Aliases for AKR1C8P Gene

Aliases for AKR1C8P Gene

  • Aldo-Keto Reductase Family 1 Member C8, Pseudogene 2 3 5
  • Aldo-Keto Reductase Family 1, Member C-Like 1 2 3
  • AKR1CL1 3 4
  • Aldo-Keto Reductase Family 1 Member C-Like Protein 1 4
  • Putative Aldo-Keto Reductase Family 1 Member C8 4
  • Protein RAKc 3
  • EC 1.1.1.- 4
  • AKR1C8P 5

External Ids for AKR1C8P Gene

Previous HGNC Symbols for AKR1C8P Gene

  • AKR1CL1

Summaries for AKR1C8P Gene

GeneCards Summary for AKR1C8P Gene

AKR1C8P (Aldo-Keto Reductase Family 1 Member C8, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR1C1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR1C8P Gene

Genomics for AKR1C8P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AKR1C8P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J005185 Enhancer 0.2 Ensembl 250.7 -0.5 -514 0.2 AKR1C8P lnc-AKR1C2-11 AKR1C4 AKR1C3
GH10J005093 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 17.1 +89.3 89286 4.6 SSRP1 CEBPA NFIC YY1 MXD4 CEBPB REST KLF11 HOMEZ CTCF AKR1C3 AKR1C8P RBM17 ENSG00000239142 HSALNG0075830 AKR1C4
GH10J005146 Enhancer 1.1 Ensembl ENCODE 18.1 +37.3 37273 2.5 SSRP1 CEBPA ATF3 CHD4 YY1 MXD4 FOXA1 KLF11 HOMEZ ZNF217 AKR1C8P AKR1C4 ARL4AP3 UCN3 AKR1C3 AKR1C5P lnc-AKR1C2-2 piR-41525-041 HSALNG0075840
GH10J005089 Enhancer 0.6 ENCODE 17.9 +95.2 95153 0.2 HOMEZ CTCF FOXA2 CTBP1 RAD21 FOXA1 DPF2 NFIB ZNF644 SMC3 AKR1C8P ENSG00000239142 FJ601684-034 HSALNG0075830 AKR1C3 AKR1C4
GH10J005234 Enhancer 1 Ensembl ENCODE 4.9 -49.4 -49414 2.4 SSRP1 CEBPA YY1 CEBPB HOMEZ THAP11 FOXA2 MAFF SMAD4 RXRA ENSG00000231039 piR-59297-034 LINC02561 UCN3 TUBAL3 AKR1C8P lnc-AKR1C4-3 AKR1C4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR1C8P on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for AKR1C8P Gene

Latest Assembly
chr10:5,154,140-5,185,187
(GRCh38/hg38)
Size:
31,048 bases
Orientation:
Minus strand

Previous Assembly
chr10:5,196,655-5,227,150
(GRCh37/hg19 by Entrez Gene)
Size:
30,496 bases
Orientation:
Minus strand

Genomic View for AKR1C8P Gene

Genes around AKR1C8P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1C8P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1C8P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1C8P Gene

Proteins for AKR1C8P Gene

  • Protein details for AKR1C8P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2L2-AKCL1_HUMAN
    Recommended name:
    Putative aldo-keto reductase family 1 member C8
    Protein Accession:
    Q5T2L2
    Secondary Accessions:
    • A6NF66
    • Q6ZN81

    Protein attributes for AKR1C8P Gene

    Size:
    129 amino acids
    Molecular mass:
    14588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AKR1C8P Gene

Post-translational modifications for AKR1C8P Gene

No Post-translational modifications

Other Protein References for AKR1C8P Gene

No data available for DME Specific Peptides for AKR1C8P Gene

Domains & Families for AKR1C8P Gene

Gene Families for AKR1C8P Gene

Suggested Antigen Peptide Sequences for AKR1C8P Gene

GenScript: Design optimal peptide antigens:
  • Aldo-keto reductase family 1 member C-like protein 1 (AKCL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T2L2

UniProtKB/Swiss-Prot:

AKCL1_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1C8P: view

Function for AKR1C8P Gene

Enzyme Numbers (IUBMB) for AKR1C8P Gene

Phenotypes From GWAS Catalog for AKR1C8P Gene

Gene Ontology (GO) - Molecular Function for AKR1C8P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity IEA --
GO:0005515 protein binding IPI 32814053
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR1C8P: view
genes like me logo Genes that share phenotypes with AKR1C8P: view

Animal Models for research

CRISPR products for research

miRNA for AKR1C8P Gene

miRTarBase miRNAs that target AKR1C8P

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1C8P

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKR1C8P Gene

Localization for AKR1C8P Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1C8P Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for AKR1C8P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AKR1C8P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for AKR1C8P Gene

Pathways & Interactions for AKR1C8P Gene

PathCards logo

SuperPathways for AKR1C8P Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKR1C8P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR1C8P: view

No data available for Pathways by source and SIGNOR curated interactions for AKR1C8P Gene

Drugs & Compounds for AKR1C8P Gene

No Compound Related Data Available

Transcripts for AKR1C8P Gene

mRNA/cDNA for AKR1C8P Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1C8P

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1C8P Gene

No ASD Table

Relevant External Links for AKR1C8P Gene

GeneLoc Exon Structure for
AKR1C8P

Expression for AKR1C8P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR1C8P Gene

Protein differential expression in normal tissues from HIPED for AKR1C8P Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKR1C8P Gene



Protein tissue co-expression partners for AKR1C8P Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR1C8P

genes like me logo Genes that share expression patterns with AKR1C8P: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1C8P Gene

Orthologs for AKR1C8P Gene

Evolution for AKR1C8P Gene

ENSEMBL:
Gene Tree for AKR1C8P (if available)
TreeFam:
Gene Tree for AKR1C8P (if available)
Alliance of Genome Resources:
Additional Orthologs for AKR1C8P

No data available for Orthologs for AKR1C8P Gene

Paralogs for AKR1C8P Gene

genes like me logo Genes that share paralogs with AKR1C8P: view

Variants for AKR1C8P Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR1C8P Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs7097295 -- p.Arg50His

Structural Variations from Database of Genomic Variants (DGV) for AKR1C8P Gene

Variant ID Type Subtype PubMed ID
dgv172e212 CNV loss 25503493
dgv350n106 CNV deletion 24896259
esv1007439 CNV deletion 20482838
esv1074345 CNV insertion 17803354
esv1314667 CNV insertion 17803354
esv2484274 CNV insertion 19546169
esv2731707 CNV deletion 23290073
esv2763913 CNV gain+loss 21179565
esv2865791 CNV insertion 24192839
esv3351321 CNV duplication 20981092
esv3622221 CNV loss 21293372
esv3622222 CNV gain 21293372
esv3622223 CNV gain 21293372
esv3622224 CNV gain 21293372
esv3622225 CNV loss 21293372
esv4943 CNV loss 18987735
esv988429 CNV insertion 20482838
nsv1036566 CNV loss 25217958
nsv1039386 CNV gain 25217958
nsv1045155 CNV loss 25217958
nsv1048081 CNV loss 25217958
nsv1050246 CNV gain 25217958
nsv1069010 CNV deletion 25765185
nsv1069447 CNV deletion 25765185
nsv1115385 CNV duplication 24896259
nsv1122484 CNV deletion 24896259
nsv1149325 CNV deletion 26484159
nsv549881 CNV loss 21841781
nsv549882 CNV loss 21841781
nsv549883 CNV loss 21841781
nsv549886 CNV loss 21841781

Variation tolerance for AKR1C8P Gene

Gene Damage Index Score: 7.10; 80.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR1C8P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1C8P
Leiden Open Variation Database (LOVD)
AKR1C8P

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for AKR1C8P Gene

Disorders for AKR1C8P Gene

Additional Disease Information for AKR1C8P

No disorders were found for AKR1C8P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR1C8P Gene

Publications for AKR1C8P Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 2 3 4
  2. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  3. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. (PMID: 31391242) Nowak M … Sommer T (Journal of cell science 2019) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for AKR1C8P Gene

Sources for AKR1C8P Gene