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Aliases for AJAP1 Gene

Aliases for AJAP1 Gene

  • Adherens Junctions Associated Protein 1 2 3 5
  • Transmembrane Protein SHREW1 2 3
  • Membrane Protein Shrew-1 3 4
  • SHREW1 3 4
  • MOT8 3 4
  • Adherens Junction-Associated Protein 1 3
  • SHREW-1 3

External Ids for AJAP1 Gene

Previous GeneCards Identifiers for AJAP1 Gene

  • GC01P004626
  • GC01P003862

Summaries for AJAP1 Gene

GeneCards Summary for AJAP1 Gene

AJAP1 (Adherens Junctions Associated Protein 1) is a Protein Coding gene. Diseases associated with AJAP1 include Dental Caries and Chromosome 1P36 Deletion Syndrome.

UniProtKB/Swiss-Prot for AJAP1 Gene

  • Plays a role in cell adhesion and cell migration.

Additional gene information for AJAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AJAP1 Gene

Genomics for AJAP1 Gene

GeneHancer (GH) Regulatory Elements for AJAP1 Gene

Promoters and enhancers for AJAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J004652 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.0 25 4.5 CTCF MXI1 RB1 BACH1 SIN3A ZNF48 RAD21 YY1 CC2D1A ZNF316 AJAP1 GC01P004654
GH01J004006 Enhancer 0.9 ENCODE 5.8 -647.2 -647218 1.6 PKNOX1 ATF1 ARNT ZNF280A TCF12 ATF7 NCOA1 MCM5 MEF2D GMEB1 PIR57428 C1orf174 WRAP73 ENSG00000272153 AJAP1 LOC105376673
GH01J004676 Enhancer 0.4 FANTOM5 dbSUPER 12.9 +21.6 21610 0.3 AJAP1 GC01P004654 GC01M004696
GH01J004675 Enhancer 0.4 ENCODE dbSUPER 12.9 +20.9 20944 0.2 AJAP1 GC01P004654 GC01M004696
GH01J004754 Enhancer 0.4 ENCODE 6.5 +100.9 100892 1.7 SP1 BACH1 AJAP1 PIR48322 GC01M004696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AJAP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AJAP1 Gene

Genomic Locations for AJAP1 Gene
137,803 bases
Plus strand
137,803 bases
Plus strand

Genomic View for AJAP1 Gene

Genes around AJAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AJAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AJAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AJAP1 Gene

Proteins for AJAP1 Gene

  • Protein details for AJAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adherens junction-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9Y229

    Protein attributes for AJAP1 Gene

    411 amino acids
    Molecular mass:
    44536 Da
    Quaternary structure:
    • Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1. Interacts with AP1M2 and BSG/CD147.
    • Sequence=CAB41245.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AJAP1 Gene

Post-translational modifications for AJAP1 Gene

  • Thr-237 and Ser-239 may be phosphorylated; however as this position is probably extracellular, the in vivo relevance is not proven.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AJAP1 Gene

No data available for DME Specific Peptides for AJAP1 Gene

Domains & Families for AJAP1 Gene

Gene Families for AJAP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for AJAP1 Gene


Suggested Antigen Peptide Sequences for AJAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AJAP1: view

No data available for UniProtKB/Swiss-Prot for AJAP1 Gene

Function for AJAP1 Gene

Molecular function for AJAP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion and cell migration.

Phenotypes From GWAS Catalog for AJAP1 Gene

Gene Ontology (GO) - Molecular Function for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding IPI 14595118
GO:0044877 protein-containing complex binding IDA 14595118
genes like me logo Genes that share ontologies with AJAP1: view
genes like me logo Genes that share phenotypes with AJAP1: view

Animal Models for AJAP1 Gene

MGI Knock Outs for AJAP1:
  • Ajap1 Ajap1<tm1b(EUCOMM)Hmgu>

Animal Model Products

miRNA for AJAP1 Gene

miRTarBase miRNAs that target AJAP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AJAP1 Gene

Localization for AJAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AJAP1 Gene

Basolateral cell membrane; Single-pass type III membrane protein. Apical cell membrane; Single-pass type III membrane protein. Cell junction, adherens junction. Note=Mainly basolateral. Localization is mediated by AP1M2.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AJAP1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005912 adherens junction IEA --
GO:0005913 cell-cell adherens junction IDA 14595118
GO:0009898 cytoplasmic side of plasma membrane IDA 14595118
GO:0009986 cell surface IDA 14595118
genes like me logo Genes that share ontologies with AJAP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AJAP1 Gene

