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Aliases for AKR1B15 Gene

Aliases for AKR1B15 Gene

  • Aldo-Keto Reductase Family 1 Member B15 2 3 5
  • Estradiol 17-Beta-Dehydrogenase AKR1B15 3 4
  • Putative Aldo-Keto Reductase Family 1 Member B15 3
  • AKR1B10L, AK1R1B7 3
  • EC 1.1.1.62 4
  • EC 1.1.1.- 4
  • AKR1B10L 3
  • AKR1R1B7 3

External Ids for AKR1B15 Gene

Previous GeneCards Identifiers for AKR1B15 Gene

  • GC07P133902
  • GC07P134233
  • GC07P128535

Summaries for AKR1B15 Gene

GeneCards Summary for AKR1B15 Gene

AKR1B15 (Aldo-Keto Reductase Family 1 Member B15) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of steroid hormones. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is AKR1B10.

UniProtKB/Swiss-Prot for AKR1B15 Gene

  • Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493).

  • Isoform 2: No oxidoreductase activity observed with the tested substrates.

Additional gene information for AKR1B15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1B15 Gene

Genomics for AKR1B15 Gene

GeneHancer (GH) Regulatory Elements for AKR1B15 Gene

Promoters and enhancers for AKR1B15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I134546 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 562.8 +1.8 1782 2.7 PKNOX1 ATF1 ARNT SIN3A ZNF2 IRF4 ZNF213 ZNF143 ATF7 KLF7 AKR1B15 GC07M134551 PIR33165 LOC105375520
GH07I134554 Promoter/Enhancer 1.1 EPDnew dbSUPER 550.4 +8.0 8044 0.1 SCRT1 CTCF LEF1 RFX1 ZNF644 RAD21 FOXA1 SCRT2 TCF7 TCF7L2 AKR1B15 PIR31593 LOC105375520
GH07I134457 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.3 -87.4 -87367 2.8 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 IRF4 ZNF213 ZNF143 KLF13 DEK AKR1B1 AKR1B15 WDR91 LOC105375519
GH07I134527 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 27.3 -18.3 -18319 1.7 FOXA2 SIN3A YY1 ZNF366 FOS SP5 ELF1 SREBF1 SP1 NFIL3 AKR1B10 AKR1B15 AKR1B1
GH07I134447 Enhancer 1.3 Ensembl ENCODE dbSUPER 33.2 -95.1 -95073 8.1 HDAC1 ATF1 ARNT NFRKB SIN3A TCF12 SCRT2 FOS CREM ZBTB2 AKR1B15 AKR1B1 LOC105375519
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AKR1B15 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AKR1B15 Gene

Genomic Locations for AKR1B15 Gene
chr7:134,546,245-134,579,875
(GRCh38/hg38)
Size:
33,631 bases
Orientation:
Plus strand
chr7:134,233,849-134,264,627
(GRCh37/hg19)

Genomic View for AKR1B15 Gene

Genes around AKR1B15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1B15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1B15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1B15 Gene

Proteins for AKR1B15 Gene

  • Protein details for AKR1B15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JRZ8-AK1BF_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member B15
    Protein Accession:
    C9JRZ8
    Secondary Accessions:
    • C9J3V2

    Protein attributes for AKR1B15 Gene

    Size:
    316 amino acids
    Molecular mass:
    36537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKR1B15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR1B15 Gene

Post-translational modifications for AKR1B15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1B15 Gene

No data available for DME Specific Peptides for AKR1B15 Gene

Domains & Families for AKR1B15 Gene

Gene Families for AKR1B15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AKR1B15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JRZ8

UniProtKB/Swiss-Prot:

AK1BF_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1B15: view

Function for AKR1B15 Gene

Molecular function for AKR1B15 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.8 uM for androsterone (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=1.9 uM for delta-4-androstenedione (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=2.5 uM for estrone (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=63.4 uM for acetoacetyl-CoA (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=19.2 uM for 3-alpha,17-beta-androstandiol (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=7.1 uM for testosterone (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=9.1 uM for 17-beta-estradiol (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; Note=kcat is 1.7 min(-1) using isoform 1 for the reduction of androsterone. kcat is 1.1 min(-1) using isoform 1 for the reduction of delta-4-androstenedione. kcat is 1.0 min(-1) using isoform 1 for the reduction of estrone. kcat is 0.5 min(-1) using isoform 1 for the reduction of acetoacetyl-CoA. kcat is 3.0 min(-1) using isoform 1 for the oxidation of 3-alpha,17- beta-androstandiol. kcat is 0.6 min(-1) using isoform 1 for the oxidation of testosterone. kcat is 0.5 min(-1) using isoform 1 for the oxidation of 17-beta-estradiol. {ECO:0000269 PubMed:25577493};
UniProtKB/Swiss-Prot CatalyticActivity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493).
UniProtKB/Swiss-Prot Function:
Isoform 2: No oxidoreductase activity observed with the tested substrates.

