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This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alterna... See more...
Aliases for ALDH3B1 Gene
Aliases for ALDH3B1 Gene
External Ids for ALDH3B1 Gene
- HGNC: 410
- NCBI Entrez Gene: 221
- Ensembl: ENSG00000006534
- OMIM®: 600466
- UniProtKB/Swiss-Prot: P43353
Previous HGNC Symbols for ALDH3B1 Gene
- ALDH7
Previous GeneCards Identifiers for ALDH3B1 Gene
- GC11P070300
- GC11P069474
- GC11P067553
- GC11P067534
- GC11P067776
- GC11P064111
Summaries for ALDH3B1 Gene
-
This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for ALDH3B1 Gene
ALDH3B1 (Aldehyde Dehydrogenase 3 Family Member B1) is a Protein Coding gene. Diseases associated with ALDH3B1 include Paranoid Schizophrenia and Hyperprolinemia. Among its related pathways are Drug metabolism - cytochrome P450 and Innate Immune System. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3B2.
UniProtKB/Swiss-Prot Summary for ALDH3B1 Gene
-
Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920). Metabolizes also benzaldehyde (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (PubMed:17382292). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292).
Additional gene information for ALDH3B1 Gene
- HGNC (410)
- NCBI Entrez Gene (221)
- Ensembl (ENSG00000006534)
- OMIM® (600466)
- UniProtKB/Swiss-Prot (P43353)
- Open Targets Platform(ENSG00000006534)
- Search for ALDH3B1 at DataMed
- Search for ALDH3B1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ALDH3B1 Gene
Genomics for ALDH3B1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ALDH3B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ALDH3B1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ALDH3B1
- Top Transcription factor binding sites by QIAGEN in the ALDH3B1 gene promoter:
-
- AML1a
- AREB6
- E47
- Egr-2
- HOXA5
- MIF-1
- Pax-5
- POU2F1
- POU2F1a
Genomic Locations for ALDH3B1 Gene
Latest Assembly
- chr11:68,008,547-68,029,282
- (GRCh38/hg38)
- Size:
- 20,736 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:67,776,017-67,796,743
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 20,727 bases
- Orientation:
- Plus strand
- chr11:67,776,048-67,796,744
- (GRCh37/hg19 by Ensembl)
- Size:
- 20,697 bases
- Orientation:
- Plus strand
Genomic View for ALDH3B1 Gene
Genes around ALDH3B1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.2 by HGNC
- 11q13.2 by Entrez Gene
- 11q13.2 by Ensembl
ALDH3B1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALDH3B1 Gene
Proteins for ALDH3B1 Gene
-
Protein details for ALDH3B1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43353-AL3B1_HUMAN
- Recommended name:
- Aldehyde dehydrogenase family 3 member B1
- Protein Accession:
- P43353
- A3FMP9
- Q53XL5
- Q8N515
- Q96CK8
Protein attributes for ALDH3B1 Gene
- Size:
- 468 amino acids
- Molecular mass:
- 51840 Da
- Quaternary structure:
- No Data Available
Protein Expression for ALDH3B1 Gene
Selected DME Specific Peptides for ALDH3B1 Gene
- P43353:
-
- NAGQTCV
- VTLELGG
- VVLKPSE
- TLELGGKNPCYVDDNCDPQ
- TLELGGK
- IAPWNYP
- GQTCVAPDY
- SGMGRYHGKF
- EKPLALY
Post-translational modifications for ALDH3B1 Gene
- Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.
-
Ubiquitination at Lys41, Lys89, Lys375, and Lys437
- NX_P43353 (NX_P43353-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ALDH3B1 Gene
Antibodies for research
- LifeSpan BioSciences ALDH3B1 Antibody
- G Biosciences Immunotag™ ALDH3B1 Antibody
- Novus Biologicals Antibodies for ALDH3B1
- Invitrogen Antibodies for ALDH3B1 (AFLGC-ALDH3B1)
-
Boster Bio Antibodies for ALDH3B1
Protein products for research
-
OriGene Purified Proteins for ALDH3B1
- Search Origene for MassSpec and Protein Over-expression Lysates for ALDH3B1
- Origene Custom Protein Services for ALDH3B1
-
Abcam proteins for ALDH3B1
Assay products for research
- antibodies-online: Show 6 available ALDH3B1 Elisa Kits ranked by validation data
- Compare Top ALDH3B1 Elisa Kits
-
Quality Products:
Domains & Families for ALDH3B1 Gene
Gene Families for ALDH3B1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ALDH3B1 Gene
- InterPro:
- Blocks:
-
- Aldehyde dehydrogenase
- ProtoNet:
Suggested Antigen Peptide Sequences for ALDH3B1 Gene
- GenScript: Design optimal peptide antigens:
-
- Aldehyde dehydrogenase (A3FMP9_HUMAN)
- Aldehyde dehydrogenase 7 (AL3B1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P43353- Family:
-
- Belongs to the aldehyde dehydrogenase family.
Function for ALDH3B1 Gene
Molecular function for ALDH3B1 Gene
- UniProtKB/Swiss-Prot Function:
- Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920). Metabolizes also benzaldehyde (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (PubMed:17382292). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:11888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.5; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.5; Evidence={ECO:0000269|PubMed:17382292, ECO:0000269|PubMed:23721920};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:23721920};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:17382292, ECO:0000269|PubMed:23721920};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate; Xref=Rhea:RHEA:59904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH; Xref=Rhea:RHEA:21660, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:17169, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.7; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH; Xref=Rhea:RHEA:11840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:17169, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.28; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH; Xref=Rhea:RHEA:59908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH; Xref=Rhea:RHEA:59912, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:142920; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH; Xref=Rhea:RHEA:59916, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748, ChEBI:CHEBI:143526; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH; Xref=Rhea:RHEA:59920, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:61748, ChEBI:CHEBI:143526; Evidence={ECO:0000269|PubMed:17382292};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=25 uM for octanal {ECO:0000269|PubMed:23721920}; KM=45.6 uM for trans-2-hexadecenal {ECO:0000269|PubMed:23721920}; KM=4.9 uM for hexadecanal {ECO:0000269|PubMed:23721920}; Vmax=4.9 pmol/min/ng enzyme with trans-2-hexadecenal {ECO:0000269|PubMed:23721920}; Vmax=5 pmol/min/ng enzyme with octanal {ECO:0000269|PubMed:23721920}; Vmax=9.7 pmol/min/ng enzyme with hexadecanal {ECO:0000269|PubMed:23721920};
Enzyme Numbers (IUBMB) for ALDH3B1 Gene
Phenotypes From GWAS Catalog for ALDH3B1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity | TAS,IBA | 21873635 |
| GO:0004029 | aldehyde dehydrogenase (NAD) activity | IEA | -- |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | IDA,TAS | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for ALDH3B1 Gene
- MGI mutant phenotypes for ALDH3B1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ALDH3B1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Two nuclei (binuclear)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased HPV16-GFP infection
- Negative genetic interaction between BLM-/- and BLM+/+
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Weakly decreased NFAT1-GFP nuclear translocation
Animal Models for ALDH3B1 Gene
- MGI Knock Outs for ALDH3B1:
-
- Aldh3b1 Aldh3b1<tm1b(EUCOMM)Wtsi>
Animal Models for research
-
Taconic Biosciences Mouse Models for ALDH3B1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ALDH3B1 - Starting at $85 >
- * ALDH3B1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ALDH3B1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDH3B1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALDH3B1
miRNA for ALDH3B1 Gene
- miRTarBase miRNAs that target ALDH3B1
-
- hsa-miR-2110 (MIRT451820)
- hsa-miR-6780b-5p (MIRT451821)
- hsa-miR-4725-3p (MIRT451822)
- hsa-miR-4271 (MIRT451823)
