Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004] See more...

Aliases for AKR7A3 Gene

Aliases for AKR7A3 Gene

  • Aldo-Keto Reductase Family 7 Member A3 2 3 5
  • Aflatoxin B1 Aldehyde Reductase Member 3 3 4
  • Aflatoxin Aldehyde Reductase 2 3
  • AFB1 Aldehyde Reductase 2 3 4
  • AFB1-AR 2 3 4
  • AFAR2 3 4
  • Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde Reductase) 2
  • Epididymis Secretory Sperm Binding Protein 3
  • Aflatoxin B1 Aldehyde Reductase 2 3
  • EC 1.-.-.- 4
  • AKR7A3 5

External Ids for AKR7A3 Gene

Previous GeneCards Identifiers for AKR7A3 Gene

  • GC01U990243
  • GC01M018634
  • GC01M018754
  • GC01M019078
  • GC01M019354
  • GC01M019481
  • GC01M019610
  • GC01M017855

Summaries for AKR7A3 Gene

Entrez Gene Summary for AKR7A3 Gene

  • Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

GeneCards Summary for AKR7A3 Gene

AKR7A3 (Aldo-Keto Reductase Family 7 Member A3) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and aldo-keto reductase (NADP) activity. An important paralog of this gene is AKR7L.

UniProtKB/Swiss-Prot Summary for AKR7A3 Gene

  • Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Additional gene information for AKR7A3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR7A3 Gene

Genomics for AKR7A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AKR7A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J019287 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 603.1 +1.0 961 2 HNRNPL SP1 ZBTB33 HNF4A RXRA MAX REST HNF4G ATF3 EZH2 AKR7A3 EMC1 MRTO4 ALDH4A1 AKR7L
GH01J019432 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -149.1 -149083 12.6 GATAD2A CTCF PRDM10 ZNF629 SOX13 RCOR2 PRDM1 RFX1 ZIC2 POLR2A CAPZB EMC1 NBL1 RNU4-28P HTR6 AKR7A2 OTUD3 AKR7A3 RN7SL277P RF00017-090
GH01J018946 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.1 +337.1 337104 11.1 SP1 HNRNPL GATAD2A TEAD4 ZNF629 TFE3 NFKBIZ KDM1A ZNF692 RCOR2 IFFO2 EMC1 ALDH4A1 AKR7A3 UBR4 AKR7A2 lnc-PAX7-7 AB372591
GH01J019764 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -475.9 -475939 3.4 JUND JUN FOS FOSL1 BHLHE40 STAT1 STAT3 MAFK ZNF366 HDAC2 TMCO4 AKR7A3 RNF186 ENSG00000235434 OTUD3 MUL1 PLA2G2A piR-50437-014 lnc-RNF186-2 HTR6
GH01J019389 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 9 -102.6 -102595 4.2 CTCF JUND STAT3 ZNF143 REST RAD21 RCOR1 TRIM22 DPF2 HDAC1 MICOS10 LOC105378614 CAPZB RNU4-28P SLC66A1 AKR7A2 AKR7A3 piR-38580-002 lnc-PQLC2-5 RF00017-090
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR7A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKR7A3

Top Transcription factor binding sites by QIAGEN in the AKR7A3 gene promoter:
  • ATF6
  • HTF
  • IRF-1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • RP58

Genomic Locations for AKR7A3 Gene

Genomic Locations for AKR7A3 Gene
chr1:19,274,229-19,289,362
(GRCh38/hg38)
Size:
15,134 bases
Orientation:
Minus strand
chr1:19,609,052-19,615,744
(GRCh37/hg19)
Size:
6,693 bases
Orientation:
Minus strand

Genomic View for AKR7A3 Gene

Genes around AKR7A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7A3 Gene

Proteins for AKR7A3 Gene

  • Protein details for AKR7A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95154-ARK73_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 3
    Protein Accession:
    O95154
    Secondary Accessions:
    • Q86SR4
    • Q8IVN6
    • Q8N5V6
    • Q8TAX1
    • Q9NUC3

    Protein attributes for AKR7A3 Gene

    Size:
    331 amino acids
    Molecular mass:
    37206 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for AKR7A3 Gene

neXtProt entry for AKR7A3 Gene

Post-translational modifications for AKR7A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR7A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKR7A3 Gene

Domains & Families for AKR7A3 Gene

Gene Families for AKR7A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AKR7A3 Gene

InterPro:
Blocks:
  • Aldo/keto reductase
ProtoNet:

Suggested Antigen Peptide Sequences for AKR7A3 Gene

GenScript: Design optimal peptide antigens:
  • AFB1 aldehyde reductase 2 (ARK73_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95154

UniProtKB/Swiss-Prot:

ARK73_HUMAN :
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
genes like me logo Genes that share domains with AKR7A3: view

Function for AKR7A3 Gene

Molecular function for AKR7A3 Gene

UniProtKB/Swiss-Prot Function:
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Enzyme Numbers (IUBMB) for AKR7A3 Gene

