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Aliases for AIDA Gene

Aliases for AIDA Gene

  • Axin Interactor, Dorsalization Associated 2 3 5
  • Axin Interaction Partner And Dorsalization Antagonist 2 3 4
  • C1orf80 3 4
  • Axin Interactor, Dorsalization-Associated Protein 3
  • Chromosome 1 Open Reading Frame 80 2

External Ids for AIDA Gene

Previous HGNC Symbols for AIDA Gene

  • C1orf80

Previous GeneCards Identifiers for AIDA Gene

  • GC01M220907
  • GC01M222841
  • GC01M193515

Summaries for AIDA Gene

GeneCards Summary for AIDA Gene

AIDA (Axin Interactor, Dorsalization Associated) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for AIDA Gene

  • Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

Additional gene information for AIDA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AIDA Gene

Genomics for AIDA Gene

GeneHancer (GH) Regulatory Elements for AIDA Gene

Promoters and enhancers for AIDA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J222710 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 718 3.9 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 BROX AIDA CICP13 ENSG00000272750 TAF1A CAPN2 DISP1 MIA3 FAM177B GC01M222708
GH01J222653 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +58.7 58674 2.8 CTCF PKNOX1 MAX STAT5A EBF1 BATF IRF4 RAD21 RELA NFATC1 BROX ENSG00000272750 AIDA TLR5 ENSG00000229399 MIA3
GH01J223704 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -993.8 -993843 5.5 HDGF PKNOX1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105373281 CICP5 CAPN2 WDR26 LOC100287497 NVL CNIH4 CAPN8 FBXO28 AIDA
GH01J222657 Enhancer 0.4 FANTOM5 dbSUPER 11.9 +55.8 55847 0.2 AIDA BROX TAF1A MIA3 ENSG00000272750 ENSG00000229399
GH01J222732 Enhancer 0.8 ENCODE 0.4 -19.4 -19444 0.2 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM GC01P222732 AIDA BROX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AIDA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AIDA gene promoter:
  • RP58
  • AREB6
  • NRSF form 2
  • NRSF form 1
  • MyoD
  • Pax-6
  • MAZR
  • POU2F1
  • POU2F1a
  • POU2F1b

Genomic Locations for AIDA Gene

Genomic Locations for AIDA Gene
chr1:222,668,013-222,713,210
(GRCh38/hg38)
Size:
45,198 bases
Orientation:
Minus strand
chr1:222,841,355-222,886,552
(GRCh37/hg19)
Size:
45,198 bases
Orientation:
Minus strand

Genomic View for AIDA Gene

Genes around AIDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AIDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AIDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AIDA Gene

Proteins for AIDA Gene

  • Protein details for AIDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BJ3-AIDA_HUMAN
    Recommended name:
    Axin interactor, dorsalization-associated protein
    Protein Accession:
    Q96BJ3
    Secondary Accessions:
    • A8K1F0
    • Q49A81
    • Q5JRA4
    • Q658P1
    • Q9H9E8

    Protein attributes for AIDA Gene

    Size:
    306 amino acids
    Molecular mass:
    35023 Da
    Quaternary structure:
    • Interacts with AXIN1.

    Alternative splice isoforms for AIDA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AIDA Gene

Post-translational modifications for AIDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AIDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AIDA Gene

Domains & Families for AIDA Gene

Gene Families for AIDA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AIDA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AIDA Gene

Graphical View of Domain Structure for InterPro Entry

Q96BJ3

UniProtKB/Swiss-Prot:

AIDA_HUMAN :
  • Belongs to the AIDA family.
Family:
  • Belongs to the AIDA family.
genes like me logo Genes that share domains with AIDA: view

Function for AIDA Gene

Molecular function for AIDA Gene

UniProtKB/Swiss-Prot Function:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).

Gene Ontology (GO) - Molecular Function for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019904 protein domain specific binding IEA --
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with AIDA: view
genes like me logo Genes that share phenotypes with AIDA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AIDA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AIDA Gene

Localization for AIDA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AIDA gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with AIDA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AIDA Gene

Pathways & Interactions for AIDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for AIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0043496 regulation of protein homodimerization activity ISS --
GO:0043508 negative regulation of JUN kinase activity IDA 17681137
GO:0046329 negative regulation of JNK cascade ISS --
genes like me logo Genes that share ontologies with AIDA: view

No data available for Pathways by source and SIGNOR curated interactions for AIDA Gene

Drugs & Compounds for AIDA Gene

(7) Drugs for AIDA Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Idarubicin Approved Pharma 226
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1603
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist 242
6-Mercaptopurine Pharma 208
Anti-Bacterial Agents Pharma 12177
genes like me logo Genes that share compounds with AIDA: view

Transcripts for AIDA Gene

mRNA/cDNA for AIDA Gene

Unigene Clusters for AIDA Gene

Axin interactor, dorsalization associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AIDA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AIDA Gene

No ASD Table

Relevant External Links for AIDA Gene

GeneLoc Exon Structure for
AIDA
ECgene alternative splicing isoforms for
AIDA

Expression for AIDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AIDA Gene

Protein differential expression in normal tissues from HIPED for AIDA Gene

This gene is overexpressed in Uterus (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AIDA Gene



Protein tissue co-expression partners for AIDA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AIDA Gene:

AIDA

SOURCE GeneReport for Unigene cluster for AIDA Gene:

Hs.156625

mRNA Expression by UniProt/SwissProt for AIDA Gene:

Q96BJ3-AIDA_HUMAN
Tissue specificity: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.

Evidence on tissue expression from TISSUES for AIDA Gene

  • Nervous system(4.8)
  • Pancreas(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with AIDA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AIDA Gene

Orthologs for AIDA Gene

This gene was present in the common ancestor of chordates.

Orthologs for AIDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AIDA 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AIDA 34 33
  • 96.62 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AIDA 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AIDA 34 33
  • 95.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Aida 16 34 33
  • 93.01 (n)
rat
(Rattus norvegicus)
Mammalia Aida 33
  • 91.91 (n)
oppossum
(Monodelphis domestica)
Mammalia AIDA 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AIDA 34 33
  • 87.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AIDA 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76000 33
zebrafish
(Danio rerio)
Actinopterygii aida 34 33
  • 74.04 (n)
OneToOne
zgc73327 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for AIDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AIDA Gene

ENSEMBL:
Gene Tree for AIDA (if available)
TreeFam:
Gene Tree for AIDA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AIDA: view image

Paralogs for AIDA Gene

Pseudogenes.org Pseudogenes for AIDA Gene

genes like me logo Genes that share paralogs with AIDA: view

No data available for Paralogs for AIDA Gene

Variants for AIDA Gene

Sequence variations from dbSNP and Humsavar for AIDA Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000015069 -- 222,706,480(-) T/C intron_variant
rs1000081598 -- 222,689,710(-) A/G intron_variant
rs1000095755 -- 222,711,862(-) G/A intron_variant
rs1000164543 -- 222,699,681(-) T/C intron_variant
rs1000175183 -- 222,696,776(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AIDA Gene

Variant ID Type Subtype PubMed ID
nsv945309 CNV duplication 23825009
esv3335605 CNV insertion 20981092
esv1787433 CNV insertion 17803354

Variation tolerance for AIDA Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AIDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AIDA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AIDA Gene

Disorders for AIDA Gene

Additional Disease Information for AIDA

No disorders were found for AIDA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AIDA Gene

Publications for AIDA Gene

  1. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. (PMID: 17681137) Rui Y … Lin SC (Developmental cell 2007) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for AIDA Gene

Sources for AIDA Gene

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