Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AKAP11 Gene

Aliases for AKAP11 Gene

  • A-Kinase Anchoring Protein 11 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 44 2 3
  • Protein Kinase A Anchoring Protein 11 2 3
  • A-Kinase Anchoring Protein, 220kDa 2 3
  • A Kinase (PRKA) Anchor Protein 11 2 3
  • A-Kinase Anchor Protein 220 KDa 3 4
  • AKAP 220 2 4
  • AKAP-11 3 4
  • AKAP220 3 4
  • PRKA11 3 4
  • Protein Kinase A-Anchoring Protein 11 4
  • A Kinase Anchor Protein 220 KDa 3
  • A-Kinase Anchor Protein 11 3
  • KIAA0629 4
  • HAKAP220 4
  • PPP1R44 3

External Ids for AKAP11 Gene

Previous GeneCards Identifiers for AKAP11 Gene

  • GC13P040846
  • GC13P036832
  • GC13P041782
  • GC13P040644
  • GC13P041744
  • GC13P042846
  • GC13P023649

Summaries for AKAP11 Gene

Entrez Gene Summary for AKAP11 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP11 Gene

AKAP11 (A-Kinase Anchoring Protein 11) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include protein kinase A binding and protein phosphatase 1 binding. An important paralog of this gene is SPHKAP.

UniProtKB/Swiss-Prot for AKAP11 Gene

  • Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Gene Wiki entry for AKAP11 Gene

Additional gene information for AKAP11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP11 Gene

Genomics for AKAP11 Gene

GeneHancer (GH) Regulatory Elements for AKAP11 Gene

Promoters and enhancers for AKAP11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J042270 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 669.5 +2.3 2295 6.4 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 AKAP11 NAA16 TNFSF11 DGKH GC13M042285
GH13J042354 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +83.9 83906 2.6 CTCF STAT5A BATF ZIC2 RAD21 IRF4 EED NFATC1 ATF7 ETV6 TNFSF11 AKAP11 DGKH VWA8 FABP3P2 LINC02341
GH13J042279 Enhancer 0.9 Ensembl ENCODE 15 +7.8 7831 0.6 LEF1 ZSCAN4 MAX ZFHX2 FOXK2 EGR1 ATF7 IKZF2 BCLAF1 RUNX3 AKAP11 GC13M042285
GH13J041959 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.1 -310.0 -309956 4.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF207 ZHX2 VWA8 DGKH ENSG00000231530 RNU6-74P AKAP11 VWA8-AS1 GC13P041978
GH13J042333 Enhancer 0.6 ENCODE 16.8 +62.7 62725 1 CTCF CBFB NR2F1 TRIM22 BATF RAD21 NFIC IKZF1 EED ZNF143 GC13M042285 AKAP11 LINC02341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AKAP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AKAP11 gene promoter:
  • Nkx2-5
  • MRF-2
  • IRF-1
  • Max1
  • c-Myc
  • NF-1
  • NF-1/L
  • RP58
  • HEN1

Genomic Locations for AKAP11 Gene

Genomic Locations for AKAP11 Gene
51,787 bases
Plus strand
51,115 bases
Plus strand

Genomic View for AKAP11 Gene

Genes around AKAP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP11 Gene

Proteins for AKAP11 Gene

  • Protein details for AKAP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein 11
    Protein Accession:
    Secondary Accessions:
    • O75124
    • Q9NUK7

    Protein attributes for AKAP11 Gene

    1901 amino acids
    Molecular mass:
    210512 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92117.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AKAP11 Gene

Post-translational modifications for AKAP11 Gene

  • Ubiquitination at Lys560
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AKAP11 Gene

Domains & Families for AKAP11 Gene

Gene Families for AKAP11 Gene

Protein Domains for AKAP11 Gene

Suggested Antigen Peptide Sequences for AKAP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP11: view

Function for AKAP11 Gene

Molecular function for AKAP11 Gene

UniProtKB/Swiss-Prot Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
GENATLAS Biochemistry:
A kinase (PRKA,regulating subunit RIIA) anchor protein 11,expressed in brain,related to rat A kinase anchoring protein AKAP220

