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This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during develop... See more...
Aliases for ALDOA Gene
Aliases for ALDOA Gene
External Ids for ALDOA Gene
- HGNC: 414
- NCBI Entrez Gene: 226
- Ensembl: ENSG00000149925
- OMIM®: 103850
- UniProtKB/Swiss-Prot: P04075
Previous GeneCards Identifiers for ALDOA Gene
- GC16M029079
- GC16P030386
- GC16P030062
- GC16P030102
- GC16P029971
- GC16P027726
- GC16P030055
- GC16P030082
Summaries for ALDOA Gene
-
This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
GeneCards Summary for ALDOA Gene
ALDOA (Aldolase, Fructose-Bisphosphate A) is a Protein Coding gene. Diseases associated with ALDOA include Glycogen Storage Disease Xii and Hemolytic Anemia. Among its related pathways are Glucose metabolism and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is ALDOC.
UniProtKB/Swiss-Prot Summary for ALDOA Gene
-
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Additional gene information for ALDOA Gene
- HGNC (414)
- NCBI Entrez Gene (226)
- Ensembl (ENSG00000149925)
- OMIM® (103850)
- UniProtKB/Swiss-Prot (P04075)
- Open Targets Platform(ENSG00000149925)
- Monarch Initiative
- Search for ALDOA at DataMed
- Search for ALDOA at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALDOA Gene
Genomics for ALDOA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ALDOA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALDOA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALDOA
- Top Transcription factor binding sites by QIAGEN in the ALDOA gene promoter:
-
- AP-1
- NF-1
- NF-1/L
Genomic Locations for ALDOA Gene
Latest Assembly
- chr16:30,064,164-30,070,457
- (GRCh38/hg38)
- Size:
- 6,294 bases
- Orientation:
- Plus strand
Previous Assembly
- chr16:30,075,600-30,081,741
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 6,142 bases
- Orientation:
- Plus strand
- chr16:30,064,411-30,081,778
- (GRCh37/hg19 by Ensembl)
- Size:
- 17,368 bases
- Orientation:
- Plus strand
Genomic View for ALDOA Gene
Genes around ALDOA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
ALDOA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALDOA Gene
Proteins for ALDOA Gene
-
Protein details for ALDOA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04075-ALDOA_HUMAN
- Recommended name:
- Fructose-bisphosphate aldolase A
- Protein Accession:
- P04075
- B4DXI7
- Q6FH76
- Q6FI10
- Q96B15
- Q9BWD9
- Q9UCN2
Protein attributes for ALDOA Gene
- Size:
- 364 amino acids
- Molecular mass:
- 39420 Da
- Quaternary structure:
-
- Homotetramer. Interacts with SNX9 and WAS (By similarity). Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+).
- Miscellaneous:
-
- In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
Three dimensional structures from OCA and Proteopedia for ALDOA Gene
Protein Expression for ALDOA Gene
Selected DME Specific Peptides for ALDOA Gene
- P04075:
-
- LEGTLLKPNMVT
- RCAQYKKDG
- KRALANSLACQGKYTPSGQ
- PWALTFS
- FSYGRALQAS
- LKAWGGKKENLKAAQ
- VPIVEPE
- GIKVDKG
- LARYASI
- PDGDHDL
- EEIAMATVTALRRTVPPAV
- ENTEENRR
- RRFYRQLL
- LSGGQSE
- VLAAVYKAL
- GVILFHET
- GILAADES
- FHETLYQK
- DFAKWRCVLKI
- GETTTQGLDGL
- ENANVLARYA
- CQYVTEKVLAA
Post-translational modifications for ALDOA Gene
Other Protein References for ALDOA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ALDOA / Aldolase A Antibody and ALDOA / Aldolase A Monoclonal Antibody
