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Aliases for AIG1 Gene

Aliases for AIG1 Gene

  • Androgen Induced 1 2 3 5
  • AIG-1 3 4
  • Androgen-Induced Gene 1 Protein 3
  • DJ95L4.1 3

External Ids for AIG1 Gene

Previous GeneCards Identifiers for AIG1 Gene

  • GC06P143315
  • GC06P143362
  • GC06P143423
  • GC06P140946

Summaries for AIG1 Gene

GeneCards Summary for AIG1 Gene

AIG1 (Androgen Induced 1) is a Protein Coding gene. Diseases associated with AIG1 include Amebiasis. An important paralog of this gene is ADTRP.

UniProtKB/Swiss-Prot for AIG1 Gene

  • May play a role in androgen-regulated growth of hair follicles.

Gene Wiki entry for AIG1 Gene

Additional gene information for AIG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIG1 Gene

Genomics for AIG1 Gene

GeneHancer (GH) Regulatory Elements for AIG1 Gene

Promoters and enhancers for AIG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J143058 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 661.3 +2.9 2940 7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC AIG1 HIVEP2 VDAC1P8 LTV1 ADAT2 ENSG00000270890 ENSG00000232618 ENSG00000227192 ENSG00000225752
GH06J142940 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.2 -114.9 -114884 8.3 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 GLIS1 HIVEP2 ADAT2 VDAC1P8 LTV1 TUBB8P2 ENSG00000270890 ENSG00000233138 AIG1 FUCA2 ENSG00000232618
GH06J143222 Enhancer 1 Ensembl ENCODE 10.5 +165.2 165172 4.9 FOXA2 RAD21 RARA ETS1 YY1 SCRT2 ATF7 RXRA ZHX2 REST PLAGL1 AIG1 ENSG00000217495 ENSG00000225752
GH06J143106 Enhancer 0.8 ENCODE 10.7 +48.2 48185 2.3 ELF3 FOXA2 THRB RAD21 RARA YY1 EGR1 CREM MIXL1 HMG20B AIG1 ENSG00000225752 ENSG00000217495
GH06J143176 Enhancer 0.8 Ensembl ENCODE 9.8 +117.4 117387 1.4 CTCF CBFA2T3 ZIC2 RAD21 CHAMP1 SNIP1 CC2D1A NFIC GLIS1 ZBTB33 LTV1 ADAT2 ENSG00000270890 AIG1 PHACTR2 LOC100131471 ENSG00000225752 ENSG00000217495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AIG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AIG1 gene promoter:
  • HNF-3beta
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • JunB
  • JunD
  • PPAR-gamma1

Genomic Locations for AIG1 Gene

Genomic Locations for AIG1 Gene
280,981 bases
Plus strand
279,809 bases
Plus strand

Genomic View for AIG1 Gene

Genes around AIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIG1 Gene

Proteins for AIG1 Gene

  • Protein details for AIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Androgen-induced gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • B4DPX2
    • C9J569
    • Q5T2H2
    • Q6N047
    • Q7Z378
    • Q8TB14
    • Q9Y3A9
    • Q9Y5B4

    Protein attributes for AIG1 Gene

    245 amino acids
    Molecular mass:
    28222 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34098.1; Type=Frameshift; Positions=182, 193, 223; Evidence={ECO:0000305}; Sequence=CAE45823.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AIG1 Gene

neXtProt entry for AIG1 Gene

Post-translational modifications for AIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AIG1 Gene

Domains & Families for AIG1 Gene

Gene Families for AIG1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for AIG1 Gene


Suggested Antigen Peptide Sequences for AIG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AIG1 family.
  • Belongs to the AIG1 family.
genes like me logo Genes that share domains with AIG1: view

Function for AIG1 Gene

Molecular function for AIG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in androgen-regulated growth of hair follicles.
UniProtKB/Swiss-Prot Induction:
By dihydrotestosterone (DHT).

