Aliases for ALDH3A1 Gene
Aliases for ALDH3A1 Gene
External Ids for ALDH3A1 Gene
- HGNC: 405
- Entrez Gene: 218
- Ensembl: ENSG00000108602
- OMIM: 100660
- UniProtKB: P30838
Previous HGNC Symbols for ALDH3A1 Gene
- ALDH3
Previous GeneCards Identifiers for ALDH3A1 Gene
- GC17M019747
- GC17M021277
- GC17M019545
- GC17M019803
- GC17M019581
- GC17M019641
- GC17M019020
Summaries for ALDH3A1 Gene
-
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
GeneCards Summary for ALDH3A1 Gene
ALDH3A1 (Aldehyde Dehydrogenase 3 Family Member A1) is a Protein Coding gene. Diseases associated with ALDH3A1 include Breast Adenocarcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and aldehyde dehydrogenase (NAD) activity. An important paralog of this gene is ALDH3A2.
UniProtKB/Swiss-Prot for ALDH3A1 Gene
-
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Additional gene information for ALDH3A1 Gene
- Monarch Initiative
- Search for ALDH3A1 at DataMed
- Search for ALDH3A1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3A1 Gene
Genomics for ALDH3A1 Gene
GeneHancer (GH) Regulatory Elements for ALDH3A1 Gene
Promoters and enhancers for ALDH3A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ALDH3A1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ALDH3A1 gene promoter:
Regulatory Element Products
Genomic Locations for ALDH3A1 Gene
Genomic Locations for ALDH3A1 Gene
- chr17:19,737,984-19,748,943
- (GRCh38/hg38)
- Size:
- 10,960 bases
- Orientation:
- Minus strand
- chr17:19,641,297-19,652,256
- (GRCh37/hg19)
Genomic View for ALDH3A1 Gene
Genes around ALDH3A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by Entrez Gene
- 17p11.2 by HGNC
- 17p11.2 by Ensembl
ALDH3A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALDH3A1 Gene
Proteins for ALDH3A1 Gene
-
Protein details for ALDH3A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30838-AL3A1_HUMAN
- Recommended name:
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Protein Accession:
- P30838
- A8K828
- Q9BT37
Protein attributes for ALDH3A1 Gene
- Size:
- 453 amino acids
- Molecular mass:
- 50395 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for ALDH3A1 Gene
Post-translational modifications for ALDH3A1 Gene
Other Protein References for ALDH3A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ALDH3A1 (Aldehyde Dehydrogenase 3-A1/ALDH3A1)
-
Custom Antibody ServicesOriGene Antibodies for ALDH3A1
- Novus Biologicals Antibodies for ALDH3A1
- Invitrogen Antibodies for ALDH3A1
- GeneTex ALDH3A1 Antibody for ALDH3A1
-
Custom Antibody ServicesProSci Antibodies for ALDH3A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ALDH3A1
- Sino Biological Antibodies for ALDH3A1
Protein Products
- R&D Systems Proteins and Enzymes for ALDH3A1 (Aldehyde Dehydrogenase 3-A1/ALDH3A1)
- Search Origene for MassSpec and Protein Over-expression Lysates for ALDH3A1
- Origene Custom Protein Services for ALDH3A1
- Sino Biological Cell Lysates for ALDH3A1
- Sino Biological Recombinant Proteins for ALDH3A1
- ProSpec Recombinant Proteins for ALDH3A1
- Search GeneTex for Proteins for ALDH3A1
-
ProSci Proteins for ALDH3A1
Assay Products
- antibodies-online: Search results for 7 available ALDH3A1 Elisa Kits ranked by validation data
- Compare Top ALDH3A1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ALDH3A1 Gene
Domains & Families for ALDH3A1 Gene
Gene Families for ALDH3A1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ALDH3A1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ALDH3A1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30838- Family:
-
- Belongs to the aldehyde dehydrogenase family.
Function for ALDH3A1 Gene
Molecular function for ALDH3A1 Gene
- UniProtKB/Swiss-Prot Function:
- ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Note=Has a high Km for acetaldehyde.;
Enzyme Numbers (IUBMB) for ALDH3A1 Gene
Phenotypes From GWAS Catalog for ALDH3A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity | IEA | -- |
| GO:0004029 | aldehyde dehydrogenase (NAD) activity | IDA | 1737758 |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0008106 | alcohol dehydrogenase (NADP+) activity | IDA | 1737758 |
Phenotypes for ALDH3A1 Gene
- MGI mutant phenotypes for ALDH3A1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ALDH3A1:
-
- Increased viability after borna disease (rVSVI9G*/BDVG) virus infection
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for ALDH3A1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ALDH3A1
-
CRISPR Products
-
OriGene CRISPR knockouts for ALDH3A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDH3A1
- genomics-online: gRNA clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- Applied Biological Materials CRISPR for ALDH3A1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALDH3A1
- GenScript: Design CRISPR guide RNA sequences for ALDH3A1
miRNA for ALDH3A1 Gene
- miRTarBase miRNAs that target ALDH3A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDH3A1
- Browse OriGene Inhibitory RNA Products For ALDH3A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDH3A1
- genomics-online: shRNA clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
Clone Products
-
OriGene ORF clones in human for ALDH3A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ALDH3A1
- VectorBuilder custom plasmid, inducible vectors for ALDH3A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALDH3A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDH3A1
- Applied Biological Materials Clones for ALDH3A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ALDH3A1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDH3A1 Gene
Localization for ALDH3A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALDH3A1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| nucleus | 3 |
| mitochondrion | 2 |
| peroxisome | 1 |
- Cytosol (4)
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 22664934 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for ALDH3A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Phenylalanine metabolism | ||
| 3 | Metabolism |
.37
|
|
| 4 | Cyclophosphamide Pathway, Pharmacodynamics | ||
| 5 | Cytochrome P450 - arranged by substrate type | ||
Pathways by source for ALDH3A1 Gene
4 BioSystems pathways for ALDH3A1 Gene
3 Reactome pathways for ALDH3A1 Gene
2 PharmGKB pathways for ALDH3A1 Gene
9 KEGG pathways for ALDH3A1 Gene
1 GeneGo (Thomson Reuters) pathway for ALDH3A1 Gene
Interacting Proteins for ALDH3A1 Gene
Selected Interacting proteins:
P30838-AL3A1_HUMAN
ENSP00000225740
for ALDH3A1 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for ALDH3A1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006081 | cellular aldehyde metabolic process | IDA | 1737758 |
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0055114 | oxidation-reduction process | IDA | 1737758 |
No data available for SIGNOR curated interactions for ALDH3A1 Gene
Drugs & Compounds for ALDH3A1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Aldophosphamide |
|
|||||
| Carboxyphosphamide |
|
|||||
| nadph |
|
53-57-6 | ||||
| 3,4-Dihydroxymandelaldehyde |
|
13023-73-9 |
|
|||
| 3,4-Dihydroxymandelic acid |
|
775-01-9 |
|
Transcripts for ALDH3A1 Gene
mRNA/cDNA for ALDH3A1 Gene
- (377) Selected AceView cDNA sequences:
- (12) Additional mRNA sequences :
- (8) REFSEQ mRNAs :
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000225740 1779 bps (uc002gwj.4)
- ENST00000395555 1495 bps (uc060cnp.1)
- ENST00000426645 781 bps (uc060cnw.1)
- ENST00000439102 1359 bps (uc060cnt.1)
- ENST00000444455 1771 bps (uc010vzd.3)
Unigene Clusters for ALDH3A1 Gene
- Aldehyde dehydrogenase 3 family, member A1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ALDH3A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDH3A1
- genomics-online: gRNA clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- Applied Biological Materials CRISPR for ALDH3A1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALDH3A1
- GenScript: Design CRISPR guide RNA sequences for ALDH3A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDH3A1
- Browse OriGene Inhibitory RNA Products For ALDH3A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDH3A1
- genomics-online: shRNA clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
Clone Products
-
OriGene ORF clones in human for ALDH3A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ALDH3A1
- VectorBuilder custom plasmid, inducible vectors for ALDH3A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALDH3A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDH3A1
- Applied Biological Materials Clones for ALDH3A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
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| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
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| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP14: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - |
| ExUns: | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||
| SP20: |
Expression for ALDH3A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Keratocytes Corneal Stroma
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
- Keratocyte-like cells(Chan AA et. al. 2013)
- Epithelial Cells
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
-
Fibroblasts
- Keratocytes Corneal Stroma
- Neural Crest (Gastrulation Derivatives)
- NULL (Sensory Organs)
- Liver (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for ALDH3A1 Gene
This gene is overexpressed in Esophagus - Mucosa (x28.6), Stomach (x10.1), and Minor Salivary Gland (x4.2).
This gene is overexpressed in Nasal epithelium (33.5), Tonsil (14.7), and Oral epithelium (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALDH3A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ALDH3A1 Gene:
ALDH3A1SOURCE GeneReport for Unigene cluster for ALDH3A1 Gene:
Hs.531682mRNA Expression by UniProt/SwissProt for ALDH3A1 Gene:
P30838-AL3A1_HUMAN
Tissue specificity:
High levels in stomach, esophagus and lung; low level in the liver and kidney.
