The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifical... See more...

Aliases for AIP Gene

Aliases for AIP Gene

  • Aryl Hydrocarbon Receptor Interacting Protein 2 3 5
  • XAP2 2 3 4
  • Hepatitis B Virus X-Associated Cellular Protein 2 2 3
  • Aryl Hydrocarbon Receptor-Associated Protein 9 2 3
  • AH Receptor-Interacting Protein 3 4
  • HBV X-Associated Protein 2 3 4
  • Immunophilin Homolog ARA9 3 4
  • FKBP Prolyl Isomerase 16 2 3
  • FK506-Binding Protein 37 2 3
  • Ah Receptor Activated 9 2 3
  • X-Associated Protein-2 2 3
  • FKBP16 2 3
  • FKBP37 2 3
  • XAP-2 3 4
  • ARA9 2 3
  • Aryl Hydrocarbon Receptor-Interacting Protein 2
  • Aryl-Hydrocarbon Receptor-Interacting Protein 4
  • SMTPHN 3
  • PITA1 3
  • AIP 5

External Ids for AIP Gene

Previous GeneCards Identifiers for AIP Gene

  • GC11P069773
  • GC11P068946
  • GC11P067500
  • GC11P067026
  • GC11P067027
  • GC11P067007
  • GC11P067251
  • GC11P063579
  • GC11P067483

Summaries for AIP Gene

Entrez Gene Summary for AIP Gene

  • The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for AIP Gene

AIP (Aryl Hydrocarbon Receptor Interacting Protein) is a Protein Coding gene. Diseases associated with AIP include Pituitary Adenoma 1, Multiple Types and Growth Hormone Secreting Pituitary Adenoma. Among its related pathways are AHR Pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transcription factor binding and transcription coactivator activity. An important paralog of this gene is AIPL1.

UniProtKB/Swiss-Prot Summary for AIP Gene

  • May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
  • Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Gene Wiki entry for AIP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AIP Gene

Genomics for AIP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AIP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AIP

Top Transcription factor binding sites by QIAGEN in the AIP gene promoter:
  • AhR
  • FAC1
  • GATA-1
  • Pax-4a
  • Pax-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for AIP Gene

Latest Assembly
chr11:67,468,179-67,491,103
(GRCh38/hg38)
Size:
22,925 bases
Orientation:
Plus strand

Previous Assembly
chr11:67,250,497-67,258,574
(GRCh37/hg19 by Entrez Gene)
Size:
8,078 bases
Orientation:
Plus strand

chr11:67,250,512-67,258,574
(GRCh37/hg19 by Ensembl)
Size:
8,063 bases
Orientation:
Plus strand

Genomic View for AIP Gene

Genes around AIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIP Gene

Proteins for AIP Gene

  • Protein details for AIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00170-AIP_HUMAN
    Recommended name:
    AH receptor-interacting protein
    Protein Accession:
    O00170
    Secondary Accessions:
    • A0SZW3
    • A0SZW4
    • A0SZW5
    • A0SZW6
    • Q2M3Q2
    • Q99606

    Protein attributes for AIP Gene

    Size:
    330 amino acids
    Molecular mass:
    37636 Da
    Quaternary structure:
    • Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

    Three dimensional structures from OCA and Proteopedia for AIP Gene

neXtProt entry for AIP Gene

Post-translational modifications for AIP Gene

  • Ubiquitination at Lys33, Lys69, Lys103, Lys112, Lys177, Lys210, Lys273, and Lys290
  • Modification sites at PhosphoSitePlus

Other Protein References for AIP Gene

No data available for DME Specific Peptides for AIP Gene

Domains & Families for AIP Gene

Gene Families for AIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AIP Gene

GenScript: Design optimal peptide antigens:
  • Aryl-hydrocarbon receptor interacting protein (A3RDR6_HUMAN)
  • Aryl-hydrocarbon receptor interacting protein (A3RDR7_HUMAN)
  • Aryl-hydrocarbon receptor interacting protein (A3RDR8_HUMAN)
  • Aryl-hydrocarbon receptor interacting protein (A3RDR9_HUMAN)
  • Truncated aryl-hydrocarbon receptor interacting protein (A3RDS0_HUMAN)
genes like me logo Genes that share domains with AIP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AIP Gene