Enzyme Numbers (IUBMB) for AKR1B15 Gene

Phenotypes From GWAS Catalog for AKR1B15 Gene

Gene Ontology (GO) - Molecular Function for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004303 estradiol 17-beta-dehydrogenase activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

Phenotypes for AKR1B15 Gene

GenomeRNAi human phenotypes for AKR1B15:
genes like me logo Genes that share phenotypes with AKR1B15: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR1B15 Gene

Localization for AKR1B15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1B15 Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1B15 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

Pathways & Interactions for AKR1B15 Gene

genes like me logo Genes that share pathways with AKR1B15: view

Pathways by source for AKR1B15 Gene

Gene Ontology (GO) - Biological Process for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006703 estrogen biosynthetic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

No data available for SIGNOR curated interactions for AKR1B15 Gene

Drugs & Compounds for AKR1B15 Gene

No Compound Related Data Available

Transcripts for AKR1B15 Gene

mRNA/cDNA for AKR1B15 Gene

Unigene Clusters for AKR1B15 Gene

Aldo-keto reductase family 1, member B15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B15 Gene

No ASD Table

Relevant External Links for AKR1B15 Gene

GeneLoc Exon Structure for
AKR1B15
ECgene alternative splicing isoforms for
AKR1B15

Expression for AKR1B15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKR1B15 Gene

mRNA differential expression in normal tissues according to GTEx for AKR1B15 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1), Stomach (x8.9), Esophagus - Mucosa (x6.4), and Vagina (x4.7).

Protein differential expression in normal tissues from HIPED for AKR1B15 Gene

This gene is overexpressed in Lung (26.7), Urine (23.4), and Saliva (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AKR1B15 Gene



Protein tissue co-expression partners for AKR1B15 Gene

NURSA nuclear receptor signaling pathways regulating expression of AKR1B15 Gene:

AKR1B15

SOURCE GeneReport for Unigene cluster for AKR1B15 Gene:

Hs.729418

mRNA Expression by UniProt/SwissProt for AKR1B15 Gene:

C9JRZ8-AK1BF_HUMAN
Tissue specificity: Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.

Evidence on tissue expression from TISSUES for AKR1B15 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with AKR1B15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1B15 Gene

Orthologs for AKR1B15 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKR1B15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1B15 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akr1b10 34
  • 76 (a)
ManyToMany
Akr1b8 34
  • 75 (a)
ManyToMany
Akr1b7 34
  • 72 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-180p18.9 34
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 34
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for AKR1B15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR1B15 Gene

ENSEMBL:
Gene Tree for AKR1B15 (if available)
TreeFam:
Gene Tree for AKR1B15 (if available)

Paralogs for AKR1B15 Gene

Paralogs for AKR1B15 Gene

(11) SIMAP similar genes for AKR1B15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKR1B15: view

Variants for AKR1B15 Gene

Sequence variations from dbSNP and Humsavar for AKR1B15 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000158376 -- 134,563,413(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000469036 -- 134,561,671(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000507347 -- 134,551,708(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000525326 -- 134,571,216(+) G/A intron_variant
rs1000623721 -- 134,566,383(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1B15 Gene

Variant ID Type Subtype PubMed ID
dgv1240e199 CNV deletion 23128226
dgv430n21 CNV loss 19592680
dgv6636n100 CNV loss 25217958
esv26694 CNV loss 19812545
esv2669756 CNV deletion 23128226
esv2735180 CNV deletion 23290073
esv27674 CNV gain 19812545
esv3443026 CNV duplication 20981092
esv3615097 CNV loss 21293372
nsv1020141 CNV gain 25217958
nsv1026859 CNV loss 25217958
nsv1031083 CNV loss 25217958
nsv981584 CNV duplication 23825009

Variation tolerance for AKR1B15 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR1B15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1B15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1B15 Gene

Disorders for AKR1B15 Gene

Additional Disease Information for AKR1B15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AKR1B15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR1B15 Gene

Publications for AKR1B15 Gene

  1. Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. (PMID: 25577493) Weber S … Barski OA (The Journal of biological chemistry 2015) 3 4 58
  2. Functional expression of novel human and murine AKR1B genes. (PMID: 21276782) Salabei JK … Barski OA (Chemico-biological interactions 2011) 3 4 58
  3. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for AKR1B15 Gene

Sources for AKR1B15 Gene

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