Phenotypes From GWAS Catalog for AKAP11 Gene

Gene Ontology (GO) - Molecular Function for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27484798
GO:0008157 protein phosphatase 1 binding TAS 10209101
GO:0051018 protein kinase A binding TAS 10209101
genes like me logo Genes that share ontologies with AKAP11: view
genes like me logo Genes that share phenotypes with AKAP11: view

Animal Models for AKAP11 Gene

MGI Knock Outs for AKAP11:

Animal Model Products

miRNA for AKAP11 Gene

miRTarBase miRNAs that target AKAP11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKAP11 Gene

Localization for AKAP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP11 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP11 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
peroxisome 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA,IEA --
GO:0005777 peroxisome IBA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with AKAP11: view

Pathways & Interactions for AKAP11 Gene

genes like me logo Genes that share pathways with AKAP11: view

Pathways by source for AKAP11 Gene

1 BioSystems pathway for AKAP11 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP11 Gene

Gene Ontology (GO) - Biological Process for AKAP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010738 regulation of protein kinase A signaling IBA --
GO:0035556 intracellular signal transduction TAS 10209101
genes like me logo Genes that share ontologies with AKAP11: view

No data available for SIGNOR curated interactions for AKAP11 Gene

Drugs & Compounds for AKAP11 Gene

No Compound Related Data Available

Transcripts for AKAP11 Gene

mRNA/cDNA for AKAP11 Gene

Unigene Clusters for AKAP11 Gene

A kinase (PRKA) anchor protein 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP6: - - -
SP7: - -

Relevant External Links for AKAP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKAP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKAP11 Gene

Protein differential expression in normal tissues from HIPED for AKAP11 Gene

This gene is overexpressed in Adrenal (18.1), Testis (15.8), Fetal heart (13.4), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKAP11 Gene

Protein tissue co-expression partners for AKAP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AKAP11 Gene:


SOURCE GeneReport for Unigene cluster for AKAP11 Gene:


mRNA Expression by UniProt/SwissProt for AKAP11 Gene:

Tissue specificity: Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.

Evidence on tissue expression from TISSUES for AKAP11 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with AKAP11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP11 Gene

Orthologs for AKAP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AKAP11 34 33
  • 99.39 (n)
(Canis familiaris)
Mammalia AKAP11 34 33
  • 86.92 (n)
(Bos Taurus)
Mammalia AKAP11 34 33
  • 84.67 (n)
(Mus musculus)
Mammalia Akap11 16 34 33
  • 81.43 (n)
(Rattus norvegicus)
Mammalia Akap11 33
  • 81.23 (n)
(Monodelphis domestica)
Mammalia AKAP11 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia AKAP11 34
  • 49 (a)
(Gallus gallus)
Aves AKAP11 34 33
  • 65.78 (n)
(Anolis carolinensis)
Reptilia AKAP11 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia akap11 33
  • 58.47 (n)
Str.612 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.30220 33
(Danio rerio)
Actinopterygii akap11 34 33
  • 55.59 (n)
Species where no ortholog for AKAP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP11 Gene

Gene Tree for AKAP11 (if available)
Gene Tree for AKAP11 (if available)
Evolutionary constrained regions (ECRs) for AKAP11: view image

Paralogs for AKAP11 Gene

Paralogs for AKAP11 Gene

(1) SIMAP similar genes for AKAP11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKAP11: view

Variants for AKAP11 Gene

Sequence variations from dbSNP and Humsavar for AKAP11 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000093202 -- 42,310,490(+) A/C intron_variant
rs1000225085 -- 42,291,475(+) A/C intron_variant
rs1000289280 -- 42,297,421(+) A/C intron_variant
rs1000301739 -- 42,285,304(+) G/A/C intron_variant
rs1000333971 -- 42,285,105(+) GGTGG/GG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP11 Gene

Variant ID Type Subtype PubMed ID
esv3350440 CNV duplication 20981092
nsv1126341 CNV deletion 24896259
nsv832590 CNV gain 17160897
nsv832591 CNV gain 17160897

Variation tolerance for AKAP11 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AKAP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP11 Gene

Disorders for AKAP11 Gene

Additional Disease Information for AKAP11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AKAP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP11 Gene

Publications for AKAP11 Gene

  1. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. (PMID: 10864471) Reinton N … Taskén K (Developmental biology 2000) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58

Products for AKAP11 Gene

Sources for AKAP11 Gene

Loading form....