- NSJ Bioreagents Aldolase Antibody (ALDOA)
-
Custom Antibody ServicesOriGene Antibodies for ALDOA
- Novus Biologicals Antibodies for ALDOA
-
Abcam antibodies for ALDOA
- Invitrogen Antibodies for ALDOA (AFLGC-ALDOA)
-
Custom Antibody ServicesProSci Antibodies for ALDOA
- aldolase A, fructose-bisphosphate [14-017]
- aldolase A, fructose-bisphosphate [13-076]
- aldolase A, fructose-bisphosphate [30-356]
- aldolase A, fructose-bisphosphate [43-518]
- aldolase A, fructose-bisphosphate [43-552]
- aldolase A, fructose-bisphosphate [70-497]
- Fructose-bisphosphate aldolase A [61-456]
- Fructose-bisphosphate aldolase A [61-457]
- aldolase A, fructose-bisphosphate [70-134]
- aldolase A, fructose-bisphosphate [70-181]
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALDOA
Protein products for research
- G Biosciences Human Fructose-bisphosphate aldolase A/ALDOA, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for ALDOA
- Origene Custom Protein Services for ALDOA
- ProSpec Recombinant Proteins for ALDOA
-
ProSci Proteins for ALDOA
Assay products for research
- Novus Biologicals ELISA Kits for ALDOA
- antibodies-online: Show 49 available ALDOA Elisa Kits ranked by validation data
- Compare Top ALDOA Elisa Kits
-
Quality Products:
- ABIN1113305
- ABIN832255
- ABIN416938
- ABIN5522787
- ABIN5669008
- ABIN2850932
- ABIN5593421
- ABIN511194
- ABIN454163
- ABIN5651565
- ABIN810575
- ABIN772705
- ABIN5674804
- ABIN5648158
- ABIN1133759
- ABIN431759
- ABIN1568292
- ABIN810576
- ABIN771384
- ABIN2541061
- ABIN5651566
- ABIN6212573
- ABIN1133760
- ABIN774061
- ABIN1558649
- ABIN6212572
-
Boster Bio ELISA Kits for ALDOA
-
Abcam assays for ALDOA
Domains & Families for ALDOA Gene
Gene Families for ALDOA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ALDOA Gene
- InterPro:
- Blocks:
-
- Fructose-bisphosphate aldolase, class-I
- ProtoNet:
Suggested Antigen Peptide Sequences for ALDOA Gene
- GenScript: Design optimal peptide antigens:
-
- Muscle-type aldolase (ALDOA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04075- Family:
-
- Belongs to the class I fructose-bisphosphate aldolase family.
Function for ALDOA Gene
Molecular function for ALDOA Gene
- UniProtKB/Swiss-Prot Function:
- Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=52 uM for fructose 1,6-bisphosphate (at 30 degrees Celsius) {ECO:0000269|PubMed:14766013}; Temperature dependence: Thermal denaturation midpoint (Tm) is 54.4 degrees Celsius. {ECO:0000269|PubMed:14766013};
- GENATLAS Biochemistry:
- aldolase A,fructose-bisphosphate,expressed in muscle (M type),and in most other tissues,(N and H types),overexpressed in most lung cancers,homotetramer,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P
Enzyme Numbers (IUBMB) for ALDOA Gene
Phenotypes From GWAS Catalog for ALDOA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0003779 | actin binding | TAS | 1008835 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004332 | fructose-bisphosphate aldolase activity | IEA,IDA | 9244396 |
| GO:0005515 | protein binding | IPI | 20849852 |
Phenotypes for ALDOA Gene
- MGI mutant phenotypes for ALDOA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALDOA:
-
- no effect
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased HPV18 LCR reporter activity
- Polylobed nuclei
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
