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Aliases for AKAP17A Gene

Aliases for AKAP17A Gene

  • A-Kinase Anchoring Protein 17A 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 17A 2 3 4
  • Protein Kinase A-Anchoring Protein 17A 3 4
  • A Kinase (PRKA) Anchor Protein 17A 2 3
  • AKAP-17A 3 4
  • DXYS155E 3 4
  • CXYorf3 3 4
  • SFRS17A 3 4
  • PRKA17A 3 4
  • 721P 3 4
  • XE7 3 4
  • Chromosome X And Y Open Reading Frame 3 2
  • B-Lymphocyte Surface Antigen 3
  • A-Kinase Anchor Protein 17A 3
  • Pseudoautosomal Gene XE7 3
  • B-Lymphocyte Antigen 4
  • Protein XE7 4
  • CCDC133 3
  • XE7Y 3

External Ids for AKAP17A Gene

Previous HGNC Symbols for AKAP17A Gene

  • CXYorf3
  • SFRS17A

Previous GeneCards Identifiers for AKAP17A Gene

  • GC0XP001710

Summaries for AKAP17A Gene

Entrez Gene Summary for AKAP17A Gene

  • This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]

GeneCards Summary for AKAP17A Gene

AKAP17A (A-Kinase Anchoring Protein 17A) is a Protein Coding gene. Diseases associated with AKAP17A include Null-Cell Leukemia and Chronic Tic Disorder. Gene Ontology (GO) annotations related to this gene include protein kinase A binding.

UniProtKB/Swiss-Prot for AKAP17A Gene

  • Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.

Gene Wiki entry for AKAP17A Gene

Additional gene information for AKAP17A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP17A Gene

Genomics for AKAP17A Gene

GeneHancer (GH) Regulatory Elements for AKAP17A Gene

Promoters and enhancers for AKAP17A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI001591 Promoter 1.8 EPDnew Ensembl 550.8 +0.5 508 1.8 PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 GLIS2 E2F8 AKAP17A P2RY8 ASMT
GH0XI001589 Enhancer 0.5 Ensembl 550.8 -1.9 -1892 0.6 GATA3 CEBPA KLF17 CEBPG AKAP17A P2RY8
GH0XI001590 Enhancer 0.4 Ensembl 550.8 -1.3 -1292 0.2 HDGF HIC1 NBN AKAP17A P2RY8
GH0XI001391 Promoter 1.9 EPDnew Ensembl 11.9 -199.2 -199192 2.4 CLOCK MLX ZFP64 YBX1 DMAP1 ZNF213 E2F8 ZNF143 ZNF263 SP3 LOC105373102 SLC25A6 AKAP17A
GH0XI001500 Enhancer 1.4 FANTOM5 Ensembl dbSUPER 16.1 -88.5 -88492 5 HDGF PKNOX1 ATF1 SMAD1 IRF4 ZNF121 ZNF766 ZNF207 ATF7 RUNX3 P2RY8 AKAP17A CSF2RA IL3RA ASMTL ASMT CRLF2 SLC25A6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AKAP17A on UCSC Golden Path with GeneCards custom track

Genomic Locations for AKAP17A Gene

Genomic Locations for AKAP17A Gene
10,928 bases
Plus strand

Genomic View for AKAP17A Gene

Genes around AKAP17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP17A Gene

Proteins for AKAP17A Gene

  • Protein details for AKAP17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein 17A
    Protein Accession:
    Secondary Accessions:
    • Q02832
    • Q2TB98
    • Q5JQ74
    • Q5JQ76
    • Q8N6U9

    Protein attributes for AKAP17A Gene

    695 amino acids
    Molecular mass:
    80735 Da
    Quaternary structure:
    • Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain. Interacts with RI and RII subunits of PKA.
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    • Sequence=AAA36187.1; Type=Frameshift; Positions=461; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP17A Gene


neXtProt entry for AKAP17A Gene

Post-translational modifications for AKAP17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP17A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKAP17A Gene

Domains & Families for AKAP17A Gene

Gene Families for AKAP17A Gene

Protein Domains for AKAP17A Gene


Suggested Antigen Peptide Sequences for AKAP17A Gene

Graphical View of Domain Structure for InterPro Entry



  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
genes like me logo Genes that share domains with AKAP17A: view

Function for AKAP17A Gene

Molecular function for AKAP17A Gene

UniProtKB/Swiss-Prot Function:
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.

Gene Ontology (GO) - Molecular Function for AKAP17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22681889
GO:0005515 protein binding IPI 16982639
GO:0051018 protein kinase A binding IDA,IEA 19840947
genes like me logo Genes that share ontologies with AKAP17A: view

Phenotypes for AKAP17A Gene

genes like me logo Genes that share phenotypes with AKAP17A: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP17A Gene

Localization for AKAP17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP17A Gene

Nucleus speckle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP17A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKAP17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19840947
GO:0005681 spliceosomal complex IEA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA,IEA 16982639
genes like me logo Genes that share ontologies with AKAP17A: view

Pathways & Interactions for AKAP17A Gene

SuperPathways for AKAP17A Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKAP17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 1438229
GO:0006397 mRNA processing IEA --
GO:0007165 signal transduction NAS 1438229
GO:0008380 RNA splicing IEA --
GO:0042113 B cell activation NAS 1438229
genes like me logo Genes that share ontologies with AKAP17A: view

No data available for Pathways by source and SIGNOR curated interactions for AKAP17A Gene

Drugs & Compounds for AKAP17A Gene

No Compound Related Data Available

Transcripts for AKAP17A Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP17A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP3: - -

Relevant External Links for AKAP17A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKAP17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKAP17A Gene

Protein differential expression in normal tissues from HIPED for AKAP17A Gene

This gene is overexpressed in Colon (20.3), Peripheral blood mononuclear cells (7.4), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKAP17A Gene

Protein tissue co-expression partners for AKAP17A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AKAP17A Gene:


mRNA Expression by UniProt/SwissProt for AKAP17A Gene:

Tissue specificity: Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.

Evidence on tissue expression from TISSUES for AKAP17A Gene

  • Blood(4.4)
  • Liver(4.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with AKAP17A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP17A Gene

Orthologs for AKAP17A Gene

This gene was present in the common ancestor of animals.

Orthologs for AKAP17A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AKAP17A 33 34
  • 90.59 (n)
(Canis familiaris)
Mammalia -- 34
  • 88 (a)
-- 34
  • 88 (a)
AKAP17A 33
  • 86.94 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
-- 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia AKAP17A 34
  • 81 (a)
(Mus musculus)
Mammalia Akap17b 34
  • 22 (a)
(Gallus gallus)
Aves AKAP17A 33 34
  • 67.08 (n)
(Anolis carolinensis)
Reptilia AKAP17A 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia akap17a 33
  • 61.38 (n)
Str.10670 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32104 33
(Danio rerio)
Actinopterygii akap17a 33 34
  • 74.44 (n)
zgc65888 33
fruit fly
(Drosophila melanogaster)
Insecta Xe7 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cux-7 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5814 34
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8023 33
Species where no ortholog for AKAP17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKAP17A Gene

Gene Tree for AKAP17A (if available)
Gene Tree for AKAP17A (if available)

Paralogs for AKAP17A Gene

(1) SIMAP similar genes for AKAP17A Gene using alignment to 1 proteins: Pseudogenes for AKAP17A Gene

genes like me logo Genes that share paralogs with AKAP17A: view

No data available for Paralogs for AKAP17A Gene

Variants for AKAP17A Gene

Sequence variations from dbSNP and Humsavar for AKAP17A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111161782 -- 1,596,662(+) T/C intron_variant
rs111161783 -- 1,596,666(+) T/A intron_variant
rs111162435 -- 1,596,680(+) C/T intron_variant
rs111256340 -- 1,593,449(+) A/G 5_prime_UTR_variant, non_coding_transcript_variant
rs111332569 -- 1,599,780(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP17A Gene

Variant ID Type Subtype PubMed ID
esv2314773 CNV deletion 18987734
esv2657890 CNV deletion 23128226
esv2739739 CNV deletion 23290073
esv2739741 CNV deletion 23290073
esv2739742 CNV deletion 23290073
esv29996 CNV loss 17803354
nsv1078146 CNV duplication 25765185
nsv1125145 CNV duplication 24896259
nsv510811 CNV deletion 20534489

Variation tolerance for AKAP17A Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKAP17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP17A Gene

Disorders for AKAP17A Gene

MalaCards: The human disease database

(2) MalaCards diseases for AKAP17A Gene - From: DISEASES

Disorder Aliases PubMed IDs
null-cell leukemia
  • null cell acute lymphoblastic leukemia
chronic tic disorder
  • chronic motor or vocal tic disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AKAP17A

genes like me logo Genes that share disorders with AKAP17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKAP17A Gene

Publications for AKAP17A Gene

  1. Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments. (PMID: 19840947) Jarnaess E … Taskén K (The Journal of biological chemistry 2009) 2 3 4 58
  2. Cloning and sequencing of a trophoblast-endothelial-activated lymphocyte surface protein: cDNA sequence and genomic structure. (PMID: 1438229) Voland JR … Dutton RW (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. (PMID: 16982639) Mangs AH … Morris BJ (Nucleic acids research 2006) 3 4 58
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 58

Products for AKAP17A Gene

Sources for AKAP17A Gene

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