Aliases for ALDH3B1 Gene
External Ids for ALDH3B1 Gene
Previous HGNC Symbols for ALDH3B1 Gene
Previous GeneCards Identifiers for ALDH3B1 Gene
This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for ALDH3B1 Gene
ALDH3B1 (Aldehyde Dehydrogenase 3 Family Member B1) is a Protein Coding gene. Diseases associated with ALDH3B1 include Paranoid Schizophrenia and Endosteal Hyperostosis, Autosomal Dominant. Among its related pathways are Innate Immune System and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3B2.
UniProtKB/Swiss-Prot Summary for ALDH3B1 Gene
Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920). Metabolizes also benzaldehyde (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (PubMed:17382292). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292).