Function for AIP Gene

Molecular function for AIP Gene

UniProtKB/Swiss-Prot Function:
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
UniProtKB/Swiss-Prot Function:
Cellular negative regulator of the hepatitis B virus (HBV) X protein.
GENATLAS Biochemistry:
arylhydrocarbon receptor associated protein,immunophilin homolog,interacting with HSP90-AHR complex,homologous to the 52kDa,FK506 binding protein (FKBP52)

Phenotypes From GWAS Catalog for AIP Gene

Gene Ontology (GO) - Molecular Function for AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IEA --
GO:0003713 transcription coactivator activity TAS 9447995
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0005515 protein binding IEA,IPI 14557246
GO:0008134 transcription factor binding TAS 9447995
genes like me logo Genes that share ontologies with AIP: view
genes like me logo Genes that share phenotypes with AIP: view

Human Phenotype Ontology for AIP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AIP Gene

MGI Knock Outs for AIP:
  • Aip Aip<tm1Bra>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AIP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AIP Gene

Localization for AIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,TAS 8972861
GO:0005829 cytosol IEA,TAS 14557246
GO:0005886 colocalizes_with plasma membrane IDA 17329248
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AIP: view

Pathways & Interactions for AIP Gene

genes like me logo Genes that share pathways with AIP: view

Pathways by source for AIP Gene

1 KEGG pathway for AIP Gene
1 Qiagen pathway for AIP Gene
  • AHR Pathway

SIGNOR curated interactions for AIP Gene

Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for AIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006626 protein targeting to mitochondrion IDA 14557246
GO:0006805 xenobiotic metabolic process IEA,TAS --
GO:0010738 regulation of protein kinase A signaling IEA --
genes like me logo Genes that share ontologies with AIP: view

Drugs & Compounds for AIP Gene

(1) Drugs for AIP Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminolevulinic acid Approved Pharma 208
genes like me logo Genes that share compounds with AIP: view

Transcripts for AIP Gene

mRNA/cDNA for AIP Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AIP

Alternative Splicing Database (ASD) splice patterns (SP) for AIP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - - - -

Relevant External Links for AIP Gene

GeneLoc Exon Structure for
AIP

Expression for AIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)
  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for AIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3), Tlymphocyte (9.3), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AIP Gene



Protein tissue co-expression partners for AIP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AIP

SOURCE GeneReport for Unigene cluster for AIP Gene:

Hs.412433

mRNA Expression by UniProt/SwissProt for AIP Gene:

O00170-AIP_HUMAN
Tissue specificity: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Evidence on tissue expression from TISSUES for AIP Gene

  • Nervous system(4.8)
  • Thyroid gland(2.5)
  • Intestine(2.4)
  • Adrenal gland(2.3)
  • Liver(2.2)
  • Lymph node(2.2)
  • Kidney(2.2)
  • Spleen(2.1)
  • Muscle(2.1)
  • Eye(2.1)
  • Lung(2.1)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AIP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pituitary gland
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • kidney
  • pancreas
Pelvis:
  • ovary
  • pelvis
  • penis
  • testicle
  • ureter
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with AIP: view

No data available for mRNA differential expression in normal tissues for AIP Gene

Orthologs for AIP Gene

This gene was present in the common ancestor of animals.

Orthologs for AIP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AIP 29 30
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AIP 29 30
  • 90.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AIP 29 30
  • 90.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Aip 29
  • 88.89 (n)
Mouse
(Mus musculus)
Mammalia Aip 29 16 30
  • 88.59 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia AIP 30
  • 44 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 40 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves AIP 29 30
  • 80.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AIP 30
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia aip 29
  • 62.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8054 29
Zebrafish
(Danio rerio)
Actinopterygii LOC100149392 29
  • 64.23 (n)
aip 30
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000725 29
  • 59.66 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG1847 29 30 31
  • 51.88 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C56C10.10 29 30 31
  • 44.62 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2723 30
  • 43 (a)
OneToMany
Species where no ortholog for AIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AIP Gene

ENSEMBL:
Gene Tree for AIP (if available)
TreeFam:
Gene Tree for AIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AIP: view image
Alliance of Genome Resources:
Additional Orthologs for AIP

Paralogs for AIP Gene

Paralogs for AIP Gene

(2) SIMAP similar genes for AIP Gene using alignment to 34 proteins:

