The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis an... See more...

Aliases for AKT3 Gene

Aliases for AKT3 Gene

  • AKT Serine/Threonine Kinase 3 2 3 5
  • RAC-Gamma Serine/Threonine-Protein Kinase 3 4
  • RAC-PK-Gamma 3 4
  • EC 2.7.11.1 4 52
  • PKB Gamma 3 4
  • STK-2 3 4
  • PKBG 3 4
  • V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) 3
  • V-Akt Murine Thymoma Viral Oncogene Homolog 3 2
  • RAC-Gamma Serine/Threonine Protein Kinase 3
  • Protein Kinase B, Gamma 2
  • Protein Kinase B Gamma 4
  • Protein Kinase Akt-3 4
  • HSALNG0012040 167
  • Lnc-CEP170-4 168
  • PKB-GAMMA 3
  • RAC-Gamma 3
  • EC 2.7.11 52
  • MPPH2 3
  • PRKBG 3
  • MPPH 3

External Ids for AKT3 Gene

Previous GeneCards Identifiers for AKT3 Gene

  • GC01M241568
  • GC01M238913
  • GC01M239853
  • GC01M240598
  • GC01M239977
  • GC01M241718
  • GC01M243653
  • GC01M214031

Summaries for AKT3 Gene

Entrez Gene Summary for AKT3 Gene

  • The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

CIViC Summary for AKT3 Gene

GeneCards Summary for AKT3 Gene

AKT3 (AKT Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with AKT3 include Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 and Polymicrogyria. Among its related pathways are Signaling by GPCR and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot Summary for AKT3 Gene

  • AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Tocris Summary for AKT3 Gene

  • Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane.

Gene Wiki entry for AKT3 Gene

Additional gene information for AKT3 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKT3 Gene

Genomics for AKT3 Gene

GeneHancer (GH) Regulatory Elements for AKT3 Gene

Promoters and enhancers for AKT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKT3

Top Transcription factor binding sites by QIAGEN in the AKT3 gene promoter:
  • FAC1
  • FOXL1
  • MEF-2A
  • POU3F2
  • Sp1

Genomic Locations for AKT3 Gene

Genomic Locations for AKT3 Gene
chr1:243,488,233-243,851,079
(GRCh38/hg38)
Size:
362,847 bases
Orientation:
Minus strand
chr1:243,651,535-244,014,381
(GRCh37/hg19)
Size:
362,847 bases
Orientation:
Minus strand

Genomic View for AKT3 Gene

Genes around AKT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKT3 Gene

Proteins for AKT3 Gene

  • Protein details for AKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y243-AKT3_HUMAN
    Recommended name:
    RAC-gamma serine/threonine-protein kinase
    Protein Accession:
    Q9Y243
    Secondary Accessions:
    • Q0VAA6
    • Q5VTI1
    • Q5VTI2
    • Q96QV3
    • Q9UFP5

    Protein attributes for AKT3 Gene

    Size:
    479 amino acids
    Molecular mass:
    55775 Da
    Quaternary structure:
    • Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6. Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity).

    Three dimensional structures from OCA and Proteopedia for AKT3 Gene

    Alternative splice isoforms for AKT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKT3 Gene

Selected DME Specific Peptides for AKT3 Gene

Q9Y243:
  • CQLMKTERP
  • YYAMKIL
  • AEIVSAL
  • GTPEYLAPE
  • RAVDWWGLGV
  • DGSFIGYKE
  • HFPQFSYSAS
  • NGGELFFHL
  • LFELILME
  • LKYSFQT
  • IKITDFGL
  • RFYGAEI
  • KEVIIAKDEVAHT
  • RDLKLEN
  • PLNNFSVA
  • NLMLDKD
  • LQWTTVIERTF
  • YLAPEVL
  • VNGGELF
  • KILKKEVI
  • PPFKPQVTSE
  • GVVMYEM
  • YLKLLGKGTFGKVILV
  • IKITDFG
  • AKSLLSGLL
  • LDKDGHIK
  • EVAHTLTE
  • LFFHLSRERVF
  • FVMEYVNGG
  • DFGLCKE
  • DRLCFVM
  • KRGEYIK
  • FQTKDRL

