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The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cau... See more...
Aliases for AHSG Gene
Aliases for AHSG Gene
External Ids for AHSG Gene
- HGNC: 349
- Entrez Gene: 197
- Ensembl: ENSG00000145192
- OMIM: 138680
- UniProtKB: P02765
Previous GeneCards Identifiers for AHSG Gene
- GC03P183102
- GC03P187587
- GC03P187732
- GC03P187651
- GC03P187813
- GC03P186330
- GC03P183739
Summaries for AHSG Gene
-
The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]
GeneCards Summary for AHSG Gene
AHSG (Alpha 2-HS Glycoprotein) is a Protein Coding gene. Diseases associated with AHSG include Alopecia-Mental Retardation Syndrome 1 and Alopecia-Intellectual Disability Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by BMP. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity and kinase inhibitor activity. An important paralog of this gene is FETUB.
UniProtKB/Swiss-Prot Summary for AHSG Gene
-
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Additional gene information for AHSG Gene
- HGNC(349)
- Entrez Gene(197)
- Ensembl(ENSG00000145192)
- OMIM(138680)
- UniProtKB(P02765)
- Open Targets Platform(ENSG00000145192)
- Monarch Initiative
- Search for AHSG at DataMed
- Search for AHSG at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AHSG Gene
Genomics for AHSG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AHSG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AHSG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AHSG
- Top Transcription factor binding sites by QIAGEN in the AHSG gene promoter:
-
- AML1a
- C/EBPalpha
- E4BP4
- FOXL1
- GATA-1
- NF-kappaB
- NF-kappaB1
- SRY
- STAT3
Genomic Locations for AHSG Gene
Genomic Locations for AHSG Gene
- chr3:186,613,060-186,621,318
- (GRCh38/hg38)
- Size:
- 8,259 bases
- Orientation:
- Plus strand
- chr3:186,330,712-186,339,107
- (GRCh37/hg19)
- Size:
- 8,396 bases
- Orientation:
- Plus strand
Genomic View for AHSG Gene
Genes around AHSG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q27.3 by HGNC
- 3q27.3 by Entrez Gene
- 3q27.3 by Ensembl
AHSG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AHSG Gene
Proteins for AHSG Gene
-
Protein details for AHSG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02765-FETUA_HUMAN
- Recommended name:
- Alpha-2-HS-glycoprotein
- Protein Accession:
- P02765
- A8K9N6
- B2R7G1
- O14961
- O14962
- Q9P152
Protein attributes for AHSG Gene
- Size:
- 367 amino acids
- Molecular mass:
- 39341 Da
- Quaternary structure:
-
- Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.
Protein Expression for AHSG Gene
Post-translational modifications for AHSG Gene
- Phosphorylated by FAM20C in the extracellular medium.
- O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).
-
Glycosylation at Asn156, Asn176, Thr270, Ser280, Ser293, Thr339, Thr341, and Ser346
- NX_P02765 (NX_P02765-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- FETUA_HUMAN (23)
Other Protein References for AHSG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences AHSG / Fetuin A Antibody
- G Biosciences Immunotag™ AHSG Antibody
- NSJ Bioreagents Fetuin-A Antibody / AHSG
- HUABIO Anti-Fetuin A/AHSG Antibody
-
Custom Antibody ServicesOriGene Antibodies for AHSG
- Novus Biologicals Antibodies for AHSG
- Invitrogen Antibodies for AHSG (AFLGC-AHSG)
-
Santa Cruz Biotechnology (SCBT) Antibodies for AHSG
- Sino Biological Antibodies for AHSG
Protein Products
- G Biosciences Human Fetuin A/AHSG, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for AHSG
- Origene Custom Protein Services for AHSG
- Sino Biological Recombinant Proteins for AHSG
- Sino Biological Cell Lysates for AHSG
- ProSpec Recombinant Proteins for AHSG
Assay Products
- RayBiotech Human Fetuin A ELISA
-
Custom Assay ServicesOriGene ELISA Kits for AHSG
- Novus Biologicals ELISA Kits for AHSG
-
Boster Bio ELISA Kits for AHSG
-
Abcam assays for AHSG
- Sino Biological Assays for AHSG
No data available for DME Specific Peptides for AHSG Gene
Domains & Families for AHSG Gene
Gene Families for AHSG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for AHSG Gene
- InterPro:
- Blocks:
-
- Cysteine protease inhibitor
- ProtoNet:
Suggested Antigen Peptide Sequences for AHSG Gene
- GenScript: Design optimal peptide antigens:
-
- Fetuin-A (FETUA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P02765- Family:
-
- Belongs to the fetuin family.
