This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during develop... See more...

Aliases for ALDOA Gene

Aliases for ALDOA Gene

  • Aldolase, Fructose-Bisphosphate A 2 3 5
  • Aldolase A, Fructose-Bisphosphate 2 3
  • Fructose-Bisphosphate Aldolase A 3 4
  • Lung Cancer Antigen NY-LU-1 3 4
  • Muscle-Type Aldolase 3 4
  • EC 4.1.2.13 4 54
  • ALDA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 87p 3
  • Fructose-1,6-Bisphosphate Triosephosphate-Lyase 3
  • HEL-S-87p 3
  • GSD12 3

External Ids for ALDOA Gene

Previous GeneCards Identifiers for ALDOA Gene

  • GC16M029079
  • GC16P030386
  • GC16P030062
  • GC16P030102
  • GC16P029971
  • GC16P030064
  • GC16P027726

Summaries for ALDOA Gene

Entrez Gene Summary for ALDOA Gene

  • This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

GeneCards Summary for ALDOA Gene

ALDOA (Aldolase, Fructose-Bisphosphate A) is a Protein Coding gene. Diseases associated with ALDOA include Glycogen Storage Disease Xii and Melanoma-Associated Retinopathy. Among its related pathways are Innate Immune System and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is LOC112694756.

UniProtKB/Swiss-Prot Summary for ALDOA Gene

  • Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).

Gene Wiki entry for ALDOA Gene

Additional gene information for ALDOA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALDOA Gene

Genomics for ALDOA Gene

GeneHancer (GH) Regulatory Elements for ALDOA Gene

Promoters and enhancers for ALDOA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ALDOA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ALDOA gene promoter:
  • AP-1
  • NF-1
  • NF-1/L

Genomic Locations for ALDOA Gene

Genomic Locations for ALDOA Gene
chr16:30,053,090-30,070,457
(GRCh38/hg38)
Size:
17,368 bases
Orientation:
Plus strand
chr16:30,064,411-30,081,778
(GRCh37/hg19)
Size:
17,368 bases
Orientation:
Plus strand

Genomic View for ALDOA Gene

Genes around ALDOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOA Gene

Proteins for ALDOA Gene

  • Protein details for ALDOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04075-ALDOA_HUMAN
    Recommended name:
    Fructose-bisphosphate aldolase A
    Protein Accession:
    P04075
    Secondary Accessions:
    • B4DXI7
    • Q6FH76
    • Q6FI10
    • Q96B15
    • Q9BWD9
    • Q9UCN2

    Protein attributes for ALDOA Gene

    Size:
    364 amino acids
    Molecular mass:
    39420 Da
    Quaternary structure:
    • Homotetramer. Interacts with SNX9 and WAS (By similarity). Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+).
    Miscellaneous:
    • In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Three dimensional structures from OCA and Proteopedia for ALDOA Gene

    Alternative splice isoforms for ALDOA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALDOA Gene

Selected DME Specific Peptides for ALDOA Gene

P04075:
  • LEGTLLKPNMVT
  • RCAQYKKDG
  • KRALANSLACQGKYTPSGQ
  • PWALTFS
  • FSYGRALQAS
  • LKAWGGKKENLKAAQ
  • VPIVEPE
  • GIKVDKG
  • LARYASI
  • PDGDHDL
  • EEIAMATVTALRRTVPPAV
  • ENTEENRR
  • RRFYRQLL
  • LSGGQSE
  • VLAAVYKAL
  • GVILFHET
  • GILAADES
  • FHETLYQK
  • DFAKWRCVLKI
  • GETTTQGLDGL
  • ENANVLARYA
  • CQYVTEKVLAA

Post-translational modifications for ALDOA Gene

  • Ubiquitination at Lys14, Lys28, Lys42, Lys87, Lys108, Lys111, Lys153, Lys230, Lys294, Lys312, Lys318, Lys322, Lys330, and Lys342
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ALDOA Gene

Gene Families for ALDOA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ALDOA Gene

Suggested Antigen Peptide Sequences for ALDOA Gene

GenScript: Design optimal peptide antigens:
  • Muscle-type aldolase (ALDOA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04075

UniProtKB/Swiss-Prot:

ALDOA_HUMAN :
  • Belongs to the class I fructose-bisphosphate aldolase family.
Family:
  • Belongs to the class I fructose-bisphosphate aldolase family.
genes like me logo Genes that share domains with ALDOA: view

Function for ALDOA Gene

Molecular function for ALDOA Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=52 uM for fructose 1,6-bisphosphate (at 30 degrees Celsius) {ECO:0000269 PubMed:14766013}; Temperature dependence: Thermal denaturation midpoint (Tm) is 54.4 degrees Celsius. {ECO:0000269 PubMed:14766013};
GENATLAS Biochemistry:
aldolase A,fructose-bisphosphate,expressed in muscle (M type),and in most other tissues,(N and H types),overexpressed in most lung cancers,homotetramer,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P

