Aliases for AKAP5 Gene
External Ids for AKAP5 Gene
Previous GeneCards Identifiers for AKAP5 Gene
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
GeneCards Summary for AKAP5 Gene
AKAP5 (A-Kinase Anchoring Protein 5) is a Protein Coding gene. Diseases associated with AKAP5 include Crouzon Syndrome With Acanthosis Nigricans and Fleck Retina, Familial Benign. Among its related pathways are Metabolism and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calmodulin binding and adenylate cyclase binding.
UniProtKB/Swiss-Prot Summary for AKAP5 Gene
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740).