This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct i... See more...

Aliases for AKAP7 Gene

Aliases for AKAP7 Gene

  • A-Kinase Anchoring Protein 7 2 3 5
  • A Kinase (PRKA) Anchor Protein 7 2 3
  • A-Kinase Anchor Protein 18 KDa 3 4
  • AKAP 18 3 4
  • AKAP15 3 4
  • AKAP18 3 4
  • Protein Kinase A-Anchoring Protein 7 Isoforms Alpha/Beta 4
  • Protein Kinase A-Anchoring Protein 7 Isoform Gamma 4
  • A-Kinase Anchor Protein 7 Isoforms Alpha And Beta 4
  • A-Kinase Anchor Protein 7 Isoform Gamma 4
  • AKAP-7 Isoforms Alpha And Beta 4
  • A-Kinase Anchor Protein 9 KDa 3
  • PRKA7 Isoforms Alpha/Beta 4
  • AKAP-7 Isoform Gamma 4
  • PRKA7 Isoform Gamma 4

External Ids for AKAP7 Gene

Previous GeneCards Identifiers for AKAP7 Gene

  • GC06P131313
  • GC06P131447
  • GC06P131508
  • GC06P129047

Summaries for AKAP7 Gene

Entrez Gene Summary for AKAP7 Gene

  • This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

GeneCards Summary for AKAP7 Gene

AKAP7 (A-Kinase Anchoring Protein 7) is a Protein Coding gene. Diseases associated with AKAP7 include Noonan Syndrome 2 and Crouzon Syndrome With Acanthosis Nigricans. Among its related pathways are Activation of cAMP-Dependent PKA and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include nucleotide binding and protein kinase A binding. An important paralog of this gene is AKAIN1.

UniProtKB/Swiss-Prot Summary for AKAP7 Gene

  • Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
  • Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Gene Wiki entry for AKAP7 Gene

Additional gene information for AKAP7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKAP7 Gene

Genomics for AKAP7 Gene

GeneHancer (GH) Regulatory Elements for AKAP7 Gene

Promoters and enhancers for AKAP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J131134 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 533.8 +0.3 264 2.5 POLR2G NCOR1 PHF8 ZFX ZIC2 POLR2A KDM6A ZBTB26 REST KLF7 AKAP7 lnc-EPB41L2-1
GH06J131249 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 504.5 +116.0 115995 3.1 POLR2A RAD21 TAF1 YY1 AKAP7 ARG1 piR-58308-309 lnc-AKAP7-1
GH06J130825 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 9.9 -308.5 -308489 4.8 EP300 FOXK2 POLR2G NCOR1 TEAD4 KDM6A TCF7 ZBTB25 TGIF2 SKI SMLR1 AKAP7 piR-56759-502 EPB41L2
GH06J130966 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 9.2 -166.5 -166544 4.4 ZSCAN5C SKI TEAD1 ATF2 TBX3 ZKSCAN8 ZSCAN9 KMT2B WT1 FOXA2 SMLR1 AKAP7 lnc-SAMD3-5 EPB41L2
GH06J131106 Enhancer 1 Ensembl ENCODE 11.2 -27.4 -27366 3.4 FOS TCF7 TRIM28 BCL11A CREB1 FOXA2 TRIM24 SAP130 FOSL2 ARNT AKAP7 EPB41L2 SMLR1 LOC102723445 HSALNG0053474 piR-50983
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKAP7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKAP7

Top Transcription factor binding sites by QIAGEN in the AKAP7 gene promoter:
  • aMEF-2
  • AP-1
  • Brachyury
  • c-Myb
  • CUTL1
  • GATA-1
  • HEN1
  • Lhx3a
  • LHX3b
  • Pbx1a

Genomic Locations for AKAP7 Gene

Genomic Locations for AKAP7 Gene
chr6:131,135,467-131,283,535
(GRCh38/hg38)
Size:
148,069 bases
Orientation:
Plus strand
chr6:131,456,806-131,604,675
(GRCh37/hg19)
Size:
147,870 bases
Orientation:
Plus strand

Genomic View for AKAP7 Gene

Genes around AKAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP7 Gene

Proteins for AKAP7 Gene

  • Protein details for AKAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M2-AKA7G_HUMAN
    Recommended name:
    A-kinase anchor protein 7 isoform gamma
    Protein Accession:
    Q9P0M2
    Secondary Accessions:
    • B4DUC3
    • Q9HCZ8

    Protein attributes for AKAP7 Gene

    Size:
    348 amino acids
    Molecular mass:
    39518 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.
    SequenceCaution:
    • Sequence=AAF28106.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKAP7 Gene

    Alternative splice isoforms for AKAP7 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for AKAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43687-AKA7A_HUMAN
    Recommended name:
    A-kinase anchor protein 7 isoforms alpha and beta
    Protein Accession:
    O43687
    Secondary Accessions:
    • A8K2K6
    • Q5TBR9
    • Q5TBS0
    • Q9HCZ8
    • Q9P0G4

    Protein attributes for AKAP7 Gene

    Size:
    104 amino acids
    Molecular mass:
    11465 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.

    Alternative splice isoforms for AKAP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP7 Gene

Post-translational modifications for AKAP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AKAP7 Gene

Domains & Families for AKAP7 Gene

Gene Families for AKAP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for AKAP7 Gene

Suggested Antigen Peptide Sequences for AKAP7 Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase A-anchoring protein 7 isoforms alpha/beta (AKA7A_HUMAN)
  • Protein kinase A-anchoring protein 7 isoform gamma (AKA7G_HUMAN)
  • cDNA, FLJ92081, Homo sapiens A kinase (PRKA) anchor protein 7 (AKAP7), transcriptvariant alpha, mRNA (Q2TAJ5_HUMAN)
  • A kinase (PRKA) anchor protein 7 (Q6P4D3_HUMAN)
genes like me logo Genes that share domains with AKAP7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AKAP7 Gene

Function for AKAP7 Gene

Molecular function for AKAP7 Gene

UniProtKB/Swiss-Prot Function:
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
UniProtKB/Swiss-Prot Function:
Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RIIA) anchor protein 7,potentially involved in ion channel activation

Phenotypes From GWAS Catalog for AKAP7 Gene

Gene Ontology (GO) - Molecular Function for AKAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 17244820
GO:0016301 kinase activity IEA --
GO:0019901 protein kinase binding IEA --
GO:0034237 protein kinase A regulatory subunit binding IBA,IEA 21873635
genes like me logo Genes that share ontologies with AKAP7: view
genes like me logo Genes that share phenotypes with AKAP7: view

Animal Models for AKAP7 Gene

MGI Knock Outs for AKAP7:
  • Akap7 Akap7<tm2b(EUCOMM)Hmgu>
  • Akap7 Akap7<tm1.1Gsm>

miRNA for AKAP7 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKAP7 Gene

Localization for AKAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP7 Gene

Nucleus. Cytoplasm.
[Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.
[Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP7 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AKAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IBA 10613906
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AKAP7: view

Pathways & Interactions for AKAP7 Gene

PathCards logo

SuperPathways for AKAP7 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
2 Signal transduction_PKA signaling
-
3 DAG and IP3 signaling
genes like me logo Genes that share pathways with AKAP7: view

Pathways by source for AKAP7 Gene

1 BioSystems pathway for AKAP7 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP7 Gene
  • Signal transduction_PKA signaling
4 Qiagen pathways for AKAP7 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • cAMP Pathway
  • PKA Signaling

Gene Ontology (GO) - Biological Process for AKAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IC --
GO:0006811 ion transport TAS --
GO:0008104 protein localization IC --
GO:0008150 biological_process ND --
GO:0010738 regulation of protein kinase A signaling IBA 21873635
genes like me logo Genes that share ontologies with AKAP7: view

No data available for SIGNOR curated interactions for AKAP7 Gene

Drugs & Compounds for AKAP7 Gene

(2) Drugs for AKAP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with AKAP7: view

Transcripts for AKAP7 Gene

mRNA/cDNA for AKAP7 Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

  • Applied Biological Materials (abm):