Aliases for AJUBA Gene
External Ids for AJUBA Gene
Previous HGNC Symbols for AJUBA Gene
Previous GeneCards Identifiers for AJUBA Gene
GeneCards Summary for AJUBA Gene
AJUBA (Ajuba LIM Protein) is a Protein Coding gene. Diseases associated with AJUBA include Wilson-Turner X-Linked Mental Retardation Syndrome and Syndromic X-Linked Intellectual Disability. Among its related pathways are Hippo signaling pathway and Adhesion. Gene Ontology (GO) annotations related to this gene include chromatin binding and actin filament binding. An important paralog of this gene is LIMD1.
UniProtKB/Swiss-Prot Summary for AJUBA Gene
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.