This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostag... See more...

Aliases for AKR1C3 Gene

Aliases for AKR1C3 Gene

  • Aldo-Keto Reductase Family 1 Member C3 2 3 4 5
  • Prostaglandin F Synthase 2 3 4
  • Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase 3 4
  • 3-Alpha Hydroxysteroid Dehydrogenase, Type II 2 3
  • Testosterone 17-Beta-Dehydrogenase 5 3 4
  • Chlordecone Reductase Homolog HAKRb 3 4
  • Dihydrodiol Dehydrogenase 3 3 4
  • Dihydrodiol Dehydrogenase X 2 3
  • 3-Alpha-HSD Type II, Brain 3 4
  • Indanol Dehydrogenase 3 4
  • HSD17B5 3 4
  • HA1753 3 4
  • PGFS 3 4
  • DD3 3 4
  • Aldo-Keto Reductase Family 1, Member C3 (3-Alpha Hydroxysteroid Dehydrogenase, Type II) 2
  • Type IIb 3-Alpha Hydroxysteroid Dehydrogenase 3
  • 17-Beta-Hydroxysteroid Dehydrogenase Type 5 4
  • 3-Alpha-Hydroxysteroid Dehydrogenase Type 2 4
  • Hydroxysteroid (17-Beta) Dehydrogenase 5 2
  • Dihydrodiol Dehydrogenase Type I 4
  • 3-Alpha-HSD Type 2 4
  • 17-Beta-HSD 5 4
  • EC 1.1.1.357 4
  • EC 1.1.1.112 4
  • EC 1.1.1.188 4
  • EC 1.1.1.239 4
  • EC 1.1.1.64 4
  • EC 1.3.1.20 4
  • EC 1.-.-.- 4
  • KIAA0119 4
  • EC 1.1.1 52
  • HluPGFS 3
  • HAKRB 3
  • HAKRe 3
  • DD-3 4
  • DDH1 4
  • DDX 3

External Ids for AKR1C3 Gene

Previous HGNC Symbols for AKR1C3 Gene

  • HSD17B5

Previous GeneCards Identifiers for AKR1C3 Gene

  • GC10P005184
  • GC10P005090
  • GC10P005126
  • GC10P005077

Summaries for AKR1C3 Gene

Entrez Gene Summary for AKR1C3 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for AKR1C3 Gene

AKR1C3 (Aldo-Keto Reductase Family 1 Member C3) is a Protein Coding gene. Diseases associated with AKR1C3 include Prostate Disease and Endometrial Cancer. Among its related pathways are Signaling by Retinoic Acid and Naphthalene metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and aldo-keto reductase (NADP) activity. An important paralog of this gene is AKR1C1.

UniProtKB/Swiss-Prot Summary for AKR1C3 Gene

  • Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Gene Wiki entry for AKR1C3 Gene

Additional gene information for AKR1C3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR1C3 Gene

Genomics for AKR1C3 Gene

GeneHancer (GH) Regulatory Elements for AKR1C3 Gene

Promoters and enhancers for AKR1C3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J005093 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 506 +60.2 60246 4 CTCF TCF12 POLR2G POLR2A TRIM28 REST ZBTB25 TGIF2 CTBP1 TEAD1 AKR1C3 AKR1C8P RBM17 ENSG00000239142 piR-46002-034
GH10J005032 Enhancer 0.8 Ensembl ENCODE 516.5 -1.8 -1753 2 FOS EP300 ZNF316 TRIM24 FOSL2 CEBPB JUN RCOR1 NFE2 NR3C1 AKR1C3 piR-58297-034 AKR1C2
GH10J005035 Promoter 0.4 EPDnew 506.4 0.0 -31 0.1 SETDB1 AKR1C3 piR-42687-001 piR-58297-034
GH10J005036 Enhancer 0.2 Ensembl 517.7 +0.1 147 0.2 AKR1C3 piR-42687-001
GH10J005017 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16 -14.7 -14653 6.6 TCF12 EP300 CTBP1 TEAD1 CTCF NCOR1 ZNF316 NFIC MAFF TRIM24 AKR1C2 AKR1C3 ENSG00000239142 UCN3 AKR1C1 lnc-AKR1C2-6 piR-58297-034
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR1C3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKR1C3

Top Transcription factor binding sites by QIAGEN in the AKR1C3 gene promoter:
  • Cart-1
  • GATA-1
  • HNF-1
  • HNF-1A
  • MRF-2
  • p53
  • Sp1

Genomic Locations for AKR1C3 Gene

Genomic Locations for AKR1C3 Gene
chr10:5,035,354-5,107,686
(GRCh38/hg38)
Size:
72,333 bases
Orientation:
Plus strand
chr10:5,077,546-5,149,878
(GRCh37/hg19)
Size:
72,333 bases
Orientation:
Plus strand

Genomic View for AKR1C3 Gene

Genes around AKR1C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1C3 Gene

Proteins for AKR1C3 Gene

  • Protein details for AKR1C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42330-AK1C3_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member C3
    Protein Accession:
    P42330
    Secondary Accessions:
    • A8K2V0
    • B4DL37
    • Q5T2L1
    • Q96DJ1
    • Q96KI8
    • Q99530
    • Q9UCX1
    • Q9UII3
    • Q9UKL9

    Protein attributes for AKR1C3 Gene

    Size:
    323 amino acids
    Molecular mass:
    36853 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04619.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKR1C3 Gene

    Alternative splice isoforms for AKR1C3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR1C3 Gene

Selected DME Specific Peptides for AKR1C3 Gene

P42330:
  • KSIGVSNFN
  • EKCKDAGL

Post-translational modifications for AKR1C3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1C3 Gene

Assay Products

  • Boster Bio ELISA Kits for AKR1C3
  • Signalway ELISA kits for AKR1C3

Domains & Families for AKR1C3 Gene

Gene Families for AKR1C3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for AKR1C3 Gene

Suggested Antigen Peptide Sequences for AKR1C3 Gene

GenScript: Design optimal peptide antigens:
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (AK1C3_HUMAN)
  • cDNA FLJ57019, highly similar to Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (B4DL37_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42330

UniProtKB/Swiss-Prot:

AK1C3_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1C3: view

Function for AKR1C3 Gene

Molecular function for AKR1C3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + trans-1,2-dihydrobenzene-1,2-diol = catechol + H(+) + NADPH; Xref=Rhea:RHEA:16729, ChEBI:CHEBI:15378, ChEBI:CHEBI:16740, ChEBI:CHEBI:18135, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.20;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34783, ChEBI:CHEBI:15378, ChEBI:CHEBI:36835, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.357; Evidence={ECO:0000269 PubMed:10622721, ECO:0000269 PubMed:11165022, ECO:0000269 PubMed:7650035, ECO:0000269 PubMed:9415401, ECO:0000269 PubMed:9927279};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH; Xref=Rhea:RHEA:34779, ChEBI:CHEBI:15378, ChEBI:CHEBI:36835, ChEBI:CHEBI:47788, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.357; Evidence={ECO:0000269 PubMed:10622721, ECO:0000269 PubMed:11165022, ECO:0000269 PubMed:7650035, ECO:0000269 PubMed:9415401, ECO:0000269 PubMed:9927279};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2; Xref=Rhea:RHEA:10140, ChEBI:CHEBI:15378, ChEBI:CHEBI:57404, ChEBI:CHEBI:57406, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.188; Evidence={ECO:0000269 PubMed:10622721, ECO:0000269 PubMed:11165022, ECO:0000269 PubMed:7650035, ECO:0000269 PubMed:9415401, ECO:0000269 PubMed:9927279};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH; Xref=Rhea:RHEA:14929, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.239; Evidence={ECO:0000269 PubMed:10622721, ECO:0000269 PubMed:11165022, ECO:0000269 PubMed:7650035, ECO:0000269 PubMed:9415401, ECO:0000269 PubMed:9927279};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:14981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.64; Evidence={ECO:0000269 PubMed:10622721, ECO:0000269 PubMed:11165022, ECO:0000269 PubMed:7650035, ECO:0000269 PubMed:9415401, ECO:0000269 PubMed:9927279};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH; Xref=Rhea:RHEA:16317, ChEBI:CHEBI:15378, ChEBI:CHEBI:16697, ChEBI:CHEBI:17404, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.112;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH; Xref=Rhea:RHEA:16321, ChEBI:CHEBI:15378, ChEBI:CHEBI:16697, ChEBI:CHEBI:17404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.112;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. Also inhibited by the flavinoid, rutin, and by selective serotonin inhibitors (SSRIs).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=142.1 uM for progesterone {ECO:0000269 PubMed:10557352}; KM=2.37 uM for 5-alpha-dihydrotestosterone {ECO:0000269 PubMed:10557352}; KM=1.0 uM for androstanediol {ECO:0000269 PubMed:10557352}; Vmax=20.1 nmol/min/mg enzyme with progesterone as substrate {ECO:0000269 PubMed:10557352}; Vmax=1.8 nmol/min/mg enzyme with 5-alpha-dihydrotestosterone as substrate {ECO:0000269 PubMed:10557352}; Vmax=4.4 nmol/min/mg enzyme with androstanediol as substrate {ECO:0000269 PubMed:10557352};
GENATLAS Biochemistry:
aldo-keto reductase family 1,member C3 (3-alpha hydroxysteroid dehydrogenase,type II),with low affinity for dihydrotestosterone,expressed in brain,kidney,liver,placenta,testis

Phenotypes From GWAS Catalog for AKR1C3 Gene

Gene Ontology (GO) - Molecular Function for AKR1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001758 retinal dehydrogenase activity IDA 21851338
GO:0004032 alditol:NADP+ 1-oxidoreductase activity IDA 21232532
GO:0004033 aldo-keto reductase (NADP) activity TAS 9792917
GO:0004745 retinol dehydrogenase activity IDA 21851338
GO:0008106 alcohol dehydrogenase (NADP+) activity IBA 21873635
genes like me logo Genes that share ontologies with AKR1C3: view
genes like me logo Genes that share phenotypes with AKR1C3: view

Animal Models for AKR1C3 Gene

MGI Knock Outs for AKR1C3:

Animal Model Products

CRISPR Products

miRNA for AKR1C3 Gene

miRTarBase miRNAs that target AKR1C3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1C3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKR1C3 Gene

Localization for AKR1C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1C3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1C3 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKR1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA 18574251
GO:0005737 cytoplasm IEA,IDA 18574251
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with AKR1C3: view

Pathways & Interactions for AKR1C3 Gene

genes like me logo Genes that share pathways with AKR1C3: view

SIGNOR curated interactions for AKR1C3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for AKR1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006693 prostaglandin metabolic process IBA,TAS 9792917
GO:0007186 G protein-coupled receptor signaling pathway IDA 18508192
GO:0007584 response to nutrient IEP 19007764
GO:0008202 steroid metabolic process IBA,IEP 20036328
genes like me logo Genes that share ontologies with AKR1C3: view

Drugs & Compounds for AKR1C3 Gene

(32) Drugs for AKR1C3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 2036
Rutin Approved, Experimental, Investigational Pharma Target 13
NADH Approved Nutra Target 0
Flufenamic acid Approved Pharma Channel blocker, Inhibitor, Pore Blocker, Antagonist, Target Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6 1
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, Full agonist, Inhibition, Inhibitor, Target, inhibitor Cox inhibitor 142

(32) Additional Compounds for AKR1C3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11b-PGF2a
  • 11-Epi-PGF2a
  • 11-Epi-PGF2alpha
  • 11-Epi-prostaglandin F2a
  • 11beta-PGF2alpha
  • 11beta-Prostaglandin F2alpha
11-Epi-PGF2a
  • 11-Epi-PGF2alpha
  • 11-Epi-prostaglandin F2a
  • 11-Epi-prostaglandin F2alpha
5alpha-Dihydrodeoxycorticosterone
  • 5alpha-Pregnan-21-ol-3,20-dione
  • Allopregnane-21-ol-3,20-dione
  • 5a-Pregnan-21-ol-3,20-dione
  • 5α-pregnan-21-ol-3,20-dione
  • 5a-Dihydrodeoxycorticosterone
5alpha-Pregnan-20alpha-ol-3-one
  • Allopregnan-20alpha-ol-3-one
  • Allopregnan-20a-ol-3-one
  • Allopregnan-20α-ol-3-one
  • 5a-Pregnan-20a-ol-3-one
  • 5α-pregnan-20α-ol-3-one
genes like me logo Genes that share compounds with AKR1C3: view

Transcripts for AKR1C3 Gene

mRNA/cDNA for AKR1C3 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1C3

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1C3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for AKR1C3 Gene

GeneLoc Exon Structure for
AKR1C3

Expression for AKR1C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR1C3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKR1C3 Gene

This gene is overexpressed in Liver (x6.6) and Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for AKR1C3 Gene

This gene is overexpressed in Liver, secretome (35.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR1C3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR1C3

SOURCE GeneReport for Unigene cluster for AKR1C3 Gene:

Hs.78183

mRNA Expression by UniProt/SwissProt for AKR1C3 Gene:

P42330-AK1C3_HUMAN
Tissue specificity: Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.

Evidence on tissue expression from TISSUES for AKR1C3 Gene

  • Liver(4.9)
  • Lung(4.9)
  • Intestine(4.6)
  • Nervous system(4.4)
  • Bone marrow(4.3)
  • Blood(2.6)
  • Kidney(2.5)
  • Adrenal gland(2.2)
  • Gall bladder(2.1)
  • Stomach(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with AKR1C3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1C3 Gene

Orthologs for AKR1C3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR1C3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1C3 31 30
  • 99.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AKR1C4 31 30
  • 81.53 (n)
ManyToMany
BT.63212 31
  • 78 (a)
ManyToMany
-- 31
  • 77 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
20ALPHA-HSD 31
  • 76 (a)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
-- 31
  • 74 (a)
ManyToMany
-- 31
  • 74 (a)
ManyToMany
-- 31
  • 74 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Akr1c18 17 31 30
  • 79.46 (n)
Akr1c20 31
  • 76 (a)
ManyToMany
Akr1c6 31
  • 76 (a)
ManyToMany
Akr1c21 31
  • 72 (a)
ManyToMany
Akr1c19 31
  • 72 (a)
ManyToMany
Akr1cl 31
  • 71 (a)
ManyToMany
Akr1c14 31
  • 69 (a)
ManyToMany
Akr1c12 31
  • 67 (a)
ManyToMany
Akr1c13 31
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Akr1c3 30
  • 78.64 (n)
dog
(Canis familiaris)
Mammalia AKR1C3 31 30
  • 72.2 (n)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 32
  • 50 (a)
CG12766 32
  • 42 (a)
CG6083 32
  • 42 (a)
CG10638 32
  • 42 (a)
CG9436 32
  • 40 (a)
BcDNA:GH10614 32
  • 40 (a)
CG2767 32
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39G8B.1b 32
  • 40 (a)
Y39G8B.1a 32
  • 40 (a)
C07D8.6 32
  • 37 (a)
T08H10.1 32
  • 37 (a)
F53F1.2 32
  • 34 (a)
ZC443.1 32
  • 34 (a)
Y39G8B.2 32
  • 33 (a)
F53F1.3 32
  • 33 (a)
C01G5.5 32
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 33
Species where no ortholog for AKR1C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AKR1C3 Gene

ENSEMBL:
Gene Tree for AKR1C3 (if available)
TreeFam:
Gene Tree for AKR1C3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKR1C3: view image

Paralogs for AKR1C3 Gene

(11) SIMAP similar genes for AKR1C3 Gene using alignment to 4 proteins:

  • AK1C3_HUMAN
  • B4DL37_HUMAN
  • S4R3D5_HUMAN
  • S4R3Z2_HUMAN
genes like me logo Genes that share paralogs with AKR1C3: view

Variants for AKR1C3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR1C3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
716665 Likely Benign: not provided 5,102,114(+) C/T MISSENSE_VARIANT
731234 Benign: not provided 5,098,866(+) G/A MISSENSE_VARIANT
771431 Benign: not provided 5,102,126(+) G/A MISSENSE_VARIANT
779103 Benign: not provided 5,099,338(+) G/A SYNONYMOUS_VARIANT
783568 Benign: not provided 5,096,522(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AKR1C3 Gene

Structural Variations from Database of Genomic Variants (DGV) for AKR1C3 Gene

Variant ID Type Subtype PubMed ID
esv2668683 CNV deletion 23128226
esv2763913 CNV gain+loss 21179565
esv3622214 CNV loss 21293372
esv3622219 CNV loss 21293372
esv3622220 CNV loss 21293372
esv3622221 CNV loss 21293372
esv3622222 CNV gain 21293372
esv3891742 CNV loss 25118596
nsv1036566 CNV loss 25217958
nsv1039386 CNV gain 25217958
nsv1045155 CNV loss 25217958
nsv1047686 CNV loss 25217958
nsv1048081 CNV loss 25217958
nsv1050246 CNV gain 25217958
nsv1161924 CNV duplication 26073780
nsv466714 CNV loss 19166990
nsv549881 CNV loss 21841781
nsv549882 CNV loss 21841781
nsv549883 CNV loss 21841781
nsv549885 CNV loss 21841781
nsv831773 CNV loss 17160897
nsv947728 CNV duplication 23825009

Variation tolerance for AKR1C3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR1C3 Gene

Human Gene Mutation Database (HGMD)
AKR1C3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1C3 Gene

Disorders for AKR1C3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for AKR1C3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate disease
  • prostate diseases
endometrial cancer
  • endometrial cancer, familial
skin squamous cell carcinoma
  • epidermoid skin carcinoma
prostate cancer
  • prostate cancer, somatic
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AKR1C3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AKR1C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR1C3 Gene

Publications for AKR1C3 Gene

  1. Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk. (PMID: 19846565) Reding KW … Malone KE (American journal of epidemiology 2009) 3 23 41 54
  2. Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer. (PMID: 19460435) Plourde M … Simard J (The Journal of steroid biochemistry and molecular biology 2009) 3 23 41 54
  3. Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia. (PMID: 18339682) Liu CY … Kaohsiung Leukemia Research Group (Carcinogenesis 2008) 3 23 41 54
  4. Nonreplication of the type 5 17beta-hydroxysteroid dehydrogenase gene association with polycystic ovary syndrome. (PMID: 17940109) Goodarzi MO … Azziz R (The Journal of clinical endocrinology and metabolism 2008) 3 23 41 54
  5. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. (PMID: 17149600) Lan Q … Chanock S (Human genetics 2007) 3 23 41 54

Products for AKR1C3 Gene

Sources for AKR1C3 Gene