Animal Models for ALDOA Gene
- MGI Knock Outs for ALDOA:
-
- Aldoa Aldoa<tm1.1(KOMP)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ALDOA - Starting at $85 >
- * ALDOA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ALDOA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDOA
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALDOA
miRNA for ALDOA Gene
- miRTarBase miRNAs that target ALDOA
-
- hsa-miR-122-5p (MIRT003085)
- mmu-miR-122-5p (MIRT003133)
- mmu-miR-541-5p (MIRT008326)
- mmu-miR-15a-5p (MIRT011797)
- mmu-miR-34b-5p (MIRT012911)
- hsa-miR-1301-3p (MIRT036065)
- hsa-miR-615-3p (MIRT040003)
- hsa-miR-92b-3p (MIRT040648)
- hsa-miR-196b-5p (MIRT042671)
- hsa-miR-324-3p (MIRT042956)
- hsa-miR-324-5p (MIRT043086)
- hsa-miR-23b-3p (MIRT046363)
- hsa-miR-1260b (MIRT052739)
- hsa-miR-5096 (MIRT495466)
- hsa-miR-197-3p (MIRT495467)
- hsa-miR-193b-5p (MIRT495468)
- hsa-miR-6069 (MIRT495469)
- hsa-miR-6131 (MIRT495470)
- hsa-miR-3663-5p (MIRT495471)
- hsa-miR-645 (MIRT495472)
- hsa-miR-4787-5p (MIRT495473)
- hsa-miR-4478 (MIRT495474)
- hsa-miR-4419b (MIRT495475)
- hsa-miR-3929 (MIRT495476)
- hsa-miR-4468 (MIRT525301)
- hsa-miR-6793-3p (MIRT525302)
- hsa-miR-935 (MIRT525303)
- hsa-miR-5009-5p (MIRT573424)
- hsa-miR-8058 (MIRT573425)
- hsa-miR-27b-3p (MIRT573426)
- hsa-miR-27a-3p (MIRT573427)
- hsa-miR-513a-5p (MIRT573428)
- hsa-miR-3134 (MIRT573429)
- hsa-miR-8082 (MIRT573430)
- hsa-miR-4534 (MIRT573431)
- hsa-miR-1179 (MIRT573432)
- hsa-miR-374c-3p (MIRT573433)
- hsa-miR-640 (MIRT629174)
- hsa-miR-4279 (MIRT629175)
- hsa-miR-378a-5p (MIRT629176)
- hsa-miR-6821-3p (MIRT629177)
- hsa-miR-6790-3p (MIRT629178)
- hsa-miR-6845-3p (MIRT629179)
- hsa-miR-6777-3p (MIRT629180)
- hsa-miR-3653-5p (MIRT629181)
- hsa-miR-3934-5p (MIRT629182)
- hsa-miR-764 (MIRT629183)
- hsa-miR-4639-3p (MIRT629184)
- hsa-miR-125a-3p (MIRT629185)
- hsa-miR-5682 (MIRT639089)
- hsa-miR-585-5p (MIRT639090)
- hsa-miR-24-3p (MIRT639091)
- hsa-miR-4284 (MIRT639092)
- hsa-miR-3622b-5p (MIRT639093)
- hsa-miR-4443 (MIRT640251)
- hsa-miR-665 (MIRT640252)
- hsa-miR-7977 (MIRT640253)
- hsa-miR-4693-5p (MIRT640254)
- hsa-miR-7847-3p (MIRT640255)
- hsa-miR-650 (MIRT640256)
- hsa-miR-3612 (MIRT640257)
- hsa-miR-6720-3p (MIRT640258)
- hsa-miR-7114-5p (MIRT640259)
- hsa-miR-668-5p (MIRT640260)
- hsa-miR-5690 (MIRT640261)
- hsa-miR-892a (MIRT640262)
- hsa-miR-4318 (MIRT640263)
- hsa-miR-4524a-3p (MIRT642481)
- hsa-miR-7110-3p (MIRT642482)
- hsa-miR-3615 (MIRT642483)
- hsa-miR-1304-3p (MIRT642484)
- hsa-miR-6812-3p (MIRT642485)
- hsa-miR-5007-5p (MIRT642486)
- hsa-miR-4797-5p (MIRT642487)
- hsa-miR-6738-3p (MIRT642488)
- hsa-miR-544a (MIRT642489)
- hsa-miR-5001-3p (MIRT642490)
- hsa-miR-4727-5p (MIRT642491)
- hsa-miR-6794-3p (MIRT642492)
- hsa-miR-873-5p (MIRT642493)
- hsa-miR-493-3p (MIRT642494)
- hsa-miR-627-3p (MIRT642495)
- hsa-miR-3667-3p (MIRT642496)
- hsa-miR-6734-3p (MIRT642497)
- hsa-miR-6876-5p (MIRT642498)
- hsa-miR-483-3p (MIRT642499)
- hsa-miR-4476 (MIRT642500)
- hsa-miR-6165 (MIRT642501)
- hsa-miR-6869-5p (MIRT669555)
- hsa-miR-3157-5p (MIRT669556)
- hsa-miR-1976 (MIRT669557)
- hsa-miR-6747-3p (MIRT669558)
- hsa-miR-6727-3p (MIRT669559)
- hsa-miR-4722-3p (MIRT669560)
- hsa-miR-4691-3p (MIRT669561)
- hsa-miR-3622b-3p (MIRT669562)
- hsa-miR-3622a-3p (MIRT669563)
- hsa-miR-5571-5p (MIRT669564)
- hsa-miR-6848-3p (MIRT676143)
