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Aliases for AKAP14 Gene

Aliases for AKAP14 Gene

  • A-Kinase Anchoring Protein 14 2 3 5
  • Protein Kinase A-Anchoring Protein 14 3 4
  • A Kinase (PRKA) Anchor Protein 14 2 3
  • A-Kinase Anchor Protein 28 KDa 3 4
  • AKAP 28 3 4
  • AKAP-14 3 4
  • AKAP28 3 4
  • PRKA14 3 4
  • A-Kinase Anchoring Protein 28 3
  • A-Kinase Anchor Protein 14 3

External Ids for AKAP14 Gene

Previous GeneCards Identifiers for AKAP14 Gene

  • GC0XP118811
  • GC0XP118913
  • GC0XP119029
  • GC0XP108526

Summaries for AKAP14 Gene

Entrez Gene Summary for AKAP14 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP14 Gene

AKAP14 (A-Kinase Anchoring Protein 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase A binding.

UniProtKB/Swiss-Prot for AKAP14 Gene

  • Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Additional gene information for AKAP14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP14 Gene

Genomics for AKAP14 Gene

GeneHancer (GH) Regulatory Elements for AKAP14 Gene

Promoters and enhancers for AKAP14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119885 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.4 -9.5 -9518 1.6 FOXA2 ARID4B MZF1 ZNF766 FOS CREM THAP11 NFYA ZBTB11 NFYC GC0XP119884 GC0XP119886 GC0XP119888 AKAP14 UPF3B
GH0XJ119896 Promoter 0.6 EPDnew 650.7 +0.3 342 0.1 RFX1 AKAP14 PIR36206 GC0XM119933
GH0XJ119895 Promoter 0.5 EPDnew 650.7 +0.0 37 0.1 AKAP14 PIR36206 GC0XM119933
GH0XJ119769 Enhancer 0.6 FANTOM5 9 -126.3 -126336 0.4 ZNF316 NFATC3 NFYB SP2 ASH1L EMSY MAFK RHOXF1 NDUFA1 RNF113A AKAP14 UPF3B SOWAHD SNORA69 GC0XM119788 GC0XM119789
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKAP14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AKAP14 gene promoter:
  • Sox5
  • HFH-1
  • FOXL1
  • FOXD1
  • FOXO3b
  • FOXO3a
  • FOXO3
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXF2

Genomic Locations for AKAP14 Gene

Genomic Locations for AKAP14 Gene
24,880 bases
Plus strand
24,880 bases
Plus strand

Genomic View for AKAP14 Gene

Genes around AKAP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP14 Gene

Proteins for AKAP14 Gene

  • Protein details for AKAP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein 14
    Protein Accession:
    Secondary Accessions:
    • A6NNZ0
    • Q86UN4
    • Q86UN5

    Protein attributes for AKAP14 Gene

    197 amino acids
    Molecular mass:
    22815 Da
    Quaternary structure:
    • Binds to type II regulatory subunits (RII).

    Alternative splice isoforms for AKAP14 Gene


neXtProt entry for AKAP14 Gene

Post-translational modifications for AKAP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP14 Gene

No data available for DME Specific Peptides for AKAP14 Gene

Domains & Families for AKAP14 Gene

Gene Families for AKAP14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AKAP14 Gene


Suggested Antigen Peptide Sequences for AKAP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AKAP14: view

No data available for UniProtKB/Swiss-Prot for AKAP14 Gene

Function for AKAP14 Gene

Molecular function for AKAP14 Gene

UniProtKB/Swiss-Prot Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Gene Ontology (GO) - Molecular Function for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12475942
GO:0034237 protein kinase A regulatory subunit binding IPI 12475942
genes like me logo Genes that share ontologies with AKAP14: view
genes like me logo Genes that share phenotypes with AKAP14: view

Animal Model Products

miRNA for AKAP14 Gene

miRTarBase miRNAs that target AKAP14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP14 Gene

Localization for AKAP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP14 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP14 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005930 axoneme IDA 12475942
GO:0005952 cAMP-dependent protein kinase complex IMP 12475942
genes like me logo Genes that share ontologies with AKAP14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AKAP14 Gene

Pathways & Interactions for AKAP14 Gene

SuperPathways for AKAP14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with AKAP14: view

No data available for Pathways by source and SIGNOR curated interactions for AKAP14 Gene

Drugs & Compounds for AKAP14 Gene

No Compound Related Data Available

Transcripts for AKAP14 Gene

mRNA/cDNA for AKAP14 Gene

Unigene Clusters for AKAP14 Gene

A kinase (PRKA) anchor protein 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP14 Gene

No ASD Table

Relevant External Links for AKAP14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKAP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKAP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP14 Gene

This gene is overexpressed in Testis (x34.8).

Protein differential expression in normal tissues from HIPED for AKAP14 Gene

This gene is overexpressed in Gallbladder (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKAP14 Gene

Protein tissue co-expression partners for AKAP14 Gene

NURSA nuclear receptor signaling pathways regulating expression of AKAP14 Gene:


SOURCE GeneReport for Unigene cluster for AKAP14 Gene:


mRNA Expression by UniProt/SwissProt for AKAP14 Gene:

Tissue specificity: Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.

Evidence on tissue expression from TISSUES for AKAP14 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with AKAP14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP14 Gene

Orthologs for AKAP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AKAP14 34 33
  • 99.49 (n)
(Canis familiaris)
Mammalia AKAP14 33
  • 69.62 (n)
(Rattus norvegicus)
Mammalia Akap14 33
  • 69.17 (n)
(Bos Taurus)
Mammalia AKAP14 34 33
  • 68.57 (n)
(Mus musculus)
Mammalia Akap14 16 34 33
  • 65.57 (n)
(Ornithorhynchus anatinus)
Mammalia AKAP14 34
  • 35 (a)
(Gallus gallus)
Aves AKAP14 34
  • 32 (a)
(Anolis carolinensis)
Reptilia AKAP14 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for AKAP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP14 Gene

Gene Tree for AKAP14 (if available)
Gene Tree for AKAP14 (if available)
Evolutionary constrained regions (ECRs) for AKAP14: view image

Paralogs for AKAP14 Gene

No data available for Paralogs for AKAP14 Gene

Variants for AKAP14 Gene

Sequence variations from dbSNP and Humsavar for AKAP14 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000172187 -- 119,919,010(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000234920 -- 119,917,958(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000339370 -- 119,899,930(+) A/C/G intron_variant
rs1000360202 -- 119,903,912(+) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000383639 -- 119,909,817(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP14 Gene

Variant ID Type Subtype PubMed ID
dgv203e180 CNV gain 20482838
dgv41e209 CNV duplication 24192839
dgv4609e59 CNV duplication 20981092
esv26416 CNV gain 19812545
esv2758888 CNV gain 17122850
esv29965 CNV gain 17803354
esv3559253 CNV deletion 23714750
esv3577191 CNV gain 25503493
esv996162 CNV insertion 20482838
esv996782 CNV insertion 20482838
nsv433462 CNV gain 18776910
nsv442815 CNV gain+loss 18776908
nsv515166 CNV gain+loss 21397061
nsv515676 CNV gain 19592680
nsv7058 CNV insertion 18451855
nsv7059 CNV insertion 18451855
nsv9969 CNV gain 18304495

Variation tolerance for AKAP14 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKAP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP14 Gene

Disorders for AKAP14 Gene

Additional Disease Information for AKAP14

No disorders were found for AKAP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP14 Gene

Publications for AKAP14 Gene

  1. Characterization of an A-kinase anchoring protein in human ciliary axonemes. (PMID: 12475942) Kultgen PL … Milgram SL (Molecular biology of the cell 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for AKAP14 Gene

Sources for AKAP14 Gene

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