Aliases for AKR7L Gene
External Ids for AKR7L Gene
Previous GeneCards Identifiers for AKR7L Gene
This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]
GeneCards Summary for AKR7L Gene
AKR7L (Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with AKR7L include Gastric Cancer. Among its related pathways are Metabolism and Aflatoxin activation and detoxification. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR7A3.
UniProtKB/Swiss-Prot Summary for AKR7L Gene
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).