Pathways & Interactions for AJAP1 Gene

SuperPathways for AJAP1 Gene

No Data Available

Interacting Proteins for AJAP1 Gene

Gene Ontology (GO) - Biological Process for AJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 16410724
GO:0007155 cell adhesion IEA --
GO:0030860 regulation of polarized epithelial cell differentiation IDA 14595118
GO:0061045 negative regulation of wound healing IDA 16410724
genes like me logo Genes that share ontologies with AJAP1: view

No data available for Pathways by source and SIGNOR curated interactions for AJAP1 Gene

Drugs & Compounds for AJAP1 Gene

No Compound Related Data Available

Transcripts for AJAP1 Gene

mRNA/cDNA for AJAP1 Gene

Unigene Clusters for AJAP1 Gene

Adherens junctions associated protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AJAP1 Gene

No ASD Table

Relevant External Links for AJAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AJAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AJAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AJAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Cortex (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for AJAP1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AJAP1 Gene

Protein tissue co-expression partners for AJAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AJAP1 Gene:


SOURCE GeneReport for Unigene cluster for AJAP1 Gene:


mRNA Expression by UniProt/SwissProt for AJAP1 Gene:

Tissue specificity: Expressed in uterus and pancreas (at protein level).

Evidence on tissue expression from TISSUES for AJAP1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with AJAP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AJAP1 Gene

Orthologs for AJAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AJAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AJAP1 34 33
  • 99.03 (n)
(Bos Taurus)
Mammalia AJAP1 34 33
  • 85.61 (n)
(Canis familiaris)
Mammalia AJAP1 34 33
  • 84.47 (n)
(Mus musculus)
Mammalia Ajap1 16 34 33
  • 81.94 (n)
(Rattus norvegicus)
Mammalia Ajap1 33
  • 80.34 (n)
(Monodelphis domestica)
Mammalia AJAP1 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia AJAP1 34
  • 44 (a)
(Gallus gallus)
Aves AJAP1 34 33
  • 68.53 (n)
(Anolis carolinensis)
Reptilia AJAP1 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ajap1 33
  • 66.33 (n)
Str.12381 33
(Danio rerio)
Actinopterygii LOC101887016 33
  • 55.26 (n)
ajap1 34
  • 46 (a)
Species where no ortholog for AJAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AJAP1 Gene

Gene Tree for AJAP1 (if available)
Gene Tree for AJAP1 (if available)
Evolutionary constrained regions (ECRs) for AJAP1: view image

Paralogs for AJAP1 Gene

No data available for Paralogs for AJAP1 Gene

Variants for AJAP1 Gene

Sequence variations from dbSNP and Humsavar for AJAP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000018816 -- 4,665,615(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000019613 -- 4,698,903(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000024199 -- 4,727,194(+) G/A intron_variant
rs1000034773 -- 4,704,586(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000059285 -- 4,772,898(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AJAP1 Gene

Variant ID Type Subtype PubMed ID
nsv1076958 CNV deletion 25765185
nsv1126171 CNV deletion 24896259
nsv1076000 CNV deletion 25765185
nsv1012423 CNV gain 25217958
esv3585076 CNV loss 21293372
esv3409614 CNV insertion 20981092
esv2651800 CNV insertion 19546169
esv1009421 CNV deletion 20482838
nsv953834 CNV deletion 24416366
nsv830981 CNV gain 17160897
nsv830870 CNV loss 17160897
nsv825475 CNV gain 20364138
nsv545160 CNV loss 21841781
nsv545159 CNV loss 21841781
nsv545158 CNV loss 21841781
nsv521535 CNV loss 19592680
nsv520031 CNV loss 19592680
nsv460617 CNV loss 19166990
nsv460505 CNV loss 19166990
nsv1136063 CNV deletion 24896259
nsv1126969 CNV deletion 24896259

Variation tolerance for AJAP1 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.05; 93.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AJAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AJAP1 Gene

Disorders for AJAP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AJAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AJAP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AJAP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AJAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AJAP1 Gene

Publications for AJAP1 Gene

  1. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. (PMID: 14595118) Bharti S … Starzinski-Powitz A (Molecular biology of the cell 2004) 2 3 4 58
  2. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 44 58
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  4. Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. (PMID: 17267690) Schreiner A … Starzinski-Powitz A (Molecular biology of the cell 2007) 3 4 58
  5. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. (PMID: 16410724) McDonald JM … Zhang W (Cancer biology & therapy 2006) 3 4 58

Products for AJAP1 Gene

Sources for AJAP1 Gene

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