Evidence on tissue expression from TISSUES for ALDH3A1 Gene
- Pancreas(4.8)
- Stomach(4.8)
- Eye(4.6)
- Lung(4.6)
- Liver(2)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ALDH3A1
-
OriGene qPCR primer pairs for ALDH3A1
- genomics-online: primer clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDH3A1 Gene
Orthologs for ALDH3A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ALDH3A1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ALDH3A1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ALDH3A1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Aldh3a1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Aldh3a1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ALDH3A1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ALDH3A2 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | aldh3a2b 34 |
|
ManyToMany | |
| aldh3a2a 34 |
|
ManyToMany | |||
| aldh3a1 34 |
|
ManyToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.864 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Aldh-III 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | alh-5 34 |
|
ManyToMany | |
| alh-4 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HFD1 36 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ALDH3H1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0186200 33 |
|
||
| Os.5577 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.4281 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6683 34 |
|
ManyToMany | |
| CSA.9635 34 |
|
ManyToMany |
- Species where no ortholog for ALDH3A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ALDH3A1 Gene
- ENSEMBL:
- Gene Tree for ALDH3A1 (if available)
- TreeFam:
- Gene Tree for ALDH3A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ALDH3A1: view image
Paralogs for ALDH3A1 Gene
(5) SIMAP similar genes for ALDH3A1 Gene using alignment to 10 proteins:
- AL3A1_HUMAN
- A8MYB8_HUMAN
- C9JKT2_HUMAN
- C9JMC5_HUMAN
- E9PNN6_HUMAN
- I3L1H6_HUMAN
- I3L3I9_HUMAN
- I3L3W9_HUMAN
- I3L4E5_HUMAN
- Q6PKA6_HUMAN
Variants for ALDH3A1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049285 | -- | 19,749,241(-) | T/C | upstream_transcript_variant | |
| rs1000222912 | -- | 19,744,520(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000557126 | -- | 19,750,189(-) | G/A | upstream_transcript_variant | |
| rs1000858181 | -- | 19,745,177(-) | G/A/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001077516 | -- | 19,750,384(-) | C/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.44;
90.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALDH3A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ALDH3A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH3A1 Gene
Disorders for ALDH3A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast adenocarcinoma |
|
|
Search ALDH3A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ALDH3A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ALDH3A1 Gene
Publications for ALDH3A1 Gene
- Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli. (PMID: 1737758) Hsu LC … Yoshida A (The Journal of biological chemistry 1992) 2 3 4 22 58
- Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. (PMID: 18854779) Ekhart C … Huitema AD (Pharmacogenetics and genomics 2008) 3 22 44 58
- Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. (PMID: 18496131) Ekhart C … Huitema AD (Pharmacogenetics and genomics 2008) 3 22 44 58
- Mutations associated with Sjögren-Larsson syndrome. (PMID: 9250352) Tsukamoto N … Yoshida A (Annals of human genetics 1997) 3 4 22 58
- Human stomach aldehyde dehydrogenase, ALDH3. (PMID: 8493892) Hsu LC … Yoshida A (Advances in experimental medicine and biology 1993) 3 4 22 58
Products for ALDH3A1 Gene
- R&D Systems Antibodies for ALDH3A1 (Aldehyde Dehydrogenase 3-A1/ALDH3A1)
- R&D Systems Proteins and Enzymes for ALDH3A1 (Aldehyde Dehydrogenase 3-A1/ALDH3A1)
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for ALDH3A1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ALDH3A1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for ALDH3A1
- Browse OriGene Inhibitory RNA Products For ALDH3A1
- OriGene qPCR primer pairs and template standards for ALDH3A1
- OriGene qPCR primer pairs for ALDH3A1
- OriGene CRISPR knockouts for ALDH3A1
- OriGene ORF clones in human for ALDH3A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ALDH3A1
- GenScript: Next-day shipping of latest version cDNA ORF clones for ALDH3A1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ALDH3A1
- GenScript Custom Assay Services for ALDH3A1
- GenScript Custom overexpressing Cell Line Services for ALDH3A1
- GenScript: Design CRISPR guide RNA sequences for ALDH3A1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ALDH3A1
- Sino Biological Human cDNA Clone for ALDH3A1
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- Sino Biological Antibodies for ALDH3A1
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ALDH3A1
- Novus Biologicals lysates and proteins for ALDH3A1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for ALDH3A1
- VectorBuilder custom plasmid, inducible vectors for ALDH3A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALDH3A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 107 available ALDH3A1 Antibodies ranked by validation data
- Compare Top ALDH3A1 Antibodies
- antibodies-online: Search results for 7 available ALDH3A1 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 21 available ALDH3A1 Proteins ranked by validation data
- Compare Top ALDH3A1 Proteins
- GeneTex ALDH3A1 Antibody for ALDH3A1
- Search GeneTex for Proteins for ALDH3A1
- Santa Cruz Biotechnology (SCBT) Antibodies for ALDH3A1
- Search Santa Cruz Biotechnology (SCBT) for ALDH3A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ALDH3A1
- Custom Antibody ServicesProSci Antibodies for ALDH3A1
- ProSci Proteins for ALDH3A1
- Horizon Cell Lines for ALDH3A1
- genomics-online: cdna clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- orf clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- genomics-online: gRNA clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- genomics-online: primer clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- genomics-online: shRNA clones - Search results for 152 available ALDH3A1 gene related products
- Overview of 152 available ALDH3A1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ALDH3A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ALDH3A1
- GeneCopoeia miRNA 3'UTR Target clone products for ALDH3A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ALDH3A1
Sources for ALDH3A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio