Aliases for AIFM2 Gene
External Ids for AIFM2 Gene
Previous HGNC Symbols for AIFM2 Gene
Previous GeneCards Identifiers for AIFM2 Gene
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
GeneCards Summary for AIFM2 Gene
AIFM2 (Apoptosis Inducing Factor Mitochondria Associated 2) is a Protein Coding gene. Diseases associated with AIFM2 include Febrile Seizures, Familial, 9. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene Expression. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADH dehydrogenase (ubiquinone) activity.
UniProtKB/Swiss-Prot Summary for AIFM2 Gene
A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels (PubMed:31634899, PubMed:31634900). May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472). Capable of DNA binding in a non-sequence specific way (PubMed:15958387).