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Aliases for AK6 Gene

Aliases for AK6 Gene

  • Adenylate Kinase 6 2 3 5
  • Coilin Interacting Nuclear ATPase Protein 2 3
  • Adrenal Gland Protein AD-004 3 4
  • EC 2.7.4.3 4 56
  • HCINAP 3 4
  • CINAP 3 4
  • Coilin-Interacting Nuclear ATPase Protein 4
  • Dual Activity Adenylate Kinase/ATPase 4
  • ATP-AMP Transphosphorylase 6 3
  • Adenylate Kinase Isoenzyme 6 3
  • Coilin Interacting Protein 3
  • AK/ATPase 4
  • CGI-137 3
  • AD-004 3
  • CIP 3

External Ids for AK6 Gene

Previous GeneCards Identifiers for AK6 Gene

  • GC00U990579
  • GC05M068647

Summaries for AK6 Gene

Entrez Gene Summary for AK6 Gene

  • This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for AK6 Gene

AK6 (Adenylate Kinase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include ATPase activity and adenylate kinase activity.

UniProtKB/Swiss-Prot for AK6 Gene

  • Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

Additional gene information for AK6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK6 Gene

Genomics for AK6 Gene

GeneHancer (GH) Regulatory Elements for AK6 Gene

Promoters and enhancers for AK6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I069367 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +0.2 162 5.4 PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 RAD17 AK6 TAF9 CCDC125 OCLN
GH05I069330 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +37.5 37499 3.4 HDGF SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 CCDC125 GC05P069334 CHCHD2P2 ENSG00000198237 ENSG00000254701 GTF2H2C SLC30A5 SMA4 AK6 CDK7
GH05I069516 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 -149.3 -149282 5.9 PKNOX1 FOXA2 ARNT NEUROD1 FEZF1 ZNF2 ZNF213 ZNF302 FOS KLF13 GTF2H2C ENSG00000198237 ENSG00000254701 GUSBP3 ENSG00000253333 CDH12P2 SLC30A5 RAD17 SMA4 OCLN
GH05I068505 Enhancer 0.7 ENCODE 4.7 +863.9 863911 1.7 KLF1 PKNOX1 JUN FEZF1 BATF FOSL1 ZFHX2 SCRT2 FOSL2 NR2F6 AK6 MARVELD2 ENSG00000249588 LOC105379012
GH05I068478 Enhancer 0.7 ENCODE 4.7 +890.5 890479 2.6 MEIS2 PKNOX1 TEAD4 TAL1 TCF12 GATA2 POLR2A NCOR1 CBFA2T2 TRIM24 AK6 LOC105379012 LOC105379013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AK6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AK6 Gene

Genomic Locations for AK6 Gene
chr5:69,350,984-69,370,013
(GRCh38/hg38)
Size:
19,030 bases
Orientation:
Minus strand
chr5:68,646,811-68,665,840
(GRCh37/hg19)

Genomic View for AK6 Gene

Genes around AK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK6 Gene

Proteins for AK6 Gene

  • Protein details for AK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D8-KAD6_HUMAN
    Recommended name:
    Adenylate kinase isoenzyme 6
    Protein Accession:
    Q9Y3D8
    Secondary Accessions:
    • A8MSZ6
    • Q5F2S9

    Protein attributes for AK6 Gene

    Size:
    172 amino acids
    Molecular mass:
    20061 Da
    Quaternary structure:
    • Monomer and homodimer (By similarity). Interacts with COIL (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for AK6 Gene

    Alternative splice isoforms for AK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK6 Gene

Selected DME Specific Peptides for AK6 Gene

Q9Y3D8:
  • DNIQCEIFQVL
  • NVGDLARE
  • TGTPGVGK
  • VDYHGCD
  • CPILDEDRV

Post-translational modifications for AK6 Gene

  • Ubiquitination at posLast=168168
  • Modification sites at PhosphoSitePlus

Other Protein References for AK6 Gene

Domains & Families for AK6 Gene

Gene Families for AK6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for AK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3D8

UniProtKB/Swiss-Prot:

KAD6_HUMAN :
  • Belongs to the adenylate kinase family. AK6 subfamily.
Family:
  • Belongs to the adenylate kinase family. AK6 subfamily.
genes like me logo Genes that share domains with AK6: view

No data available for Suggested Antigen Peptide Sequences for AK6 Gene

Function for AK6 Gene

Molecular function for AK6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=192 uM for AMP {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; KM=45 uM for ATP (for adenylate kinase activity) {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; KM=332 uM for ATP (for ATPase activity) {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Vmax=1.27 umol/min/mg enzyme for ATPase activity {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Vmax=982 nmol/min/mg enzyme for the forward adenylate kinase reaction {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Vmax=955 nmol/min/mg enzyme for the reverse adenylate kinase reaction {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Note=kcat is 6.3 sec(-1) for adenylate kinase activity. kcat is 4.8 sec(-1) for ATPase activity.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + AMP = 2 ADP.
UniProtKB/Swiss-Prot Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

