This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceral... See more...

Aliases for ALDOC Gene

Aliases for ALDOC Gene

  • Aldolase, Fructose-Bisphosphate C 2 3 5
  • Aldolase C, Fructose-Bisphosphate 2 3
  • Fructose-Bisphosphate Aldolase C 3 4
  • Brain-Type Aldolase 3 4
  • EC 4 51
  • ALDC 3 4
  • Fructose-1,6-Biphosphate Triosephosphate Lyase 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Fructoaldolase C 3
  • Aldolase 3 3
  • ALDOC 5

External Ids for ALDOC Gene

Previous GeneCards Identifiers for ALDOC Gene

  • GC17M026745
  • GC17M028799
  • GC17M027045
  • GC17M023924
  • GC17M026900
  • GC17M023109
  • GC17M028576
  • GC17M029281
  • GC17M029381
  • GC17M029403
  • GC17M029698
  • GC17M028578
  • GC17M028669
  • GC17M028763
  • GC17M028808
  • GC17M028913
  • GC17M029006
  • GC17M029110
  • GC17M029192
  • GC17M029957

Summaries for ALDOC Gene

Entrez Gene Summary for ALDOC Gene

  • This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDOC Gene

ALDOC (Aldolase, Fructose-Bisphosphate C) is a Protein Coding gene. Diseases associated with ALDOC include Prostate Carcinoma In Situ. Among its related pathways are Glucose metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytoskeletal protein binding and fructose-bisphosphate aldolase activity. An important paralog of this gene is ALDOA.

Gene Wiki entry for ALDOC Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALDOC Gene

Genomics for ALDOC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALDOC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028576 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 53 2.2 TBP SP1 MXD4 CEBPA NR2C1 MNT IKZF1 SMAD5 MBD2 POLR2A ALDOC SUPT6H PHF12 SPAG5-AS1 RSKR KIAA0100 NUFIP2 ENSG00000264577 TMEM199 UNC119
GH17J028575 Promoter 0.6 EPDnew 250.7 +1.4 1368 0.1 EBF1 CTCF GATA2 ALDOC HSALNG0115480 KIAA0100 PIGS ENSG00000258472 RF00017-2319
GH17J028574 Promoter 0.4 EPDnew 250.7 +2.2 2222 0.1 CTCF ALDOC ENSG00000265168 HSALNG0115480 PIGS ENSG00000258472 RF00017-2319
GH17J028578 Promoter 0.3 EPDnew 250.7 -1.5 -1501 0.1 ALDOC SPAG5 SPAG5-AS1 RSKR KIAA0100 lnc-ALDOC-2 ENSG00000258472 RF00017-2319
GH17J028546 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 +26.6 26553 7.7 ZSCAN16 MXD4 NR2C1 DEK SMAD5 CTCF ZIC2 ZNF610 THAP11 SIN3A UNC119 PIGS ENSG00000264577 NUFIP2 LOC101927018 PHF12 ENSG00000265205 SDF2 FOXN1 SUPT6H
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALDOC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALDOC

Top Transcription factor binding sites by QIAGEN in the ALDOC gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun

Genomic Locations for ALDOC Gene

Latest Assembly
3,849 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,776 bases
Minus strand

(GRCh37/hg19 by Ensembl)
4,150 bases
Minus strand

Genomic View for ALDOC Gene

Genes around ALDOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOC Gene

Proteins for ALDOC Gene

  • Protein details for ALDOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fructose-bisphosphate aldolase C
    Protein Accession:
    Secondary Accessions:
    • B2R5R3
    • Q3SYL3
    • Q6FH94
    • Q6P0L5

    Protein attributes for ALDOC Gene

    364 amino acids
    Molecular mass:
    39456 Da
    Quaternary structure:
    • Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.
    • Sequence=AAI03761.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    • In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Three dimensional structures from OCA and Proteopedia for ALDOC Gene

neXtProt entry for ALDOC Gene

Selected DME Specific Peptides for ALDOC Gene


Post-translational modifications for ALDOC Gene

  • Ubiquitination at Lys28, Lys42, Lys111, and Lys330
  • Modification sites at PhosphoSitePlus

Domains & Families for ALDOC Gene

Gene Families for ALDOC Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ALDOC Gene

  • Fructose-bisphosphate aldolase, class-I

Suggested Antigen Peptide Sequences for ALDOC Gene

GenScript: Design optimal peptide antigens:
  • Fructose-bisphosphate aldolase (A8MVZ9_HUMAN)
  • Brain-type aldolase (ALDOC_HUMAN)
  • Fructose-bisphosphate aldolase (B7Z1N6_HUMAN)
  • Fructose-bisphosphate aldolase (B7Z3K7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I fructose-bisphosphate aldolase family.
  • Belongs to the class I fructose-bisphosphate aldolase family.
genes like me logo Genes that share domains with ALDOC: view

Function for ALDOC Gene

Molecular function for ALDOC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=; Evidence={ECO:0000269|PubMed:15537755};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate {ECO:0000269|PubMed:15537755}; KM=16 mM for fructose 1-phosphate {ECO:0000269|PubMed:15537755};
GENATLAS Biochemistry:
aldolase C,fructose-bisphosphate,160kDa,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P

Enzyme Numbers (IUBMB) for ALDOC Gene

Phenotypes From GWAS Catalog for ALDOC Gene

Gene Ontology (GO) - Molecular Function for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004332 fructose-bisphosphate aldolase activity IEA,IDA 9244396
GO:0005515 protein binding IPI 11399750
GO:0008092 cytoskeletal protein binding IDA 9244396
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with ALDOC: view
genes like me logo Genes that share phenotypes with ALDOC: view

Animal Models for ALDOC Gene

MGI Knock Outs for ALDOC:
  • Aldoc Aldoc<tm1.1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDOC

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDOC Gene

Localization for ALDOC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALDOC gene
Compartment Confidence
cytosol 5
extracellular 4
cytoskeleton 4
nucleus 3
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IC 9244396
GO:0034774 secretory granule lumen TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ALDOC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALDOC Gene

Pathways & Interactions for ALDOC Gene

genes like me logo Genes that share pathways with ALDOC: view

Pathways by source for ALDOC Gene

UniProtKB/Swiss-Prot P09972-ALDOC_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Gene Ontology (GO) - Biological Process for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006000 fructose metabolic process TAS 3105602
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IEA,IBA 21873635
GO:0030388 fructose 1,6-bisphosphate metabolic process IDA 9244396
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with ALDOC: view

No data available for SIGNOR curated interactions for ALDOC Gene

Drugs & Compounds for ALDOC Gene

(3) Drugs for ALDOC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1687
D-erythrose 4-phosphate Experimental Pharma 0
Dihydroxyacetone phosphate Investigational Pharma 0

(5) Additional Compounds for ALDOC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fructose 1,6-bisphosphate
  • 1,6-Di-O-phosphono-beta-D-fructofuranose
  • BETA FRUCTOSE 1,6-diphosphATE
  • Fosfructose
  • 1,6-Di-O-phosphono-b-D-fructofuranose
  • 1,6-Di-O-phosphono-β-D-fructofuranose
fructose 1-phosphate
  • beta-D-Fructose 1-phosphate
  • b-D-Fructose 1-phosphate
  • b-D-Fructose 1-phosphoric acid
  • beta-D-Fructose 1-phosphoric acid
  • Β-D-fructose 1-phosphate
80875-93-0, 15978-08-2
  • (+-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • Aldotriose
  • alpha,beta-Dihydroxypropionaldehyde
glyceraldehyde 3-phosphate
  • (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
  • Glyceraldehyde 3-phosphate
  • Glyceraldehyde 3-phosphoric acid
  • Glyceraldehyde-3-phosphoric acid
  • D-Glyceraldehyde 3-phosphoric acid
Sedoheptulose 1,7-bisphosphate
  • altro-Heptulose 1,7-biphosphate
  • D-altro-Heptulose 1,7-biphosphate
  • D-Sedoheptulose 1,7-bisphosphate
  • altro-Heptulose 1,7-biphosphoric acid
  • Sedoheptulose 1,7-bisphosphoric acid
genes like me logo Genes that share compounds with ALDOC: view

