The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulat... See more...

Aliases for AKAP14 Gene

Aliases for AKAP14 Gene

  • A-Kinase Anchoring Protein 14 2 3 5
  • AKAP28 2 3 4
  • Protein Kinase A-Anchoring Protein 14 3 4
  • A Kinase (PRKA) Anchor Protein 14 2 3
  • A-Kinase Anchor Protein 28 KDa 3 4
  • A-Kinase Anchor Protein 14 3 4
  • AKAP 28 3 4
  • AKAP-14 3 4
  • PRKA14 3 4
  • A-Kinase Anchoring Protein 28 3
  • AKAP14 5

External Ids for AKAP14 Gene

Previous GeneCards Identifiers for AKAP14 Gene

  • GC0XP118811
  • GC0XP118913
  • GC0XP119029
  • GC0XP108526

Summaries for AKAP14 Gene

Entrez Gene Summary for AKAP14 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP14 Gene

AKAP14 (A-Kinase Anchoring Protein 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase A binding.

UniProtKB/Swiss-Prot Summary for AKAP14 Gene

  • Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Additional gene information for AKAP14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AKAP14 Gene

Genomics for AKAP14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AKAP14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119885 Promoter/Enhancer 1.1 EPDnew ENCODE 600.4 -9.5 -9518 1.6 SP1 IRF2 CEBPA SP2 ZNF766 FOXA2 MEF2D CREB1 CREM MBD2 lnc-AKAP14-4 lnc-AKAP14-5 lnc-NDUFA1-2 AKAP14 UPF3B NDUFA1 RF00017-8657
GH0XJ119896 Promoter 0.4 EPDnew 600.7 +0.3 342 0.1 RFX1 AKAP14 lnc-NKAP-5 NKAP RF00017-8657
GH0XJ119895 Promoter 0.3 EPDnew 600.7 +0.0 37 0.1 AKAP14 lnc-NKAP-5 NKAP RF00017-8657
GH0XJ119769 Enhancer 0.5 FANTOM5 9 -126.3 -126336 0.4 SP2 ZNF316 NFATC3 EMSY MAFK RHOXF1 NDUFA1 RNF113A AKAP14 UPF3B HSALNG0139786 SOWAHD SNORA69 RPL39 RF00017-8657
GH0XJ119941 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.3 +47.5 47459 3 BRCA1 CREB1 GATAD2A ATF7 PRDM10 ZNF629 RFX1 SIX5 NFKBIZ POLR2A NKAP RHOXF1P3 RHOXF1-AS1 NKRF RHOXF1 AKAP14 RF00017-8657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKAP14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AKAP14

Top Transcription factor binding sites by QIAGEN in the AKAP14 gene promoter:
  • FOXD1
  • FOXF2
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • HFH-1
  • Sox5

Genomic Locations for AKAP14 Gene

Genomic Locations for AKAP14 Gene
chrX:119,895,837-119,920,716
(GRCh38/hg38)
Size:
24,880 bases
Orientation:
Plus strand
chrX:119,029,800-119,054,679
(GRCh37/hg19)
Size:
24,880 bases
Orientation:
Plus strand

Genomic View for AKAP14 Gene

Genes around AKAP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP14 Gene

Proteins for AKAP14 Gene

  • Protein details for AKAP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UN6-AKA28_HUMAN
    Recommended name:
    A-kinase anchor protein 14
    Protein Accession:
    Q86UN6
    Secondary Accessions:
    • A6NNZ0
    • Q86UN4
    • Q86UN5

    Protein attributes for AKAP14 Gene

    Size:
    197 amino acids
    Molecular mass:
    22815 Da
    Quaternary structure:
    • Binds to type II regulatory subunits (RII).

    Alternative splice isoforms for AKAP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP14 Gene

Post-translational modifications for AKAP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP14 Gene

No data available for DME Specific Peptides for AKAP14 Gene

Domains & Families for AKAP14 Gene

Gene Families for AKAP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AKAP14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKAP14 Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase A-anchoring protein 14 (AKA28_HUMAN)
genes like me logo Genes that share domains with AKAP14: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AKAP14 Gene

Function for AKAP14 Gene

Molecular function for AKAP14 Gene

UniProtKB/Swiss-Prot Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Gene Ontology (GO) - Molecular Function for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12475942
GO:0034237 protein kinase A regulatory subunit binding IBA,IPI 12475942
genes like me logo Genes that share ontologies with AKAP14: view
genes like me logo Genes that share phenotypes with AKAP14: view

Animal Model Products

CRISPR Products

miRNA for AKAP14 Gene

miRTarBase miRNAs that target AKAP14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKAP14

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP14 Gene

Localization for AKAP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP14 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005930 axoneme IDA 12475942
GO:0005952 cAMP-dependent protein kinase complex IMP 12475942
genes like me logo Genes that share ontologies with AKAP14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AKAP14 Gene

Pathways & Interactions for AKAP14 Gene

PathCards logo

SuperPathways for AKAP14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with AKAP14: view

No data available for Pathways by source and SIGNOR curated interactions for AKAP14 Gene

Drugs & Compounds for AKAP14 Gene

No Compound Related Data Available

Transcripts for AKAP14 Gene

mRNA/cDNA for AKAP14 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AKAP14

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP14 Gene

No ASD Table

Relevant External Links for AKAP14 Gene

GeneLoc Exon Structure for
AKAP14

Expression for AKAP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKAP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP14 Gene

This gene is overexpressed in Testis (x34.8).

Protein differential expression in normal tissues from HIPED for AKAP14 Gene

This gene is overexpressed in Gallbladder (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKAP14 Gene



Protein tissue co-expression partners for AKAP14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AKAP14

SOURCE GeneReport for Unigene cluster for AKAP14 Gene:

Hs.592245

mRNA Expression by UniProt/SwissProt for AKAP14 Gene:

Q86UN6-AKA28_HUMAN
Tissue specificity: Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.

Evidence on tissue expression from TISSUES for AKAP14 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with AKAP14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP14 Gene

Orthologs for AKAP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AKAP14 30 31
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AKAP14 30
  • 69.62 (n)
Rat
(Rattus norvegicus)
Mammalia Akap14 30
  • 69.17 (n)
Cow
(Bos Taurus)
Mammalia AKAP14 30 31
  • 68.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Akap14 30 17 31
  • 65.57 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia AKAP14 31
  • 35 (a)
OneToOne
Chicken
(Gallus gallus)
Aves AKAP14 31
  • 32 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AKAP14 31
  • 37 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 31 (a)
OneToOne
Species where no ortholog for AKAP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for AKAP14 Gene

ENSEMBL:
Gene Tree for AKAP14 (if available)
TreeFam:
Gene Tree for AKAP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AKAP14: view image

Paralogs for AKAP14 Gene

No data available for Paralogs for AKAP14 Gene

Variants for AKAP14 Gene

Additional dbSNP identifiers (rs#s) for AKAP14 Gene

Structural Variations from Database of Genomic Variants (DGV) for AKAP14 Gene

Variant ID Type Subtype PubMed ID
dgv203e180 CNV gain 20482838
dgv41e209 CNV duplication 24192839
dgv4609e59 CNV duplication 20981092
esv26416 CNV gain 19812545
esv2758888 CNV gain 17122850
esv29965 CNV gain 17803354
esv3559253 CNV deletion 23714750
esv3577191 CNV gain 25503493
esv996162 CNV insertion 20482838
esv996782 CNV insertion 20482838
nsv433462 CNV gain 18776910
nsv442815 CNV gain+loss 18776908
nsv515166 CNV gain+loss 21397061
nsv515676 CNV gain 19592680
nsv7058 CNV insertion 18451855
nsv7059 CNV insertion 18451855
nsv9969 CNV gain 18304495

Variation tolerance for AKAP14 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKAP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKAP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AKAP14 Gene

Disorders for AKAP14 Gene

No disorders were found for AKAP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP14 Gene

Publications for AKAP14 Gene

  1. Characterization of an A-kinase anchoring protein in human ciliary axonemes. (PMID: 12475942) Kultgen PL … Milgram SL (Molecular biology of the cell 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. (PMID: 27503909) Teixeira FR … Laman H (The Biochemical journal 2016) 3

Products for AKAP14 Gene

Sources for AKAP14 Gene