Post-translational modifications for AKT3 Gene

  • Phosphorylation on Thr-305 and Ser-472 is required for full activity.
  • Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
  • O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1.
  • Glycosylation at Thr302 and Thr309
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for AKT3
  • Boster Bio Antibodies for AKT3

Domains & Families for AKT3 Gene

Gene Families for AKT3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for AKT3 Gene

Suggested Antigen Peptide Sequences for AKT3 Gene

GenScript: Design optimal peptide antigens:
  • STK-2 (AKT3_HUMAN)
  • AKT3 protein (Q56A86_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y243

UniProtKB/Swiss-Prot:

AKT3_HUMAN :
  • Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Domain:
  • Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
genes like me logo Genes that share domains with AKT3: view

Function for AKT3 Gene

Molecular function for AKT3 Gene

UniProtKB/Swiss-Prot Function:
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=87.9 uM for ATP (for purified and in vitro activated AKT3) {ECO:0000269 PubMed:16540465}; KM=12.4 uM for peptide substrate (for purified and in vitro activated AKT3) {ECO:0000269 PubMed:16540465}; KM=118.7 uM for ATP (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465}; KM=2.3 uM for peptide substrate (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465};
GENATLAS Biochemistry:
V-akt murine thymoma viral oncogen homolog 3,general mediator of cell survival,induced by insulin growth factor 1,AKT3 and others,widely expressed but not in liver and skeletal muscle

Enzyme Numbers (IUBMB) for AKT3 Gene

Phenotypes From GWAS Catalog for AKT3 Gene

Gene Ontology (GO) - Molecular Function for AKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS 10092583
GO:0004674 protein serine/threonine kinase activity IBA,IDA 16540465
GO:0005515 protein binding IPI 12176997
GO:0005524 ATP binding IDA 16540465
genes like me logo Genes that share ontologies with AKT3: view
genes like me logo Genes that share phenotypes with AKT3: view

Human Phenotype Ontology for AKT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AKT3 Gene

MGI Knock Outs for AKT3:

Clone Products

  • Addgene plasmids for AKT3

No data available for Transcription Factor Targets and HOMER Transcription for AKT3 Gene

Localization for AKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKT3 Gene

Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKT3 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AKT3: view

Pathways & Interactions for AKT3 Gene

PathCards logo

SuperPathways for AKT3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Regulation of lipid metabolism Insulin signaling-generic cascades
.59
.59
.51
.47
.44
.43
.35
.34
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.38
4 Endometrial cancer
.44
5 Toll-like Receptor Signaling Pathway
genes like me logo Genes that share pathways with AKT3: view

Pathways by source for AKT3 Gene

35 Qiagen pathways for AKT3 Gene
  • Akt Signaling
  • AMPK Enzyme Complex Pathway
  • cAMP Pathway
  • CD28 Signaling in T-Helper Cell
  • CTLA4 Signaling
2 Cell Signaling Technology pathways for AKT3 Gene

SIGNOR curated interactions for AKT3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for AKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IMP 18524868
GO:0001938 positive regulation of endothelial cell proliferation IMP 25323119
GO:0006468 protein phosphorylation TAS 10092583
GO:0007165 signal transduction IMP,TAS 18524868
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with AKT3: view

Drugs & Compounds for AKT3 Gene

(61) Drugs for AKT3 Gene - From: ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Everolimus Approved Pharma inhibitor, Biomarker mTOR inhibitor, mTOR Inhibitors, Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1952
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Potent aromatase (CYP19) inhibitor, Aromatase Inhibitors, Hormone therapy 325
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2480
Fulvestrant Approved, Investigational Pharma Antagonist Estrogen receptor antagonist,high affinity, Hormone therapy 277
Paclitaxel Approved, Vet_approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 3559

(4) Additional Compounds for AKT3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
API-2
35943-35-2

(5) Tocris Compounds for AKT3 Gene

Compound Action Cas Number
10-DEBC hydrochloride Selective Akt/PKB inhibitor 925681-41-0
API-2 Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral 35943-35-2
Perifosine PKB/Akt inhibitor; also modulates Kv2.1 current 157716-52-4
PHT 427 Dual Akt and PDK1 inhibitor; antitumor 1191951-57-1
SC 79 Akt activator 305834-79-1