- hsa-miR-1255b-5p (MIRT451824)
- hsa-miR-1255a (MIRT451825)
- hsa-miR-6894-5p (MIRT451826)
- hsa-miR-6077 (MIRT451827)
- hsa-miR-107 (MIRT451828)
- hsa-miR-103a-3p (MIRT451829)
- hsa-miR-3605-5p (MIRT451830)
- hsa-miR-4468 (MIRT451831)
- hsa-miR-6840-3p (MIRT451832)
- hsa-miR-6838-5p (MIRT451833)
- hsa-miR-497-5p (MIRT451834)
- hsa-miR-424-5p (MIRT451835)
- hsa-miR-195-5p (MIRT451836)
- hsa-miR-16-5p (MIRT451837)
- hsa-miR-15b-5p (MIRT451838)
- hsa-miR-15a-5p (MIRT451839)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDH3B1
- Browse OriGene Inhibitory RNA Products For ALDH3B1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDH3B1
Clone products for research
- Applied Biological Materials (abm): Clones for ALDH3B1 - Starting at $45 >
- * ALDH3B1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207483
- MR207483
- MR207483L3
- MR207483L4
- RC202242
- RC202242L3
- RC202242L4
- RC221335
- RC221335L3
- RC221335L4
- RC228913
- RC228913L3
- RC228913L4
- RC237071
- RC237651
- RG202242
- RG221335
- RG228913
- RR213434
- RR213434L3
- RR213434L4
- MR207483L3V
- MR207483L4V
- RC202242L3V
- RC202242L4V
- RC221335L3V
- RC221335L4V
- RC228913L3V
- RC228913L4V
- RR213434L3V
- RR213434L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ALDH3B1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDH3B1
Cell Lines for research
-
Horizon Cell Lines for ALDH3B1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDH3B1 Gene
Localization for ALDH3B1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALDH3B1 Gene
- Cell membrane. Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 20699116 |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030667 | secretory granule membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ALDH3B1 Gene
Pathways & Interactions for ALDH3B1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Metabolism |
.40
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | Phenylalanine metabolism | ||
| 5 | Sphingolipid metabolism | ||
Pathways by source for ALDH3B1 Gene
2 BioSystems pathways for ALDH3B1 Gene
7 Reactome pathways for ALDH3B1 Gene
9 KEGG pathways for ALDH3B1 Gene
UniProtKB/Swiss-Prot P43353-AL3B1_HUMAN
- Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Interacting Proteins for ALDH3B1 Gene
Selected Interacting proteins:
P43353-AL3B1_HUMAN
ENSP00000473990
for ALDH3B1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ALDH3B1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006066 | alcohol metabolic process | TAS | 7828891 |
| GO:0006068 | ethanol catabolic process | IEA | -- |
| GO:0006081 | cellular aldehyde metabolic process | IEA | -- |
| GO:0006629 | lipid metabolic process | TAS | 7828891 |
| GO:0030148 | sphingolipid biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for ALDH3B1 Gene
Drugs & Compounds for ALDH3B1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
|||
| 3,4-Dihydroxymandelic acid |
|
775-01-9 |
|
|||
| 3,4-Dihydroxyphenylacetaldehyde |
|
5707-55-1 |
|
|||
| 3-Aminopropionaldehyde |
|
352-92-1 |
|
|||
| 3-Carbamoyl-2-phenylpropionaldehyde |
|
|
Transcripts for ALDH3B1 Gene
mRNA/cDNA for ALDH3B1 Gene
- 5 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342456 2811 nts (view in UCSC)
- ENST00000527514 603 nts (view in UCSC)
- ENST00000612297 1231 nts (view in UCSC)
- ENST00000614849 2280 nts (view in UCSC)
- ENST00000615368 5884 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ALDH3B1 - Starting at $85 >
- * ALDH3B1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ALDH3B1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDH3B1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALDH3B1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDH3B1
- Browse OriGene Inhibitory RNA Products For ALDH3B1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDH3B1
Clone products for research
- Applied Biological Materials (abm): Clones for ALDH3B1 - Starting at $45 >
- * ALDH3B1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207483
- MR207483
- MR207483L3
- MR207483L4
- RC202242
- RC202242L3
- RC202242L4
- RC221335
- RC221335L3
- RC221335L4
- RC228913
- RC228913L3
- RC228913L4
- RC237071
- RC237651
- RG202242
- RG221335
- RG228913
- RR213434
- RR213434L3
- RR213434L4
- MR207483L3V
- MR207483L4V
- RC202242L3V
- RC202242L4V
- RC221335L3V
- RC221335L4V
- RC228913L3V
- RC228913L4V
- RR213434L3V
- RR213434L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ALDH3B1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDH3B1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ALDH3B1 Gene
- GeneLoc Exon Structure for
- ALDH3B1
Expression for ALDH3B1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Lung (Respiratory System)
- Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ALDH3B1 Gene
This gene is overexpressed in Whole Blood (x9.2) and Lung (x4.2).
