Aliases for AKR7A2 Gene
External Ids for AKR7A2 Gene
Previous GeneCards Identifiers for AKR7A2 Gene
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for AKR7A2 Gene
AKR7A2 (Aldo-Keto Reductase Family 7 Member A2) is a Protein Coding gene. Diseases associated with AKR7A2 include Gamma-Amino Butyric Acid Metabolism Disorder and Succinic Semialdehyde Dehydrogenase Deficiency. Among its related pathways are Drug metabolism - cytochrome P450 and Naphthalene metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and phenanthrene-9,10-epoxide hydrolase activity. An important paralog of this gene is AKR7L.
UniProtKB/Swiss-Prot Summary for AKR7A2 Gene
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.