Aliases for AJAP1 Gene

Aliases for AJAP1 Gene

  • Adherens Junctions Associated Protein 1 2 3 5
  • SHREW1 2 3 4
  • MOT8 2 3 4
  • Adherens Junction-Associated Protein 1 3 4
  • Transmembrane Protein SHREW1 2 3
  • Membrane Protein Shrew-1 3 4
  • SHREW-1 2 3
  • AJAP1 5

External Ids for AJAP1 Gene

Previous GeneCards Identifiers for AJAP1 Gene

  • GC01P004626
  • GC01P004714
  • GC01P003862

Summaries for AJAP1 Gene

GeneCards Summary for AJAP1 Gene

AJAP1 (Adherens Junctions Associated Protein 1) is a Protein Coding gene. Diseases associated with AJAP1 include Dental Caries and Migraine, Familial Hemiplegic, 2.

UniProtKB/Swiss-Prot Summary for AJAP1 Gene

Additional gene information for AJAP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AJAP1 Gene

Genomics for AJAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AJAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J004652 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.8 792 2.4 CTCF POLR2A EZH2 RAD21 SIN3A ZNF143 BACH1 GATA2 TRIM22 AJAP1 HSALNG0000402 HSALNG0000403
GH01J004653 Enhancer 0.4 Ensembl dbSUPER 600.7 -0.7 -708 0.2 EZH2 AJAP1 HSALNG0000402 lnc-AJAP1-10 C1orf174
GH01J004006 Enhancer 1 Ensembl ENCODE 5.7 -647.2 -647209 2.4 ARHGAP35 CREB1 ATF7 ZNF512 IKZF1 JUND ETV6 MTA2 PKNOX1 MTA1 WRAP73 C1orf174 AJAP1 piR-34383 LINC02780 piR-35729-001
GH01J004676 Enhancer 0.4 FANTOM5 dbSUPER 12.9 +21.7 21733 0.3 AJAP1 HSALNG0000403 HSALNG0000404
GH01J004675 Enhancer 0.3 ENCODE dbSUPER 12.9 +21.1 21067 0.2 AJAP1 HSALNG0000403 HSALNG0000404
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AJAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AJAP1

Genomic Locations for AJAP1 Gene

Genomic Locations for AJAP1 Gene
137,926 bases
Plus strand
137,803 bases
Plus strand

Genomic View for AJAP1 Gene

Genes around AJAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AJAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AJAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AJAP1 Gene

Proteins for AJAP1 Gene

  • Protein details for AJAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adherens junction-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9Y229

    Protein attributes for AJAP1 Gene

    411 amino acids
    Molecular mass:
    44536 Da
    Quaternary structure:
    • Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1. Interacts with AP1M2 and BSG/CD147.
    • Sequence=CAB41245.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AJAP1 Gene

Post-translational modifications for AJAP1 Gene

  • Thr-237 and Ser-239 may be phosphorylated; however as this position is probably extracellular, the in vivo relevance is not proven.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AJAP1 Gene

No data available for DME Specific Peptides for AJAP1 Gene

Domains & Families for AJAP1 Gene

Gene Families for AJAP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for AJAP1 Gene


Suggested Antigen Peptide Sequences for AJAP1 Gene

GenScript: Design optimal peptide antigens:
  • Membrane protein shrew-1 (AJAP1_HUMAN)
genes like me logo Genes that share domains with AJAP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AJAP1 Gene

Function for AJAP1 Gene

Molecular function for AJAP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion and cell migration.

Phenotypes From GWAS Catalog for AJAP1 Gene

Gene Ontology (GO) - Molecular Function for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17267690
GO:0008013 beta-catenin binding IPI 14595118
GO:0044877 protein-containing complex binding IDA 14595118
genes like me logo Genes that share ontologies with AJAP1: view
genes like me logo Genes that share phenotypes with AJAP1: view

Animal Models for AJAP1 Gene

MGI Knock Outs for AJAP1:
  • Ajap1 Ajap1<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for AJAP1 Gene

miRTarBase miRNAs that target AJAP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AJAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AJAP1 Gene

Localization for AJAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AJAP1 Gene

Basolateral cell membrane. Single-pass type III membrane protein. Apical cell membrane. Single-pass type III membrane protein. Cell junction, adherens junction. Note=Mainly basolateral. Localization is mediated by AP1M2.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AJAP1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005912 adherens junction IBA,IDA 14595118
GO:0009898 cytoplasmic side of plasma membrane IBA,IDA 14595118
GO:0009986 cell surface IDA 14595118
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AJAP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AJAP1 Gene

