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Aliases for AJUBA Gene

Aliases for AJUBA Gene

  • Ajuba LIM Protein 2 3 5
  • JUB 3 4
  • LIM Domain-Containing Protein Ajuba 3
  • Jub, Ajuba Homolog (Xenopus Laevis) 2
  • Jub, Ajuba Homolog 3

External Ids for AJUBA Gene

Previous HGNC Symbols for AJUBA Gene

  • JUB

Previous GeneCards Identifiers for AJUBA Gene

  • GC14M023441

Summaries for AJUBA Gene

GeneCards Summary for AJUBA Gene

AJUBA (Ajuba LIM Protein) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include chromatin binding and actin filament binding. An important paralog of this gene is WTIP.

UniProtKB/Swiss-Prot for AJUBA Gene

  • Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Gene Wiki entry for AJUBA Gene

Additional gene information for AJUBA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AJUBA Gene

Genomics for AJUBA Gene

GeneHancer (GH) Regulatory Elements for AJUBA Gene

Promoters and enhancers for AJUBA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.7 +2.7 2736 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN HAUS4 PRMT5 C14orf93 RBM23 LOC102724814 PABPN1 MMP14
GH14J022973 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 650.4 +8.1 8110 1.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ETS1 ARID2 ZNF143 ATF7 AJUBA HAUS4 THTPA ACIN1 ENSG00000259132
GH14J022972 Promoter 0.8 EPDnew 650.4 +10.4 10404 0.1 PAF1 ZFHX2 ZNF614 POLR2A EGR2 AJUBA ACIN1 CDH24 PSMB5 PRMT5 PSMB11 C14orf93 THTPA ENSG00000259132 HAUS4
GH14J022927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.9 +53.0 53035 3.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 PRMT5 ENSG00000257285 LOC101926933 TRR-ACG1-3 ACIN1 HAUS4 NGDN LOC102724814 RBM23 C14orf93
GH14J023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.8 -87.8 -87820 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 RBM23 LOC102724814 NGDN HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AJUBA on UCSC Golden Path with GeneCards custom track

Genomic Locations for AJUBA Gene

Genomic Locations for AJUBA Gene
chr14:22,971,174-22,982,642
(GRCh38/hg38)
Size:
11,469 bases
Orientation:
Minus strand
chr14:23,440,383-23,451,851
(GRCh37/hg19)
Size:
11,469 bases
Orientation:
Minus strand

Genomic View for AJUBA Gene

Genes around AJUBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AJUBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AJUBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AJUBA Gene

Proteins for AJUBA Gene

  • Protein details for AJUBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IF1-AJUBA_HUMAN
    Recommended name:
    LIM domain-containing protein ajuba
    Protein Accession:
    Q96IF1
    Secondary Accessions:
    • A8MX18
    • D3DS37

    Protein attributes for AJUBA Gene

    Size:
    538 amino acids
    Molecular mass:
    56934 Da
    Quaternary structure:
    • Interacts with GRB2, PIP5K1B and SLC1A2 (By similarity). Interacts with AURKA; the interaction occurs during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1 and with F-actin. Interacts with LATS2; the interaction occurs during mitosis and the complex regulates organization of the spindle apparatus through recruitment of TUBG to the centrosome. Forms a complex with SQSTM1, PRKCZ and TRAF6. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly (via the LIM domains) with GFI1; the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes, and is independent of the GFI1 SNAG domain. Interacts with HDAC1, HDAC2 and HDAC3. Interacts with SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts (via LIM domains) with SNAI1 (via SNAG domain).
    Miscellaneous:
    • Ajuba means curiosity in Urdu, an Indian dialect.

    Alternative splice isoforms for AJUBA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AJUBA Gene

Post-translational modifications for AJUBA Gene

  • Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for AJUBA

No data available for DME Specific Peptides for AJUBA Gene

Domains & Families for AJUBA Gene

Gene Families for AJUBA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for AJUBA Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IF1

UniProtKB/Swiss-Prot:

AJUBA_HUMAN :
  • LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments.
  • Belongs to the zyxin/ajuba family.
Domain:
  • LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments.
  • LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between LATS2 and AJUBA required the second LIM domain of AJUBA.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with AJUBA: view