- hsa-miR-6843-3p (MIRT676144)
- hsa-miR-433-3p (MIRT676145)
- hsa-miR-150-5p (MIRT676146)
- hsa-miR-186-3p (MIRT676147)
- hsa-miR-498 (MIRT679682)
- hsa-miR-4772-3p (MIRT679683)
- hsa-miR-4726-3p (MIRT679684)
- hsa-miR-6764-5p (MIRT679685)
- hsa-miR-1915-3p (MIRT679686)
- hsa-miR-6840-3p (MIRT679687)
- hsa-miR-4684-5p (MIRT708339)
- hsa-miR-103a-2-5p (MIRT708340)
- hsa-miR-942-5p (MIRT708341)
- hsa-miR-6728-3p (MIRT708342)
- hsa-miR-1251-5p (MIRT708343)
- hsa-miR-517-5p (MIRT708344)
- hsa-miR-554 (MIRT708345)
- hsa-miR-1225-3p (MIRT736093)
- hsa-miR-1233-5p (MIRT736223)
- hsa-miR-1273h-5p (MIRT736849)
- hsa-miR-129-1-3p (MIRT737106)
- hsa-miR-129-2-3p (MIRT737117)
- hsa-miR-149-3p (MIRT737695)
- hsa-miR-151a-5p (MIRT737837)
- hsa-miR-151b (MIRT737852)
- hsa-miR-200a-5p (MIRT738762)
- hsa-miR-200b-5p (MIRT738774)
- hsa-miR-30b-3p (MIRT739739)
- hsa-miR-335-5p (MIRT741344)
- hsa-miR-3689a-3p (MIRT742241)
- hsa-miR-3689b-3p (MIRT742311)
- hsa-miR-3689c (MIRT742381)
- hsa-miR-4481 (MIRT745095)
- hsa-miR-454-5p (MIRT746146)
- hsa-miR-4687-5p (MIRT746994)
- hsa-miR-4695-5p (MIRT747165)
- hsa-miR-4728-3p (MIRT747783)
- hsa-miR-4728-5p (MIRT747791)
- hsa-miR-4745-5p (MIRT748166)
- hsa-miR-505-5p (MIRT749575)
- hsa-miR-5193 (MIRT749959)
- hsa-miR-6087 (MIRT751896)
- hsa-miR-6515-3p (MIRT753274)
- hsa-miR-676-5p (MIRT755076)
- hsa-miR-6778-5p (MIRT755420)
- hsa-miR-6779-3p (MIRT755472)
- hsa-miR-6779-5p (MIRT755480)
- hsa-miR-6780a-5p (MIRT755556)
- hsa-miR-6785-5p (MIRT755786)
- hsa-miR-6791-3p (MIRT756030)
- hsa-miR-6799-5p (MIRT756281)
- hsa-miR-6805-5p (MIRT756465)
- hsa-miR-6829-3p (MIRT757084)
- hsa-miR-6881-3p (MIRT758344)
- hsa-miR-6883-5p (MIRT758371)
- hsa-miR-7106-5p (MIRT758830)
- hsa-miR-877-3p (MIRT760369)
- hsa-miR-1227-3p (MIRT761380)
- hsa-miR-1234-3p (MIRT761472)
- hsa-miR-1244 (MIRT761510)
- hsa-miR-1262 (MIRT761693)
- hsa-miR-1273g-3p (MIRT761906)
- hsa-miR-1281 (MIRT762132)
- hsa-miR-1470 (MIRT762735)
- hsa-miR-18a-3p (MIRT763226)
- hsa-miR-3145-5p (MIRT764995)
- hsa-miR-3925-3p (MIRT767677)
- hsa-miR-4252 (MIRT767970)
- hsa-miR-4290 (MIRT768398)
- hsa-miR-4485-5p (MIRT769605)
- hsa-miR-455-3p (MIRT770260)
- hsa-miR-4701-3p (MIRT771303)
- hsa-miR-4703-3p (MIRT771344)
- hsa-miR-4738-3p (MIRT771819)
- hsa-miR-508-5p (MIRT773118)
- hsa-miR-5089-5p (MIRT773235)
- hsa-miR-510-3p (MIRT773317)
- hsa-miR-542-3p (MIRT773953)
- hsa-miR-552-3p (MIRT774638)
- hsa-miR-619-5p (MIRT776047)
- hsa-miR-622 (MIRT776072)
- hsa-miR-6499-3p (MIRT776188)
- hsa-miR-6506-5p (MIRT776596)
- hsa-miR-6516-5p (MIRT777054)
- hsa-miR-653-5p (MIRT777281)
- hsa-miR-661 (MIRT777403)
- hsa-miR-6736-5p (MIRT778054)
- hsa-miR-6776-5p (MIRT778736)
- hsa-miR-6807-5p (MIRT779546)
- hsa-miR-6836-3p (MIRT780042)
- hsa-miR-6850-3p (MIRT780380)
- hsa-miR-6861-5p (MIRT780587)
- hsa-miR-6871-3p (MIRT780695)
- hsa-miR-6890-3p (MIRT781132)
- hsa-miR-7107-5p (MIRT781413)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDOA
- Browse OriGene Inhibitory RNA Products For ALDOA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDOA
Clone products for research
- Applied Biological Materials (abm): Clones for ALDOA - Starting at $45 >
- * ALDOA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205592
- MG219504
- MG219505
- MR205592
- MR205592L3
- MR205592L4
- MR219504
- MR219504L3
- MR219504L4
- MR219505
- MR219505L3
- MR219505L4
- RC202576
- RC202576L1