  • AIP_HUMAN
  • A3RDR6_HUMAN
  • A3RDR7_HUMAN
  • A3RDR8_HUMAN
  • A3RDR9_HUMAN
  • A3RDS0_HUMAN
  • A3RDS1_HUMAN
  • A5JGZ4_HUMAN
  • A7KS92_HUMAN
  • A7KS93_HUMAN
  • A7KS94_HUMAN
  • A7YDK1_HUMAN
  • A7YDK2_HUMAN
  • A7YDK4_HUMAN
  • A7YDK6_HUMAN
  • A7YDK7_HUMAN
  • A7YDK9_HUMAN
  • A8BQF1_HUMAN
  • B7SBB1_HUMAN
  • C0JXB8_HUMAN
  • C0JXB9_HUMAN
  • C8CHN4_HUMAN
  • C8CK04_HUMAN
  • C8CK05_HUMAN
  • D0EKE4_HUMAN
  • D0EKE5_HUMAN
  • D0EKE6_HUMAN
  • D0EKE7_HUMAN
  • D2CVN5_HUMAN
  • D5LTB3_HUMAN
  • E5L4L0_HUMAN
  • E9PMH2_HUMAN
  • G9I2H4_HUMAN
  • V9GYQ3_HUMAN
genes like me logo Genes that share paralogs with AIP: view

Variants for AIP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AIP Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
1000149 Uncertain Significance: not provided 67,487,094(+) T/A
NM_003977.4(AIP):c.188T>A (p.Ile63Asn)
MISSENSE
1001451 Uncertain Significance: not provided 67,489,381(+) T/C
NM_003977.4(AIP):c.394T>C (p.Ser132Pro)
MISSENSE
1001466 Uncertain Significance: not provided 67,487,021(+) C/G
NM_003977.4(AIP):c.115C>G (p.Arg39Gly)
MISSENSE_VARIANT,FIVE_PRIME_UTR
1001937 Uncertain Significance: not provided 67,487,167(+) G/T
NM_003977.4(AIP):c.261G>T (p.Gln87His)
MISSENSE
1004235 Uncertain Significance: not provided 67,490,047(+) C/T
NM_003977.4(AIP):c.478C>T (p.Pro160Ser)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for AIP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for AIP Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
esv2422195 CNV duplication 17116639
nsv368 CNV insertion 18451855
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv527056 CNV loss 19592680
nsv825960 CNV gain 20364138

Variation tolerance for AIP Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AIP Gene

Human Gene Mutation Database (HGMD)
AIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIP
Leiden Open Variation Database (LOVD)
AIP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIP Gene

Disorders for AIP Gene

MalaCards: The human disease database

(34) MalaCards diseases for AIP Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
pituitary adenoma 1, multiple types
  • pita1
growth hormone secreting pituitary adenoma
  • growth hormone producing adenoma of the pituitary
acromegaly
  • growth hormone excess
familial isolated pituitary adenoma
  • familial isolated pituitary adenoma syndrome
inherited cancer-predisposing syndrome
  • hereditary cancer-predisposing syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AIP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AIP_HUMAN
  • Pituitary adenoma 1, multiple types (PITA1) [MIM:102200]: A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported. {ECO:0000269 PubMed:16728643, ECO:0000269 PubMed:17244780, ECO:0000269 PubMed:17299063, ECO:0000269 PubMed:17341560, ECO:0000269 PubMed:17360484, ECO:0000269 PubMed:18410548}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]: Most common type of hormonally active pituitary adenoma. {ECO:0000269 PubMed:16728643, ECO:0000305 PubMed:17244780}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for AIP

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with AIP: view

No data available for Genatlas for AIP Gene

Publications for AIP Gene

  1. Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. (PMID: 17360484) Georgitsi M … Aaltonen LA (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 22 72
  2. Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. (PMID: 17244780) Daly AF … Beckers A (The Journal of clinical endocrinology and metabolism 2007) 3 4 22 72
  3. Pituitary adenoma predisposition caused by germline mutations in the AIP gene. (PMID: 16728643) Vierimaa O … Aaltonen LA (Science (New York, N.Y.) 2006) 3 4 40 72
  4. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. (PMID: 8972861) Kuzhandaivelu N … Seto E (Nucleic acids research 1996) 2 3 4 22
  5. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. (PMID: 23300914) Morgan RM … Prodromou C (PloS one 2012) 3 4 72

Products for AIP Gene

Sources for AIP Gene