Pathways & Interactions for AJAP1 Gene

PathCards logo

SuperPathways for AJAP1 Gene

No Data Available

Interacting Proteins for AJAP1 Gene

Gene Ontology (GO) - Biological Process for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 16410724
GO:0007155 cell adhesion IEA --
GO:0030860 regulation of polarized epithelial cell differentiation IDA 14595118
GO:0061045 negative regulation of wound healing IDA 16410724
genes like me logo Genes that share ontologies with AJAP1: view

No data available for Pathways by source and SIGNOR curated interactions for AJAP1 Gene

Drugs & Compounds for AJAP1 Gene

No Compound Related Data Available

Transcripts for AJAP1 Gene

mRNA/cDNA for AJAP1 Gene

9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AJAP1

Alternative Splicing Database (ASD) splice patterns (SP) for AJAP1 Gene

No ASD Table

Relevant External Links for AJAP1 Gene

GeneLoc Exon Structure for

Expression for AJAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AJAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AJAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Cortex (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for AJAP1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AJAP1 Gene

Protein tissue co-expression partners for AJAP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AJAP1

SOURCE GeneReport for Unigene cluster for AJAP1 Gene:


mRNA Expression by UniProt/SwissProt for AJAP1 Gene:

Tissue specificity: Expressed in uterus and pancreas (at protein level).

Evidence on tissue expression from TISSUES for AJAP1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with AJAP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AJAP1 Gene

Orthologs for AJAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AJAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AJAP1 30 31
  • 99.03 (n)
(Bos Taurus)
Mammalia AJAP1 30 31
  • 85.61 (n)
(Canis familiaris)
Mammalia AJAP1 30 31
  • 84.47 (n)
(Mus musculus)
Mammalia Ajap1 30 17 31
  • 81.94 (n)
(Rattus norvegicus)
Mammalia Ajap1 30
  • 80.34 (n)
(Monodelphis domestica)
Mammalia AJAP1 31
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia AJAP1 31
  • 44 (a)
(Gallus gallus)
Aves AJAP1 30 31
  • 68.53 (n)
(Anolis carolinensis)
Reptilia AJAP1 31
  • 57 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ajap1 30
  • 66.33 (n)
Str.12381 30
(Danio rerio)
Actinopterygii LOC101887016 30
  • 55.26 (n)
ajap1 31
  • 46 (a)
Species where no ortholog for AJAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AJAP1 Gene

Gene Tree for AJAP1 (if available)
Gene Tree for AJAP1 (if available)
Evolutionary constrained regions (ECRs) for AJAP1: view image

Paralogs for AJAP1 Gene

No data available for Paralogs for AJAP1 Gene

Variants for AJAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AJAP1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
758736 Likely Benign: not provided 4,711,890(+) C/T INTRON_VARIANT
778204 Benign: not provided 4,712,475(+) G/A MISSENSE_VARIANT
787731 Benign: not provided 4,711,974(+) C/T MISSENSE_VARIANT
rs242056 - p.Gly263Arg

Additional dbSNP identifiers (rs#s) for AJAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AJAP1 Gene

Variant ID Type Subtype PubMed ID
esv1009421 CNV deletion 20482838
esv2651800 CNV insertion 19546169
esv3409614 CNV insertion 20981092
esv3585076 CNV loss 21293372
nsv1012423 CNV gain 25217958
nsv1076000 CNV deletion 25765185
nsv1076958 CNV deletion 25765185
nsv1126171 CNV deletion 24896259
nsv1126969 CNV deletion 24896259
nsv1136063 CNV deletion 24896259
nsv460505 CNV loss 19166990
nsv460617 CNV loss 19166990
nsv520031 CNV loss 19592680
nsv521535 CNV loss 19592680
nsv545158 CNV loss 21841781
nsv545159 CNV loss 21841781
nsv545160 CNV loss 21841781
nsv825475 CNV gain 20364138
nsv830870 CNV loss 17160897
nsv830981 CNV gain 17160897
nsv953834 CNV deletion 24416366

Variation tolerance for AJAP1 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.05; 93.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AJAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AJAP1 Gene

Disorders for AJAP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AJAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
migraine, familial hemiplegic, 2
  • fhm2
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
dystonia, dopa-responsive, due to sepiapterin reductase deficiency
  • sepiapterin reductase deficiency; srd
osteogenesis imperfecta, type i
  • oi1
- elite association - COSMIC cancer census association via MalaCards
Search AJAP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AJAP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AJAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AJAP1 Gene

Publications for AJAP1 Gene

  1. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. (PMID: 14595118) Bharti S … Starzinski-Powitz A (Molecular biology of the cell 2004) 2 3 4
  2. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 41
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  4. Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. (PMID: 17267690) Schreiner A … Starzinski-Powitz A (Molecular biology of the cell 2007) 3 4
  5. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. (PMID: 16410724) McDonald JM … Zhang W (Cancer biology & therapy 2006) 3 4

Products for AJAP1 Gene

Sources for AJAP1 Gene