Both spliced and un-spliced long non-coding RNAs are transcribed from this gene. This gene overlaps on the opposite strand the second intron of the insulin-like growth factor 2 receptor gene; a CpG island associated with the second intron denotes an active promoter that drives the expression of this gene. The related mouse gene is responsible for silencing the insulin-like grow... See more...

Aliases for AIRN Gene

Subcategory (RNA class) for AIRN Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for AIRN Gene

  • Antisense Of IGF2R Non-Protein Coding RNA 2 3 5
  • IGF2R Antisense RNA 1 (Non-Protein Coding) 2 3
  • AIRN 2 168
  • Antisense Of IGF2R RNA (Non-Protein Coding) 2
  • Non-Protein Coding RNA 88 2
  • HSALNG0054798 167
  • NONHSAG045306 92
  • NCRNA00088 3
  • IGF2R-AS1 3
  • IGF2R-AS 3
  • IGF2RAS 3
  • AIR 3

External Ids for AIRN Gene

Previous GeneCards Identifiers for AIRN Gene

  • GC00U922835
  • GC06U901606
  • GC06M160424

Summaries for AIRN Gene

Entrez Gene Summary for AIRN Gene

  • Both spliced and un-spliced long non-coding RNAs are transcribed from this gene. This gene overlaps on the opposite strand the second intron of the insulin-like growth factor 2 receptor gene; a CpG island associated with the second intron denotes an active promoter that drives the expression of this gene. The related mouse gene is responsible for silencing the insulin-like growth factor 2 receptor gene and flanking genes in the imprinted gene cluster of mice. This gene may be expressed in Wilms tumors. [provided by RefSeq, Feb 2013]

GeneCards Summary for AIRN Gene

AIRN (Antisense Of IGF2R Non-Protein Coding RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AIRN include Wilms Tumor 1 and Astrocytoma.

Additional gene information for AIRN Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AIRN Gene

Genomics for AIRN Gene

GeneHancer (GH) Regulatory Elements for AIRN Gene

Promoters and enhancers for AIRN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J160003 Enhancer 1 FANTOM5 Ensembl dbSUPER 500.7 +1.9 1863 6 REST RBM22 EHMT2 TAF15 ZBTB33 PCBP1 AGO2 ZNF202 ATF3 AGO1 AIRN GQ166646 IGF2R MAS1 ENSG00000236823 SLC22A1
GH06J160027 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -22.0 -22002 5.1 REST CTCF ZNF384 RBM22 SPI1 JUND RAD21 RXRA TAF1 PBX3 LOC729603 SLC22A1 lnc-SLC22A2-3 AIRN IGF2R
GH06J160013 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -7.5 -7464 3.9 NFIC HOMEZ ZBTB33 ZNF614 ARID4B ELF3 FOXA2 ELF1 ETV5 FOXA1 IGF2R SLC22A1 LOC729603 AIRN lnc-SLC22A2-3
GH06J160009 Enhancer 0.5 Ensembl ENCODE dbSUPER 0.7 -2.9 -2863 1.9 IGF2R SLC22A3 AIRN lnc-SLC22A2-3
GH06J160035 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.3 -29.1 -29052 3.3 JUND FOS POLR2A RBM22 MYC lnc-SLC22A2-3 SLC22A1 LOC729603 AIRN IGF2R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AIRN on UCSC Golden Path with GeneCards custom track

Genomic Locations for AIRN Gene

Genomic Locations for AIRN Gene
chr6:160,003,290-160,007,664
(GRCh38/hg38)
Size:
4,375 bases
Orientation:
Minus strand
chr6:160,424,323-160,428,696
(GRCh37/hg19)
Size:
4,374 bases
Orientation:
Minus strand

Genomic View for AIRN Gene

Genes around AIRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIRN Gene

Proteins for AIRN Gene

Post-translational modifications for AIRN Gene

No Post-translational modifications

No data available for DME Specific Peptides for AIRN Gene

Domains & Families for AIRN Gene

Gene Families for AIRN Gene

genes like me logo Genes that share domains with AIRN: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AIRN Gene

Function for AIRN Gene

Phenotypes From GWAS Catalog for AIRN Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AIRN Gene

Localization for AIRN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIRN gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AIRN Gene

Pathways & Interactions for AIRN Gene

PathCards logo

SuperPathways for AIRN Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for AIRN Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for AIRN Gene

Drugs & Compounds for AIRN Gene

No Compound Related Data Available

Transcripts for AIRN Gene

mRNA/cDNA for AIRN Gene

3 RNACentral transcripts :
2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 NONCODE transcripts :
1 LncBook transcripts :
2 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIRN Gene

No ASD Table

Relevant External Links for AIRN Gene

GeneLoc Exon Structure for
AIRN

Expression for AIRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AIRN Gene

mRNA differential expression in normal tissues according to GTEx for AIRN Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Cortex (x6.0), and Brain - Hypothalamus (x4.0).

SOURCE GeneReport for Unigene cluster for AIRN Gene:

Hs.742166
genes like me logo Genes that share expression patterns with AIRN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AIRN Gene

Orthologs for AIRN Gene

Evolution for AIRN Gene

ENSEMBL:
Gene Tree for AIRN (if available)
TreeFam:
Gene Tree for AIRN (if available)

No data available for Orthologs for AIRN Gene

Paralogs for AIRN Gene

No data available for Paralogs for AIRN Gene

Variants for AIRN Gene

Additional dbSNP identifiers (rs#s) for AIRN Gene

Structural Variations from Database of Genomic Variants (DGV) for AIRN Gene

Variant ID Type Subtype PubMed ID
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
nsv1074441 CNV deletion 25765185

Additional Variant Information for AIRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIRN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for AIRN Gene

Disorders for AIRN Gene

MalaCards: The human disease database

(2) MalaCards diseases for AIRN Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
wilms tumor 1
  • wt1
astrocytoma
  • astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search AIRN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AIRN

genes like me logo Genes that share disorders with AIRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AIRN Gene

Publications for AIRN Gene

  1. Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter. (PMID: 19008856) Stricker SH … Barlow DP (The EMBO journal 2008) 2 3 54
  2. Identification of the human homolog of the imprinted mouse Air non-coding RNA. (PMID: 18789384) Yotova IY … Barlow DP (Genomics 2008) 2 3 54
  3. A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter. (PMID: 22396659) Koerner MV … Barlow DP (PLoS genetics 2012) 3 54
  4. Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs. (PMID: 21915889) Saxena A … Carninci P (BioEssays : news and reviews in molecular, cellular and developmental biology 2011) 3 54
  5. Kcnq1ot1: a chromatin regulatory RNA. (PMID: 21345374) Kanduri C (Seminars in cell & developmental biology 2011) 3 54

Products for AIRN Gene

Sources for AIRN Gene