Transcripts for ALDOC Gene

mRNA/cDNA for ALDOC Gene

19 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDOC

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11
SP2: -
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for ALDOC Gene

GeneLoc Exon Structure for

Expression for ALDOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALDOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDOC Gene

This gene is overexpressed in Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for ALDOC Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.9), Spinal cord (7.2), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALDOC Gene

Protein tissue co-expression partners for ALDOC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALDOC

SOURCE GeneReport for Unigene cluster for ALDOC Gene:


Evidence on tissue expression from TISSUES for ALDOC Gene

  • Nervous system(5)
  • Eye(4.8)
  • Liver(4.6)
  • Intestine(4.4)
  • Heart(4.2)
  • Muscle(2.9)
  • Skin(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ALDOC: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDOC Gene

Orthologs for ALDOC Gene

This gene was present in the common ancestor of animals.

Orthologs for ALDOC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALDOC 30 31
  • 99.54 (n)
(Monodelphis domestica)
Mammalia ALDOC 31
  • 95 (a)
(Canis familiaris)
Mammalia ALDOC 30 31
  • 93.32 (n)
(Bos Taurus)
Mammalia ALDOC 30 31
  • 92.67 (n)
(Ornithorhynchus anatinus)
Mammalia ALDOC 31
  • 91 (a)
(Mus musculus)
Mammalia Aldoc 30 17 31
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Aldoc 30
  • 90.45 (n)
(Gallus gallus)
Aves ALDOC 30 31
  • 81.5 (n)
(Anolis carolinensis)
Reptilia ALDOC 31
  • 87 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia aldoc 30
  • 77.29 (n)
Str.3134 30
African clawed frog
(Xenopus laevis)
Amphibia aldoc-prov 30
(Danio rerio)
Actinopterygii aldoca 31
  • 79 (a)
aldocb 30
  • 76.49 (n)
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta Ald 31 32
  • 67 (a)
CG5432 31 32
  • 57 (a)
(Caenorhabditis elegans)
Secernentea T05D4.1 32
  • 65 (a)
F01F1.12b 32
  • 62 (a)
aldo-2 31
  • 61 (a)
F01F1.12a 32
  • 61 (a)
aldo-1 30 31
  • 60.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11039 31
  • 70 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5322 30
Species where no ortholog for ALDOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ALDOC Gene

Gene Tree for ALDOC (if available)
Gene Tree for ALDOC (if available)
Evolutionary constrained regions (ECRs) for ALDOC: view image

Paralogs for ALDOC Gene

Paralogs for ALDOC Gene

(2) SIMAP similar genes for ALDOC Gene using alignment to 7 proteins:

  • C9J8F3_HUMAN
genes like me logo Genes that share paralogs with ALDOC: view

Variants for ALDOC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALDOC Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs371687048 Likely Benign: not provided 28,573,782(-) G/T
NM_005165.3(ALDOC):c.952C>A (p.Arg318=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ALDOC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ALDOC Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958

Variation tolerance for ALDOC Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALDOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDOC Gene

Disorders for ALDOC Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALDOC Gene - From: COP

Disorder Aliases PubMed IDs
prostate carcinoma in situ
  • carcinoma in situ of prostate
- elite association - COSMIC cancer census association via MalaCards
Search ALDOC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ALDOC

genes like me logo Genes that share disorders with ALDOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALDOC Gene

Publications for ALDOC Gene

  1. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. (PMID: 19405953) Martins-de-Souza D … Dias-Neto E (BMC psychiatry 2009) 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PMID: 15537755) Arakaki TL … Allen KN (Protein science : a publication of the Protein Society 2004) 3 4
  4. Phospholipase D2 directly interacts with aldolase via Its PH domain. (PMID: 11876650) Kim JH … Ryu SH (Biochemistry 2002) 3 4
  5. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. (PMID: 11399750) Lu M … Gluck SL (The Journal of biological chemistry 2001) 3 4

Products for ALDOC Gene

Sources for ALDOC Gene