Aliases for AKR1B15 Gene
External Ids for AKR1B15 Gene
Previous GeneCards Identifiers for AKR1B15 Gene
GeneCards Summary for AKR1B15 Gene
AKR1B15 (Aldo-Keto Reductase Family 1 Member B15) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of steroid hormones. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is AKR1B10.
UniProtKB/Swiss-Prot Summary for AKR1B15 Gene
Isoform 1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).
Isoform 2: No oxidoreductase activity observed with the tested substrates.