Function for AHSG Gene
Molecular function for AHSG Gene
- UniProtKB/Swiss-Prot Function:
- Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
- GENATLAS Biochemistry:
- HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily)
Phenotypes From GWAS Catalog for AHSG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004866 | endopeptidase inhibitor activity | IBA | 21873635 |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0019210 | kinase inhibitor activity | NAS | 12203945 |
Phenotypes for AHSG Gene
- MGI mutant phenotypes for AHSG:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for AHSG:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AHSG - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for AHSG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHSG
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Clone Products
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- Sino Biological Human cDNA Clone for AHSG
- Addgene plasmids for AHSG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHSG
Cell Line Products
-
Horizon Cell Lines for AHSG
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for AHSG Gene
Localization for AHSG Gene
Subcellular locations from UniProtKB/Swiss-Prot for AHSG Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | IEA,NAS | 11922920 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0031012 | extracellular matrix | IBA | 21873635 |
Pathways & Interactions for AHSG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Glucose / Energy Metabolism | ||
| 4 | Signaling by BMP | ||
Pathways by source for AHSG Gene
1 BioSystems pathway for AHSG Gene
7 Reactome pathways for AHSG Gene
1 Cell Signaling Technology pathway for AHSG Gene
Interacting Proteins for AHSG Gene
GPS-Prot Interaction Network for AHSG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | NAS | 12153747 |
| GO:0001503 | ossification | IEA | -- |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006907 | pinocytosis | NAS | 12773197 |
| GO:0006953 | acute-phase response | IDA | 12153747 |
No data available for SIGNOR curated interactions for AHSG Gene
Drugs & Compounds for AHSG Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 249 | ||
| Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target, chelator | 0 | ||
| Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, chelator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for AHSG Gene
mRNA/cDNA for AHSG Gene
- 4 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000411641 1574 nts (view in UCSC)
- ENST00000273784 1553 nts (view in UCSC)
- ENST00000478441 1269 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AHSG - Select products 50% OFF >
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-
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-
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AHSG
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Clone Products
- Applied Biological Materials (abm): Clones for AHSG - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for AHSG
- Addgene plasmids for AHSG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHSG
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | - |
Relevant External Links for AHSG Gene
- GeneLoc Exon Structure for
- AHSG
Expression for AHSG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Left Ventricle
- Right Ventricle
- Left Atrium
- Right Atrium
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Autopod
- Zeugopod
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
- NULL (Uncategorized)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Gut Tube (Gastrointestinal Tract)
- Smooth Muscle (Muscoskeletal System)
- Epithelial Cells (Uncategorized)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for AHSG Gene
This gene is overexpressed in Liver (x52.7).
This gene is overexpressed in Serum (13.6), Lavage (12.3), Plasma (9.8), Synovial fluid (9.1), and Monocytes (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AHSG Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AHSG
SOURCE GeneReport for Unigene cluster for AHSG Gene:
Hs.324746mRNA Expression by UniProt/SwissProt for AHSG Gene:
P02765-FETUA_HUMAN
Tissue specificity:
Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
Evidence on tissue expression from TISSUES for AHSG Gene
- Liver(5)
- Blood(4.7)
- Nervous system(4.5)
- Bone marrow(4.4)
- Saliva(4.3)
- Heart(3.3)
- Kidney(2.8)
- Lung(2.6)
- Muscle(2.5)
- Bone(2.4)
- Intestine(2.3)
- Pancreas(2.3)
- Urine(2.3)
- Skin(2.2)
Primer Products
-
OriGene qPCR primer pairs for AHSG
-
OriGene qPCR primer pairs and template standards for AHSG
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AHSG Gene
Orthologs for AHSG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AHSG 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | AHSG 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | AHSG 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ahsg 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ahsg 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | AHSG 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | AHSG 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | AHSG 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | AHSG 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ahsg 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ahsg 30 |
|
||
| AHSG 31 |
|
OneToOne |
- Species where no ortholog for AHSG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for AHSG Gene
- ENSEMBL:
- Gene Tree for AHSG (if available)
- TreeFam:
- Gene Tree for AHSG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AHSG: view image
Paralogs for AHSG Gene
Variants for AHSG Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for AHSG Gene
- FETUA_HUMAN-P02765
- There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AHSG Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 728698 | Benign: not provided | 186,613,349(+) | C/T | MISSENSE_VARIANT | |
| 737830 | Benign: not provided | 186,617,180(+) | C/T | INTRON_VARIANT | |
| 747405 | Benign: not provided | 186,620,608(+) | C/G | MISSENSE_VARIANT | |
| 753004 | Likely Benign: not provided | 186,620,903(+) | G/C | SYNONYMOUS_VARIANT | |
| 774853 | Benign: not provided | 186,620,845(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759206 | CNV | loss | 17122850 |
| nsv508974 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.22;
39.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AHSG Gene
SNP Genotyping and Copy Number Assay Products
Disorders for AHSG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alopecia-mental retardation syndrome 1 |
|
|
| alopecia-intellectual disability syndrome |
|
|
| alopecia-mental retardation syndrome |
|
|
| alopecia |
|
|
| epstein-barr virus hepatitis |
|
|
Search AHSG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FETUA_HUMAN- Alopecia-mental retardation syndrome 1 (APMR1) [MIM:203650]: A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation. {ECO:0000269 PubMed:28054173}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Additional Disease Information for AHSG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for AHSG Gene
Publications for AHSG Gene
- Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PMID: 9322749) Osawa M … Takeichi S (Gene 1997) 2 3 4 23
- Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. (PMID: 20031641) Fisher E … Weikert C (Circulation. Cardiovascular genetics 2009) 3 23 41
- Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease? (PMID: 18337634) Axelsson J … Stenvinkel P (American journal of nephrology 2008) 3 23 41
- AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects. (PMID: 18316360) Andersen G … Pedersen O (Diabetes 2008) 3 23 41
- Association and linkage analysis of COL1A1 and AHSG gene polymorphisms with femoral neck bone geometric parameters in both Caucasian and Chinese nuclear families. (PMID: 17303000) Jiang H … Deng HW (Acta pharmacologica Sinica 2007) 3 23 41
ExternalLinks
Products for AHSG Gene
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- antibodies-online: Show 56 available Fetuin A Antibodies ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for AHSG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AHSG
- Horizon Cell Lines for AHSG
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AHSG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AHSG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for AHSG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AHSG
Sources for AHSG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB