Aliases for AIFM2 Gene
External Ids for AIFM2 Gene
Previous HGNC Symbols for AIFM2 Gene
Previous GeneCards Identifiers for AIFM2 Gene
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
GeneCards Summary for AIFM2 Gene
AIFM2 (Apoptosis Inducing Factor Mitochondria Associated 2) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADH dehydrogenase (ubiquinone) activity.
UniProtKB/Swiss-Prot Summary for AIFM2 Gene
Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.