(31) ApexBio Compounds for AKT3 Gene

Compound Action Cas Number
10-DEBC hydrochloride Selective Akt/PKB inhibitor 925681-41-0
3CAI 28755-03-5
A-674563 Akt1/PKA/CDK2 inhibitor,potent and selective 552325-73-2
Afuresertib 1047644-62-1
AKT inhibitor VIII Allosteric Akt kinase inhibitor 612847-09-3
AKT Kinase Inhibitor 842148-40-7
AKT/mTOR Set I
AT13148 Multi-AGC kinase inhibitor,ATP-competitive 1056901-62-2
AT7867 Akt1/2/3 and p70S6K/PKA inhibitor 857531-00-1
AZD5363 AKT inhibitor,pyrrolopyrimidine derived 1143532-39-1
BX795 PDK1 inhibitor 702675-74-9
CCT128930 AKT inhibitor 885499-61-6
CH5424802 ALK inhibitor,potent and ATP-competitive 1256580-46-7
FPA 124 902779-59-3
GDC-0068 (RG7440) Pan-AKT inhibitor,highly selective 1001264-89-6
GSK1838705A IGF-IR/IR/ALK inhibitor, ATP-competitive 1116235-97-2
GSK2141795 1047634-65-0
GSK2141795 hydrochloride 1047635-80-2
GSK690693 Pan-AKT inhibitor,ATP-competitive and potent 937174-76-0
Isobavachalcone Diverse biological activity compound 20784-50-3
Miltefosine PI3K/Akt inhibitor 58066-85-6
MK-2206 dihydrochloride Akt1/2/3 inhibitor 1032350-13-2
Palomid 529 PI3K/Akt/mTOR inhibitor 914913-88-5
Perifosine Akt inhibitor 157716-52-4
PHT-427 Akt and PDPK1 inhibitor 1191951-57-1
PIT 1 53501-41-0
SC 66 871361-88-5
SC 79 Akt activator 305834-79-1
TAE684 (NVP-TAE684) ALK inhibitor,potent and selective 761439-42-3
TIC10 Potent Akt/ERK inhibitor 41276-02-2
Triciribine Akt inhibitor,highly selective 35943-35-2
genes like me logo Genes that share compounds with AKT3: view

Drug Products

Transcripts for AKT3 Gene

mRNA/cDNA for AKT3 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
4 RNACentral transcripts :
1 LncBook transcripts :
1 LNCipedia transcripts :

Clone Products

  • Addgene plasmids for AKT3

Alternative Splicing Database (ASD) splice patterns (SP) for AKT3 Gene

No ASD Table

Relevant External Links for AKT3 Gene

GeneLoc Exon Structure for
AKT3

Expression for AKT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AKT3 Gene

This gene is overexpressed in Fetal Brain (12.2), Peripheral blood mononuclear cells (11.3), Uterus (8.5), Ovary (7.6), and Rectum (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKT3 Gene



Protein tissue co-expression partners for AKT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKT3

SOURCE GeneReport for Unigene cluster for AKT3 Gene:

Hs.498292

mRNA Expression by UniProt/SwissProt for AKT3 Gene:

Q9Y243-AKT3_HUMAN
Tissue specificity: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.

Evidence on tissue expression from TISSUES for AKT3 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Eye(2.7)
  • Pancreas(2.2)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AKT3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • lip
  • meninges
  • mouth
  • nose
  • skull
Thorax:
  • chest wall
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
Abdomen:
  • abdominal wall
  • kidney
Pelvis:
  • pelvis
Limb:
  • digit
  • finger
  • foot
  • hand
  • knee
  • lower limb
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with AKT3: view

No data available for mRNA differential expression in normal tissues for AKT3 Gene

Orthologs for AKT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKT3 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia AKT3 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKT3 31 30
  • 99.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AKT3 31 30
  • 96.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AKT3 31 30
  • 95.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akt3 30
  • 94.09 (n)
mouse
(Mus musculus)
Mammalia Akt3 17 31 30
  • 94.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AKT3 31
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKT3 31 30
  • 90.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKT3 31
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AKT3 31
  • 93 (a)
OneToOne
akt3a 30
  • 80.17 (n)