Phenotypes From GWAS Catalog for AKR7A3 Gene

Gene Ontology (GO) - Molecular Function for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0009055 electron transfer activity TAS 10383892
GO:0016491 oxidoreductase activity IEA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with AKR7A3: view
genes like me logo Genes that share phenotypes with AKR7A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR7A3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR7A3 Gene

Localization for AKR7A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR7A3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR7A3 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 3
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with AKR7A3: view

Pathways & Interactions for AKR7A3 Gene

genes like me logo Genes that share pathways with AKR7A3: view

Pathways by source for AKR7A3 Gene

1 PharmGKB pathway for AKR7A3 Gene
1 KEGG pathway for AKR7A3 Gene

Gene Ontology (GO) - Biological Process for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006081 cellular aldehyde metabolic process TAS 10383892
GO:0006805 xenobiotic metabolic process TAS --
GO:0022900 electron transport chain IEA --
GO:0046222 aflatoxin metabolic process IEA --
GO:0046223 aflatoxin catabolic process IEA --
genes like me logo Genes that share ontologies with AKR7A3: view

No data available for SIGNOR curated interactions for AKR7A3 Gene

Drugs & Compounds for AKR7A3 Gene

(2) Additional Compounds for AKR7A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aflatoxin B1
  • AFB1
  • AFBI
  • HSDB-3453
  • Aflatoxin b
  • Aflatoxin b1, (6ar-cis)-isomer, 14C-labeled
1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
genes like me logo Genes that share compounds with AKR7A3: view

Transcripts for AKR7A3 Gene

mRNA/cDNA for AKR7A3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR7A3

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7A3 Gene

No ASD Table

Relevant External Links for AKR7A3 Gene

GeneLoc Exon Structure for
AKR7A3

Expression for AKR7A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR7A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)
  • Kidney (Urinary System)
  • Stomach (Gastrointestinal Tract)
  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for AKR7A3 Gene

This gene is overexpressed in Pancreas (x19.6), Stomach (x10.8), and Liver (x7.3).

Protein differential expression in normal tissues from HIPED for AKR7A3 Gene

This gene is overexpressed in Liver (16.6), Stomach (13.1), Liver, secretome (12.2), Breast (6.7), and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR7A3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR7A3

SOURCE GeneReport for Unigene cluster for AKR7A3 Gene:

Hs.6980

mRNA Expression by UniProt/SwissProt for AKR7A3 Gene:

O95154-ARK73_HUMAN
Tissue specificity: Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.

Evidence on tissue expression from TISSUES for AKR7A3 Gene

  • Liver(4.6)
  • Stomach(2.3)
  • Kidney(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with AKR7A3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR7A3 Gene

Orthologs for AKR7A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AKR7A3 30 31
  • 95.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AKR7A2 31
  • 87 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Akr7a3 30
  • 82.16 (n)
Mouse
(Mus musculus)
Mammalia Akr7a5 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 62 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 69 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25232 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.2085 30
Zebrafish
(Danio rerio)
Actinopterygii akr7a3 31
  • 65 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 20 (a)
OneToMany
AAD14 33
Bread mold
(Neurospora crassa)
Ascomycetes NCU07240 30
  • 53.95 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
Species where no ortholog for AKR7A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AKR7A3 Gene

ENSEMBL:
Gene Tree for AKR7A3 (if available)
TreeFam:
Gene Tree for AKR7A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKR7A3: view image

Paralogs for AKR7A3 Gene

(2) SIMAP similar genes for AKR7A3 Gene using alignment to 1 proteins:

  • ARK73_HUMAN
genes like me logo Genes that share paralogs with AKR7A3: view

Variants for AKR7A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR7A3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
712826 Benign: not provided 19,282,768(-) T/C MISSENSE_VARIANT
732007 Likely Benign: not provided 19,285,957(-) T/G SYNONYMOUS_VARIANT
736804 Likely Benign: not provided 19,288,489(-) C/T INTRON_VARIANT
773106 Benign: not provided 19,285,999(-) A/G INTRON_VARIANT
rs1738023 - p.Asn215Asp

Additional dbSNP identifiers (rs#s) for AKR7A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for AKR7A3 Gene

Variant ID Type Subtype PubMed ID
dgv25e199 CNV deletion 23128226
esv26443 CNV loss 19812545
esv3552788 CNV deletion 23714750
esv3585392 CNV loss 21293372
esv3585393 CNV loss 21293372
nsv945807 CNV duplication 23825009

Variation tolerance for AKR7A3 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.08; 96.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR7A3 Gene

Human Gene Mutation Database (HGMD)
AKR7A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR7A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR7A3 Gene

Disorders for AKR7A3 Gene

Additional Disease Information for AKR7A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for AKR7A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR7A3 Gene

Publications for AKR7A3 Gene

  1. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. (PMID: 10383892) Knight LP … Sutter TR (Carcinogenesis 1999) 2 3 4 23
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 41
  3. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. (PMID: 18416522) Bodreddigari S … Sutter TR (Chemical research in toxicology 2008) 4 23
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for AKR7A3 Gene

  • Signalway ELISA kits for AKR7A3
  • Signalway Proteins for AKR7A3

Sources for AKR7A3 Gene