- RC202576L2
- RC202576L3
- RC202576L4
- RC203900
- RC203900L3
- RC203900L4
- RC203908
- RC203908L3
- RC203908L4
- RC225547
- RC225547L3
- RC225547L4
- RC234037
- RG202576
- RG203900
- RG203908
- RG225547
- RG234037
- RR202442
- RR202442L3
- RR202442L4
- RR216485
- RR216486
- MR205592L3V
- MR205592L4V
- MR219504L3V
- MR219504L4V
- MR219505L3V
- MR219505L4V
- RC202576L1V
- RC202576L2V
- RC202576L3V
- RC202576L4V
- RC203900L3V
- RC203900L4V
- RC203908L3V
- RC203908L4V
- RC225547L3V
- RC225547L4V
- RR202442L3V
- RR202442L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ALDOA
- Addgene plasmids for ALDOA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDOA
No data available for Transcription Factor Targets and HOMER Transcription for ALDOA Gene
Localization for ALDOA Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALDOA Gene
- Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| cytoskeleton | 4 |
| nucleus | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA | 23580065 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
Pathways & Interactions for ALDOA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
.46
|
.35
.01
|
| 2 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | Carbon metabolism | ||
| 5 | Metabolism |
.40
|
|
Pathways by source for ALDOA Gene
7 BioSystems pathways for ALDOA Gene
12 Reactome pathways for ALDOA Gene
7 KEGG pathways for ALDOA Gene
1 GeneGo (Thomson Reuters) pathway for ALDOA Gene
- Glycolysis and gluconeogenesis (short map)
1 Cell Signaling Technology pathway for ALDOA Gene
UniProtKB/Swiss-Prot P04075-ALDOA_HUMAN
- Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006000 | fructose metabolic process | IMP | 14615364 |
| GO:0006094 | gluconeogenesis | TAS | -- |
| GO:0006096 | glycolytic process | IEA,IMP | 14615364 |
| GO:0006754 | ATP biosynthetic process | IMP | 14615364 |
Drugs & Compounds for ALDOA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | Target | 1687 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target, ligand | 0 | ||
| Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, ligand | 0 | ||
| 1,6-DI-O-PHOSPHONO-D-MANNITOL | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| fructose 1-phosphate |
|
80875-93-0, 15978-08-2 | ||||
| glyceraldehyde |
|
56-82-6 | ||||
| glyceraldehyde 3-phosphate |
|
591-57-1 | ||||
| Fructose 1,6-bisphosphate |
|
34693-15-7 |
|
|||
| Sedoheptulose 1,7-bisphosphate |
|
815-91-8 |
|
Drug products for research
- G Biosciences Human Fructose-bisphosphate aldolase A/ALDOA, Liquid
Transcripts for ALDOA Gene
mRNA/cDNA for ALDOA Gene
- 10 REFSEQ mRNAs :
- 28 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000395240 1447 nts (view in UCSC)
- ENST00000412304 1603 nts (view in UCSC)
- ENST00000562168 666 nts (view in UCSC)
- ENST00000562302 502 nts (view in UCSC)
- ENST00000562679 906 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ALDOA - Starting at $85 >
- * ALDOA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ALDOA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDOA
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALDOA
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDOA
- Browse OriGene Inhibitory RNA Products For ALDOA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDOA
Clone products for research
- Applied Biological Materials (abm): Clones for ALDOA - Starting at $45 >
