This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in... See more...

Aliases for AKR7L Gene

Aliases for AKR7L Gene

  • Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene) 2 3 5
  • AFAR3 2 3 4
  • Aflatoxin B1 Aldehyde Reductase Member 4 3 4
  • Aldo-Keto Reductase Family 7-Like 2 3
  • AFB1 Aldehyde Reductase 3 3 4
  • Aldoketoreductase 7-Like 3 4
  • AFB1-AR 3 3 4
  • AKR7A4 3 4
  • Aldo-Keto Reductase Family 7 Pseudogene 3
  • EC 1.-.-.- 4
  • AFB1-AR3 3
  • AKR7L 5

External Ids for AKR7L Gene

Previous GeneCards Identifiers for AKR7L Gene

  • GC01M019466
  • GC01M019592
  • GC01M017838

Summaries for AKR7L Gene

Entrez Gene Summary for AKR7L Gene

  • This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]

GeneCards Summary for AKR7L Gene

AKR7L (Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with AKR7L include Gastric Cancer. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR7A3.

UniProtKB/Swiss-Prot Summary for AKR7L Gene

  • Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

Additional gene information for AKR7L Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR7L Gene

Genomics for AKR7L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AKR7L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J019271 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 600.7 +0.7 657 3.4 SP1 YY1 GABPA ZBTB33 JUND HNF4A EGR1 RXRA ZNF507 MAX AKR7L EMC1 RNU6-1099P SLC66A1 AKR7A2 OTUD3 TAS1R2 MRTO4 AKR7A3 ENSG00000272084
GH01J019310 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.1 -39.2 -39221 6.8 ARHGAP35 SP1 HNRNPL TEAD4 TFE3 ZNF512 LEF1 IKZF1 ZNF692 POLR2A AKR7A2 SLC66A1 OTUD3 UBR4 AKR7L EMC1 ENSG00000272084 RF00017-089 lnc-AKR7A2-1 MICOS10
GH01J019366 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.7 -98.3 -98314 13 CTCF SCRT2 ESR1 NFE2 PRDM4 RCOR1 HNF4A ZNF143 XRCC5 RAD21 CAPZB SLC66A1 AKR7A2 RNU6-1099P HTR6 RNU4-28P NBL1 AKR7L piR-38580-002 lnc-PQLC2-5
GH01J019359 Enhancer 0.8 Ensembl ENCODE dbSUPER 9.8 -88.0 -88044 5.7 ZNF600 SCRT2 ESR1 SCRT1 CTCF HNF4A CAPZB SLC66A1 AKR7A2 RNU6-1099P RNU4-28P AKR7L piR-38580-002 lnc-AKR7A2-2 MICOS10 lnc-AKR7A2-3
GH01J019285 Enhancer 0.4 Ensembl dbSUPER 8.8 -11.2 -11207 0.4 JUND AKR7A2 SLC66A1 AKR7L MRTO4 AKR7A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR7L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKR7L

Top Transcription factor binding sites by QIAGEN in the AKR7L gene promoter:
  • HTF
  • IRF-1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-5
  • RP58

Genomic Locations for AKR7L Gene

Genomic Locations for AKR7L Gene
chr1:19,265,982-19,274,194
(GRCh38/hg38)
Size:
8,213 bases
Orientation:
Minus strand
chr1:19,592,476-19,600,688
(GRCh37/hg19)
Size:
8,213 bases
Orientation:
Minus strand

Genomic View for AKR7L Gene

Genes around AKR7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7L Gene

Proteins for AKR7L Gene

  • Protein details for AKR7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHP1-ARK74_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 4
    Protein Accession:
    Q8NHP1
    Secondary Accessions:
    • Q5U614

    Protein attributes for AKR7L Gene

    Size:
    331 amino acids
    Molecular mass:
    36970 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35351.1; Type=Erroneous translation; Note==Erroneous CDS prediction.; Evidence={ECO:0000305};

    Alternative splice isoforms for AKR7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR7L Gene

Post-translational modifications for AKR7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR7L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKR7L Gene

Domains & Families for AKR7L Gene

Protein Domains for AKR7L Gene

Suggested Antigen Peptide Sequences for AKR7L Gene

GenScript: Design optimal peptide antigens:
  • Aldoketoreductase 7-like (ARK74_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHP1

UniProtKB/Swiss-Prot:

ARK74_HUMAN :
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
genes like me logo Genes that share domains with AKR7L: view

No data available for Gene Families for AKR7L Gene

Function for AKR7L Gene

Molecular function for AKR7L Gene

UniProtKB/Swiss-Prot Function:
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

Enzyme Numbers (IUBMB) for AKR7L Gene

Phenotypes From GWAS Catalog for AKR7L Gene

Gene Ontology (GO) - Molecular Function for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR7L: view
genes like me logo Genes that share phenotypes with AKR7L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR7L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKR7L Gene

Localization for AKR7L Gene

Gene Ontology (GO) - Cellular Components for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with AKR7L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for AKR7L Gene

Pathways & Interactions for AKR7L Gene

genes like me logo Genes that share pathways with AKR7L: view

Pathways by source for AKR7L Gene

Interacting Proteins for AKR7L Gene

Gene Ontology (GO) - Biological Process for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR7L: view

No data available for SIGNOR curated interactions for AKR7L Gene

Drugs & Compounds for AKR7L Gene

(2) Drugs for AKR7L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 227
Selenocysteine Experimental Pharma 0

(2) Additional Compounds for AKR7L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aflatoxin B1
  • AFB1
  • AFBI
  • HSDB-3453
  • Aflatoxin b
  • Aflatoxin b1, (6ar-cis)-isomer, 14C-labeled
1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
genes like me logo Genes that share compounds with AKR7L: view

Transcripts for AKR7L Gene

mRNA/cDNA for AKR7L Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR7L

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7L Gene

No ASD Table

Relevant External Links for AKR7L Gene

GeneLoc Exon Structure for
AKR7L

Expression for AKR7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR7L Gene

mRNA differential expression in normal tissues according to GTEx for AKR7L Gene

This gene is overexpressed in Liver (x14.7), Small Intestine - Terminal Ileum (x6.4), Stomach (x5.4), and Pancreas (x5.1).

Protein differential expression in normal tissues from HIPED for AKR7L Gene

This gene is overexpressed in Liver (22.8), Kidney (14.5), Lung (8.6), and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR7L Gene



Protein tissue co-expression partners for AKR7L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR7L

SOURCE GeneReport for Unigene cluster for AKR7L Gene:

Hs.662342

mRNA Expression by UniProt/SwissProt for AKR7L Gene:

Q8NHP1-ARK74_HUMAN
Tissue specificity: Mainly expressed in uterus.
genes like me logo Genes that share expression patterns with AKR7L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR7L Gene

Orthologs for AKR7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7L Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia AKR7A2 31
  • 37 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia AKR7L 31
  • 27 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 26 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 20 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii akr7a3 31
  • 24 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 5 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 16 (a)
OneToMany
Species where no ortholog for AKR7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AKR7L Gene

ENSEMBL:
Gene Tree for AKR7L (if available)
TreeFam:
Gene Tree for AKR7L (if available)

Paralogs for AKR7L Gene

(2) SIMAP similar genes for AKR7L Gene using alignment to 1 proteins:

  • ARK74_HUMAN
genes like me logo Genes that share paralogs with AKR7L: view

Variants for AKR7L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR7L Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2235795 - p.Ala255Thr
rs2982534 - p.Phe322Val

Structural Variations from Database of Genomic Variants (DGV) for AKR7L Gene

Variant ID Type Subtype PubMed ID
dgv25e199 CNV deletion 23128226
esv26443 CNV loss 19812545
esv3552788 CNV deletion 23714750
esv3585392 CNV loss 21293372
nsv945806 CNV duplication 23825009

Additional Variant Information for AKR7L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR7L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Variation tolerance for AKR7L Gene

Disorders for AKR7L Gene

MalaCards: The human disease database

(1) MalaCards diseases for AKR7L Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search AKR7L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AKR7L

genes like me logo Genes that share disorders with AKR7L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR7L Gene

Publications for AKR7L Gene

  1. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PMID: 12879023) Praml C … Schwab M (Oncogene 2003) 2 3 4
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein JL … Alzheimer's Disease Neuroimaging Initiative (NeuroImage 2010) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for AKR7L Gene

Sources for AKR7L Gene