Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AHSA2P Gene

Aliases for AHSA2P Gene

  • Activator Of HSP90 ATPase Homolog 2, Pseudogene 2 3 5
  • Activator Of HSP90 ATPase Homolog 2 2 3
  • AHSA2 3 4
  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 (Yeast) 2
  • AHA1, Activator Of Heat Shock 90kDa Protein ATPase Homolog 2 3
  • Activator Of 90 KDa Heat Shock Protein ATPase Homolog 2 3
  • Activator Of HSP90 ATPase Homolog 2 Pseudogene 4
  • AHA1 3
  • Hch1 3

External Ids for AHSA2P Gene

Previous HGNC Symbols for AHSA2P Gene

  • AHSA2

Summaries for AHSA2P Gene

GeneCards Summary for AHSA2P Gene

AHSA2P (Activator Of HSP90 ATPase Homolog 2, Pseudogene) is a Pseudogene.

UniProtKB/Swiss-Prot for AHSA2P Gene

  • Co-chaperone that stimulates HSP90 ATPase activity.

Additional gene information for AHSA2P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AHSA2P Gene

Genomics for AHSA2P Gene

GeneHancer (GH) Regulatory Elements for AHSA2P Gene

Promoters and enhancers for AHSA2P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J061176 Promoter/Enhancer 1.6 Ensembl ENCODE 709.1 +1.3 1316 5 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B AHSA2P LOC339803 NONOP2 ENSG00000232713 XPO1 REL USP34 LOC105377633 ENSG00000273302
GH02J061015 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 66.3 -159.5 -159520 4.4 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PUS10 PEX13 AHSA2P PAPOLG ENSG00000236498 USP34 CCT4 ENSG00000232713 XPO1 NONOP2
GH02J061886 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.5 +710.9 710885 3.5 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CCT4 COMMD1 AHSA2P ENSG00000236498 ENSG00000232713 ENSG00000273302 USP34 XPO1 NONOP2 PUS10
GH02J061534 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31 +360.0 359972 5.2 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 XPO1 CCT4 USP34 REL ENSG00000232713 AHSA2P LOC339803 NONOP2 PAPOLG ENSG00000236498
GH02J061144 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 35.3 -32.3 -32338 1.8 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ATF7 NFKBIZ RXRA LOC339803 C2orf74 PIR40098 AHSA2P PIR46388 ENSG00000274769 KIAA1841
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AHSA2P on UCSC Golden Path with GeneCards custom track

Genomic Locations for AHSA2P Gene

Genomic Locations for AHSA2P Gene
chr2:61,177,418-61,191,203
(GRCh38/hg38)
Size:
13,786 bases
Orientation:
Plus strand
chr2:61,404,553-61,418,338
(GRCh37/hg19)

Genomic View for AHSA2P Gene

Genes around AHSA2P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AHSA2P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AHSA2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AHSA2P Gene

Proteins for AHSA2P Gene

  • Protein details for AHSA2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q719I0-AHSA2_HUMAN
    Recommended name:
    Putative activator of 90 kDa heat shock protein ATPase homolog 2
    Protein Accession:
    Q719I0
    Secondary Accessions:
    • B3KS51
    • D6W5E0
    • Q8NDU5

    Protein attributes for AHSA2P Gene

    Size:
    299 amino acids
    Molecular mass:
    33806 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AHSA2P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AHSA2P Gene

Post-translational modifications for AHSA2P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AHSA2P Gene

Domains & Families for AHSA2P Gene

Gene Families for AHSA2P Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AHSA2P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AHSA2P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q719I0

UniProtKB/Swiss-Prot:

AHSA2_HUMAN :
  • Belongs to the AHA1 family.
Family:
  • Belongs to the AHA1 family.
genes like me logo Genes that share domains with AHSA2P: view

Function for AHSA2P Gene

Molecular function for AHSA2P Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that stimulates HSP90 ATPase activity.

Phenotypes From GWAS Catalog for AHSA2P Gene

Gene Ontology (GO) - Molecular Function for AHSA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with AHSA2P: view

Phenotypes for AHSA2P Gene

genes like me logo Genes that share phenotypes with AHSA2P: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AHSA2P Gene

Localization for AHSA2P Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AHSA2P gene
Compartment Confidence
cytoskeleton 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AHSA2P Gene

Pathways & Interactions for AHSA2P Gene

SuperPathways for AHSA2P Gene

No Data Available

Interacting Proteins for AHSA2P Gene

Gene Ontology (GO) - Biological Process for AHSA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with AHSA2P: view

No data available for Pathways by source and SIGNOR curated interactions for AHSA2P Gene

Drugs & Compounds for AHSA2P Gene

No Compound Related Data Available

Transcripts for AHSA2P Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AHSA2P Gene

No ASD Table

Relevant External Links for AHSA2P Gene

GeneLoc Exon Structure for
AHSA2P
ECgene alternative splicing isoforms for
AHSA2P

Expression for AHSA2P Gene

NURSA nuclear receptor signaling pathways regulating expression of AHSA2P Gene:

AHSA2P

Evidence on tissue expression from TISSUES for AHSA2P Gene

  • Nervous system(4.6)
  • Intestine(4.3)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AHSA2P Gene

Orthologs for AHSA2P Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AHSA2P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AHSA2 34 33
  • 98.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AHSA2 33
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Ahsa2 34
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AHSA2 34
  • 24 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AHSA2 34
  • 24 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AHSA2 34
  • 21 (a)
OneToOne
chicken
(Gallus gallus)
Aves AHSA2 34
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1416 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G10.8 34
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHA1 34
  • 6 (a)
ManyToMany
HCH1 34
  • 5 (a)
ManyToMany
Species where no ortholog for AHSA2P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AHSA2P Gene

ENSEMBL:
Gene Tree for AHSA2P (if available)
TreeFam:
Gene Tree for AHSA2P (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AHSA2P: view image

Paralogs for AHSA2P Gene

No data available for Paralogs for AHSA2P Gene

Variants for AHSA2P Gene

Sequence variations from dbSNP and Humsavar for AHSA2P Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_038256 A breast cancer sample p.Met248Thr
rs1000339052 -- 61,190,074(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000561399 -- 61,184,945(+) C/T intron_variant
rs1000632388 -- 61,179,945(+) T/C intron_variant
rs1000643119 -- 61,186,961(+) T/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AHSA2P Gene

Variant ID Type Subtype PubMed ID
esv2760616 CNV loss 21179565
nsv819479 CNV loss 19587683

Variation tolerance for AHSA2P Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AHSA2P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AHSA2P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AHSA2P Gene

Disorders for AHSA2P Gene

No disorders were found for AHSA2P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for AHSA2P Gene

Publications for AHSA2P Gene

  1. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PMID: 12504007) Panaretou B … Prodromou C (Molecular cell 2002) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PMID: 12604615) Lotz GP … Obermann WM (The Journal of biological chemistry 2003) 3 22 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L … Cho JH (Nature 2012) 3 58

Products for AHSA2P Gene

Sources for AHSA2P Gene

Content
Loading form....