This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2... See more...

Aliases for AKR1B10 Gene

Aliases for AKR1B10 Gene

  • Aldo-Keto Reductase Family 1 Member B10 2 3 4 5
  • Aldose Reductase-Related Protein 2 3 4
  • Small Intestine Reductase 2 3 4
  • Aldo-Keto Reductase Family 1, Member B11 (Aldose Reductase-Like) 2 3
  • Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) 2 3
  • Aldose Reductase-Like Peptide 2 3
  • Aldose Reductase-Like 1 2 3
  • SI Reductase 3 4
  • AKR1B11 3 4
  • ARL-1 3 4
  • HARP 3 4
  • ARP 3 4
  • Aldose Reductase-Like 4
  • EC 1.1.1.300 4
  • EC 1.1.1.21 52
  • EC 1.1.1.54 4
  • EC 1.1.1 52
  • AKR1B12 3
  • ALDRLn 3
  • ARL1 3
  • HIS 3
  • HSI 3

External Ids for AKR1B10 Gene

Previous HGNC Symbols for AKR1B10 Gene

  • AKR1B11

Previous GeneCards Identifiers for AKR1B10 Gene

  • GC07P132555
  • GC07P133614
  • GC07P133628
  • GC07P133669
  • GC07P133862
  • GC07P134212
  • GC07P128514

Summaries for AKR1B10 Gene

Entrez Gene Summary for AKR1B10 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKR1B10 Gene

AKR1B10 (Aldo-Keto Reductase Family 1 Member B10) is a Protein Coding gene. Diseases associated with AKR1B10 include Hepatocellular Carcinoma and Human Granulocytic Anaplasmosis. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include aldo-keto reductase (NADP) activity and indanol dehydrogenase activity. An important paralog of this gene is AKR1B15.

UniProtKB/Swiss-Prot Summary for AKR1B10 Gene

  • Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).

Gene Wiki entry for AKR1B10 Gene

Additional gene information for AKR1B10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR1B10 Gene

Genomics for AKR1B10 Gene

GeneHancer (GH) Regulatory Elements for AKR1B10 Gene

Promoters and enhancers for AKR1B10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J134527 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.4 1379 3.7 TCF12 POLR2G ZNF316 FOXA2 MAFF SAP130 FOSL2 RFX5 MAFK NFE2 AKR1B10 AKR1B15 AKR1B1 NONHSAG048859.2 RF00017-6652
GH07J134514 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.4 -12.0 -12042 2.5 CTCF TCF12 JUND FOS EP300 RAD21 MYC TRIM22 SMC3 CTBP1 AKR1B10 AKR1B15 piR-48965-137 RF00017-6652
GH07J134531 Enhancer 0.9 ENCODE dbSUPER 0.4 +5.1 5061 2.5 TCF12 POLR2G EP300 FOS NR3C1 FOSL2 CEBPB CHD2 JUN RCOR1 AKR1B15 NONHSAG048859.2 AKR1B10 RF00017-6652
GH07J134508 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -16.4 -16350 4.9 ZNF217 CTCF TCF12 REST RAD21 SMC3 TRIM25 FOS ATF3 SIN3A AKR1B15 AKR1B1 piR-48965-137 AKR1B10
GH07J134522 Enhancer 0.4 Ensembl 0.7 -4.9 -4866 1.4 CEBPG CEBPB EP300 AKR1B15 AKR1B10 piR-48965-137 RF00017-6652
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR1B10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKR1B10

Top Transcription factor binding sites by QIAGEN in the AKR1B10 gene promoter:
  • AhR
  • Arnt
  • ATF6
  • Egr-1
  • Egr-4
  • Evi-1
  • SRF
  • SRF (504 AA)
  • YY1

Genomic Locations for AKR1B10 Gene

Genomic Locations for AKR1B10 Gene
chr7:134,527,567-134,541,414
(GRCh38/hg38)
Size:
13,848 bases
Orientation:
Plus strand
chr7:134,212,344-134,226,166
(GRCh37/hg19)
Size:
13,823 bases
Orientation:
Plus strand

Genomic View for AKR1B10 Gene

Genes around AKR1B10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1B10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1B10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1B10 Gene

Proteins for AKR1B10 Gene

  • Protein details for AKR1B10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60218-AK1BA_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member B10
    Protein Accession:
    O60218
    Secondary Accessions:
    • A4D1P1
    • O75890
    • Q6FHF3
    • Q8IWZ1

    Protein attributes for AKR1B10 Gene

    Size:
    316 amino acids
    Molecular mass:
    36020 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Has no counterpart in murine and rat species.

    Three dimensional structures from OCA and Proteopedia for AKR1B10 Gene

neXtProt entry for AKR1B10 Gene

Selected DME Specific Peptides for AKR1B10 Gene

O60218:
  • EAVKVAID
  • GLGTWKS
  • NIQVFDF
  • HPYLTQEKLI
  • IPKSVTP
  • LFIVSKLW
  • VTAYSPLGS
  • VTAYSPLGSPDRP
  • GYRHIDCA
  • AKPEDPSLLEDP
  • AIDAGYRH

Post-translational modifications for AKR1B10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1B10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for AKR1B10 Gene

Gene Families for AKR1B10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for AKR1B10 Gene

Suggested Antigen Peptide Sequences for AKR1B10 Gene

GenScript: Design optimal peptide antigens:
  • Small intestine reductase (AK1BA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60218

UniProtKB/Swiss-Prot:

AK1BA_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1B10: view

Function for AKR1B10 Gene

Molecular function for AKR1B10 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.300; Evidence={ECO:0000269 PubMed:12732097, ECO:0000269 PubMed:18087047};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78272, ChEBI:CHEBI:78273; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH; Xref=Rhea:RHEA:54920, ChEBI:CHEBI:15378, ChEBI:CHEBI:45479, ChEBI:CHEBI:45487, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=allyl alcohol + NADP(+) = acrolein + H(+) + NADPH; Xref=Rhea:RHEA:12168, ChEBI:CHEBI:15368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16605, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.54; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:58416, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:142617; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH; Xref=Rhea:RHEA:58336, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142593, ChEBI:CHEBI:142606; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH; Xref=Rhea:RHEA:58420, ChEBI:CHEBI:15378, ChEBI:CHEBI:15825, ChEBI:CHEBI:16019, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-hex-2-en-1-ol + NADP(+) = (E)-2-hexenal + H(+) + NADPH; Xref=Rhea:RHEA:58424, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:141205; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH; Xref=Rhea:RHEA:58428, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:82334, ChEBI:CHEBI:142625; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:58432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58972, ChEBI:CHEBI:142624; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH; Xref=Rhea:RHEA:58436, ChEBI:CHEBI:15378, ChEBI:CHEBI:17998, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:63910; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Retinaldehyde reductase activity is inhibited by tolrestat.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6000 uM for D,L-glyceraldehyde {ECO:0000269 PubMed:18087047}; KM=0.6 uM for all-trans-retinal {ECO:0000269 PubMed:18087047}; KM=0.7 uM for 9-cis-retinal {ECO:0000269 PubMed:18087047}; KM=37 uM for pyridine-3-aldehyde {ECO:0000269 PubMed:12732097}; KM=110 uM for acrolein {ECO:0000269 PubMed:19563777}; KM=87 uM for 3-methyl-2-butenal {ECO:0000269 PubMed:19563777}; KM=30 uM for 4-hydroxynonenal {ECO:0000269 PubMed:19563777}; KM=61 uM for (E)-2-hexenal {ECO:0000269 PubMed:19563777}; KM=95 uM for (E,E)-2,4-hexadienal {ECO:0000269 PubMed:19563777}; KM=532 uM for GS-acrolein {ECO:0000269 PubMed:19563777}; KM=245 uM for GS-3-methyl-2-butenal {ECO:0000269 PubMed:19563777}; KM=145 uM for GS-(E)-2-hexenal {ECO:0000269 PubMed:19563777}; KM=77 uM for GS-(E,E)-2,4-hexadienal {ECO:0000269 PubMed:19563777}; KM=330 uM for (E)-4-hydroxynon-2-enal {ECO:0000269 PubMed:19013440}; KM=300 uM for (E)-4-oxonon-2-enal {ECO:0000269 PubMed:19013440}; KM=50 uM for 4-methylpentanal {ECO:0000269 PubMed:19013440}; Vmax=3122 nmol/min/mg enzyme with acrolein {ECO:0000269 PubMed:19563777}; Vmax=2647 nmol/min/mg enzyme with 3-methyl-2-butenal as substrate {ECO:0000269 PubMed:19563777}; Vmax=2658 nmol/min/mg enzyme with (E)-2-hexenal as substrate {ECO:0000269 PubMed:19563777}; Vmax=2160 nmol/min/mg enzyme with (E,E)-2,4-hexadienal as substrate {ECO:0000269 PubMed:19563777}; Vmax=3298 nmol/min/mg enzyme with 4-hydroxynonenal {ECO:0000269 PubMed:19563777}; Vmax=64 nmol/min/mg enzyme with GS-acrolein {ECO:0000269 PubMed:19563777}; Vmax=1960 nmol/min/mg enzyme with GS-3-methyl-2-butenal as substrate {ECO:0000269 PubMed:19563777}; Vmax=2049 nmol/min/mg enzyme with GS-(E)-2-hexenal {ECO:0000269 PubMed:19563777}; Vmax=4004 nmol/min/mg enzyme with GS-(E,E)-2,4-hexadienal as substrate {ECO:0000269 PubMed:19563777}; Note=kcat is 640 min(-1) for glyceraldehyde as substrate (PubMed:12732097). kcat is 185 min(-1) for pyridine-3-aldehyde as substrate (PubMed:12732097). kcat is 116 min(-1) for acrolein as substrate. kcat is 103 min(-1) for 3-methyl-2-butenal as substrate. kcat is 97 min(-1) for(E)-2-hexenal as substrate. kcat is 82 min(-1) for (E,E)-2,4-hexadienal as substrate. kcat is 120 min(-1) for 4-hydroxynonenal as substrate. kcat is 3 min(-1) for GS-acrolein as substrate. kcat is 70 min(-1) for GS- 3-methyl-2-butenal as substrate. kcat is 71 min(-1) for GS-(E)- 2-hexenal as substrate. kcat is 147 min(-1) for (E,E)-2,4- hexadienal as substrate (PubMed:19563777). kcat is 35 min(-1) for D,L-glyceraldehyde as substrate. kcat is 27 min(-1) for all- trans-retinal as substrate. kcat is 1 min(-1) for 9-cis-retinal as substrate (PubMed:18087047). kcat is 43 min(-1) for 4- hydroxynon-2-enal (PubMed:19013440). kcat is 40 min(-1) for (E)- 4-oxonon-2-enal (PubMed:19013440). kcat is 25 min(-1) for 4- methylpentanal (PubMed:19013440). {ECO:0000269 PubMed:12732097, ECO:0000269 PubMed:18087047, ECO:0000269 PubMed:19013440, ECO:0000269 PubMed:19563777};
UniProtKB/Swiss-Prot Induction:
Overexpressed in certain types of cancers, including hepatocellular carcinoma and lung cancer associated with tobacco smoking.

Enzyme Numbers (IUBMB) for AKR1B10 Gene

Phenotypes From GWAS Catalog for AKR1B10 Gene

Gene Ontology (GO) - Molecular Function for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001758 retinal dehydrogenase activity IDA 21851338
GO:0004032 alditol:NADP+ 1-oxidoreductase activity IBA 21873635
GO:0004033 aldo-keto reductase (NADP) activity TAS 9565553
GO:0005515 protein binding IPI 18056116
GO:0008106 alcohol dehydrogenase (NADP+) activity IDA 19013440
genes like me logo Genes that share ontologies with AKR1B10: view
genes like me logo Genes that share phenotypes with AKR1B10: view

Animal Models for AKR1B10 Gene

MGI Knock Outs for AKR1B10:
  • Akr1b8 Akr1b8<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1B10

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKR1B10 Gene

Localization for AKR1B10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1B10 Gene

Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1B10 gene
Compartment Confidence
extracellular 4
mitochondrion 4
cytosol 4
lysosome 4
nucleus 3
plasma membrane 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IBA 21873635
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AKR1B10: view

Pathways & Interactions for AKR1B10 Gene

genes like me logo Genes that share pathways with AKR1B10: view

UniProtKB/Swiss-Prot O60218-AK1BA_HUMAN

  • Pathway: Cofactor metabolism; retinol metabolism.

Gene Ontology (GO) - Biological Process for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0016488 farnesol catabolic process IDA 21187079
GO:0042572 retinol metabolic process IEA --
GO:0044597 daunorubicin metabolic process IMP 20837989
GO:0044598 doxorubicin metabolic process IMP 20837989
genes like me logo Genes that share ontologies with AKR1B10: view

No data available for SIGNOR curated interactions for AKR1B10 Gene

Drugs & Compounds for AKR1B10 Gene

(18) Drugs for AKR1B10 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lumateperone Approved, Investigational Pharma Enzyme, Enzyme 0
Sulindac Approved, Investigational Pharma Target, inhibitor Anti-inflammatory agent;COX inhibitor 37
Glycerol Approved, Investigational Pharma 208
Propylene glycol Approved, Investigational Pharma 0
Sorbitol Approved Pharma 64

(9) Additional Compounds for AKR1B10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Alpha-D-Glucose
  • alpha-D-GLC
  • alpha-Dextrose
  • a-D-GLC
  • α-D-GLC
  • a-D-Glucose
492-62-6
Beta-D-Galactose
  • beta-D-Gal
  • Gal-beta
  • b-D-Gal
  • β-D-gal
  • b-D-Galactose
7296-64-2
Galactitol
  • (2R,3S,4R,5S)-Hexane-1,2,3,4,5,6-hexol
  • D-Dulcitol
  • D-Galactitol
  • Dulcitol
  • Dulcose
608-66-2
glyceraldehyde
  • (+-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • Aldotriose
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton

(3) ApexBio Compounds for AKR1B10 Gene

Compound Action Cas Number
Alrestatin 51411-04-2
EBPC 4450-98-0
Tolrestat 82964-04-3
genes like me logo Genes that share compounds with AKR1B10: view

Drug Products

Transcripts for AKR1B10 Gene

mRNA/cDNA for AKR1B10 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1B10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B10 Gene

No ASD Table

Relevant External Links for AKR1B10 Gene

GeneLoc Exon Structure for
AKR1B10

Expression for AKR1B10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR1B10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKR1B10 Gene

This gene is overexpressed in Stomach (x15.4), Esophagus - Mucosa (x10.4), Vagina (x5.6), Colon - Transverse (x4.4), and Bladder (x4.2).

Protein differential expression in normal tissues from HIPED for AKR1B10 Gene

This gene is overexpressed in Pancreatic juice (20.0), Stomach (11.5), Cardia (10.2), and Islet of Langerhans (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR1B10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR1B10

SOURCE GeneReport for Unigene cluster for AKR1B10 Gene:

Hs.116724

mRNA Expression by UniProt/SwissProt for AKR1B10 Gene:

O60218-AK1BA_HUMAN
Tissue specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.

Evidence on tissue expression from TISSUES for AKR1B10 Gene

  • Intestine(4.4)
  • Pancreas(4.1)
  • Lung(4)
  • Liver(2.8)
  • Stomach(2.4)
  • Gall bladder(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with AKR1B10: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1B10 Gene

Orthologs for AKR1B10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1B10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1B10 31 30
  • 99.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AKR1B10 30
  • 83.98 (n)
-- 31
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Akr1b10 31
  • 83 (a)
ManyToMany
Akr1b8 17 31 30
  • 81.43 (n)
Akr1b7 31
  • 80 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Akr1b8 30
  • 81.43 (n)
chicken
(Gallus gallus)
Aves AKR1B10 30
  • 71.9 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-180p18.9 31
  • 66 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 31 32 30
  • 62.37 (n)
OneToMany
CG12766 32
  • 47 (a)
CG6083 32
  • 47 (a)
BcDNA:GH10614 32
  • 42 (a)
CG10638 32
  • 42 (a)
CG2767 32
  • 42 (a)
CG9436 32
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea T08H10.1 32
  • 46 (a)
Y39G8B.1b 32
  • 45 (a)
Y39G8B.1a 32
  • 44 (a)
C07D8.6 32
  • 40 (a)
F53F1.3 32
  • 35 (a)
F53F1.2 32
  • 35 (a)
ZC443.1 32
  • 35 (a)
Y39G8B.2 32
  • 34 (a)
C35D10.6 32
  • 32 (a)
C01G5.5 32
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL107C 30
  • 50.29 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21627g 30
  • 50.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRE3 30
  • 49.14 (n)
ARA1 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G21250 30
  • 48.62 (n)
rice
(Oryza sativa)
Liliopsida Os02g0123500 30
  • 49.94 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08384 30
  • 52.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Cin.1520 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1520 30
Species where no ortholog for AKR1B10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AKR1B10 Gene

ENSEMBL:
Gene Tree for AKR1B10 (if available)
TreeFam:
Gene Tree for AKR1B10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKR1B10: view image

Paralogs for AKR1B10 Gene

(11) SIMAP similar genes for AKR1B10 Gene using alignment to 1 proteins:

  • AK1BA_HUMAN

Pseudogenes.org Pseudogenes for AKR1B10 Gene

genes like me logo Genes that share paralogs with AKR1B10: view

Variants for AKR1B10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR1B10 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2303312 - p.Pro87Ser
rs3735042 - p.Met286Thr
rs4728329 - p.Asn313Asp

Additional dbSNP identifiers (rs#s) for AKR1B10 Gene

Structural Variations from Database of Genomic Variants (DGV) for AKR1B10 Gene

Variant ID Type Subtype PubMed ID
dgv1240e199 CNV deletion 23128226
dgv430n21 CNV loss 19592680
dgv6636n100 CNV loss 25217958
esv2669756 CNV deletion 23128226
esv2735180 CNV deletion 23290073
esv3443026 CNV duplication 20981092
esv3615097 CNV loss 21293372
nsv1020141 CNV gain 25217958
nsv1026859 CNV loss 25217958
nsv1031083 CNV loss 25217958
nsv970580 CNV duplication 23825009

Variation tolerance for AKR1B10 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKR1B10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1B10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1B10 Gene

Disorders for AKR1B10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for AKR1B10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
human granulocytic anaplasmosis
  • hge
lung cancer
  • adenocarcinoma of lung
hypotrichosis 2
  • hypt2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AKR1B10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AKR1B10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR1B10 Gene

Publications for AKR1B10 Gene

  1. Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. (PMID: 9765596) Hyndman DJ … Flynn TG (Biochimica et biophysica acta 1998) 2 3 4 23 54
  2. Identification and characterization of a novel human aldose reductase-like gene. (PMID: 9565553) Cao D … Chung SS (The Journal of biological chemistry 1998) 2 3 4 23 54
  3. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. (PMID: 19563777) Zhong L … Cao D (Biochemical and biophysical research communications 2009) 3 4 23 54
  4. Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway. (PMID: 21585341) Luo DX … Cao D (The Biochemical journal 2011) 3 4 54
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54

Products for AKR1B10 Gene

Sources for AKR1B10 Gene