Aliases for AKAP6 Gene
External Ids for AKAP6 Gene
Previous GeneCards Identifiers for AKAP6 Gene
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]
GeneCards Summary for AKAP6 Gene
AKAP6 (A-Kinase Anchoring Protein 6) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include ion channel binding and protein kinase A binding. An important paralog of this gene is CEP68.
UniProtKB/Swiss-Prot for AKAP6 Gene
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.