Fructose-1,6-bisphosphate aldolase (EC is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are d... See more...

Aliases for ALDOB Gene

Aliases for ALDOB Gene

  • Aldolase, Fructose-Bisphosphate B 2 3 5
  • Aldolase B, Fructose-Bisphosphate 2 3
  • Fructose-Bisphosphate Aldolase B 3 4
  • Liver-Type Aldolase 3 4
  • EC 4 51
  • ALDB 3 4
  • Aldolase B, Fructose-Bisphosphatase 3
  • Aldolase 2 3
  • ALDO2 3
  • ALDOB 5

External Ids for ALDOB Gene

Previous GeneCards Identifiers for ALDOB Gene

  • GC09M094983
  • GC09M095927
  • GC09M097641
  • GC09M099563
  • GC09M101263
  • GC09M103222
  • GC09M104182
  • GC09M073782

Summaries for ALDOB Gene

Entrez Gene Summary for ALDOB Gene

  • Fructose-1,6-bisphosphate aldolase (EC is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

GeneCards Summary for ALDOB Gene

ALDOB (Aldolase, Fructose-Bisphosphate B) is a Protein Coding gene. Diseases associated with ALDOB include Fructose Intolerance, Hereditary and Sedoheptulokinase Deficiency. Among its related pathways are Glucose metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and ATPase binding. An important paralog of this gene is ALDOC.

Gene Wiki entry for ALDOB Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALDOB Gene

Genomics for ALDOB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ALDOB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J101430 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 258.6 +8.3 8276 20.9 MXD4 CEBPA PLRG1 ZFP64 ZNF217 CTCF HOMEZ KDM6A THAP11 CEBPB ALDOB HSALNG0073314 LOC105376184 ZNF189 PGAP4 RNF20 MRPL50 BAAT ENSG00000270982 HSALNG0073313
GH09J101421 Enhancer 0.8 ENCODE 20.2 +27.8 27793 0.9 MXD4 CEBPA HOMEZ THAP11 FOXA2 SMAD4 SAP130 RXRA MIER3 ETV4 ALDOB ZNF189 NONHSAG053057.2 HSALNG0073312
GH09J101418 Enhancer 0.7 Ensembl dbSUPER 12.3 +31.2 31239 1.2 CEBPA ZBTB33 CEBPG KDM1A NFIL3 HLF MAX ZNF680 YY1 CEBPB HSALNG0073309 HSALNG0073310 NONHSAG053057.2 ALDOB BAAT ZNF189
GH09J101452 Enhancer 0.5 ENCODE dbSUPER 8.8 -4.0 -3997 1.8 ATF2 ZNF644 TMEM246-AS1 PGAP4 RNF20 ZNF189 MRPL50 ALDOB ENSG00000270982 LOC105376184
GH09J101456 Enhancer 0.6 Ensembl 7.2 -7.3 -7337 0.8 CTCF HOMEZ THAP11 RAD21 RXRB ZNF580 NR2F6 ARID4B NFIL3 SMC3 TMEM246-AS1 RF00017-7776 PGAP4 RNF20 ALDOB LOC105376184
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALDOB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALDOB

Top Transcription factor binding sites by QIAGEN in the ALDOB gene promoter:
  • AML1a
  • STAT5A

Genomic Locations for ALDOB Gene

Latest Assembly
29,105 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
15,215 bases
Minus strand

(GRCh37/hg19 by Ensembl)
15,246 bases
Minus strand

Genomic View for ALDOB Gene

Genes around ALDOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOB Gene

Proteins for ALDOB Gene

  • Protein details for ALDOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fructose-bisphosphate aldolase B
    Protein Accession:
    Secondary Accessions:
    • Q13741
    • Q13742
    • Q5T7D6

    Protein attributes for ALDOB Gene

    364 amino acids
    Molecular mass:
    39473 Da
    Quaternary structure:
    • Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.
    • In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Three dimensional structures from OCA and Proteopedia for ALDOB Gene

neXtProt entry for ALDOB Gene

Selected DME Specific Peptides for ALDOB Gene


Post-translational modifications for ALDOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALDOB Gene

Domains & Families for ALDOB Gene

Gene Families for ALDOB Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for ALDOB Gene

  • Fructose-bisphosphate aldolase, class-I

Suggested Antigen Peptide Sequences for ALDOB Gene

GenScript: Design optimal peptide antigens:
  • Liver-type aldolase (ALDOB_HUMAN)
  • Fructose-bisphosphate aldolase (C9J4K3_HUMAN)
  • Fructose-bisphosphate aldolase (Q5T7D5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I fructose-bisphosphate aldolase family.
  • Belongs to the class I fructose-bisphosphate aldolase family.
genes like me logo Genes that share domains with ALDOB: view