Function for AJUBA Gene

Molecular function for AJUBA Gene

UniProtKB/Swiss-Prot Function:
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Gene Ontology (GO) - Molecular Function for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IDA 18805794
GO:0005515 protein binding IPI 15778465
GO:0045294 alpha-catenin binding IDA 12417594
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AJUBA: view
genes like me logo Genes that share phenotypes with AJUBA: view

Animal Models for AJUBA Gene

MGI Knock Outs for AJUBA:

Animal Model Products

miRNA for AJUBA Gene

miRTarBase miRNAs that target AJUBA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AJUBA Gene

Localization for AJUBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AJUBA Gene

Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AJUBA gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20616046
GO:0005634 nucleus IDA,IEA 18805794
GO:0005667 transcription factor complex IBA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with AJUBA: view

Pathways & Interactions for AJUBA Gene

genes like me logo Genes that share pathways with AJUBA: view

Gene Ontology (GO) - Biological Process for AJUBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001666 response to hypoxia IDA 22286099
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with AJUBA: view

No data available for SIGNOR curated interactions for AJUBA Gene

Drugs & Compounds for AJUBA Gene

No Compound Related Data Available

Transcripts for AJUBA Gene

mRNA/cDNA for AJUBA Gene

Unigene Clusters for AJUBA Gene

Ajuba LIM protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AJUBA Gene

No ASD Table

Relevant External Links for AJUBA Gene

GeneLoc Exon Structure for
AJUBA
ECgene alternative splicing isoforms for
AJUBA

Expression for AJUBA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AJUBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AJUBA Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for AJUBA Gene

This gene is overexpressed in Heart (26.4), Fetal Liver (22.7), Placenta (10.6), and Fetal heart (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AJUBA Gene



Protein tissue co-expression partners for AJUBA Gene

NURSA nuclear receptor signaling pathways regulating expression of AJUBA Gene:

AJUBA

SOURCE GeneReport for Unigene cluster for AJUBA Gene:

Hs.655832

Evidence on tissue expression from TISSUES for AJUBA Gene

  • Liver(4.5)
genes like me logo Genes that share expression patterns with AJUBA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AJUBA Gene

Orthologs for AJUBA Gene

This gene was present in the common ancestor of animals.

Orthologs for AJUBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AJUBA 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AJUBA 34 33
  • 91.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AJUBA 34 33
  • 91.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AJUBA 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ajuba 16 34 33
  • 88.27 (n)
rat
(Rattus norvegicus)
Mammalia Ajuba 33
  • 88.17 (n)
zebrafish
(Danio rerio)
Actinopterygii ajuba 34
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jub 34
  • 25 (a)
OneToMany
Species where no ortholog for AJUBA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AJUBA Gene

ENSEMBL:
Gene Tree for AJUBA (if available)
TreeFam:
Gene Tree for AJUBA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AJUBA: view image

Paralogs for AJUBA Gene

Paralogs for AJUBA Gene

(8) SIMAP similar genes for AJUBA Gene using alignment to 4 proteins:

  • AJUBA_HUMAN
  • G3V481_HUMAN
  • G3V5F5_HUMAN
  • H0YJL9_HUMAN
genes like me logo Genes that share paralogs with AJUBA: view

Variants for AJUBA Gene

Sequence variations from dbSNP and Humsavar for AJUBA Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000329378 -- 22,973,266(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000331319 -- 22,979,519(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000807294 -- 22,979,914(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000870961 -- 22,974,475(-) A/G genic_downstream_transcript_variant, intron_variant
rs1001070161 -- 22,980,930(-) A/C/G genic_upstream_transcript_variant, intron_variant

Variation tolerance for AJUBA Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AJUBA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AJUBA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AJUBA Gene

Disorders for AJUBA Gene

Additional Disease Information for AJUBA

No disorders were found for AJUBA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AJUBA Gene

Publications for AJUBA Gene

  1. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PMID: 22286099) Foxler DE … Sharp TV (Nature cell biology 2012) 3 4 58
  2. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. (PMID: 20616046) James V … Sharp TV (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
  3. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. (PMID: 20303269) Das Thakur M … Longmore GD (Current biology : CB 2010) 3 4 58
  4. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. (PMID: 18331720) Langer EM … Longmore GD (Developmental cell 2008) 3 4 58
  5. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. (PMID: 18805794) Montoya-Durango DE … Grimes HL (The Journal of biological chemistry 2008) 3 4 58

Products for AJUBA Gene

Sources for AJUBA Gene

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