This gene is overexpressed in Nasal epithelium (60.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALDH3B1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ALDH3B1
SOURCE GeneReport for Unigene cluster for ALDH3B1 Gene:
Hs.523841mRNA Expression by UniProt/SwissProt for ALDH3B1 Gene:
P43353-AL3B1_HUMAN
Tissue specificity:
Highest expression in kidney and lung.
Evidence on tissue expression from TISSUES for ALDH3B1 Gene
- Kidney(4.2)
- Lung(4.2)
Primer products for research
-
OriGene qPCR primer pairs for ALDH3B1
-
OriGene qPCR primer pairs and template standards for ALDH3B1
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDH3B1 Gene
Orthologs for ALDH3B1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | ALDH3B1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ALDH3B1 30 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ALDH3B1 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Aldh3b1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Aldh3b1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | ALDH3B1 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aldh3b1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | aldh3b1 30 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Aldh-III 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005124 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | alh-5 31 |
|
ManyToMany | |
| alh-4 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HFD1 30 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B12540g 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7577 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os.18249 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.1546 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04013 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6683 31 |
|
ManyToMany | |
| CSA.9635 31 |
|
ManyToMany |
- Species where no ortholog for ALDH3B1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ALDH3B1 Gene
- ENSEMBL:
- Gene Tree for ALDH3B1 (if available)
- TreeFam:
- Gene Tree for ALDH3B1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALDH3B1: view image
Paralogs for ALDH3B1 Gene
Paralogs for ALDH3B1 Gene
(4) SIMAP similar genes for ALDH3B1 Gene using alignment to 4 proteins:
- AL3B1_HUMAN
- S4R374_HUMAN
- S4R3D9_HUMAN
- S4R3R5_HUMAN
Variants for ALDH3B1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1221n100 | CNV | gain | 25217958 |
| dgv156n27 | CNV | loss | 19166990 |
| dgv1981n54 | CNV | gain | 21841781 |
| dgv1983n54 | CNV | loss | 21841781 |
| esv2759835 | CNV | gain+loss | 17122850 |
| nsv1038960 | CNV | loss | 25217958 |
| nsv428260 | CNV | gain | 18775914 |
| nsv468606 | CNV | gain | 19166990 |
| nsv468615 | CNV | loss | 19166990 |
| nsv469856 | CNV | gain | 16826518 |
| nsv469964 | CNV | loss | 18288195 |
| nsv475863 | CNV | novel sequence insertion | 20440878 |
| nsv555277 | CNV | loss | 21841781 |
| nsv555278 | CNV | loss | 21841781 |
| nsv825963 | CNV | gain | 20364138 |
| nsv8836 | CNV | gain | 18304495 |
| nsv951026 | CNV | deletion | 24416366 |
| nsv983037 | CNV | duplication | 23825009 |
Gene Damage Index Score:
2.86;
48.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALDH3B1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ALDH3B1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ALDH3B1 Gene
Disorders for ALDH3B1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paranoid schizophrenia |
|
|
| hyperprolinemia |
|
|
Search ALDH3B1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALDH3B1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ALDH3B1 Gene
Publications for ALDH3B1 Gene
- Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. (PMID: 7828891) Hsu LC … Yoshida A (Gene 1994) 2 3 4 23
- Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. (PMID: 19159868) Wang Y … Shen Y (Biological psychiatry 2009) 3 23 41
- Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1. (PMID: 23721920) Kitamura T … Kihara A (Biochimica et biophysica acta 2013) 3 4
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41
- Expression and initial characterization of human ALDH3B1. (PMID: 17382292) Marchitti SA … Vasiliou V (Biochemical and biophysical research communications 2007) 3 4
ExternalLinks
Products for ALDH3B1 Gene
- Custom Antibody ServicesOriGene Antibodies for ALDH3B1
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- MG207483
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Sources for ALDH3B1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (30) HomoloGene
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- (36) Pseudogene
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- (38) dbSNP
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- (44) Atlas
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