Aliases for AKR1B15 Gene

Aliases for AKR1B15 Gene

  • Aldo-Keto Reductase Family 1 Member B15 2 3 4 5
  • Estradiol 17-Beta-Dehydrogenase AKR1B15 3 4
  • Testosterone 17beta-Dehydrogenase 3 4
  • Farnesol Dehydrogenase 3 4
  • Putative Aldo-Keto Reductase Family 1 Member B15 3
  • AKR1B10L, AK1R1B7 3
  • EC 1.1.1.300 4
  • EC 1.1.1.216 4
  • EC 1.1.1.54 4
  • EC 1.1.1.64 4
  • EC 1.1.1.- 4
  • AKR1B10L 3
  • AKR1R1B7 3

External Ids for AKR1B15 Gene

Previous GeneCards Identifiers for AKR1B15 Gene

  • GC07P133902
  • GC07P134233
  • GC07P128535

Summaries for AKR1B15 Gene

GeneCards Summary for AKR1B15 Gene

AKR1B15 (Aldo-Keto Reductase Family 1 Member B15) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of steroid hormones. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is AKR1B10.

UniProtKB/Swiss-Prot Summary for AKR1B15 Gene

  • [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).
  • [Isoform 2]: No oxidoreductase activity observed with the tested substrates.

Additional gene information for AKR1B15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR1B15 Gene

Genomics for AKR1B15 Gene

GeneHancer (GH) Regulatory Elements for AKR1B15 Gene

Promoters and enhancers for AKR1B15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J134546 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 512.7 +1.8 1779 2.7 CTCF ZSCAN5C TCF12 SIX5 TRIM28 REST KLF4 HES1 CUX1 RELA AKR1B15 RF02002-042 LOC105375520 RF00017-6652
GH07J134527 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 48.3 -17.3 -17299 3.7 TCF12 POLR2G ZNF316 FOXA2 MAFF SAP130 FOSL2 RFX5 MAFK NFE2 AKR1B10 AKR1B15 AKR1B1 NONHSAG048859.2 RF00017-6652
GH07J134457 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 33.3 -87.4 -87396 2.9 ZBTB40 EP300 CTCF ZSCAN5C TCF12 POLR2G SP1 RBAK PHF8 TEAD4 AKR1B1 HSALNG0061509 AKR1B15 lnc-SLC35B4-4
GH07J134447 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 33.2 -95.1 -95073 8.1 CTCF TCF12 FOS CTBP1 EP300 MYC HINFP NCOR1 NFRKB NEUROD1 AKR1B15 AKR1B1 lnc-SLC35B4-4 HSALNG0061509
GH07J134508 Enhancer 1 Ensembl ENCODE dbSUPER 42.6 -35.0 -35028 4.9 ZNF217 CTCF TCF12 REST RAD21 SMC3 TRIM25 FOS ATF3 SIN3A AKR1B15 AKR1B1 piR-48965-137 AKR1B10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR1B15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKR1B15

Genomic Locations for AKR1B15 Gene

Genomic Locations for AKR1B15 Gene
chr7:134,546,245-134,579,875
(GRCh38/hg38)
Size:
33,631 bases
Orientation:
Plus strand
chr7:134,233,849-134,264,627
(GRCh37/hg19)
Size:
30,779 bases
Orientation:
Plus strand

Genomic View for AKR1B15 Gene

Genes around AKR1B15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1B15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1B15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1B15 Gene

Proteins for AKR1B15 Gene

  • Protein details for AKR1B15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JRZ8-AK1BF_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member B15
    Protein Accession:
    C9JRZ8
    Secondary Accessions:
    • C9J3V2

    Protein attributes for AKR1B15 Gene

    Size:
    316 amino acids
    Molecular mass:
    36537 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Has no counterpart in murine species.

    Alternative splice isoforms for AKR1B15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR1B15 Gene

Post-translational modifications for AKR1B15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1B15 Gene

No data available for DME Specific Peptides for AKR1B15 Gene

Domains & Families for AKR1B15 Gene

Gene Families for AKR1B15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for AKR1B15 Gene

Suggested Antigen Peptide Sequences for AKR1B15 Gene

GenScript: Design optimal peptide antigens:
  • Aldo-keto reductase family 1 member B15 (AK1BF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

C9JRZ8

UniProtKB/Swiss-Prot:

AK1BF_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1B15: view

Function for AKR1B15 Gene

Molecular function for AKR1B15 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: No oxidoreductase activity observed with the tested substrates.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:14981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.64; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:42120, ChEBI:CHEBI:15378, ChEBI:CHEBI:15994, ChEBI:CHEBI:16330, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+); Xref=Rhea:RHEA:46628, ChEBI:CHEBI:2710, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+); Xref=Rhea:RHEA:42156, ChEBI:CHEBI:15378, ChEBI:CHEBI:16032, ChEBI:CHEBI:36713, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=allyl alcohol + NADP(+) = acrolein + H(+) + NADPH; Xref=Rhea:RHEA:12168, ChEBI:CHEBI:15368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16605, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.54; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-hex-2-en-1-ol + NADP(+) = (E)-2-hexenal + H(+) + NADPH; Xref=Rhea:RHEA:58424, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:141205; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + nonan-2-one = (3E)-3-nonen-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH; Xref=Rhea:RHEA:14697, ChEBI:CHEBI:15378, ChEBI:CHEBI:15894, ChEBI:CHEBI:16619, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.216; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetoin + NADP(+) = diacetyl + H(+) + NADPH; Xref=Rhea:RHEA:35607, ChEBI:CHEBI:15378, ChEBI:CHEBI:15688, ChEBI:CHEBI:16583, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:58416, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:142617; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the inhibitor JF0064.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.8 uM for androsterone (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=1.9 uM for delta-4-androstenedione (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=2.5 uM for estrone (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=63.4 uM for acetoacetyl-CoA (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=19.2 uM for 3-alpha,17-beta-androstandiol (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=7.1 uM for testosterone (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=9.1 uM for 17-beta-estradiol (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=1 uM for all-trans-retinal {ECO:0000269 PubMed:26222439}; KM=0.16 uM for 9-cis-retinal {ECO:0000269 PubMed:26222439}; KM=880 uM for D,L-glyceraldehyde {ECO:0000269 PubMed:26222439}; KM=2.9 uM for pyridine-3-aldehyde {ECO:0000269 PubMed:26222439}; KM=3.1 uM for hexanal {ECO:0000269 PubMed:26222439}; KM=36 uM for acrolein {ECO:0000269 PubMed:26222439}; KM=5 uM for trans-2-hexenal {ECO:0000269 PubMed:26222439}; KM=2.2 uM for 4-hydroxy-2-nonenal {ECO:0000269 PubMed:26222439}; KM=1.7 uM for 3-nonen-2-one {ECO:0000269 PubMed:26222439}; KM=1 uM for 2,3-butanedione {ECO:0000269 PubMed:26222439}; KM=1 uM for farnesal {ECO:0000269 PubMed:26222439}; KM=5.7 uM for NADPH {ECO:0000269 PubMed:26222439}; Note=kcat is 1.7 min(-1) using isoform 1 for the reduction of androsterone. kcat is 1.1 min(-1) using isoform 1 for the reduction of delta-4-androstenedione. kcat is 1.0 min(-1) using isoform 1 for the reduction of estrone. kcat is 0.5 min(-1) using isoform 1 for the reduction of acetoacetyl-CoA. kcat is 3.0 min(-1) using isoform 1 for the oxidation of 3-alpha,17- beta-androstandiol. kcat is 0.6 min(-1) using isoform 1 for the oxidation of testosterone. kcat is 0.5 min(-1) using isoform 1 for the oxidation of 17-beta-estradiol (PubMed:25577493). kcat is 10.7 min(-1) with D,L-glyceraldehyde as substrate. kcat is 9 min(-1) with pyridine-3-aldehyde as substrate. kcat is 7.3 min(- 1) with hexanal as substrate. kcat is 9 min(-1) with acrolein as substrate. kcat is 11.3 min(-1) with trans-2-hexenal as substrate. kcat is 5.2 min(-1) with 4-hydroxy-2-nonenal as substrate. kcat is 4.8 min(-1) with farnesal as substrate. kcat is 1.7 min(-1) with 2,3-butanedione as substrate. kcat is 5.4 min(-1) with all-trans-retinaldehyde as substrate. kcat is 3.8 min(-1) with 9-cis-retinal as substrate (PubMed:26222439). {ECO:0000269 PubMed:25577493, ECO:0000269 PubMed:26222439};

