Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALG10 Gene

Aliases for ALG10 Gene

  • ALG10, Alpha-1,2-Glucosyltransferase 2 3 5
  • Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2- Glucosyltransferase 2 3
  • Asparagine-Linked Glycosylation Protein 10 Homolog A 3 4
  • Alpha-1,2-Glucosyltransferase ALG10-A 3 4
  • Alpha-2-Glucosyltransferase ALG10-A 3 4
  • ALG10A 3 4
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog (S. Pombe) 2
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog (Yeast) 2
  • Asparagine-Linked Glycosylation 10 Homolog (Yeast, Alpha-1,2-Glucosyltransferase) 3
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog 3
  • Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol Alpha-1,2-Glucosyltransferase 3
  • Derepression Of ITR1 Expression 2 Homolog (S. Cerevisiae) 2
  • Derepression Of ITR1 Expression 2 Homolog 3
  • Potassium Channel Regulator 1 3
  • Alpha2-Glucosyltransferase 3
  • EC 4
  • EC 56
  • EC 2.4.1 56
  • DIE2 3
  • KCR1 3

External Ids for ALG10 Gene

Previous GeneCards Identifiers for ALG10 Gene

  • GC12P034075
  • GC12P034066
  • GC12P033915

Summaries for ALG10 Gene

Entrez Gene Summary for ALG10 Gene

  • This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]

GeneCards Summary for ALG10 Gene

ALG10 (ALG10, Alpha-1,2-Glucosyltransferase) is a Protein Coding gene. Diseases associated with ALG10 include Long Qt Syndrome 2. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring hexosyl groups and dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity. An important paralog of this gene is ALG10B.

UniProtKB/Swiss-Prot for ALG10 Gene

  • Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.

Additional gene information for ALG10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG10 Gene

Genomics for ALG10 Gene

GeneHancer (GH) Regulatory Elements for ALG10 Gene

Promoters and enhancers for ALG10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I034021 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 569.4 +0.1 66 2.1 FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ALG10 ENSG00000256538 ENSG00000245482
GH12I033586 Enhancer 1.2 Ensembl ENCODE 8.3 -433.9 -433910 3.5 PKNOX1 SMAD1 ARNT NEUROD1 IRF4 ZNF207 FOS REST ZNF592 MEF2D ALG10 YARS2 GC12P033578 LOC105369726
GH12I034125 Enhancer 0.8 Ensembl ENCODE 7.8 +104.0 104020 1 ZNF639 IRF2 TAF9B ZBTB11 ZBTB40 ZNF318 PRDM10 PRDM1 ALG10 ENSG00000255628 ENSG00000245482
GH12I034218 Enhancer 0.8 ENCODE 6.3 +196.4 196421 0.7 ATF1 ARNT ZNF2 RAD21 YY1 ARID2 ZNF366 ZNF143 ZNF654 ZNF362 ENSG00000255652 ALG10 DUX4L27
GH12I033669 Enhancer 0.3 ENCODE 6.2 -351.3 -351292 2.2 POU5F1 ALG10 LOC105369726 GC12P033578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ALG10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALG10 gene promoter:

Genomic Locations for ALG10 Gene

Genomic Locations for ALG10 Gene
7,414 bases
Plus strand

Genomic View for ALG10 Gene

Genes around ALG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG10 Gene

Proteins for ALG10 Gene

  • Protein details for ALG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q6NS98
    • Q96DU0
    • Q96SM6

    Protein attributes for ALG10 Gene

    473 amino acids
    Molecular mass:
    55606 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ALG10 Gene

Selected DME Specific Peptides for ALG10 Gene


Post-translational modifications for ALG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALG10 Gene

Gene Families for ALG10 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ALG10 Gene


Suggested Antigen Peptide Sequences for ALG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ALG10 glucosyltransferase family.
  • Belongs to the ALG10 glucosyltransferase family.
genes like me logo Genes that share domains with ALG10: view

Function for ALG10 Gene

Molecular function for ALG10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
UniProtKB/Swiss-Prot Function:
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.

Enzyme Numbers (IUBMB) for ALG10 Gene

Phenotypes From GWAS Catalog for ALG10 Gene

Gene Ontology (GO) - Molecular Function for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ALG10: view
genes like me logo Genes that share phenotypes with ALG10: view

Animal Models for ALG10 Gene

MGI Knock Outs for ALG10:

Animal Model Products

miRNA for ALG10 Gene

miRTarBase miRNAs that target ALG10

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALG10 Gene

Localization for ALG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG10 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALG10 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG10: view

Pathways & Interactions for ALG10 Gene

genes like me logo Genes that share pathways with ALG10: view

UniProtKB/Swiss-Prot Q5BKT4-AG10A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process IEA --
genes like me logo Genes that share ontologies with ALG10: view

