This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protei... See more...

Aliases for AKR1A1 Gene

Aliases for AKR1A1 Gene

  • Aldo-Keto Reductase Family 1 Member A1 2 3 4 5
  • Aldehyde Reductase 2 3 4
  • ALR 2 3 4
  • Dihydrodiol Dehydrogenase 3 2 3
  • Glucuronolactone Reductase 3 4
  • Glucuronate Reductase 3 4
  • EC 1.1.1.2 4 51
  • ALDR1 3 4
  • DD3 2 3
  • Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) 2
  • Epididymis Secretory Sperm Binding Protein Li 165mP 3
  • Epididymis Secretory Protein Li 6 3
  • Alcohol Dehydrogenase [NADP(+)] 4
  • Alcohol Dehydrogenase 3
  • EC 1.1.1.372 4
  • HEL-S-165mP 3
  • EC 1.1.1.54 4
  • EC 1.1.1.19 4
  • EC 1.1.1.20 4
  • EC 1.1.1 51
  • HEL-S-6 3
  • AKR1A1 5
  • ARM 3

External Ids for AKR1A1 Gene

Previous GeneCards Identifiers for AKR1A1 Gene

  • GC01P045743
  • GC01P045016
  • GC01P045446
  • GC01P045429
  • GC01P045685
  • GC01P045789
  • GC01P046017
  • GC01P044128

Summaries for AKR1A1 Gene

Entrez Gene Summary for AKR1A1 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

GeneCards Summary for AKR1A1 Gene

AKR1A1 (Aldo-Keto Reductase Family 1 Member A1) is a Protein Coding gene. Diseases associated with AKR1A1 include Fetal Alcohol Syndrome and Ethylene Glycol Poisoning. Among its related pathways are Glucose metabolism and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alditol:NADP+ 1-oxidoreductase activity. An important paralog of this gene is AKR1B1.

UniProtKB/Swiss-Prot Summary for AKR1A1 Gene

  • Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity).

Gene Wiki entry for AKR1A1 Gene

Additional gene information for AKR1A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKR1A1 Gene

Genomics for AKR1A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AKR1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKR1A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKR1A1

Top Transcription factor binding sites by QIAGEN in the AKR1A1 gene promoter:
  • c-Myc
  • C/EBPbeta
  • Max

Genomic Locations for AKR1A1 Gene

Genomic Locations for AKR1A1 Gene
chr1:45,550,543-45,570,051
(GRCh38/hg38)
Size:
19,509 bases
Orientation:
Plus strand
chr1:46,016,215-46,035,723
(GRCh37/hg19)
Size:
19,509 bases
Orientation:
Plus strand

Genomic View for AKR1A1 Gene

Genes around AKR1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1A1 Gene

Proteins for AKR1A1 Gene

  • Protein details for AKR1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14550-AK1A1_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member A1
    Protein Accession:
    P14550
    Secondary Accessions:
    • A8KAL8
    • D3DQ04
    • Q6IAZ4

    Protein attributes for AKR1A1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36573 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AKR1A1 Gene

neXtProt entry for AKR1A1 Gene

Selected DME Specific Peptides for AKR1A1 Gene

P14550:
  • RSPAQILLRWQVQRKVICIPKS
  • ALEALVAKGLV
  • VFDFTFSPEEMKQL
  • VTAYSPLGS
  • GYRHIDCA
  • AAIYGNE
  • MPLIGLGT
  • GLGTWKS
  • PDEPVLLEEPVVLALAEK
  • DLYLMHWP

Post-translational modifications for AKR1A1 Gene

  • Ubiquitination at Lys153
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for AKR1A1
  • Boster Bio Antibodies for AKR1A1

Domains & Families for AKR1A1 Gene

Gene Families for AKR1A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for AKR1A1 Gene

Suggested Antigen Peptide Sequences for AKR1A1 Gene

GenScript: Design optimal peptide antigens:
  • Aldo-keto reductase family 1 member A1 (AK1A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14550

UniProtKB/Swiss-Prot:

