Aliases for AKR1E2 Gene
External Ids for AKR1E2 Gene
Previous HGNC Symbols for AKR1E2 Gene
The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for AKR1E2 Gene
AKR1E2 (Aldo-Keto Reductase Family 1 Member E2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 1,5-anhydro-D-fructose reductase activity. An important paralog of this gene is AKR1B1.
UniProtKB/Swiss-Prot Summary for AKR1E2 Gene
Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078).