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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
AKR1A1 (Aldo-Keto Reductase Family 1 Member A1) is a Protein Coding gene. Diseases associated with AKR1A1 include Fetal Alcohol Syndrome and Ethylene Glycol Poisoning. Among its related pathways are Cytochrome P450 - arranged by substrate type and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alditol:NADP+ 1-oxidoreductase activity. An important paralog of this gene is AKR1B1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | TAS,IBA | 21873635 |
GO:0004033 | aldo-keto reductase (NADP) activity | TAS | -- |
GO:0004745 | NOT retinol dehydrogenase activity | ISS | -- |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0008106 | alcohol dehydrogenase (NADP+) activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 23580065 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type | ||
2 | Pentose and glucuronate interconversions | ||
3 | Metabolism |
.40
|
|
4 | Cyclophosphamide Pathway, Pharmacodynamics | ||
5 | superpathway of tryptophan utilization |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006006 | glucose metabolic process | TAS | 2498333 |
GO:0006081 | cellular aldehyde metabolic process | TAS | 2498333 |
GO:0019640 | glucuronate catabolic process to xylulose 5-phosphate | TAS | -- |
GO:0019853 | L-ascorbic acid biosynthetic process | IEA | -- |
GO:0022900 | electron transport chain | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | Enzyme, substrate | 3481 | ||
NADH | Approved | Nutra | Enzyme, substrate | 0 | ||
Glycerol | Approved, Investigational | Pharma | 205 | |||
Zinc | Approved, Investigational | Pharma | 1687 | |||
Certolizumab pegol | Approved | Pharma | Enzyme, substrate | 150 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
1-Hexanol |
|
111-27-3 |
|
|||
1-Pentanol |
|
71-41-0 |
|
|||
6-Hydroxyhexanoic acid |
|
1191-25-9 |
|
|||
Adipate semialdehyde |
|
928-81-4 |
|
|||
glyceraldehyde |
|
56-82-6 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP19: | - | - | - | - | - |
ExUns: | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | ||||||||||||
SP3: | - | - | - | - | |||||||||
SP4: | - | - | - | - | |||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | |||||||||||||
SP8: | - | - | - | ||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | |||||||||||||
SP12: | |||||||||||||
SP13: | |||||||||||||
SP14: | |||||||||||||
SP15: | |||||||||||||
SP16: | |||||||||||||
SP17: | |||||||||||||
SP18: | - | - | - | - | |||||||||
SP19: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AKR1A1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AKR1A1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AKR1A1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Akr1a1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Akr1a1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | AKR1A1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AKR1A1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AKR1A1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | AKR1A1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | akr1a1 30 |
|
||
Str.11963 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.10170 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | akr1a1b 30 31 |
|
OneToOne | |
Dr.13132 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1439 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6084 32 |
|
|
|
CG6083 31 32 |
|
OneToMany | |||
CG9436 31 32 |
|
OneToMany | |||
CG2767 32 |
|
|
|||
CG10638 31 32 |
|
OneToMany | |||
CG10863 31 |
|
OneToMany | |||
CG12766 31 32 |
|
OneToMany | |||
ARY 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | Y39G8B.1 31 |
|
OneToMany | |
Y39G8B.1a 32 |
|
|
|||
Y39G8B.1b 32 |
|
|
|||
T08H10.1 31 32 |
|
OneToMany | |||
C07D8.6 31 32 |
|
OneToMany | |||
ZC443.1 32 |
|
|
|||
F53F1.3 32 |
|
|
|||
F53F1.2 32 |
|
|
|||
Y39G8B.2 31 32 |
|
OneToMany | |||
C01G5.5 32 |
|
|
|||
C35D10.6 32 |
|
|
|||
K07C5.2 32 |
|
|
|||
C07D8.5 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GRE3 31 |
|
OneToMany | |
GCY1 33 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G37760 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3560 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12012 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC26F1.07 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04510 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
CSA.5991 31 |
|
ManyToMany |