Enzyme Numbers (IUBMB) for AK6 Gene

Gene Ontology (GO) - Molecular Function for AK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 adenylate kinase activity IDA,IEA 15630091
GO:0005515 protein binding IPI 16079131
GO:0005524 ATP binding IBA,IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with AK6: view

Animal Model Products

No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AK6 Gene

Localization for AK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK6 Gene

Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005730 NOT nucleolus IDA 16079131
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with AK6: view

No data available for Subcellular locations from COMPARTMENTS for AK6 Gene

Pathways & Interactions for AK6 Gene

genes like me logo Genes that share pathways with AK6: view

Gene Ontology (GO) - Biological Process for AK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015949 nucleobase-containing small molecule interconversion TAS --
GO:0016310 phosphorylation IEA --
GO:0046939 nucleotide phosphorylation IEA --
GO:0046940 nucleoside monophosphate phosphorylation IEA --
genes like me logo Genes that share ontologies with AK6: view

No data available for SIGNOR curated interactions for AK6 Gene

Drugs & Compounds for AK6 Gene

No Compound Related Data Available

Transcripts for AK6 Gene

mRNA/cDNA for AK6 Gene

(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for AK6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - - - - - -
SP10:

Relevant External Links for AK6 Gene

GeneLoc Exon Structure for
AK6
ECgene alternative splicing isoforms for
AK6

Expression for AK6 Gene

Protein differential expression in normal tissues from HIPED for AK6 Gene

This gene is overexpressed in Bone (23.4), Kidney (17.1), and Colon (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AK6 Gene



Protein tissue co-expression partners for AK6 Gene

NURSA nuclear receptor signaling pathways regulating expression of AK6 Gene:

AK6

mRNA Expression by UniProt/SwissProt for AK6 Gene:

Q9Y3D8-KAD6_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AK6 Gene

Orthologs for AK6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK6 33
  • 100 (n)
dog
(Canis familiaris)
Mammalia TAF9 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF9 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf9 34
  • 95 (a)
OneToOne
Ak6 33 16
  • 86.55 (n)
rat
(Rattus norvegicus)
Mammalia Ak6 33
  • 84.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF9 34
  • 86 (a)
OneToMany
AK6 33
  • 75.24 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia taf9 33
  • 74.07 (n)
zebrafish
(Danio rerio)
Actinopterygii taf9 34
  • 81 (a)
OneToMany
zgc:86811 33
  • 70.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ak6 33
  • 54.81 (n)
e(y)1 34
  • 34 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000272 33
  • 50.68 (n)
worm
(Caenorhabditis elegans)
Secernentea E02H1.6 33
  • 57.14 (n)
taf-9 34
  • 31 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12386g 33
  • 54.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP7 36 33
  • 53.69 (n)
TAF9 34
  • 29 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL150W 33
  • 51.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60340 33
  • 57.87 (n)
rice
(Oryza sativa)
Liliopsida Os07g0412400 33
  • 57.06 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10220 33
  • 54.51 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC830.11c 33
  • 53.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
Species where no ortholog for AK6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK6 Gene

ENSEMBL:
Gene Tree for AK6 (if available)
TreeFam:
Gene Tree for AK6 (if available)

Paralogs for AK6 Gene

(1) SIMAP similar genes for AK6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AK6: view

No data available for Paralogs for AK6 Gene

Variants for AK6 Gene

Sequence variations from dbSNP and Humsavar for AK6 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000028016 -- 69,353,901(-) C/T intron_variant
rs1000101039 -- 69,352,446(-) C/G intron_variant
rs1000138339 -- 69,353,298(-) C/T intron_variant
rs1000489369 -- 69,353,565(-) G/C intron_variant
rs1000544145 -- 69,359,222(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AK6 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
nsv428117 CNV gain+loss 18775914
nsv821643 CNV loss 15273396
nsv968187 CNV duplication 23825009
nsv980655 CNV duplication 23825009

Variation tolerance for AK6 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AK6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK6 Gene

Disorders for AK6 Gene

No disorders were found for AK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AK6 Gene

Publications for AK6 Gene

  1. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. (PMID: 16079131) Santama N … Lamond AI (The Journal of biological chemistry 2005) 2 3 4 58
  2. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. (PMID: 22038794) Drakou CE … Zographos SE (Proteins 2012) 3 4 58
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 3 4 58
  4. The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus. (PMID: 15630091) Ren H … Su XD (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 58
  5. Protein preparation, crystallization and preliminary X-ray analysis of human adrenal gland protein AD-004. (PMID: 15213396) Ren H … Su XD (Acta crystallographica. Section D, Biological crystallography 2004) 3 4 58

Products for AK6 Gene

Sources for AK6 Gene

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