Aliases for AKR7L Gene
External Ids for AKR7L Gene
Previous GeneCards Identifiers for AKR7L Gene
This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]
GeneCards Summary for AKR7L Gene
AKR7L (Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with AKR7L include Gastric Cancer. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR7A3.
UniProtKB/Swiss-Prot Summary for AKR7L Gene
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).