AK1A1_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1A1: view

Function for AKR1A1 Gene

Molecular function for AKR1A1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH; Xref=Rhea:RHEA:15937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.2; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=allyl alcohol + NADP(+) = acrolein + H(+) + NADPH; Xref=Rhea:RHEA:12168, ChEBI:CHEBI:15368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16605, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.54; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH; Xref=Rhea:RHEA:23592, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.372; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH; Xref=Rhea:RHEA:38111, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27975, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.372; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH; Xref=Rhea:RHEA:27986, ChEBI:CHEBI:15378, ChEBI:CHEBI:17158, ChEBI:CHEBI:27957, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH; Xref=Rhea:RHEA:58336, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142593, ChEBI:CHEBI:142606; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH; Xref=Rhea:RHEA:58668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60777, ChEBI:CHEBI:142685; Evidence={ECO:0000250|UniProtKB:P51635};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH; Xref=Rhea:RHEA:14909, ChEBI:CHEBI:13115, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142686; EC=1.1.1.19; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH; Xref=Rhea:RHEA:18925, ChEBI:CHEBI:15378, ChEBI:CHEBI:17587, ChEBI:CHEBI:18268, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.20; Evidence={ECO:0000250|UniProtKB:P51635};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde; Xref=Rhea:RHEA:58776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28345, ChEBI:CHEBI:45213, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000269|PubMed:10510318};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=1426 nmol/min/mg enzyme for 4-hydroxynonenal {ECO:0000269|PubMed:10510318}; Vmax=268 nmol/min/mg enzyme for acrolein {ECO:0000269|PubMed:10510318}; Vmax=3460 nmol/min/mg enzyme for pyridine-3-carbaldehyde {ECO:0000269|PubMed:10510318}; Vmax=4273 nmol/min/mg enzyme for methylglyoxal {ECO:0000269|PubMed:10510318}; Vmax=1263 nmol/min/mg enzyme for D,L-glyceraldehyde {ECO:0000269|PubMed:10510318}; Vmax=5562 nmol/min/mg enzyme for D-glucuronic acid {ECO:0000269|PubMed:10510318}; Vmax=4983 nmol/min/mg enzyme for succinic semialdehyde {ECO:0000269|PubMed:10510318};
GENATLAS Biochemistry:
aldehyde reductase 1,monomeric NADPH dependent,expressed in many organs predominantly in kidney,cortex,liver,thyroid,small intestine,cytosolic reducing various biogenic and xenobiotic aldehyde compounds,with two alternatively spliced transcripts encoding the same protein

Enzyme Numbers (IUBMB) for AKR1A1 Gene

Phenotypes From GWAS Catalog for AKR1A1 Gene

Gene Ontology (GO) - Molecular Function for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004032 alditol:NADP+ 1-oxidoreductase activity TAS,IBA 21873635
GO:0004033 aldo-keto reductase (NADP) activity TAS --
GO:0004745 NOT retinol dehydrogenase activity ISS --
GO:0005515 protein binding IPI 21044950
GO:0008106 alcohol dehydrogenase (NADP+) activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with AKR1A1: view
genes like me logo Genes that share phenotypes with AKR1A1: view

Animal Models for AKR1A1 Gene

MGI Knock Outs for AKR1A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1A1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKR1A1 Gene

Localization for AKR1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1A1 Gene

Cytoplasm, cytosol. Apical cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1A1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 4
nucleus 3
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AKR1A1: view

Pathways & Interactions for AKR1A1 Gene

genes like me logo Genes that share pathways with AKR1A1: view

Gene Ontology (GO) - Biological Process for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS 2498333
GO:0006081 cellular aldehyde metabolic process TAS 2498333
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS --
GO:0019853 L-ascorbic acid biosynthetic process IBA --
GO:0022900 electron transport chain IEA --
genes like me logo Genes that share ontologies with AKR1A1: view

No data available for SIGNOR curated interactions for AKR1A1 Gene

Drugs & Compounds for AKR1A1 Gene

(64) Drugs for AKR1A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme, substrate 3266
NADH Approved Nutra Enzyme, substrate 0
Glycerol Approved, Investigational Pharma 197
Zinc Approved, Investigational Pharma 1594
Certolizumab pegol Approved Pharma Enzyme, substrate 144

(82) Additional Compounds for AKR1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
71-41-0
6-Hydroxyhexanoic acid
  • 5-Carboxypentanol
  • 5-Hydroxypentanecarboxylic acid
  • 6-Hydroxy caproic acid
  • 6-Hydroxycaproic acid
  • 6-Hydroxyhexanoate
1191-25-9
Adipate semialdehyde
  • 1-Hexanal-6-carboxylic acid
  • 5-Carbohydroxy-1-pentanal
  • 5-Formylvaleric acid
  • 6-Hydroxy caproic acid
  • Adipic acid monoaldehyde
928-81-4
glyceraldehyde
  • (+-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • Aldotriose
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
genes like me logo Genes that share compounds with AKR1A1: view

Transcripts for AKR1A1 Gene

mRNA/cDNA for AKR1A1 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1A1

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1A1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - -
SP17: - -
SP18:
SP19: - - - - -

ExUns: 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - -
SP19:

Relevant External Links for AKR1A1 Gene

GeneLoc Exon Structure for
AKR1A1

Expression for AKR1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR1A1 Gene

Protein differential expression in normal tissues from HIPED for AKR1A1 Gene

This gene is overexpressed in Liver, secretome (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR1A1 Gene



Protein tissue co-expression partners for AKR1A1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKR1A1

SOURCE GeneReport for Unigene cluster for AKR1A1 Gene:

Hs.474584

mRNA Expression by UniProt/SwissProt for AKR1A1 Gene:

P14550-AK1A1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.

Evidence on tissue expression from TISSUES for AKR1A1 Gene

  • Liver(4.7)
  • Kidney(4.7)
  • Intestine(4.5)
  • Nervous system(4)
  • Skin(3.8)
  • Lung(3.4)
  • Eye(2.8)
  • Heart(2.6)
  • Muscle(2.5)
  • Stomach(2.5)
  • Adrenal gland(2.3)
  • Blood(2.3)
  • Thyroid gland(2.3)
  • Spleen(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with AKR1A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1A1 Gene

Orthologs for AKR1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AKR1A1 30 31
  • 99.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AKR1A1 30 31
  • 90.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AKR1A1 30 31
  • 90.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Akr1a1 30 17 31
  • 87.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Akr1a1 30
  • 87.59 (n)
Oppossum
(Monodelphis domestica)
Mammalia AKR1A1 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AKR1A1 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves AKR1A1 30 31
  • 71.79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AKR1A1 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia akr1a1 30
  • 69.18 (n)
Str.11963 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.10170 30
Zebrafish
(Danio rerio)
Actinopterygii akr1a1b 30 31
  • 65.62 (n)
OneToOne
Dr.13132 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1439 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG6084 32
  • 49 (a)
CG6083 31 32
  • 45 (a)
OneToMany
CG9436 31 32
  • 42 (a)
OneToMany
CG2767 32
  • 42 (a)
CG10638 31 32
  • 41 (a)
OneToMany
CG10863 31
  • 40 (a)
OneToMany
CG12766 31 32
  • 39 (a)
OneToMany
ARY 31
  • 31 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y39G8B.1 31
  • 46 (a)
OneToMany
Y39G8B.1a 32
  • 45 (a)
Y39G8B.1b 32
  • 45 (a)
T08H10.1 31 32
  • 41 (a)
OneToMany
C07D8.6 31 32
  • 39 (a)
OneToMany
ZC443.1 32
  • 37 (a)
F53F1.3 32
  • 35 (a)
F53F1.2 32
  • 34 (a)
Y39G8B.2 31 32
  • 32 (a)
OneToMany
C01G5.5 32
  • 31 (a)
C35D10.6 32
  • 31 (a)
K07C5.2 32
  • 31 (a)
C07D8.5 31
  • 28 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRE3 31
  • 37 (a)
OneToMany
GCY1 33 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G37760 30
  • 51.14 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3560 30
Barley
(Hordeum vulgare)
Liliopsida Hv.12012 30
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26F1.07 30
  • 49.94 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04510 30
  • 48.86 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
ManyToMany
CSA.5991 31
  • 15 (a)
ManyToMany
Species where no ortholog for AKR1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AKR1A1 Gene

ENSEMBL:
Gene Tree for AKR1A1 (if available)
TreeFam:
Gene Tree for AKR1A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKR1A1: view image

Paralogs for AKR1A1 Gene

(11) SIMAP similar genes for AKR1A1 Gene using alignment to 4 proteins:

  • AK1A1_HUMAN
  • Q5T621_HUMAN
  • V9GYG2_HUMAN
  • V9GYP9_HUMAN

Pseudogenes.org Pseudogenes for AKR1A1 Gene

genes like me logo Genes that share paralogs with AKR1A1: view

Variants for AKR1A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKR1A1 Gene