Aliases for AIF1 Gene
External Ids for AIF1 Gene
Previous GeneCards Identifiers for AIF1 Gene
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
GeneCards Summary for AIF1 Gene
AIF1 (Allograft Inflammatory Factor 1) is a Protein Coding gene. Diseases associated with AIF1 include Chronic Inflammatory Demyelinating Polyneuropathy and Neuropathy, Hereditary Sensory And Autonomic, Type Vi. Among its related pathways are Spinal Cord Injury. Gene Ontology (GO) annotations related to this gene include calcium ion binding and actin filament binding. An important paralog of this gene is AIF1L.
UniProtKB/Swiss-Prot Summary for AIF1 Gene
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.