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Aliases for AKR7A3 Gene

Aliases for AKR7A3 Gene

  • Aldo-Keto Reductase Family 7 Member A3 2 3 5
  • Aflatoxin Aldehyde Reductase 2 3
  • AFB1 Aldehyde Reductase 2 3 4
  • AFB1-AR 2 3 4
  • AFAR2 3 4
  • Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde Reductase) 2
  • Aflatoxin B1 Aldehyde Reductase Member 3 3
  • Aflatoxin B1 Aldehyde Reductase 2 3
  • EC 1.-.-.- 4

External Ids for AKR7A3 Gene

Previous GeneCards Identifiers for AKR7A3 Gene

  • GC01U990243
  • GC01M018634
  • GC01M018754
  • GC01M019078
  • GC01M019354
  • GC01M019481
  • GC01M019610
  • GC01M017855

Summaries for AKR7A3 Gene

Entrez Gene Summary for AKR7A3 Gene

  • Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

GeneCards Summary for AKR7A3 Gene

AKR7A3 (Aldo-Keto Reductase Family 7 Member A3) is a Protein Coding gene. Diseases associated with AKR7A3 include Pancreas Adenocarcinoma. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include electron transfer activity and aldo-keto reductase (NADP) activity. An important paralog of this gene is AKR7L.

UniProtKB/Swiss-Prot for AKR7A3 Gene

  • Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Additional gene information for AKR7A3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7A3 Gene

Genomics for AKR7A3 Gene

GeneHancer (GH) Regulatory Elements for AKR7A3 Gene

Promoters and enhancers for AKR7A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I019288 Promoter/Enhancer 1.3 EPDnew Ensembl dbSUPER 550.8 +0.5 545 0.4 EZH2 AKR7A3 EMC1 AKR7L
GH01I019287 Enhancer 1 FANTOM5 ENCODE dbSUPER 553.2 +1.3 1300 1.1 RXRA MAX REST ATF3 HNF4G HNF4A ZBTB33 EZH2 AKR7A3 EMC1 MRTO4 ALDH4A1 AKR7L
GH01I019432 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.8 -162.5 -162495 39.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 CAPZB EMC1 NBL1 RNU4-28P HTR6 AKR7A2 OTUD3 AKR7A3 PQLC2 UBR4
GH01I018946 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.2 +337.2 337166 10.9 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 IFFO2 EMC1 ALDH4A1 AKR7A3 UBR4 AKR7A2 ENSG00000255275
GH01I019764 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -476.3 -476302 2.3 HDAC1 STAT1 JUN CBFA2T3 FOSL1 JUND ZNF366 HDAC2 ID3 STAT3 TMCO4 AKR7A3 ENSG00000235434 RNF186 PLA2G2A GC01P019759
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AKR7A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AKR7A3 gene promoter:

Genomic Locations for AKR7A3 Gene

Genomic Locations for AKR7A3 Gene
chr1:19,274,325-19,289,346
(GRCh38/hg38)
Size:
15,022 bases
Orientation:
Minus strand
chr1:19,609,052-19,615,744
(GRCh37/hg19)

Genomic View for AKR7A3 Gene

Genes around AKR7A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR7A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7A3 Gene

Proteins for AKR7A3 Gene

  • Protein details for AKR7A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95154-ARK73_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 3
    Protein Accession:
    O95154
    Secondary Accessions:
    • Q86SR4
    • Q8IVN6
    • Q8N5V6
    • Q8TAX1
    • Q9NUC3

    Protein attributes for AKR7A3 Gene

    Size:
    331 amino acids
    Molecular mass:
    37206 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for AKR7A3 Gene

neXtProt entry for AKR7A3 Gene

Post-translational modifications for AKR7A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR7A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKR7A3 Gene

Domains & Families for AKR7A3 Gene

Gene Families for AKR7A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AKR7A3 Gene

Suggested Antigen Peptide Sequences for AKR7A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95154

UniProtKB/Swiss-Prot:

ARK73_HUMAN :
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
genes like me logo Genes that share domains with AKR7A3: view

Function for AKR7A3 Gene

Molecular function for AKR7A3 Gene

UniProtKB/Swiss-Prot Function:
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Enzyme Numbers (IUBMB) for AKR7A3 Gene

Phenotypes From GWAS Catalog for AKR7A3 Gene

Gene Ontology (GO) - Molecular Function for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity TAS --
GO:0005515 protein binding IPI 16189514
GO:0009055 electron transfer activity TAS 10383892
GO:0016491 oxidoreductase activity IEA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with AKR7A3: view
genes like me logo Genes that share phenotypes with AKR7A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR7A3 Gene