Phenotypes From GWAS Catalog for AIG1 Gene

Gene Ontology (GO) - Molecular Function for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0016787 hydrolase activity IMP 27018888
genes like me logo Genes that share ontologies with AIG1: view
genes like me logo Genes that share phenotypes with AIG1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIG1 Gene

Localization for AIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AIG1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIG1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IDA,IEA 27018888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AIG1: view

Pathways & Interactions for AIG1 Gene

No Data Available

Interacting Proteins for AIG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NVV5-AIG1_HUMAN ENSP00000350509 for AIG1 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for AIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042758 long-chain fatty acid catabolic process IMP 27018888
genes like me logo Genes that share ontologies with AIG1: view

No data available for Pathways by source and SIGNOR curated interactions for AIG1 Gene

Drugs & Compounds for AIG1 Gene

No Compound Related Data Available

Transcripts for AIG1 Gene

Unigene Clusters for AIG1 Gene

Androgen-induced 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIG1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for AIG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AIG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AIG1 Gene

mRNA differential expression in normal tissues according to GTEx for AIG1 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for AIG1 Gene

This gene is overexpressed in Ovary (12.8) and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AIG1 Gene

Protein tissue co-expression partners for AIG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AIG1 Gene:


SOURCE GeneReport for Unigene cluster for AIG1 Gene:


mRNA Expression by UniProt/SwissProt for AIG1 Gene:

Tissue specificity: Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.

Evidence on tissue expression from TISSUES for AIG1 Gene

  • Skin(4.3)
  • Nervous system(3.4)
  • Liver(2.2)
  • Kidney(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with AIG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AIG1 Gene

Orthologs for AIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AIG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AIG1 34 33
  • 97.74 (n)
(Bos Taurus)
Mammalia AIG1 34 33
  • 93.98 (n)
(Canis familiaris)
Mammalia AIG1 34 33
  • 91.52 (n)
(Ornithorhynchus anatinus)
Mammalia AIG1 34
  • 89 (a)
(Mus musculus)
Mammalia Aig1 16 34 33
  • 88.99 (n)
(Rattus norvegicus)
Mammalia Aig1 33
  • 88.16 (n)
(Monodelphis domestica)
Mammalia AIG1 34
  • 62 (a)
(Gallus gallus)
Aves AIG1 34 33
  • 79.39 (n)
(Anolis carolinensis)
Reptilia AIG1 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo15a 33
  • 74.63 (n)
(Danio rerio)
Actinopterygii aig1 34 33
  • 70.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008626 33
  • 54.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3625 34
  • 33 (a)
CG6149 34
  • 32 (a)
CG11601 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for AIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIG1 Gene

Gene Tree for AIG1 (if available)
Gene Tree for AIG1 (if available)
Evolutionary constrained regions (ECRs) for AIG1: view image

Paralogs for AIG1 Gene

Paralogs for AIG1 Gene

(1) SIMAP similar genes for AIG1 Gene using alignment to 8 proteins:

  • Q5T2H0_HUMAN
  • Q5T2H3_HUMAN
  • Q5T2H4_HUMAN
  • R9RV30_HUMAN
  • R9RVP2_HUMAN Pseudogenes for AIG1 Gene

genes like me logo Genes that share paralogs with AIG1: view

Variants for AIG1 Gene

Sequence variations from dbSNP and Humsavar for AIG1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000000816 -- 143,288,462(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000008913 -- 143,154,915(+) T/G intron_variant
rs1000038448 -- 143,240,562(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000042624 -- 143,217,507(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000056236 -- 143,211,168(+) GAGTGAGTGAGTG/GAGTGAGTGAGTGAGTG genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AIG1 Gene

Variant ID Type Subtype PubMed ID
esv2659568 CNV deletion 23128226
esv2664367 CNV deletion 23128226
esv275228 CNV gain+loss 21479260
esv29171 CNV loss 19812545
esv3412403 CNV insertion 20981092
esv3540580 CNV deletion 23714750
esv3571432 CNV loss 25503493
esv3576234 CNV gain 25503493
esv3611090 CNV loss 21293372
esv3611092 CNV loss 21293372
esv3611093 CNV loss 21293372
nsv476666 CNV novel sequence insertion 20440878
nsv476772 CNV novel sequence insertion 20440878
nsv478750 CNV novel sequence insertion 20440878
nsv949863 CNV duplication 24416366
nsv965775 CNV duplication 23825009

Variation tolerance for AIG1 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AIG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIG1 Gene

Disorders for AIG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AIG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards
Search AIG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AIG1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AIG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AIG1 Gene

Publications for AIG1 Gene

  1. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. (PMID: 11266118) Seo J … Kim M (Molecules and cells 2001) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for AIG1 Gene

Sources for AIG1 Gene

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