No data available for SIGNOR curated interactions for ALG10 Gene

Drugs & Compounds for ALG10 Gene

(1) Drugs for ALG10 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2100

(2) Additional Compounds for ALG10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
Dolichyl b-D-glucosyl phosphate
  • Dolichol monophosphate glucose
  • Dolichyl b-D-glucosyl phosphate
  • Dolichyl b-delta-glucosyl phosphate
  • Dolichyl beta-D-glucosyl phosphate
  • Dolichyl beta-delta-glucosyl phosphate
genes like me logo Genes that share compounds with ALG10: view

Transcripts for ALG10 Gene

Unigene Clusters for ALG10 Gene

ALG10, alpha-1,2-glucosyltransferase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG10 Gene

No ASD Table

Relevant External Links for ALG10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALG10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALG10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ALG10 Gene

This gene is overexpressed in Placenta (43.5), Platelet (17.0), and Blymphocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALG10 Gene

Protein tissue co-expression partners for ALG10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ALG10 Gene:


SOURCE GeneReport for Unigene cluster for ALG10 Gene:


Evidence on tissue expression from TISSUES for ALG10 Gene

  • Nervous system(4.4)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ALG10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALG10 Gene

Orthologs for ALG10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALG10 33 34
  • 98.87 (n)
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
ALG10 33
  • 90.77 (n)
(Bos Taurus)
Mammalia ALG10 33 34
  • 90.77 (n)
(Rattus norvegicus)
Mammalia Alg10 33
  • 84.85 (n)
(Mus musculus)
Mammalia Alg10b 33 16 34
  • 83.44 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
(Gallus gallus)
Aves ALG10 33 34
  • 71.2 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alg10 33
  • 66.52 (n)
(Danio rerio)
Actinopterygii LOC100331575 33
  • 59.38 (n)
alg10 34
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002420 33
  • 45.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta Alg10 33 34
  • 45.3 (n)
(Caenorhabditis elegans)
Secernentea tag-179 34
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIE2 33 34
  • 46.21 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15797g 33
  • 45.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL138C 33
  • 44.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02410 33
  • 47.4 (n)
(Oryza sativa)
Liliopsida Os04g0503700 33
  • 48.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg10 33
  • 49.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14005 33
Species where no ortholog for ALG10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG10 Gene

Gene Tree for ALG10 (if available)
Gene Tree for ALG10 (if available)

Paralogs for ALG10 Gene

Paralogs for ALG10 Gene

(1) SIMAP similar genes for ALG10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ALG10: view

Variants for ALG10 Gene

Sequence variations from dbSNP and Humsavar for ALG10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs121908850 risk-factor, Long QT syndrome 2 34,026,832(+) G/A/T coding_sequence_variant, missense_variant
rs1000087603 -- 34,027,877(+) C/A 3_prime_UTR_variant
rs1000118372 -- 34,028,173(+) G/A 3_prime_UTR_variant
rs1000191532 -- 34,028,391(+) A/G downstream_transcript_variant
rs1001462174 -- 34,021,972(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ALG10 Gene

Variant ID Type Subtype PubMed ID
dgv1432n100 CNV gain 25217958
dgv1433n100 CNV gain 25217958
dgv1436n100 CNV gain 25217958
dgv1437n100 CNV gain 25217958
dgv2502n54 CNV gain 21841781
dgv2503n54 CNV gain 21841781
dgv2512n54 CNV gain 21841781
dgv2513n54 CNV gain 21841781
esv2677888 CNV deletion 23128226
esv2759892 CNV gain+loss 17122850
esv2761043 CNV gain+loss 21179565
esv34883 CNV gain 17911159
esv3581460 CNV gain 25503493
esv3629134 CNV gain 21293372
esv3892179 CNV gain 25118596
esv3892180 CNV gain 25118596
nsv469348 CNV gain 19166990
nsv469350 CNV gain 19166990
nsv520568 CNV gain 19592680
nsv523443 CNV gain 19592680
nsv527701 CNV gain 19592680
nsv558295 CNV gain 21841781
nsv818908 CNV gain 17921354
nsv983307 CNV duplication 23825009

Variation tolerance for ALG10 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALG10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG10 Gene

Disorders for ALG10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALG10 Gene - From: OMIM, ClinVar, and GTR

Disorder Aliases PubMed IDs
long qt syndrome 2
  • long qt syndrome 9
- elite association - COSMIC cancer census association via MalaCards
Search ALG10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ALG10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ALG10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALG10 Gene

Publications for ALG10 Gene

  1. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. (PMID: 12200473) Oriol R … Codogno P (Molecular biology and evolution 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ALG10 Gene

Sources for ALG10 Gene

Loading form....