Function for ALDOB Gene

Molecular function for ALDOB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate {ECO:0000269|PubMed:10970798}; KM=2.3 mM for fructose 1-phosphate {ECO:0000269|PubMed:10970798};
GENATLAS Biochemistry:
aldolase B,fructose-bisphosphate,homotetramer,fructose metabolism,induced after feeding a carbohydrate diet,energy pathway,same affinity for F-1-P and F-1,6-P

Enzyme Numbers (IUBMB) for ALDOB Gene

Phenotypes From GWAS Catalog for ALDOB Gene

Gene Ontology (GO) - Molecular Function for ALDOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004332 fructose-bisphosphate aldolase activity IEA,IDA 9244396
GO:0005515 protein binding IPI 18000879
GO:0008092 cytoskeletal protein binding IDA 9244396
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with ALDOB: view
genes like me logo Genes that share phenotypes with ALDOB: view

Human Phenotype Ontology for ALDOB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ALDOB Gene

MGI Knock Outs for ALDOB:
  • Aldob Aldob<tm1(KOMP)Vlcg>
  • Aldob Aldob<tm2b(EUCOMM)Wtsi>

miRNA for ALDOB Gene

miRTarBase miRNAs that target ALDOB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDOB

No data available for Transcription Factor Targets and HOMER Transcription for ALDOB Gene

Localization for ALDOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDOB Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALDOB gene
Compartment Confidence
extracellular 4
cytoskeleton 4
cytosol 4
nucleus 3
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ALDOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA 18000879
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0034451 centriolar satellite IDA 18000879
genes like me logo Genes that share ontologies with ALDOB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ALDOB Gene

Pathways & Interactions for ALDOB Gene

genes like me logo Genes that share pathways with ALDOB: view

Pathways by source for ALDOB Gene

UniProtKB/Swiss-Prot P05062-ALDOB_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

SIGNOR curated interactions for ALDOB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ALDOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006000 fructose metabolic process IMP 3383242
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IEA,IDA 10625657
GO:0006116 NADH oxidation IDA 17576770
GO:0030388 fructose 1,6-bisphosphate metabolic process IDA 9244396
genes like me logo Genes that share ontologies with ALDOB: view

Drugs & Compounds for ALDOB Gene

(13) Drugs for ALDOB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1687
1,6-Fructose Diphosphate (Linear Form) Experimental Pharma Target 0
sn-glycerol 3-phosphate Experimental Pharma Target 0
D-erythrose 4-phosphate Experimental Pharma 0
Dihydroxyacetone phosphate Investigational Pharma Target 0

(9) Additional Compounds for ALDOB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
fructose 1-phosphate
  • beta-D-Fructose 1-phosphate
  • b-D-Fructose 1-phosphate
  • b-D-Fructose 1-phosphoric acid
  • beta-D-Fructose 1-phosphoric acid
  • Β-D-fructose 1-phosphate
80875-93-0, 15978-08-2
glyceraldehyde 3-phosphate
  • (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
  • Glyceraldehyde 3-phosphate
  • Glyceraldehyde 3-phosphoric acid
  • Glyceraldehyde-3-phosphoric acid
  • D-Glyceraldehyde 3-phosphoric acid
Fructose 1,6-bisphosphate
  • 1,6-Di-O-phosphono-beta-D-fructofuranose
  • BETA FRUCTOSE 1,6-diphosphATE
  • Fosfructose
  • 1,6-Di-O-phosphono-b-D-fructofuranose
  • 1,6-Di-O-phosphono-β-D-fructofuranose
  • (+-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • Aldotriose
  • alpha,beta-Dihydroxypropionaldehyde
Sedoheptulose 1,7-bisphosphate
  • altro-Heptulose 1,7-biphosphate
  • D-altro-Heptulose 1,7-biphosphate
  • D-Sedoheptulose 1,7-bisphosphate
  • altro-Heptulose 1,7-biphosphoric acid
  • Sedoheptulose 1,7-bisphosphoric acid
genes like me logo Genes that share compounds with ALDOB: view

Transcripts for ALDOB Gene

mRNA/cDNA for ALDOB Gene

10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDOB

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOB Gene

No ASD Table

Relevant External Links for ALDOB Gene

GeneLoc Exon Structure for

Expression for ALDOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALDOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDOB Gene

This gene is overexpressed in Liver (x23.0), Kidney - Cortex (x20.2), and Small Intestine - Terminal Ileum (x7.4).

Protein differential expression in normal tissues from HIPED for ALDOB Gene

This gene is overexpressed in Liver, secretome (25.4), Liver (19.0), and Kidney (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALDOB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALDOB

SOURCE GeneReport for Unigene cluster for ALDOB Gene:


Evidence on tissue expression from TISSUES for ALDOB Gene

  • Liver(5)
  • Kidney(4)
  • Intestine(3.1)
  • Pancreas(2.9)
  • Blood(2.4)
  • Gall bladder(2.3)
  • Heart(2.2)
  • Nervous system(2.1)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDOB Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • salivary gland
  • skull
  • breast
  • chest wall
  • clavicle
  • diaphragm
  • esophagus
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • pelvis
  • testicle
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with ALDOB: view

Primer products for research

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ALDOB Gene

Orthologs for ALDOB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDOB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALDOB 30 31
  • 99.73 (n)
(Canis familiaris)
Mammalia ALDOB 30 31
  • 92.95 (n)
(Bos Taurus)
Mammalia ALDOB 30 31
  • 92.12 (n)
(Mus musculus)
Mammalia Aldob 30 17 31
  • 90.75 (n)
(Ornithorhynchus anatinus)
Mammalia ALDOB 31
  • 90 (a)
(Rattus norvegicus)
Mammalia Aldob 30
  • 89.84 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 86 (a)
-- 31
  • 83 (a)
(Gallus gallus)
Aves ALDOB 30 31
  • 75.55 (n)
(Anolis carolinensis)
Reptilia ALDOB 31
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia aldob 30
  • 68.32 (n)
(Danio rerio)
Actinopterygii aldob 30 31
  • 71.06 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Ald 31 32
  • 63 (a)
CG5432 31 32
  • 51 (a)
(Caenorhabditis elegans)
Secernentea aldo-2 31
  • 60 (a)
aldo-1 31
  • 59 (a)
F01F1.12a 32
  • 59 (a)
F01F1.12b 32
  • 59 (a)
T05D4.1 32
  • 58 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13172 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11039 31
  • 64 (a)
Species where no ortholog for ALDOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ALDOB Gene

Gene Tree for ALDOB (if available)
Gene Tree for ALDOB (if available)
Evolutionary constrained regions (ECRs) for ALDOB: view image

Paralogs for ALDOB Gene

Paralogs for ALDOB Gene

(2) SIMAP similar genes for ALDOB Gene using alignment to 2 proteins:

  • Q5T7D5_HUMAN
genes like me logo Genes that share paralogs with ALDOB: view

Variants for ALDOB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALDOB Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
912447 Uncertain Significance: Hereditary fructosuria 101,421,306(-) A/G
912448 Uncertain Significance: Hereditary fructosuria 101,421,600(-) G/A
912482 Uncertain Significance: Hereditary fructosuria 101,428,496(-) C/T
NM_000035.4(ALDOB):c.352G>A (p.Gly118Arg)
912483 Uncertain Significance: Hereditary fructosuria 101,428,504(-) G/A
NM_000035.4(ALDOB):c.344C>T (p.Pro115Leu)
912484 Uncertain Significance: Hereditary fructosuria 101,429,809(-) C/T
NM_000035.4(ALDOB):c.270G>A (p.Gln90=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ALDOB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ALDOB Gene

Variant ID Type Subtype PubMed ID
esv3404834 CNV insertion 20981092
nsv523287 CNV loss 19592680

Variation tolerance for ALDOB Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ALDOB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDOB Gene

Disorders for ALDOB Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALDOB Gene - From: OMI, CVR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ALDOB in MalaCards View complete list of genes associated with diseases


  • Hereditary fructose intolerance (HFI) [MIM:229600]: Autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. {ECO:0000269 PubMed:10024431, ECO:0000269 PubMed:10970798, ECO:0000269 PubMed:12205126, ECO:0000269 PubMed:15532022, ECO:0000269 PubMed:15880727, ECO:0000269 PubMed:1967768, ECO:0000269 PubMed:20848650, ECO:0000269 PubMed:2336380, ECO:0000269 PubMed:3383242, ECO:0000269 PubMed:8162030, ECO:0000269 PubMed:8299883}. Note=The disease is caused by variants affecting the gene represented in this entry.

Genatlas disease for ALDOB Gene

fructose intolerance,hereditary,characterized by vomiting,nausea,sweating associated with hypoglycemia and metabolic acidosis after exposure ef dietary fructose after weaning,leading to chronic toxicity and cirrhosis of liver in case of persistent intake

Additional Disease Information for ALDOB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ALDOB: view

Publications for ALDOB Gene

  1. The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. (PMID: 15880727) Santer R … Schneppenheim R (Human mutation 2005) 2 3 4 23
  2. Molecular analysis of aldolase B genes in hereditary fructose intolerance. (PMID: 1967768) Cross NC … Mascali G (Lancet (London, England) 1990) 3 4 23 74
  3. Increased prevalence of mutant null alleles that cause hereditary fructose intolerance in the American population. (PMID: 20033295) Coffee EM … Tolan DR (Journal of inherited metabolic disease 2010) 3 23 41
  4. Aldolase B mutations and prevalence of hereditary fructose intolerance in a Polish population. (PMID: 16406649) Gruchota J … Płoski R (Molecular genetics and metabolism 2006) 3 23 41
  5. Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. (PMID: 15532022) Esposito G … Salvatore F (Human mutation 2004) 3 4 23

Products for ALDOB Gene

Sources for ALDOB Gene