- * ALDOA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205592
- MG219504
- MG219505
- MR205592
- MR205592L3
- MR205592L4
- MR219504
- MR219504L3
- MR219504L4
- MR219505
- MR219505L3
- MR219505L4
- RC202576
- RC202576L1
- RC202576L2
- RC202576L3
- RC202576L4
- RC203900
- RC203900L3
- RC203900L4
- RC203908
- RC203908L3
- RC203908L4
- RC225547
- RC225547L3
- RC225547L4
- RC234037
- RG202576
- RG203900
- RG203908
- RG225547
- RG234037
- RR202442
- RR202442L3
- RR202442L4
- RR216485
- RR216486
- MR205592L3V
- MR205592L4V
- MR219504L3V
- MR219504L4V
- MR219505L3V
- MR219505L4V
- RC202576L1V
- RC202576L2V
- RC202576L3V
- RC202576L4V
- RC203900L3V
- RC203900L4V
- RC203908L3V
- RC203908L4V
- RC225547L3V
- RC225547L4V
- RR202442L3V
- RR202442L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ALDOA
- Addgene plasmids for ALDOA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDOA
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: |
| ExUns: | 9e | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||||||||||||||||
| SP23: | |||||||||||||||||||||||||||||||||||||||||||
| SP24: |
Relevant External Links for ALDOA Gene
- GeneLoc Exon Structure for
- ALDOA
Expression for ALDOA Gene
mRNA differential expression in normal tissues according to GTEx for ALDOA Gene
This gene is overexpressed in Muscle - Skeletal (x10.0).
This gene is overexpressed in Tonsil (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALDOA Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALDOA
SOURCE GeneReport for Unigene cluster for ALDOA Gene:
Hs.513490Evidence on tissue expression from TISSUES for ALDOA Gene
- Heart(5)
- Nervous system(5)
- Lung(5)
- Eye(5)
- Liver(4.9)
- Muscle(4.9)
- Skin(4.9)
- Blood(4.8)
- Intestine(4.8)
- Pancreas(4.6)
- Kidney(4.6)
- Stomach(4)
- Thyroid gland(3.7)
- Bone(3.1)
- Bone marrow(3.1)
- Lymph node(3)
- Spleen(2.9)
- Adrenal gland(2.8)
- Gall bladder(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDOA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- skeletal muscle
- skeleton
Regions:
Head and neck:
- eye
- eyelid
- face
- forehead
- head
- mouth
- neck
- scalp
Abdomen:
- abdominal wall
- biliary tract
- gallbladder
- liver
- pancreas
- spleen
Pelvis:
- fallopian tube
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vas deferens
- vulva
General:
- blood
- hair
- red blood cell
- skin
- spinal column
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for ALDOA
-
OriGene qPCR primer pairs and template standards for ALDOA
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALDOA Gene
Orthologs for ALDOA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ALDOA 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| ALDOA 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Aldoart2 31 |
|
OneToMany | |
| Aldoa 30 17 31 |
|
OneToMany | |||
| Aldoart1 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | ALDOA 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Aldoa 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ALDOA 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ALDOA 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ALDOA 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aldoa 30 |
|
||
| Str.6670 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53030 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | aldoab 31 |
|
OneToMany | |
| aldoaa 30 31 |
|
OneToMany |
|