgv1437n100 CNV gain 25217958
dgv2502n54 CNV gain 21841781
dgv2503n54 CNV gain 21841781
dgv2512n54 CNV gain 21841781
dgv2513n54 CNV gain 21841781
esv2677888 CNV deletion 23128226
esv2759892 CNV gain+loss 17122850
esv2761043 CNV gain+loss 21179565
esv34883 CNV gain 17911159
esv3581460 CNV gain 25503493
esv3629134 CNV gain 21293372
esv3892179 CNV gain 25118596
esv3892180 CNV gain 25118596
nsv469348 CNV gain 19166990
nsv469350 CNV gain 19166990
nsv520568 CNV gain 19592680
nsv523443 CNV gain 19592680
nsv527701 CNV gain 19592680
nsv558295 CNV gain 21841781
nsv818908 CNV gain 17921354
nsv983307 CNV duplication 23825009

Variation tolerance for ALG10 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALG10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALG10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG10 Gene

Disorders for ALG10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALG10 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
long qt syndrome 2
  • lqt2
familial long qt syndrome
  • congenital long qt syndrome
long qt syndrome 1
  • lqt1
toxic myocarditis
ivic syndrome
  • radial ray defects, hearing impairment, external ophthalmoplegia, and thrombocytopenia
- elite association - COSMIC cancer census association via MalaCards
Search ALG10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ALG10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ALG10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALG10 Gene

Publications for ALG10 Gene

  1. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. (PMID: 12200473) Oriol R … Codogno P (Molecular biology and evolution 2002) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

ExternalLinks

View latest publications for ALG10 gene in Mastermind

Products for ALG10 Gene

  • Addgene plasmids for ALG10

Sources for ALG10 Gene