Aliases for AKR1A1 Gene
Aliases for AKR1A1 Gene
External Ids for AKR1A1 Gene
- HGNC: 380
- Entrez Gene: 10327
- Ensembl: ENSG00000117448
- OMIM: 103830
- UniProtKB: P14550
Previous GeneCards Identifiers for AKR1A1 Gene
- GC01P045743
- GC01P045016
- GC01P045446
- GC01P045429
- GC01P045685
- GC01P045789
- GC01P046017
- GC01P044128
Summaries for AKR1A1 Gene
-
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
GeneCards Summary for AKR1A1 Gene
AKR1A1 (Aldo-Keto Reductase Family 1 Member A1) is a Protein Coding gene. Diseases associated with AKR1A1 include Ethylene Glycol Poisoning and Fetal Alcohol Syndrome. Among its related pathways are Cytochrome P450 - arranged by substrate type and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alditol:NADP+ 1-oxidoreductase activity. An important paralog of this gene is AKR1B1.
UniProtKB/Swiss-Prot for AKR1A1 Gene
-
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Additional gene information for AKR1A1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1A1 Gene
Genomics for AKR1A1 Gene
GeneHancer (GH) Regulatory Elements for AKR1A1 Gene
Promoters and enhancers for AKR1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AKR1A1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AKR1A1 gene promoter:
Regulatory Element Products
Genomic Locations for AKR1A1 Gene
Genomic Locations for AKR1A1 Gene
- chr1:45,550,543-45,570,051
- (GRCh38/hg38)
- Size:
- 19,509 bases
- Orientation:
- Plus strand
- chr1:46,016,215-46,035,723
- (GRCh37/hg19)
Genomic View for AKR1A1 Gene
Genes around AKR1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by Entrez Gene
- 1p34.1 by HGNC
- 1p34.1 by Ensembl
AKR1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AKR1A1 Gene
Proteins for AKR1A1 Gene
-
Protein details for AKR1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14550-AK1A1_HUMAN
- Recommended name:
- Alcohol dehydrogenase [NADP(+)]
- Protein Accession:
- P14550
- A8KAL8
- D3DQ04
- Q6IAZ4
Protein attributes for AKR1A1 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 36573 Da
- Quaternary structure:
-
- Monomer.
Protein Expression for AKR1A1 Gene
Post-translational modifications for AKR1A1 Gene
Other Protein References for AKR1A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for AKR1A1
- Invitrogen Antibodies for AKR1A1
- GeneTex AKR1A1 Antibody for AKR1A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for AKR1A1
- Sino Biological Antibodies for AKR1A1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for AKR1A1
- Origene Custom Protein Services for AKR1A1
- Sino Biological Recombinant Proteins for AKR1A1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for AKR1A1
- Search GeneTex for Proteins for AKR1A1
Assay Products
No data available for DME Specific Peptides for AKR1A1 Gene
Domains & Families for AKR1A1 Gene
Gene Families for AKR1A1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for AKR1A1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AKR1A1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P14550- Family:
-
- Belongs to the aldo/keto reductase family.
Function for AKR1A1 Gene
Molecular function for AKR1A1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
- UniProtKB/Swiss-Prot CatalyticActivity:
- An alcohol + NADP(+) = an aldehyde + NADPH.
- GENATLAS Biochemistry:
- aldehyde reductase 1,monomeric NADPH dependent,expressed in many organs predominantly in kidney,cortex,liver,thyroid,small intestine,cytosolic reducing various biogenic and xenobiotic aldehyde compounds,with two alternatively spliced transcripts encoding the same protein
Enzyme Numbers (IUBMB) for AKR1A1 Gene
Phenotypes From GWAS Catalog for AKR1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | IEA | -- |
| GO:0004033 | aldo-keto reductase (NADP) activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0008106 | alcohol dehydrogenase (NADP+) activity | IBA,IEA | -- |
| GO:0009055 | electron transfer activity | TAS | 2498333 |
Phenotypes for AKR1A1 Gene
- MGI mutant phenotypes for AKR1A1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for AKR1A1:
-
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance
Animal Models for AKR1A1 Gene
- MGI Knock Outs for AKR1A1:
-
- Akr1a1 Akr1a1<tm1Maka>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AKR1A1
-
CRISPR Products
-
OriGene CRISPR knockouts for AKR1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AKR1A1
- genomics-online: gRNA clones - Search results for available AKR1A1 gene related products
- Applied Biological Materials CRISPR for AKR1A1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AKR1A1
- GenScript: Design CRISPR guide RNA sequences for AKR1A1
miRNA for AKR1A1 Gene
- miRTarBase miRNAs that target AKR1A1
-
- hsa-mir-34a-5p (MIRT025351)
- hsa-let-7b-5p (MIRT032282)
- hsa-mir-186-5p (MIRT045288)
- hsa-mir-1207-5p (MIRT790043)
- hsa-mir-1286 (MIRT790086)
- hsa-mir-1468-5p (MIRT790117)
- hsa-mir-3688-5p (MIRT790340)
- hsa-mir-4474-3p (MIRT790472)
- hsa-mir-4736 (MIRT790600)
- hsa-mir-4763-3p (MIRT790621)
- hsa-mir-6861-3p (MIRT791051)
- hsa-mir-7108-5p (MIRT791091)
- hsa-mir-7150 (MIRT791102)
- hsa-mir-891a-3p (MIRT791149)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AKR1A1
- Browse OriGene Inhibitory RNA Products For AKR1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1A1
- genomics-online: shRNA clones - Search results for available AKR1A1 gene related products
Clone Products
-
OriGene ORF clones in human for AKR1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AKR1A1
- VectorBuilder custom plasmid, inducible vectors for AKR1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKR1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AKR1A1
- genomics-online: cdna clones - Search results for available AKR1A1 gene related products
- orf clones - Search results for available AKR1A1 gene related products
- Applied Biological Materials Clones for AKR1A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AKR1A1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKR1A1 Gene
Localization for AKR1A1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 23580065 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016324 | apical plasma membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for AKR1A1 Gene
Pathways & Interactions for AKR1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type | ||
| 2 | Metabolism |
.37
|
|
| 3 | Porphyrin and chlorophyll metabolism | ||
| 4 | Cyclophosphamide Pathway, Pharmacodynamics | ||
| 5 | superpathway of tryptophan utilization | ||
Pathways by source for AKR1A1 Gene
4 BioSystems pathways for AKR1A1 Gene
6 Reactome pathways for AKR1A1 Gene
4 KEGG pathways for AKR1A1 Gene
2 GeneGo (Thomson Reuters) pathways for AKR1A1 Gene
Interacting Proteins for AKR1A1 Gene
Selected Interacting proteins:
P14550-AK1A1_HUMAN
ENSP00000312606
for AKR1A1 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for AKR1A1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006006 | glucose metabolic process | TAS | 2498333 |
| GO:0006081 | cellular aldehyde metabolic process | TAS | 2498333 |
| GO:0019640 | glucuronate catabolic process to xylulose 5-phosphate | TAS | -- |
| GO:0019853 | L-ascorbic acid biosynthetic process | IEA | -- |
| GO:0022900 | electron transport chain | IEA | -- |
No data available for SIGNOR curated interactions for AKR1A1 Gene
Drugs & Compounds for AKR1A1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| 6-Hydroxyhexanoic acid |
|
1191-25-9 |
|
|||
| Adipate semialdehyde |
|
928-81-4 |
|
Transcripts for AKR1A1 Gene
mRNA/cDNA for AKR1A1 Gene
- (653) Selected AceView cDNA sequences:
- (11) Additional mRNA sequences :
- (6) REFSEQ mRNAs :
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000351829 1166 bps (uc001coe.4)
- ENST00000372070 1818 bps (uc001cod.4)
- ENST00000434299 840 bps (uc057fzz.1)
- ENST00000471651 1018 bps (uc031tzm.2)
- ENST00000473038 948 bps (uc057gae.1)
Unigene Clusters for AKR1A1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for AKR1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AKR1A1
- genomics-online: gRNA clones - Search results for available AKR1A1 gene related products
- Applied Biological Materials CRISPR for AKR1A1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AKR1A1
- GenScript: Design CRISPR guide RNA sequences for AKR1A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AKR1A1
- Browse OriGene Inhibitory RNA Products For AKR1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1A1
- genomics-online: shRNA clones - Search results for available AKR1A1 gene related products
Clone Products
-
OriGene ORF clones in human for AKR1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AKR1A1
- VectorBuilder custom plasmid, inducible vectors for AKR1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKR1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AKR1A1
- genomics-online: cdna clones - Search results for available AKR1A1 gene related products
- orf clones - Search results for available AKR1A1 gene related products
- Applied Biological Materials Clones for AKR1A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - |
| ExUns: | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | ||||||||||||
| SP3: | - | - | - | - | |||||||||
| SP4: | - | - | - | - | |||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | - | - | - | ||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | |||||||||||||
| SP14: | |||||||||||||
| SP15: | |||||||||||||
| SP16: | |||||||||||||
| SP17: | |||||||||||||
| SP18: | - | - | - | - | |||||||||
| SP19: |
Expression for AKR1A1 Gene
This gene is overexpressed in Liver, secretome (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR1A1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AKR1A1 Gene:
AKR1A1SOURCE GeneReport for Unigene cluster for AKR1A1 Gene:
Hs.474584mRNA Expression by UniProt/SwissProt for AKR1A1 Gene:
P14550-AK1A1_HUMAN
Tissue specificity:
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
Evidence on tissue expression from TISSUES for AKR1A1 Gene
- Liver(4.7)
- Kidney(4.6)
- Intestine(4.4)
- Nervous system(3.9)
- Lung(3.3)
- Skin(3.3)
- Eye(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for AKR1A1
-
OriGene qPCR primer pairs for AKR1A1
- genomics-online: primer clones - Search results for available AKR1A1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1A1 Gene
Orthologs for AKR1A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AKR1A1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | AKR1A1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AKR1A1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Akr1a1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Akr1a1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AKR1A1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | AKR1A1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AKR1A1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | AKR1A1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | akr1a1 33 |
|
||
| Str.11963 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10170 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | akr1a1b 34 33 |
|
OneToOne | |
| Dr.13132 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1439 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6084 35 |
|
|
|
| CG6083 34 35 |
|
OneToMany | |||
| CG9436 34 35 |
|
OneToMany | |||
| CG2767 35 |
|
|
|||
| CG10638 34 35 |
|
OneToMany | |||
| CG10863 34 |
|
OneToMany | |||
| CG12766 34 35 |
|
OneToMany | |||
| ARY 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | Y39G8B.1 34 |
|
OneToMany | |
| Y39G8B.1b 35 |
|
|
|||
| Y39G8B.1a 35 |
|
|
|||
| T08H10.1 34 35 |
|
OneToMany | |||
| C07D8.6 34 35 |
|
OneToMany | |||
| ZC443.1 35 |
|
|
|||
| F53F1.3 35 |
|
|
|||
| F53F1.2 35 |
|
|
|||
| Y39G8B.2 34 35 |
|
OneToMany | |||
| C35D10.6 35 |
|
|
|||
| K07C5.2 35 |
|
|
|||
| C01G5.5 35 |
|
|
|||
| C07D8.5 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GRE3 34 |
|
OneToMany | |
| GCY1 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G37760 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3560 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.12012 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC26F1.07 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04510 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| CSA.5991 34 |
|
ManyToMany |
- Species where no ortholog for AKR1A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for AKR1A1 Gene
- ENSEMBL:
- Gene Tree for AKR1A1 (if available)
- TreeFam:
- Gene Tree for AKR1A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AKR1A1: view image
Paralogs for AKR1A1 Gene
Paralogs for AKR1A1 Gene
(11) SIMAP similar genes for AKR1A1 Gene using alignment to 4 proteins:
- AK1A1_HUMAN
- Q5T621_HUMAN
- V9GYG2_HUMAN
- V9GYP9_HUMAN
Pseudogenes.org Pseudogenes for AKR1A1 Gene
Variants for AKR1A1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042735 | -- | 45,567,730(+) | G/A | intron_variant | |
| rs1000104279 | -- | 45,566,449(+) | C/T | intron_variant | |
| rs1000185295 | -- | 45,561,221(+) | G/A/C | intron_variant | |
| rs1000189368 | -- | 45,551,675(+) | C/T | intron_variant | |
| rs1000521210 | -- | 45,562,725(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3585910 | CNV | loss | 21293372 |
| esv3893512 | CNV | gain | 25118596 |
| nsv829726 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.64;
56.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AKR1A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AKR1A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1A1 Gene
Disorders for AKR1A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ethylene glycol poisoning |
|
|
| fetal alcohol syndrome |
|
|
| methanol poisoning |
|
|
| alcohol abuse |
|
|
| alzheimer disease mitochondrial |
|
|
Search AKR1A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AKR1A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AKR1A1 Gene
Publications for AKR1A1 Gene
- The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32. (PMID: 10393438) Fujii J … Taniguchi N (Cytogenetics and cell genetics 1999) 2 3 4 22 58
- Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. (PMID: 17149600) Lan Q … Chanock S (Human genetics 2007) 3 22 44 58
- Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. (PMID: 10510318) O'connor T … Hayes JD (The Biochemical journal 1999) 3 4 22 58
- The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. (PMID: 2498333) Bohren KM … Gabbay KH (The Journal of biological chemistry 1989) 2 3 4 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
Products for AKR1A1 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for AKR1A1
- Browse OriGene ELISA Kits
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- OriGene qPCR primer pairs for AKR1A1
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- OriGene ORF clones in human for AKR1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Transfection Reagent
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- Novus Biologicals proteins and lysates for AKR1A1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- ProSpec Recombinant Proteins for AKR1A1
- VectorBuilder custom plasmid, inducible vectors for AKR1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKR1A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 133 available AKR1A1 Antibodies ranked by validation data
- Compare Top AKR1A1 Antibodies
- antibodies-online: Search results for 1 available AKR1A1 Elisa Kits ranked by validation data
- Compare Top AKR1A1 Elisa Kits
- antibodies-online: Search results for 17 available AKR1A1 Proteins ranked by validation data
- Compare Top AKR1A1 Proteins
- GeneTex AKR1A1 Antibody for AKR1A1
- Search GeneTex for Proteins for AKR1A1
- Santa Cruz Biotechnology (SCBT) Antibodies for AKR1A1
- Search Santa Cruz Biotechnology (SCBT) for AKR1A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AKR1A1
- Horizon Cell Lines for AKR1A1
- genomics-online: cdna clones - Search results for available AKR1A1 gene related products
- orf clones - Search results for available AKR1A1 gene related products
- genomics-online: gRNA clones - Search results for available AKR1A1 gene related products
- genomics-online: primer clones - Search results for available AKR1A1 gene related products
- genomics-online: shRNA clones - Search results for available AKR1A1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AKR1A1
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- GeneCopoeia miRNA 3'UTR Target clone products for AKR1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKR1A1
Sources for AKR1A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148)