Localization for AKR7A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR7A3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR7A3 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with AKR7A3: view

Pathways & Interactions for AKR7A3 Gene

genes like me logo Genes that share pathways with AKR7A3: view

Pathways by source for AKR7A3 Gene

1 PharmGKB pathway for AKR7A3 Gene
1 KEGG pathway for AKR7A3 Gene

Gene Ontology (GO) - Biological Process for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006081 cellular aldehyde metabolic process TAS 10383892
GO:0006805 xenobiotic metabolic process TAS --
GO:0022900 electron transport chain IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR7A3: view

No data available for SIGNOR curated interactions for AKR7A3 Gene

Drugs & Compounds for AKR7A3 Gene

(2) Additional Compounds for AKR7A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aflatoxin B1
  • AFB1
  • AFBI
1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
genes like me logo Genes that share compounds with AKR7A3: view

Transcripts for AKR7A3 Gene

mRNA/cDNA for AKR7A3 Gene

Unigene Clusters for AKR7A3 Gene

Aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7A3 Gene

No ASD Table

Relevant External Links for AKR7A3 Gene

GeneLoc Exon Structure for
AKR7A3
ECgene alternative splicing isoforms for
AKR7A3

Expression for AKR7A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKR7A3 Gene

mRNA differential expression in normal tissues according to GTEx for AKR7A3 Gene

This gene is overexpressed in Pancreas (x19.6), Stomach (x10.8), and Liver (x7.3).

Protein differential expression in normal tissues from HIPED for AKR7A3 Gene

This gene is overexpressed in Liver (16.6), Stomach (13.1), Liver, secretome (12.2), Breast (6.7), and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AKR7A3 Gene



NURSA nuclear receptor signaling pathways regulating expression of AKR7A3 Gene:

AKR7A3

SOURCE GeneReport for Unigene cluster for AKR7A3 Gene:

Hs.6980

mRNA Expression by UniProt/SwissProt for AKR7A3 Gene:

O95154-ARK73_HUMAN
Tissue specificity: Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.

Evidence on tissue expression from TISSUES for AKR7A3 Gene

  • Liver(4.5)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with AKR7A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR7A3 Gene

Orthologs for AKR7A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR7A3 33 34
  • 95.76 (n)
cow
(Bos Taurus)
Mammalia AKR7A2 34
  • 87 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Akr7a3 33
  • 82.16 (n)
mouse
(Mus musculus)
Mammalia Akr7a5 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2085 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25232 33
zebrafish
(Danio rerio)
Actinopterygii akr7a3 34
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 20 (a)
OneToMany
AAD14 36
bread mold
(Neurospora crassa)
Ascomycetes NCU07240 33
  • 53.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Species where no ortholog for AKR7A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR7A3 Gene

ENSEMBL:
Gene Tree for AKR7A3 (if available)
TreeFam:
Gene Tree for AKR7A3 (if available)

Paralogs for AKR7A3 Gene

Paralogs for AKR7A3 Gene

(2) SIMAP similar genes for AKR7A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKR7A3: view

Variants for AKR7A3 Gene

Sequence variations from dbSNP and Humsavar for AKR7A3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000234503 -- 19,288,888(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000681625 -- 19,288,090(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000859018 -- 19,284,421(-) C/T intron_variant
rs1001689945 -- 19,284,886(-) C/A intron_variant
rs1001753417 -- 19,280,353(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AKR7A3 Gene

Variant ID Type Subtype PubMed ID
dgv25e199 CNV deletion 23128226
esv26443 CNV loss 19812545
esv3552788 CNV deletion 23714750
esv3585392 CNV loss 21293372
esv3585393 CNV loss 21293372
nsv945807 CNV duplication 23825009

Variation tolerance for AKR7A3 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.08; 96.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR7A3 Gene

Human Gene Mutation Database (HGMD)
AKR7A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR7A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR7A3 Gene

Disorders for AKR7A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AKR7A3 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AKR7A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AKR7A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR7A3 Gene

Publications for AKR7A3 Gene

  1. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. (PMID: 10383892) Knight LP … Sutter TR (Carcinogenesis 1999) 2 3 4 22 58
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  3. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. (PMID: 18416522) Bodreddigari S … Sutter TR (Chemical research in toxicology 2008) 4 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for AKR7A3 Gene

Sources for AKR7A3 Gene

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