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This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
ALDH3B1 (Aldehyde Dehydrogenase 3 Family Member B1) is a Protein Coding gene. Diseases associated with ALDH3B1 include Paranoid Schizophrenia and Hyperprolinemia. Among its related pathways are Drug metabolism - cytochrome P450 and Innate Immune System. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3B2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity | TAS,IBA | 21873635 |
GO:0004029 | aldehyde dehydrogenase (NAD) activity | IEA | -- |
GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | IDA,TAS | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 20699116 |
GO:0005829 | cytosol | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0030667 | secretory granule membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Metabolism |
.40
|
|
3 | Innate Immune System |
.61
|
|
4 | Phenylalanine metabolism | ||
5 | Sphingolipid metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006066 | alcohol metabolic process | TAS | 7828891 |
GO:0006068 | ethanol catabolic process | IEA | -- |
GO:0006081 | cellular aldehyde metabolic process | IEA | -- |
GO:0006629 | lipid metabolic process | TAS | 7828891 |
GO:0030148 | sphingolipid biosynthetic process | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
|||
3,4-Dihydroxymandelic acid |
|
775-01-9 |
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3,4-Dihydroxyphenylacetaldehyde |
|
5707-55-1 |
|
|||
3-Aminopropionaldehyde |
|
352-92-1 |
|
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3-Carbamoyl-2-phenylpropionaldehyde |
|
|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | ALDH3B1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ALDH3B1 30 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ALDH3B1 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Aldh3b1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Aldh3b1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | ALDH3B1 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aldh3b1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | aldh3b1 30 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Aldh-III 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005124 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | alh-5 31 |
|
ManyToMany | |
alh-4 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HFD1 30 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B12540g 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7577 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.18249 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.1546 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04013 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6683 31 |
|
ManyToMany | |
CSA.9635 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1221n100 | CNV | gain | 25217958 |
dgv156n27 | CNV | loss | 19166990 |
dgv1981n54 | CNV | gain | 21841781 |
dgv1983n54 | CNV | loss | 21841781 |
esv2759835 | CNV | gain+loss | 17122850 |
nsv1038960 | CNV | loss | 25217958 |
nsv428260 | CNV | gain | 18775914 |
nsv468606 | CNV | gain | 19166990 |
nsv468615 | CNV | loss | 19166990 |
nsv469856 | CNV | gain | 16826518 |
nsv469964 | CNV | loss | 18288195 |
nsv475863 | CNV | novel sequence insertion | 20440878 |
nsv555277 | CNV | loss | 21841781 |
nsv555278 | CNV | loss | 21841781 |
nsv825963 | CNV | gain | 20364138 |
nsv8836 | CNV | gain | 18304495 |
nsv951026 | CNV | deletion | 24416366 |
nsv983037 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
paranoid schizophrenia |
|
|
hyperprolinemia |
|
|