Enzyme Numbers (IUBMB) for AKR1B15 Gene

Phenotypes From GWAS Catalog for AKR1B15 Gene

Gene Ontology (GO) - Molecular Function for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004032 alditol:NADP+ 1-oxidoreductase activity IBA 21873635
GO:0004303 estradiol 17-beta-dehydrogenase activity TAS --
GO:0008106 alcohol dehydrogenase (NADP+) activity IBA 21873635
GO:0016491 oxidoreductase activity IBA 21873635
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

Phenotypes for AKR1B15 Gene

genes like me logo Genes that share phenotypes with AKR1B15: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR1B15 Gene

Localization for AKR1B15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1B15 Gene

[Isoform 1]: Mitochondrion.
[Isoform 2]: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1B15 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA 21873635
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with AKR1B15: view

Pathways & Interactions for AKR1B15 Gene

genes like me logo Genes that share pathways with AKR1B15: view

Pathways by source for AKR1B15 Gene

Gene Ontology (GO) - Biological Process for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006703 estrogen biosynthetic process TAS --
GO:0042572 retinol metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

No data available for SIGNOR curated interactions for AKR1B15 Gene

Drugs & Compounds for AKR1B15 Gene

(1) Drugs for AKR1B15 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lumateperone Approved, Investigational Pharma Enzyme 0
genes like me logo Genes that share compounds with AKR1B15: view

Transcripts for AKR1B15 Gene

mRNA/cDNA for AKR1B15 Gene

4 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B15 Gene

No ASD Table

Relevant External Links for AKR1B15 Gene

GeneLoc Exon Structure for
AKR1B15

Expression for AKR1B15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR1B15 Gene

mRNA differential expression in normal tissues according to GTEx for AKR1B15 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1), Stomach (x8.9), Esophagus - Mucosa (x6.4), and Vagina (x4.7).

Protein differential expression in normal tissues from HIPED for AKR1B15 Gene

This gene is overexpressed in Lung (26.7), Urine (23.4), and Saliva (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKR1B15 Gene



Protein tissue co-expression partners for AKR1B15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR1B15

SOURCE GeneReport for Unigene cluster for AKR1B15 Gene:

Hs.729418

mRNA Expression by UniProt/SwissProt for AKR1B15 Gene:

C9JRZ8-AK1BF_HUMAN
Tissue specificity: Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.

Evidence on tissue expression from TISSUES for AKR1B15 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with AKR1B15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1B15 Gene

Orthologs for AKR1B15 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKR1B15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1B15 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akr1b10 31
  • 76 (a)
ManyToMany
Akr1b8 31
  • 75 (a)
ManyToMany
Akr1b7 31
  • 72 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-180p18.9 31
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 31
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for AKR1B15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR1B15 Gene

ENSEMBL:
Gene Tree for AKR1B15 (if available)
TreeFam:
Gene Tree for AKR1B15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKR1B15: view image

Paralogs for AKR1B15 Gene

(11) SIMAP similar genes for AKR1B15 Gene using alignment to 1 proteins:

  • AK1BF_HUMAN
genes like me logo Genes that share paralogs with AKR1B15: view

Variants for AKR1B15 Gene

Additional dbSNP identifiers (rs#s) for AKR1B15 Gene

Structural Variations from Database of Genomic Variants (DGV) for AKR1B15 Gene

Variant ID Type Subtype PubMed ID
dgv1240e199 CNV deletion 23128226
dgv430n21 CNV loss 19592680
dgv6636n100 CNV loss 25217958
esv26694 CNV loss 19812545
esv2669756 CNV deletion 23128226
esv2735180 CNV deletion 23290073
esv27674 CNV gain 19812545
esv3443026 CNV duplication 20981092
esv3615097 CNV loss 21293372
nsv1020141 CNV gain 25217958
nsv1026859 CNV loss 25217958
nsv1031083 CNV loss 25217958
nsv981584 CNV duplication 23825009

Variation tolerance for AKR1B15 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR1B15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1B15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR1B15 Gene

Disorders for AKR1B15 Gene

Additional Disease Information for AKR1B15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AKR1B15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR1B15 Gene

Publications for AKR1B15 Gene

  1. Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. (PMID: 25577493) Weber S … Barski OA (The Journal of biological chemistry 2015) 2 3 4 54
  2. Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase. (PMID: 26222439) Giménez-Dejoz J … Porté S (PloS one 2015) 3 4 54
  3. Functional expression of novel human and murine AKR1B genes. (PMID: 21276782) Salabei JK … Barski OA (Chemico-biological interactions 2011) 3 4 54
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  5. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 41 54

Products for AKR1B15 Gene

Sources for AKR1B15 Gene