Enzyme Numbers (IUBMB) for ALDOA Gene

Phenotypes From GWAS Catalog for ALDOA Gene

Gene Ontology (GO) - Molecular Function for ALDOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003779 actin binding TAS 1008835
GO:0003824 catalytic activity IEA --
GO:0004332 fructose-bisphosphate aldolase activity IEA,IDA 9244396
GO:0005515 protein binding IPI 20849852
genes like me logo Genes that share ontologies with ALDOA: view
genes like me logo Genes that share phenotypes with ALDOA: view

Human Phenotype Ontology for ALDOA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ALDOA Gene

MGI Knock Outs for ALDOA:
  • Aldoa Aldoa<tm1.1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ALDOA Gene

miRTarBase miRNAs that target ALDOA

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for ALDOA Gene

Localization for ALDOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDOA Gene

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALDOA gene
Compartment Confidence
cytosol 5
extracellular 4
cytoskeleton 4
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ALDOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 23580065
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with ALDOA: view

Pathways & Interactions for ALDOA Gene

genes like me logo Genes that share pathways with ALDOA: view

Pathways by source for ALDOA Gene

UniProtKB/Swiss-Prot P04075-ALDOA_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

SIGNOR curated interactions for ALDOA Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ALDOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006000 fructose metabolic process IMP 14615364
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IEA,IMP 14615364
GO:0006754 ATP biosynthetic process IMP 14615364
genes like me logo Genes that share ontologies with ALDOA: view

Drugs & Compounds for ALDOA Gene

(18) Drugs for ALDOA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2741
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0
1,6-DI-O-PHOSPHONO-D-MANNITOL Experimental Pharma Target 0
1,6-Fructose Diphosphate (Linear Form) Experimental Pharma Target 0

(14) Additional Compounds for ALDOA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
fructose 1-phosphate
  • D-Fructose 1-phosphate
  • D-Fructose-1-P
  • D-Fructose-1-phosphate
  • Fructose-1-P
  • Fructose-1-phosphate
15978-08-2
glyceraldehyde
  • (+-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • Aldotriose
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
D-Erythrose 4-phosphate
  • 4-O-phosphono-D-Erythrose
  • ERYTHOSE-4-phosphATE
  • D-Erythrose 4-phosphoric acid
  • ERYTHOSE-4-phosphoric acid
  • D-Erythrose 4-PO4
585-18-2
Sedoheptulose 1,7-bisphosphate
  • altro-Heptulose 1,7-biphosphate
  • D-altro-Heptulose 1,7-biphosphate
  • D-Sedoheptulose 1,7-bisphosphate
  • altro-Heptulose 1,7-biphosphoric acid
  • Sedoheptulose 1,7-bisphosphoric acid
genes like me logo Genes that share compounds with ALDOA: view

Transcripts for ALDOA Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - - - -
SP7:
SP8:
SP9: - - - - - - -
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17: - - - -
SP18: - - - - - -
SP19: - - - - -
SP20: -
SP21: - - - - - -
SP22:
SP23: -
SP24:

ExUns: 9e ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - -
SP12: - - -
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21: - -
SP22:
SP23:
SP24:

Relevant External Links for ALDOA Gene

GeneLoc Exon Structure for
ALDOA
ECgene alternative splicing isoforms for
ALDOA

Expression for ALDOA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALDOA Gene

mRNA differential expression in normal tissues according to GTEx for ALDOA Gene

This gene is overexpressed in Muscle - Skeletal (x10.0).

Protein differential expression in normal tissues from HIPED for ALDOA Gene

This gene is overexpressed in Tonsil (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALDOA Gene



Protein tissue co-expression partners for ALDOA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ALDOA Gene:

ALDOA

SOURCE GeneReport for Unigene cluster for ALDOA Gene:

Hs.513490

Evidence on tissue expression from TISSUES for ALDOA Gene

  • Eye(5)
  • Lung(5)
  • Nervous system(5)
  • Liver(4.9)
  • Muscle(4.9)
  • Blood(4.8)
  • Skin(4.8)
  • Intestine(4.7)
  • Pancreas(4.5)
  • Heart(4.4)
  • Kidney(4.4)
  • Stomach(3.8)
  • Thyroid gland(3.4)
  • Bone(2.8)
  • Adrenal gland(2.5)
  • Bone marrow(2.5)
  • Gall bladder(2.5)
  • Lymph node(2.4)
  • Spleen(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDOA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • forehead
  • head
  • mouth
  • neck
  • scalp
Abdomen:
  • abdominal wall
  • biliary tract
  • gallbladder
  • liver
  • pancreas
  • spleen
Pelvis:
  • fallopian tube
  • ovary
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
General:
  • blood
  • hair
  • red blood cell
  • skin
  • spinal column
  • white blood cell
genes like me logo Genes that share expression patterns with ALDOA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALDOA Gene

Orthologs for ALDOA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALDOA 33 32
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 95 (a)
OneToMany
ALDOA 32
  • 91.75 (n)
-- 33
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Aldoart2 33
  • 93 (a)
OneToMany
Aldoa 17 33 32
  • 90.11 (n)
Aldoart1 33
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ALDOA 33 32
  • 92.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aldoa 32
  • 89.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ALDOA 33
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALDOA 33
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALDOA 33
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aldoa 32
  • 80.68 (n)
Str.6670 32