Aliases for ALDOB Gene
External Ids for ALDOB Gene
Previous GeneCards Identifiers for ALDOB Gene
Fructose-1,6-bisphosphate aldolase (EC 126.96.36.199) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
GeneCards Summary for ALDOB Gene
ALDOB (Aldolase, Fructose-Bisphosphate B) is a Protein Coding gene. Diseases associated with ALDOB include Fructose Intolerance, Hereditary and Sedoheptulokinase Deficiency. Among its related pathways are Glucose metabolism and FOXA2 and FOXA3 transcription factor networks. Gene Ontology (GO) annotations related to this gene include identical protein binding and ATPase binding. An important paralog of this gene is ALDOC.